Combined administration of levetiracetam and valproic acid attenuates age-related hyperactivity of CA3 place cells, reduces place field area, and increases spatial information content in aged rat hippocampus

Hippocampus

Volumn 25, Issue 12, 2015, Pages 1541-1555

  Robitsek, Jonathan ^a   Ratner, Marcia H ^a   Stewart, Tara ^a   Eichenbaum, Howard ^b   Farb, David H ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY   (United States)

Author keywords

Aging; Levetiracetam; Memory; Place cells; Valproic acid

Indexed keywords

AGENTS ACTING ON THE PERIPHERAL NERVOUS AND NEUROMUSCULAR SYSTEMS; ETIRACETAM; VALPROIC ACID; CENTRAL NERVOUS SYSTEM AGENTS; PIRACETAM;

ACTION POTENTIAL; AGE; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CELL ACTIVITY; CELL COUNT; CELL SIZE; COGNITION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENTORHINAL CORTEX; EXPERIMENTAL HYPERACTIVITY; FIRING RATE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; IN VIVO STUDY; LOW DRUG DOSE; MALE; MICROENVIRONMENT; MORRIS WATER MAZE TEST; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SPATIAL LEARNING; SPATIAL MEMORY; AGING; ANALOGS AND DERIVATIVES; ANIMAL; COMPARATIVE STUDY; DEPTH PERCEPTION; DRUG EFFECTS; DRUG POTENTIATION; EXPLORATORY BEHAVIOR; LONG EVANS RAT; MAZE TEST; PERCEPTIVE DISCRIMINATION; PHYSIOLOGY;

ACTION POTENTIALS; AGING; ANIMALS; CA1 REGION, HIPPOCAMPAL; CA3 REGION, HIPPOCAMPAL; CENTRAL NERVOUS SYSTEM AGENTS; DISCRIMINATION (PSYCHOLOGY); DRUG SYNERGISM; EXPLORATORY BEHAVIOR; MALE; MAZE LEARNING; NEURONS; PIRACETAM; RATS, LONG-EVANS; SPACE PERCEPTION; SPATIAL MEMORY; VALPROIC ACID;

EID: 84954228925     PISSN: 10509631     EISSN: 10981063     Source Type: Journal    
DOI: 10.1002/hipo.22474     Document Type: Article

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