Induction of autophagy by the MG-132 proteasome inhibitor is associated with endoplasmic reticulum stress in MCF-7 cells

Molecular Medicine Reports

Volumn 13, Issue 1, 2016, Pages 796-804

  Bao, Wenhua ^a   Gu, Yiqi ^a   Ta, La ^b   Wang, Keren ^a   Xu, Zheli ^a  

^a CHINA JAPAN UNION HOSPITAL OF JILIN UNIVERSITY   (China)

^b Affiliated Hospital of Inner Mongolia Medical University   (China)

Author keywords

Autophagy; Cell death; Endoplasmic reticulum stress; Proteasome inhibitors

Indexed keywords

3 METHYLADENINE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CASPASE 12; CASPASE 3; GLUCOSE REGULATED PROTEIN 78; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 1; PROTEIN BAX; PROTEIN BCL 2; SALUBRINAL; 3-METHYLADENINE; ADENINE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; CINNAMIC ACID DERIVATIVE; LEUPEPTIN; PROTEASOME INHIBITOR; THIOUREA;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CELL VIABILITY; DNA DAMAGE; ENDOPLASMIC RETICULUM STRESS; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LIGHT CHAIN; MCF 7 CELL LINE; MOLECULARLY TARGETED THERAPY; MTT ASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; DRUG EFFECTS; DRUG POTENTIATION; MCF-7 CELL LINE;

ADENINE; APOPTOSIS; AUTOPHAGY; CINNAMATES; DRUG SYNERGISM; ENDOPLASMIC RETICULUM STRESS; HUMANS; LEUPEPTINS; MCF-7 CELLS; PROTEASOME INHIBITORS; THIOUREA;

EID: 84954287300     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.4599     Document Type: Article

References (39)

1. Rubinsztein DC: The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 443: 780-786, 2006.
2. Hershko A: The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle. Cell Death Differ 12: 1191-1197, 2005.
3. Momose I, Iijima M, Kawada M and Ikeda D: A new proteasome inhibitor, TP-110, induces apoptosis in human prostate cancer PC-3 cells. Biosci Biotechnol Biochem 71: 1036-1043, 2007.
4. Yang H, Landis-Piwowar KR, Chen D, Milacic V and Dou QP: Natural compounds with proteasome inhibitory activity for cancer prevention and treatment. Curr Protein Pept Sci 9: 227-239, 2008.
5. Fan WH, Hou Y, Meng FK, Wang XF, Luo YN and Ge PF: Proteasome inhibitor MG-132 induces C6 glioma cell apoptosis via oxidative stress. Acta Pharmacol Sin 32: 619-625, 2011.
6. Testa U: Proteasome inhibitors in cancer therapy. Curr Drug Targets 10: 968-981, 2009.
7. Levine B and Kroemer G: Autophagy in the pathogenesis of disease. Cell 132: 27-42, 2008.
8. Shintani T and Klionsky DJ: Autophagy in health and disease: A double-edged sword. Science 306: 990-995, 2004.
9. Ge PF, Zhang JZ, Wang XF, Meng FK, Li WC, Luan YX, Ling F and Luo YN: Inhibition of autophagy induced by proteasome inhibition increases cell death in human SHG-44 glioma cells. Acta Pharmacol Sin 30: 1046-1052, 2009.
10. Zhu K, Dunner K Jr and McConkey DJ: Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells. Oncogene 29: 451-462, 2010.
11. Nishikawa T, Tsuno NH, Okaji Y, Shuno Y, Sasaki K, Hongo K, Sunami E, Kitayama J, Takahashi K and Nagawa H: Inhibition of autophagy potentiates sulforaphane-induced apoptosis in human colon cancer cells. Ann Surg Oncol 17: 592-602, 2010.
12. Davids LM, Kleemann B, Cooper S and Kidson SH: Melanomas display increased cytoprotection to hypericin-mediated cytotoxicity through the induction of autophagy. Cell Biol Int 33: 1065-1072, 2009.
13. Katayama M, Kawaguchi T, Berger MS and Pieper RO: DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells. Cell Death Differ 14: 548-558, 2007.
14. Li J, Qin Z and Liang Z: The prosurvival role of autophagy in Resveratrol-induced cytotoxicity in human U251 glioma cells. BMC Cancer 9: 215, 2009.
15. Apel A, Herr I, Schwarz HP, Rodemann HP and Mayer A: Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res 68: 1485-1494, 2008.
16. Kim KW, Hwang M, Moretti L, Jaboin JJ, Cha YI and Lu B: Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer. Autophagy 4: 659-668, 2008.
17. Vazquez-Martin A, Oliveras-Ferraros C and Menendez JA: Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab. PloS One 4: e6251, 2009.
18. Song J, Qu Z, Guo X, Zhao Q, Zhao X, Gao L, Sun K, Shen F, Wu M and Wei L: Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells. Autophagy 5: 1131-1144, 2009.
19. Moretti L, Cha YI, Niermann KJ and Lu B: Switch between apoptosis and autophagy: Radiation-induced endoplasmic reticulum stress? Cell Cycle 6: 793-798, 2007.
20. DeGracia DJ and Montie HL: Cerebral ischemia and the unfolded protein response. J Neurochem 91: 1-8, 2004.
21. Kapoor A and Sanyal AJ: Endoplasmic reticulum stress and the unfolded protein response. Clin Liver Dis 13: 581-590, 2009.
22. Fujita E, Kouroku Y, Isoai A, Kumagai H, Misutani A, Matsuda C, Hayashi YK and Momoi T: Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: Ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II). Hum Mol Genet 16: 618-629, 2007.
23. Yorimitsu T, Nair U, Yang Z and Klionsky DJ: Endoplasmic reticulum stress triggers autophagy. J Biol Chem 281: 30299-30304, 2006.
24. Gavilán MP, Pintado C, Gavilán E, Jiménez S, Ríos RM, Vitorica J, Castaño A and Ruano D: Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition. Aging Cell 8: 654-665, 2009.
25. Younce CW and Kolattukudy PE: MCP-1 causes cardiomyoblast death via autophagy resulting from ER stress caused by oxidative stress generated by inducing a novel zinc-finger protein, MCPIP. Biochem J 426: 43-53, 2010.
26. Zhou F, van Laar T, Huang H and Zhang L: APP and APLP1 are degraded through autophagy in response to proteasome inhibition in neuronal cells. Protein Cell 2: 377-383, 2011.
27. Tanida I, Ueno T and Kominami E: LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol 36: 2503-2318, 2004.
28. Heath-Engel HM, Chang NC and Shore GC: The endoplasmic reticulum in apoptosis and autophagy: Role of the BCL-2 protein family. Oncogene 27: 6419-6433, 2008.
29. Oyadomari S and Mori M: Roles of CHOP/GADDI53 in endoplasmic reticulum stress. Cell Death Differ 11: 381-389, 2004.
30. Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehrecke EH and Lenardo MJ: Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304: 1500-1502, 2004.
31. Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT and Sulzer D: Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305: 1292-1295, 2004.
32. Rubinsztein DC, DiFiglia M, Heintz N, Dutt P, Freundt E, Welsh S, Baehrecke EH and Lenardo MJ: Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy 1: 11-22, 2005.
33. Li J, Hou N, Faried A, Tsutsumi S, Takeuchi T and Kuwano H: Inhibition of autophagy by 3-MA enhances the effect of 5-FU-induced apoptosis in colon cancer cells. Ann Surg Oncol 16: 761-771, 2009.
34. Huang S and Sinicrope FA: Celecoxib-induced apoptosis is enhanced by ABT-737 and by inhibition of autophagy in human colorectal cancer cells. Autophagy 6: 256-269, 2010.
35. Walls KC, Ghosh AP, Franklin AV, Klocke BJ, Ballestas M, Shacka JJ, Zhang J and Roth KA: Lysosome dysfunction triggers Atg7-dependent neural apoptosis. J Biol Chem 285: 10497-10507, 2010.
36. McMillan DR, Gething MJ and Sambrook J: The cellular response to unfolded proteins: Intercompartmental signaling. Curr Opin Biotechnol 5: 540-545, 1994.
37. Gao B, Zhang XY, Han R, Zhang TT, Chen C, Qin ZH and Sheng R: The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning. Acta Pharmacol Sin 34: 657-666, 2013.
38. Hoyer-Hansen M and Jäättelä M: Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium. Cell Death Differ 14: 1576-1582, 2007.
39. Ding WX, Ni HM, Gao W, Yoshimori T, Stolz DB, Ron D and Yin XM: Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am J Pathol 171: 513-524, 2007.