Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling

European Journal of Immunology

Volumn 46, Issue 4, 2016, Pages 971-980

  Slowicka, Karolina ^a,b   Vereecke, Lars ^a,b   Mc Guire, Conor ^a,b   Sze, Mozes ^a,b   Maelfait, Jonathan ^c   Kolpe, Annasaheb ^b,d   Saelens, Xavier ^b,d   Beyaert, Rudi ^a,b   van Loo, Geert ^a,b  

^a Inflammation Research Center   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d Medical Biotechnology Centre   (Belgium)

Author keywords

Autophagy Inflammation Innate immunity Interferon NF B Optineurin

Indexed keywords

BETA INTERFERON; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR; INTERFERON REGULATORY FACTOR 3; OPTINEURIN; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; EYE PROTEIN; INTERFERON; IRF3 PROTEIN, MOUSE; LIPOPOLYSACCHARIDE; OPTN PROTEIN, MOUSE; POLYINOSINIC POLYCYTIDYLIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BACTERIAL CLEARANCE; BONE MARROW DERIVED MACROPHAGE; COLONY FORMING UNIT; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; GENE TARGETING; IN VIVO STUDY; INFLAMMATION; INNATE IMMUNITY; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SALMONELLA; SALMONELLOSIS; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; FIBROBLAST; GENETICS; IMMUNOLOGY; INFLUENZA A VIRUS (H3N2); KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; MICROBIOLOGY; ORTHOMYXOVIRUS INFECTION; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; VIROLOGY;

ANIMALS; EYE PROTEINS; FIBROBLASTS; INFLUENZA A VIRUS, H3N2 SUBTYPE; INTERFERON REGULATORY FACTOR-3; INTERFERON TYPE I; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; ORTHOMYXOVIRIDAE INFECTIONS; POLY I-C; SALMONELLA INFECTIONS; SALMONELLA TYPHIMURIUM; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84954289010     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201545863     Document Type: Article

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