Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patients

Immunology

Volumn 144, Issue 1, 2015, Pages 45-55

  Smith, Andrew M ^a   Sewell, Gavin W ^b   Levine, Adam P ^b   Chew, Thean S ^b   Dunne, Jenny ^b   O'Shea, Nuala R ^b   Smith, Philip J ^b   Harrison, Penelope J ^b   Macdonald, Carol M ^b   Bloom, Stuart L ^c   Segal, Anthony W ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

Author keywords

Cytokine; Gene expression; Immunodeficiency; Inflammation; Inflammatory bowel disease

Indexed keywords

CYTOKINE; OPTN PROTEIN, HUMAN; TRANSCRIPTION FACTOR IIIA;

ADULT; CLINICAL TRIAL; CROHN DISEASE; FEMALE; GENE EXPRESSION REGULATION; HUMAN; IMMUNOLOGY; INFLAMMATION; MACROPHAGE; MALE; MIDDLE AGED; MULTICENTER STUDY; PATHOLOGY; TUMOR CELL LINE;

ADULT; CELL LINE, TUMOR; CROHN DISEASE; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; MACROPHAGES; MALE; MIDDLE AGED; TRANSCRIPTION FACTOR TFIIIA;

EID: 84918818211     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12338     Document Type: Article

References (40)

1. Casanova JL, Abel L. Revisiting Crohn's disease as a primary immunodeficiency of macrophages. J Exp Med 2009; 206:1839-43.
2. Halfvarson J. Genetics in twins with Crohn's disease: less pronounced than previously believed? Inflamm Bowel Dis 2011; 17:6-12.
3. Barrett JC, Hansoul S, Nicolae DL et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008; 40:955-62.
4. Jostins L, Ripke S, Weersma RK et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 2012; 491:119-24.
5. Parkes M. Evidence from genetics for a role of autophagy and innate immunity in IBD pathogenesis. Dig Dis 2012; 30:330-3.
6. Vinh DC, Behr MA. Crohn's as an immune deficiency: from apparent paradox to evolving paradigm. Expert Rev Clin Immunol 2013; 9:17-30.
7. Campos N, Magro F, Castro AR et al. Macrophages from IBD patients exhibit defective tumour necrosis factor-α secretion but otherwise normal or augmented pro-inflammatory responses to infection. Immunobiology 2011; 216:961-70.
8. Sewell GW, Rahman FZ, Levine AP et al. Defective tumor necrosis factor release from Crohn's disease macrophages in response to toll-like receptor activation: relationship to phenotype and genome-wide association susceptibility loci. Inflamm Bowel Dis 2012; 18:2120-7.
9. Smith AM, Rahman FZ, Hayee B et al. Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J Exp Med 2009; 206:1883-97.
10. Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol 2001; 1:135-45.
11. Shaw MH, Reimer T, Kim YG, Nunez G. NOD-like receptors (NLRs): bona fide intracellular microbial sensors. Curr Opin Immunol 2008; 20:377-82.
12. Sewell GW, Marks DJ, Segal AW. The immunopathogenesis of Crohn's disease: a three-stage model. Curr Opin Immunol 2009; 21:506-13.
13. van Heel DA, Ghosh S, Butler M et al. Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease. Lancet 2005; 365:1794-6.
14. Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB. J Biol Chem 2001; 276:4812-8.
15. Marks DJ, Segal AW. Innate immunity in inflammatory bowel disease: a disease hypothesis. J Pathol 2008; 214:260-6.
16. Segal AW, Loewi G. Neutrophil dysfunction in Crohn's disease. Lancet 1976; 2:219-21.
17. Stow JL, Murray RZ. Intracellular trafficking and secretion of inflammatory cytokines. Cytokine Growth Factor Rev 2013; 24:227-39.
18. Lacy P, Stow JL. Cytokine release from innate immune cells: association with diverse membrane trafficking pathways. Blood 2011; 118:9-18.
19. Glocker EO, Kotlarz D, Boztug K et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med 2009; 361:2033-45.
20. Harvey RF, Bradshaw JM. A simple index of Crohn's disease activity. Lancet 1980; 1:514.
21. Gentleman RC, Carey VJ, Bates DM et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004; 5:R80.
22. Johnson WE, Li C, Rabinovic A. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics 2007; 8:118-27.
23. Smyth GK. Limma: Linear Models for Microarray Data. In: Gentleman R, Carey V, Huber W, Irizarry R, Dudoit S, eds. Bioinformatics and Computational Biology Solutions Using R and Bioconductor. New York: Springer, 2005: 397-420.
24. Hochberg Y, Benjamini Y. More powerful procedures for multiple significance testing. Stat Med 1990; 9:811-8.
25. Roden DL, Sewell GW, Lobley A, Levine AP, Smith AM, Segal AW. ZODET: software for the identification, analysis and visualisation of outlier genes in microarray expression data. PLoS One 2014; 9:e81123.
26. Gleason CE, Ordureau A, Gourlay R, Arthur JS, Cohen P. Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β. J Biol Chem 2011; 286:35663-74.
27. Munitic I, Giardino Torchia ML, Meena NP, Zhu G, Li CC, Ashwell JD. Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells. J Immunol 2013; 191:6231-40.
28. Sahlender DA, Roberts RC, Arden SD et al. Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis. J Cell Biol 2005; 169:285-95.
29. Tumbarello DA, Waxse BJ, Arden SD, Bright NA, Kendrick-Jones J, Buss F. Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome. Nat Cell Biol 2012; 14:1024-35.
30. Korac J, Schaeffer V, Kovacevic I et al. Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates. J Cell Sci 2013; 126:580-92.
31. Abecasis GR, Auton A, Brooks LD et al. An integrated map of genetic variation from 1, 092 human genomes. Nature 2012; 491:56-65.
32. Marks DJ, Harbord MW, MacAllister R et al. Defective acute inflammation in Crohn's disease: a clinical investigation. Lancet 2006; 367:668-78.
33. Micaroni M, Stanley AC, Khromykh T et al. Rab6a/a' are important Golgi regulators of pro-inflammatory TNF secretion in macrophages. PLoS One 2013; 8:e57034.
34. Manderson AP, Kay JG, Hammond LA, Brown DL, Stow JL. Subcompartments of the macrophage recycling endosome direct the differential secretion of IL-6 and TNF-α. J Cell Biol 2007; 178:57-69.
35. Stanley AC, Lieu ZZ, Wall AA et al. Recycling endosome-dependent and -independent mechanisms for IL-10 secretion in LPS-activated macrophages. J Leukoc Biol 2012; 92:1227-39.
36. Narita M, Young AR, Arakawa S et al. Spatial coupling of mTOR and autophagy augments secretory phenotypes. Science 2011; 332:966-70.
37. Tomlins SA, Rhodes DR, Perner S et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 2005; 310:644-8.
38. Ying H, Yue BY. Cellular and molecular biology of optineurin. Int Rev Cell Mol Biol 2012; 294:223-58.
39. Dimas AS, Deutsch S, Stranger BE et al. Common regulatory variation impacts gene expression in a cell type-dependent manner. Science 2009; 325:1246-50.
40. Hemani G, Shakhbazov K, Westra HJ et al. Detection and replication of epistasis influencing transcription in humans. Nature 2014; 508:249-53.