Unmasking silent endothelial activation in the cardiovascular system using molecular magnetic resonance imaging

Theranostics

Volumn 5, Issue 11, 2015, Pages 1187-1202

  Belliere, Julie ^a,b   de Lizarrondo, Sara Martinez ^a   Choudhury, Robin P ^c   Quenault, Aurélien ^a   Le Béhot, Audrey ^a   Delage, Christine ^a,b   Chauveau, Dominique ^a,b,d   Schanstra, Joost P ^a,b   Bascands, Jean Loup ^a,b   Vivien, Denis ^a   Gauberti, Maxime ^a  

^a INSERM   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d CHU RANGUEIL   (France)

Author keywords

ICAM 1; Inflammation; MPIO; USPIO; VCAM 1

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; VASCULAR CELL ADHESION MOLECULE 1;

ACUTE KIDNEY FAILURE; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD VESSEL; CARDIOVASCULAR SYSTEM; CELL ACTIVATION; CONTROLLED STUDY; DIABETES MELLITUS; ENDOTHELIUM CELL; INFLAMMATION; KIDNEY BLOOD VESSEL; MALE; MOLECULAR IMAGING; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; SYSTEMIC DISEASE; ANIMAL; CARDIOVASCULAR DISEASES; DISEASE MODEL; PATHOLOGY; PROCEDURES; VASCULAR ENDOTHELIUM;

ANIMALS; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; MAGNETIC RESONANCE IMAGING; MICE; MOLECULAR IMAGING;

EID: 84954234720     PISSN: None     EISSN: 18387640     Source Type: Journal    
DOI: 10.7150/thno.11835     Document Type: Article

References (40)

1. McAteer MA, Sibson NR, von Zur Muhlen C, Schneider JE, Lowe AS, Warrick N, et al. In vivo magnetic resonance imaging of acute brain inflammation using microparticles of iron oxide. Nature medicine. 2007; 13: 1253-8.
2. Hasegawa Y, Saito T, Ogihara T, Ishigaki Y, Yamada T, Imai J, et al. Blockade of the nuclear factor-kappaB pathway in the endothelium prevents insulin resistance and prolongs life spans. Circulation. 2012; 125: 1122-33.
3. Kim JK. Endothelial nuclear factor kappaB in obesity and aging: is endothelial nuclear factor kappaB a master regulator of inflammation and insulin resistance? Circulation. 2012; 125: 1081-3.
4. Jefferson A, Ruparelia N, Choudhury RP. Exogenous microparticles of iron oxide bind to activated endothelial cells but, unlike monocytes, do not trigger an endothelial response. Theranostics. 2013; 3: 428-36.
5. Leuschner F, Nahrendorf M. Molecular imaging of coronary atherosclerosis and myocardial infarction: considerations for the bench and perspectives for the clinic. Circulation research. 2011; 108: 593-606.
6. Quillard T, Libby P. Molecular imaging of atherosclerosis for improving diagnostic and therapeutic development. Circulation research. 2012; 111: 231-44.
7. Gauberti M, Montagne A, Quenault A, Vivien D. Molecular magnetic resonance imaging of brain-immune interactions. Frontiers in cellular neuroscience. 2014; 8: 389.
8. McAteer MA, Choudhury RP. Targeted molecular imaging of vascular inflammation in cardiovascular disease using nano-and micro-sized agents. Vascul Pharmacol. 2013; 58: 31-8.
9. Mahmoudi M, Sheibani S, Milani AS, Rezaee F, Gauberti M, Dinarvand R, et al. Crucial role of the protein corona for the specific targeting of nanoparticles. Nanomedicine (London, England). 2015; 10: 215-26.
10. de Haas HJ, Arbustini E, Fuster V, Kramer CM, Narula J. Molecular imaging of the cardiac extracellular matrix. Circulation research. 2014; 114: 903-15.
11. Gauberti M, Montagne A, Marcos-Contreras OA, Le Behot A, Maubert E, Vivien D. Ultra-sensitive molecular MRI of vascular cell adhesion molecule-1 reveals a dynamic inflammatory penumbra after strokes. Stroke. 2013; 44: 1988-96.
12. Homsi E, Janino P, de Faria JB. Role of caspases on cell death, inflammation, and cell cycle in glycerol-induced acute renal failure. Kidney Int. 2006; 69: 1385-92.
13. Belliere J, Casemayou A, Ducasse L, Zakaroff-Girard A, Martins F, Iacovoni JS, et al. Specific Macrophage Subtypes Influence the Progression of Rhabdomyolysis-Induced Kidney Injury. J Am Soc Nephrol. 2014.
14. Schanstra JP, Bachvarova M, Neau E, Bascands JL, Bachvarov D. Gene expression profiling in the remnant kidney model of wild type and kinin B1 and B2 receptor knockout mice. Kidney Int. 2007; 72: 442-54.
15. Jefferson A, Wijesurendra RS, McAteer MA, Digby JE, Douglas G, Bannister T, et al. Molecular imaging with optical coherence tomography using ligand-conjugated microparticles that detect activated endothelial cells: rational design through target quantification. Atherosclerosis. 2011; 219: 579-87.
16. Gauberti M, Martinez de Lizarrondo S, Orset C, Vivien D. Lack of secondary microthrombosis after thrombin-induced stroke in mice and non-human primates. Journal of thrombosis and haemostasis: JTH. 2014; 12: 409-14.
17. Gakuba C, Gauberti M, Mazighi M, Defer G, Hanouz JL, Vivien D. Preclinical evidence toward the use of ketamine for recombinant tissue-type plasminogen activator-mediated thrombolysis under anesthesia or sedation. Stroke. 2011; 42: 2947-9.
18. Montagne A, Gauberti M, Macrez R, Jullienne A, Briens A, Raynaud JS, et al. Ultra-sensitive molecular MRI of cerebrovascular cell activation enables early detection of chronic central nervous system disorders. NeuroImage. 2012; 63: 760-70.
19. Le Behot A, Gauberti M, Martinez De Lizarrondo S, Montagne A, Lemarchand E, Repesse Y, et al. GpIbalpha-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice. Blood. 2014; 123: 3354-63.
20. Melemenidis S, Jefferson A, Ruparelia N, Akhtar AM, Xie J, Allen D, et al. Molecular magnetic resonance imaging of angiogenesis in vivo using polyvalent cyclic RGD-iron oxide microparticle conjugates. Theranostics. 2015; 5: 515-29.
21. Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E, et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Annals of the New York Academy of Sciences. 2000; 908: 244-54.
22. Weissleder R, Nahrendorf M, Pittet MJ. Imaging macrophages with nanoparticles. Nature materials. 2014; 13: 125-38.
23. Majmudar MD, Yoo J, Keliher EJ, Truelove JJ, Iwamoto Y, Sena B, et al. Polymeric nanoparticle PET/MR imaging allows macrophage detection in atherosclerotic plaques. Circulation research. 2013; 112: 755-61.
24. Shlipak MG, Fried LF, Crump C, Bleyer AJ, Manolio TA, Tracy RP, et al. Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency. Circulation. 2003; 107: 87-92.
25. Popov D, Sima A, Stern D, Simionescu M. The pathomorphological alterations of endocardial endothelium in experimental diabetes and diabetes associated with hyperlipidemia. Acta diabetologica. 1996; 33: 41-7.
26. Yamashita T, Sekiguchi A, Iwasaki YK, Date T, Sagara K, Tanabe H, et al. Recruitment of immune cells across atrial endocardium in human atrial fibrillation. Circulation journal: official journal of the Japanese Circulation Society. 2010; 74: 262-70.
27. Kurniati NF, van Meurs M, Vom Hagen F, Jongman RM, Moser J, Zwiers PJ, et al. Pleiotropic effects of angiopoietin-2 deficiency do not protect mice against endotoxin-induced acute kidney injury. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association-European Renal Association. 2013; 28: 567-75.
28. Raeburn CD, Calkins CM, Zimmerman MA, Song Y, Ao L, Banerjee A, et al. ICAM-1 and VCAM-1 mediate endotoxemic myocardial dysfunction independent of neutrophil accumulation. American journal of physiology Regulatory, integrative and comparative physiology. 2002; 283: R477-86.
29. Omote K, Gohda T, Murakoshi M, Sasaki Y, Kazuno S, Fujimura T, et al. Role of the TNF pathway in the progression of diabetic nephropathy in KK-A(y) mice. American journal of physiology Renal physiology. 2014; 306: F1335-47.
30. Liu JJ, Yeoh LY, Sum CF, Tavintharan S, Ng XW, Liu S, et al. Vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1, is associated with diabetic kidney disease in Asians with type 2 diabetes. Journal of diabetes and its complications. 2015; 29: 707-12.
31. Akhtar AM, Schneider JE, Chapman SJ, Jefferson A, Digby JE, Mankia K, et al. In vivo quantification of VCAM-1 expression in renal ischemia reperfusion injury using non-invasive magnetic resonance molecular imaging. PloS one. 2010; 5: e12800.
32. Jefferson A, Wijesurendra RS, McAteer MA, Choudhury RP. Development and application of endothelium-targeted microparticles for molecular magnetic resonance imaging. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012; 4: 247-56.
33. Mulder WJ, Jaffer FA, Fayad ZA, Nahrendorf M. Imaging and nanomedicine in inflammatory atherosclerosis. Science translational medicine. 2014; 6: 239sr1.
34. Chakravarty R, Goel S, Cai W. Nanobody: the "magic bullet" for molecular imaging? Theranostics. 2014; 4: 386-98.
35. Orbay H, Hong H, Zhang Y, Cai W. Positron emission tomography imaging of atherosclerosis. Theranostics. 2013; 3: 894-902.
36. Gaberel T, Gakuba C, Hebert M, Montagne A, Agin V, Rubio M, et al. Intracerebral hematomas disappear on T2*-weighted images during normobaric oxygen therapy. Stroke. 2013; 44: 3482-9.
37. Gaberel T, Gakuba C, Goulay R, Martinez De Lizarrondo S, Hanouz JL, Emery E, et al. Impaired glymphatic perfusion after strokes revealed by contrast-enhanced MRI: a new target for fibrinolysis? Stroke. 2014; 45: 3092-6.
38. Zhang YD, Wang J, Zhang J, Wang X, Jiang X. Effect of iodinated contrast media on renal function evaluated with dynamic three-dimensional MR renography. Radiology. 2014; 270: 409-15.
39. Thurman JM, Serkova NJ. Nanosized contrast agents to noninvasively detect kidney inflammation by magnetic resonance imaging. Adv Chronic Kidney Dis. 2013; 20: 488-99.
40. Broisat A, Hernot S, Toczek J, De Vos J, Riou LM, Martin S, et al. Nanobodies targeting mouse/human VCAM1 for the nuclear imaging of atherosclerotic lesions. Circulation research. 2012; 110: 927-37.