Downregulation of miR-30c promotes renal fibrosis by target CTGF in diabetic nephropathy

Journal of Diabetes and its Complications

Volumn 30, Issue 3, 2016, Pages 406-414

  Wang, Jinyang ^a,b   Duan, Lijun ^a   Guo, Tiankang ^b   Gao, Yanbin ^c   Tian, Limin ^a,b   Liu, Jing ^a,b   Wang, Shaocheng ^d   Yang, Jinkui ^e  

^a GANSU PROVINCIAL HOSPITAL   (China)

^b Gansu Key Laboratory of Endocrine and metabolism   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d TIANJIN MEDICAL UNIVERSITY   (China)

^e CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Connective tissue growth factor (CTGF); Diabetic nephropathy (DN); MicroRNAs (miRs); Renal fibrosis; Renal structure and function

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; MICRORNA; MICRORNA 30C; UNCLASSIFIED DRUG; CTGF PROTEIN, MOUSE; MIRN30D MICRORNA, MOUSE;

ARTICLE; CONFOCAL LASER MICROSCOPY; CYTOPLASM; DIABETIC NEPHROPATHY; DOWN REGULATION; ELECTRON MICROSCOPE; EPITHELIUM CELL; GENETIC TRANSFECTION; IN SITU HYBRIDIZATION; KIDNEY CORTEX; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY PARENCHYMA; KIDNEY STRUCTURE; KIDNEY TUBULE CELL; LUCIFERASE ASSAY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; DISEASE MODEL; FIBROSIS; GENETICS; HUMAN; KIDNEY; METABOLISM; MOUSE; PATHOLOGY;

ANIMALS; CONNECTIVE TISSUE GROWTH FACTOR; DIABETIC NEPHROPATHIES; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FIBROSIS; HUMANS; KIDNEY; MICE; MICE, INBRED C57BL; MICRORNAS;

EID: 84954289114     PISSN: 10568727     EISSN: 1873460X     Source Type: Journal    
DOI: 10.1016/j.jdiacomp.2015.12.011     Document Type: Article

References (51)

1. K. Al-Rubeaan, A.M. Youssef, S.N. Subhani, N.A. Ahmad, A.H. Al-Sharqawi, and H.M. Al-Mutlaq D. AlNaqeb Diabetic nephropathy and its risk factors in a society with a type 2 diabetes epidemic: A Saudi National Diabetes Registry-based study PLoS One 9 2 2014 e88956
2. D.M. Bradham, A. Igarashi, R.L. Potter, and G.R. Grotendorst Connective tissue growth factor: A cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10 Journal of Cell Biology 114 6 1991 1285 1294
3. R.F. Duisters, A.J. Tijsen, B. Schroen, J.J. Leenders, V. Lentink, I. van Der Made, E.E. Creemers miR-133 and miR-30 regulate connective tissue growth factor: Implications for a role of microRNAs in myocardial matrix remodeling Circulation Research 104 2 2009 170 178 (176p following 178)
4. A. Ernst, B. Campos, J. Meier, F. Devens, F. Liesenberg, and M. Wolter B. Radlwimmer De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures Oncogene 29 23 2010 3411 3422
5. N. Faherty, S.P. Curran, H. O'Donovan, F. Martin, C. Godson, D.P. Brazil, and J.K. Crean CCN2/CTGF increases expression of miR-302 microRNAs, which target the TGFbeta type II receptor with implications for nephropathic cell phenotypes Journal of Cell Science 125 Pt 23 2012 5621 5629
6. P. Fioretto, and M. Mauer Diabetic nephropathy: diabetic nephropathy-challenges in pathologic classification Nature Reviews Nephrology 6 9 2010 508 510
7. J.L. Fox, M. Dews, A.J. Minn, and A. Thomas-Tikhonenko Targeting of TGFbeta signature and its essential component CTGF by miR-18 correlates with improved survival in glioblastoma RNA 19 2 2013 177 190
8. R.E. Gilbert, and M.E. Cooper The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury? Kidney International 56 5 1999 1627 1637
9. T. Gohda, A. Mima, J.Y. Moon, and K. Kanasaki Combat diabetic nephropathy: from pathogenesis to treatment Journal of diabetes research 2014 2014 207140
10. A. Gutierrez-Escolano, E. Santacruz-Vazquez, and F. Gomez-Perez Dysregulated microRNAs involved in contrast-induced acute kidney injury in rat and human Renal Failure 37 9 2015 1498 1506
11. A.J. Hanley, K. Williams, M.P. Stern, and S.M. Haffner Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: The San Antonio Heart Study Diabetes Care 25 7 2002 1177 1184
12. T.H. Hostetter Progression of renal disease and renal hypertrophy Annual Review of Physiology 57 1995 263 278
13. H.C. Huang, and P.A. Preisig G1 kinases and transforming growth factor-beta signaling are associated with a growth pattern switch in diabetes-induced renal growth Kidney International 58 1 2000 162 172
14. P. Kantharidis, B. Wang, R.M. Carew, and H.Y. Lan Diabetes complications: The microRNA perspective Diabetes 60 7 2011 1832 1837
15. R.G. Lehmann, J.R. Miller, and G.E. Kozerski Degradation of silicone polymer in a field soil under natural conditions Chemosphere 41 5 2000 743 749
16. H.Y. Li, F.F. Hou, X. Zhang, P.Y. Chen, S.X. Liu, and J.X. Feng D. Xie Advanced oxidation protein products accelerate renal fibrosis in a remnant kidney model Journal of the American Society of Nephrology 18 2 2007 528 538
17. J. Li, S. Donath, Y. Li, D. Qin, B.S. Prabhakar, and P. Li miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway PLoS Genetics 6 1 2010 e1000795
18. L. Liu, W. Lin, Q. Zhang, W. Cao, and Z. Liu TGF-beta induces miR-30d down-regulation and podocyte injury through Smad2/3 and HDAC3-associated transcriptional repression Journal of molecular medicine (Berlin, Germany) 2015 10.1007/s00109-015-1340-9
19. R.M. Mason Connective tissue growth factor(CCN2), a pathogenic factor in diabetic nephropathy. What does it do? How does it do it? Journal of Cell Communication and Signaling 3 2 2009 95 104
20. R.M. Mason, and N.A. Wahab Extracellular matrix metabolism in diabetic nephropathy Journal of the American Society of Nephrology 14 5 2003 1358 1373
21. S.V. McLennan, X.Y. Wang, V. Moreno, D.K. Yue, and S.M. Twigg Connective tissue growth factor mediates high glucose effects on matrix degradation through tissue inhibitor of matrix metalloproteinase type 1: Implications for diabetic nephropathy Endocrinology 145 12 2004 5646 5655
22. T. Miyazaki, I. Aoyama, M. Ise, H. Seo, and T. Niwa An oral sorbent reduces overload of indoxyl sulphate and gene expression of TGF-beta1 in uraemic rat kidneys Nephrology, Dialysis, Transplantation 15 11 2000 1773 1781
23. M. Murphy, C. Godson, S. Cannon, S. Kato, H.S. Mackenzie, F. Martin, and H.R. Brady Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells Journal of Biological Chemistry 274 9 1999 5830 5834
24. S. Nishi, M. Ueno, S. Hisaki, N. Iino, S. Iguchi, and Y. Oyama F. Gejyo Ultrastructural characteristics of diabetic nephropathy Medical Electron Microscopy 33 2 2000 65 73
25. G. Obernosterer, J. Martinez, and M. Alenius Locked nucleic acid-based in situ detection of microRNAs in mouse tissue sections Nature Protocols 2 6 2007 1508 1514
26. R. Osterby Morphometric studies of the peripheral glomerular basement membrane. II. Topography of the initial lesions Diabetologia 9 2 1973 108 114
27. S. Ozcan MiR-30 family and EMT in human fetal pancreatic islets Islets 1 3 2009 283 285
28. K.V. Pandit, J. Milosevic, and N. Kaminski MicroRNAs in idiopathic pulmonary fibrosis Translational Research 157 4 2011 191 199
29. M.W. Pfaffl A new mathematical model for relative quantification in real-time RT-PCR Nucleic Acids Research 29 9 2001 e45
30. W. Qin, A.C. Chung, X.R. Huang, X.M. Meng, D.S. Hui, and C.M. Yu H.Y. Lan TGF-beta/Smad3 signaling promotes renal fibrosis by inhibiting miR-29 Journal of the American Society of Nephrology 22 8 2011 1462 1474
31. B.L. Riser, M. Denichilo, P. Cortes, C. Baker, J.M. Grondin, J. Yee, and R.G. Narins Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis Journal of the American Society of Nephrology 11 1 2000 25 38
32. O.V. Sakharova, M.W. Taal, and B.M. Brenner Pathogenesis of diabetic nephropathy: focus on transforming growth factor-beta and connective tissue growth factor Current Opinion in Nephrology and Hypertension 10 6 2001 727 738
33. G. Santulli, G. Iaccarino, N. De Luca, B. Trimarco, and G. Condorelli Atrial fibrillation and microRNAs Frontiers in Physiology 5 2014 15
34. T.D. Schmittgen, E.J. Lee, J. Jiang, A. Sarkar, L. Yang, T.S. Elton, and C. Chen Real-time PCR quantification of precursor and mature microRNA Methods 44 1 2008 31 38
35. S. Shi, L. Yu, C. Chiu, Y. Sun, J. Chen, and G. Khitrov E.P. Bottinger Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis Journal of the American Society of Nephrology 19 11 2008 2159 2169
36. X. Tang, L. Muniappan, G. Tang, and S. Ozcan Identification of glucose-regulated miRNAs from pancreatic {beta} cells reveals a role for miR-30d in insulin transcription RNA 15 2 2009 287 293
37. S.E. Thomson, S.V. McLennan, P.D. Kirwan, S.J. Heffernan, A. Hennessy, D.K. Yue, and S.M. Twigg Renal connective tissue growth factor correlates with glomerular basement membrane thickness and prospective albuminuria in a non-human primate model of diabetes: Possible predictive marker for incipient diabetic nephropathy Journal of Diabetes and its Complications 22 4 2008 284 294
38. X. Tu, X. Zheng, H. Li, Z. Cao, H. Chang, and S. Luan J. Zhang MicroRNA-30 Protects Against Carbon Tetrachloride-induced Liver Fibrosis by Attenuating Transforming Growth Factor Beta Signaling in Hepatic Stellate Cells Toxicological Sciences 146 1 2015 157 169
39. S. Vettori, S. Gay, and O. Distler Role of MicroRNAs in Fibrosis The Open Rheumatology Journal 6 2012 130 139
40. G. Viberti, and N.M. Wheeldon Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus: A blood pressure-independent effect Circulation 106 6 2002 672 678
41. N.A. Wahab, L. Schaefer, B.S. Weston, O. Yiannikouris, A. Wright, and A. Babelova R.M. Mason Glomerular expression of thrombospondin-1, transforming growth factor beta and connective tissue growth factor at different stages of diabetic nephropathy and their interdependent roles in mesangial response to diabetic stimuli Diabetologia 48 12 2005 2650 2660
42. N.A. Wahab, N. Yevdokimova, B.S. Weston, T. Roberts, X.J. Li, H. Brinkman, and R.M. Mason Role of connective tissue growth factor in the pathogenesis of diabetic nephropathy Biochemistry Journal 359 Pt 1 2001 77 87
43. J.Y. Wang, Y.B. Gao, N. Zhang, D.W. Zou, L.P. Xu, and Z.Y. Zhu J.K. Yang Tongxinluo ameliorates renal structure and function by regulating miR-21-induced epithelial-to-mesenchymal transition in diabetic nephropathy American Journal of Physiology. Renal Physiology 306 5 2014 F486 F495
44. A. Wronska, I. Kurkowska-Jastrzebska, and G. Santulli Application of microRNAs in diagnosis and treatment of cardiovascular disease Acta Physiologica (Oxford, England) 213 1 2015 60 83
45. J. Wu, C. Zheng, Y. Fan, C. Zeng, Z. Chen, and W. Qin Z. Liu Downregulation of microRNA-30 facilitates podocyte injury and is prevented by glucocorticoids Journal of the American Society of Nephrology 25 1 2014 92 104
46. J. Wu, C. Zheng, X. Wang, S. Yun, Y. Zhao, and L. Liu Z. Liu MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes Journal of Clinical Investigation 125 11 2015 4091 4106
47. H. Yang, Y. Huang, X. Chen, J. Liu, Y. Lu, and L. Bu Z. Liu The role of CTGF in the diabetic rat retina and its relationship with VEGF and TGF-beta(2), elucidated by treatment with CTGFsiRNA Acta Ophthalmologica 88 6 2010 652 659
48. T. Yokozawa, T. Nakagawa, K. Wakaki, and F. Koizumi Animal model of diabetic nephropathy Experimental and Toxicological Pathology 53 5 2001 359 363
49. F. Yu, H. Deng, H. Yao, Q. Liu, F. Su, and E. Song Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells Oncogene 29 29 2010 4194 4204
50. J. Zhang, H. Zhang, J. Liu, X. Tu, Y. Zang, and J. Zhu J. Zhang miR-30 inhibits TGF-beta1-induced epithelial-to-mesenchymal transition in hepatocyte by targeting Snail1 Biochemical and Biophysical Research Communications 417 3 2012 1100 1105
51. K. Zhong, K. Chen, L. Han, and B. Li MicroRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18 BMC Cancer 14 2014 703