Effect of cinnamon, cardamom, saffron and ginger consumption on blood pressure and a marker of endothelial function in patients with type 2 diabetes mellitus: A randomized controlled clinical trial

Blood Pressure

Volumn 25, Issue 3, 2016, Pages 133-140

  Azimi, Paria ^a,b   Ghiasvand, Reza ^a,b   Feizi, Awat ^b   Hosseinzadeh, Javad ^a,b   Bahreynian, Maryam ^a,b   Hariri, Mitra ^a,b   Khosravi Boroujeni, Hossein ^c  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c GRIFFITH UNIVERSITY   (Australia)

Author keywords

Blood pressure; diabetes mellitus type 2; endothelial function; herbal

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1;

ADULT; ANTHROPOMETRY; ARTICLE; BLOOD PRESSURE; CARDAMOM; CONTROLLED STUDY; CROCUS SATIVUS; DIASTOLIC BLOOD PRESSURE; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM; FEMALE; FOOD INTAKE; GINGER; HERBAL MEDICINE; HUMAN; INTERVENTION STUDY; MAJOR CLINICAL STUDY; MALE; MEDICINAL PLANT; NON INSULIN DEPENDENT DIABETES MELLITUS; PARALLEL DESIGN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SYSTOLIC BLOOD PRESSURE; TEA; ANALYSIS; BLOOD; BLOOD PRESSURE MEASUREMENT; CHEMISTRY; CINNAMOMUM ZEYLANICUM; COMPLICATION; CROCUS; DIABETES MELLITUS, TYPE 2; ELETTARIA; FUNCTIONAL FOOD; HYPERTENSION; MIDDLE AGED; PATHOPHYSIOLOGY;

BLOOD PRESSURE; BLOOD PRESSURE DETERMINATION; CINNAMOMUM ZEYLANICUM; CROCUS; DIABETES MELLITUS, TYPE 2; ELETTARIA; ENDOTHELIUM; FEMALE; FUNCTIONAL FOOD; GINGER; HUMANS; HYPERTENSION; INTERCELLULAR ADHESION MOLECULE-1; MALE; MIDDLE AGED; PLANTS, MEDICINAL;

EID: 84954290053     PISSN: 08037051     EISSN: 16511999     Source Type: Journal    
DOI: 10.3109/08037051.2015.1111020     Document Type: Article

References (33)

1. S.Smyth, A.Heron Diabetes and obesity: the twin epidemics. Nat Med. 2006;12:75–80.
2. D.Meetoo, P.Mcgovern, R.Safadi An epidemiological overview of diabetes across the world. Br J Nurs. 2007;16:1002–1007.
3. H.Harati, F.Hadaegh, N.Saadat, F.Azizi Population-based incidence of type 2 diabetes and its associated risk factors: results from a six-year cohort study in Iran. BMC Public Health. 2009;9:186–194.
4. D.Darko, A.Dornhorst, F.Kelly, J.Ritter, P.Chowienczyk Lack of effect of oral vitamin C on blood pressure, oxidative stress and endothelial function in type II diabetes. Clin Sci. 2002;103:339–344.
5. S.Cottone, G.Mule, E.Nardi, A.Vadala, et al. C-reactive protein and intercellular adhesion molecule-1 are stronger predictors of oxidant stress than blood pressure in established hypertension. J Hypertens. 2007;25:423–428.
6. K.Mahn, C.Borrás, G.A.Knock, P.Taylor, I.Y.Khan, D.Sugden, et al. Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo. FASEB J. 2005;19:1755–1757.
7. C.K.Ferrari Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging. Biogerontology. 2004;5:275–289.
8. B.Qin, K.S.Panickar, R.A.Anderson Cinnamon: potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes. J Diabetes Sci Technol. 2010;4:685–693.
9. A.Kelble Spices and type 2 diabetes. Nutr Food Sci. 2005;35:81–87.
10. D.F.Fitzpatrick, S.L.Hirschfield, T.Ricci, P.Jantzen, R.G.Coffey Endothelium-dependent vasorelaxation caused by various plant extracts. Nutr Food Sci. 1995;26:90–95.
11. R.Akilen, Z.Pimlott, A.Tsiami, N.Robinson Effect of short-term administration of cinnamon on blood pressure in patients with prediabetes and type 2 diabetes. Nutrition. 2013;29:1192–1196.
12. M.Vafa, F.Mohammadi, F.Shidfar, M.S.Sormaghi, I.Heidari, B.Golestan, F.Amiri Effects of cinnamon consumption on glycemic status, lipid profile and body composition in type 2 diabetic patients. Int J Prevent Med. 2012;3:531–536.
13. R.Kaur, N.Khannab Pathophysiology and risk factors related to hypertension and its cure using herbal drugs. Spatula DD. 2012;2:245–256.
14. S.Verma, V.Jain, S.Katewa Blood pressure lowering, fibrinolysis enhancing and antioxidant activities of cardamom (Elettaria cardamomum). Indian J Biochem Biophys. 2009;46:503–506.
15. A.H.Gilani, Q.Jabeen, A.-U.Khan, A.J.Shah Gut modulatory, blood pressure lowering, diuretic and sedative activities of cardamom. J Ethnopharmacol. 2008;115: 463–472.
16. L.Xi, Z.Qian, G.Xu, S.Zheng, S.Sun, N.Wen, et al. Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats. J Nutr Biochem. 2007;18:64–72.
17. S.-Y.He, Z.-Y.Qian, N.Wen, F.-T.Tang, G.-L.Xu, C.-H.Zhou Influence of crocetin on experimental atherosclerosis in hyperlipidamic-diet quails. Eur J Phycol. 2007;554:191–195.
18. M.Imenshahidi, H.Hosseinzadeh, Y.Javadpour Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother Res. 2010;24:990–994.
19. B.Gout, C.Bourges, S.Paineau-Dubreuil Satiereal, a Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy women. Nutr Res. 2010;30:305–313.
20. T.-F.Tzeng, S.-S.Liou, C.J.Chang, I.-M.Liu Zerumbone, a tropical ginger sesquiterpene, ameliorates streptozotocin-induced diabetic nephropathy in rats by reducing the hyperglycemia-induced inflammatory response. Nutr Metab. 2013;10:64–76.
21. S.Atashak, M.Peeri, M.A.Azarbayjani, S.R.Stannard, M.M.Haghighi Obesity-related cardiovascular risk factors after long-term resistance training and ginger supplementation. J Sports Sci Med. 2011;10:685–691.
22. D.Machin, M.J.Campbell, S.-B.Tan, S.-H.Tan Sample size tables for clinical studies. 3rd ed. Chichester: John Wiley & Sons; 2011.
23. C.Craig, A.Marshall, M.Sjöström, A.Bauman, M.Booth, B.Ainsworth, et al.; IPAQ Consensus Group; IPAQ Reliability and Validity Study Group. International Physical Activity Questionnaire (IPAQ): 12-country reliability and validity. Med Sci Sports Exerc. 2003;35: 1381–1395.
24. A.S.De Vriese, T.J.Verbeuren, J.Van de Voorde, N.H.Lameire, P.M.Vanhoutte Endothelial dysfunction in diabetes. Br J Pharmacol. 2000;130:963–974.
25. T.Elhadd, G.Kennedy, R.Robb, M.McLaren, R.Jung, J.Belch Elevated soluble cell adhesion molecules E-selectin and intercellular cell adhesion molecule-1 in type-2 diabetic patients with and without asymptomatic peripheral arterial disease. Int Angiol. 2004;23:128–133.
26. M.Xiang, Z.-Y.Qian, C.-H.Zhou, J.Liu, W.-N.Li Crocetin inhibits leukocyte adherence to vascular endothelial cells induced by AGEs. J Ethnopharmacol. 2006;107:25–31.
27. Y.Song, X.Wei, H.Ding, X.Cheng Influence of effective part of Zingiber officinal on expression of monocyte chemotactic protein-1 and adhesion molecules. China Journal of Chinese Materia Medica. 2007;32:2062–2065.
28. B.-C.Liao, C.-W.Hsieh, Y.-C.Liu, T.-T.Tzeng, Y.-W.Sun, B.-S.Wung Cinnamaldehyde inhibits the tumor necrosis factor-α-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-κB activation: effects upon IκB and Nrf2. Toxicol Appl Pharmacol. 2008;229:161–171.
29. UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ. 1998;317:703.
30. M.N.Ghayur, A.H.Gilani Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. J Cardiovasc Pharmacol. 2005;45:74–80.
31. M.Imenshahidi, B.M.Razavi, A.Faal, A.Gholampoor, S.M.Mousavi, H.Hosseinzadeh Effects of chronic crocin treatment on desoxycorticosterone acetate (doca)-salt hypertensive rats. Iran J Basic Med Sci. 2014; 17:9–13.
32. M.-H.Modaghegh, M.Shahabian, H.-A.Esmaeili, O.Rajbai, H.Hosseinzadeh Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers. Phytomedicine. 2008;15:1032–1037.
33. P.Lund-Johansen Hemodynamic effects of calcium antagonists in hypertension. In: M.Epstein, editor. Calcium antagonists in clinical medicine. 1992. p. 62–98.