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Volumn 21, Issue 22, 2015, Pages 5164-5172

Cellular Senescence Markers p16INK4a and p21CIP1/WAF Are Predictors of Hodgkin Lymphoma Outcome

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 1A; TUMOR MARKER;

EID: 84954150815     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-15-0508     Document Type: Article
Times cited : (39)

References (49)
  • 1
    • 84862856999 scopus 로고    scopus 로고
    • Predicting treatment outcome in classical Hodgkin lymphoma: Genomic advances
    • Derenzini E, Younes A. Predicting treatment outcome in classical Hodgkin lymphoma: Genomic advances. Genome Med 2011;3:26.
    • (2011) Genome Med , vol.3 , pp. 26
    • Derenzini, E.1    Younes, A.2
  • 2
    • 0347286860 scopus 로고    scopus 로고
    • Part II Hodgkin's lymphoma-diagnosis and treatment
    • Diehl V, Thomas RK, Re D. Part II: Hodgkin's lymphoma-diagnosis and treatment. Lancet Oncol 2004;5:19-26.
    • (2004) Lancet Oncol , vol.5 , pp. 19-26
    • Diehl, V.1    Thomas, R.K.2    Re, D.3
  • 3
    • 0036920018 scopus 로고    scopus 로고
    • Serum levels of soluble CD30 improve International Prognostic Score in predicting the outcome of advanced Hodgkin's lymphoma
    • Zanotti R, Trolese A, Ambrosetti A, Nadali G, Visco C, Ricetti MM, et al. Serum levels of soluble CD30 improve International Prognostic Score in predicting the outcome of advanced Hodgkin's lymphoma. Ann Oncol 2002;13:1908-14.
    • (2002) Ann Oncol , vol.13 , pp. 1908-1914
    • Zanotti, R.1    Trolese, A.2    Ambrosetti, A.3    Nadali, G.4    Visco, C.5    Ricetti, M.M.6
  • 4
    • 0032523174 scopus 로고    scopus 로고
    • Serum level of the soluble form of the CD30 molecule identifies patients with Hodgkin's disease at high risk of unfavorable outcome
    • Nadali G, Tavecchia L, Zanolin E, Bonfante V, Viviani S, Camerini E, et al. Serum level of the soluble form of the CD30 molecule identifies patients with Hodgkin's disease at high risk of unfavorable outcome. Blood 1998;91:3011-6.
    • (1998) Blood , vol.91 , pp. 3011-3016
    • Nadali, G.1    Tavecchia, L.2    Zanolin, E.3    Bonfante, V.4    Viviani, S.5    Camerini, E.6
  • 5
    • 20044367117 scopus 로고    scopus 로고
    • Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells
    • Alvaro T, Lejeune M, Salvado MT, Bosch R, Garcia JF, Jaen J, et al. Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells. Clin Cancer Res 2005;11:1467-73.
    • (2005) Clin Cancer Res , vol.11 , pp. 1467-1473
    • Alvaro, T.1    Lejeune, M.2    Salvado, M.T.3    Bosch, R.4    Garcia, J.F.5    Jaen, J.6
  • 6
    • 34547652282 scopus 로고    scopus 로고
    • HLAclass II expression by Hodgkin Reed-Sternberg cells is an independent prognostic factor in classical Hodgkin's lymphoma
    • Diepstra A, van ImhoffGW, Karim-Kos HE, van den Berg A, te Meerman GJ, NiensM, et al.HLAclass II expression by Hodgkin Reed-Sternberg cells is an independent prognostic factor in classical Hodgkin's lymphoma. J Clin Oncol 2007;25:3101-8.
    • (2007) J Clin Oncol , vol.25 , pp. 3101-3108
    • Diepstra, A.1    Van Imhoff, G.W.2    Karim-Kos, H.E.3    Van Den Berg, A.4    Te Meerman, G.J.5    Niens, M.6
  • 7
    • 84868587140 scopus 로고    scopus 로고
    • Gene expression profiling of microdissected Hodgkin Reed-Sternberg cells correlates with treatment outcome in classical Hodgkin lymphoma
    • SteidlC,Diepstra A, Lee T, Chan FC, Farinha P, Tan K, et al. Gene expression profiling of microdissected Hodgkin Reed-Sternberg cells correlates with treatment outcome in classical Hodgkin lymphoma. Blood 2012;120: 3530-40.
    • (2012) Blood , vol.120 , pp. 3530-3540
    • Steidlcdiepstra, A.1    Lee, T.2    Chan, F.C.3    Farinha, P.4    Tan, K.5
  • 8
    • 0029134785 scopus 로고
    • Hodgkin's disease with monoclonal and polyclonal populations of Reed-Sternberg cells
    • Hummel M, Ziemann K, Lammert H, Pileri S, Sabattini E, Stein H. Hodgkin's disease with monoclonal and polyclonal populations of Reed-Sternberg cells. N Engl J Med 1995;333:901-6.
    • (1995) N Engl J Med , vol.333 , pp. 901-906
    • Hummel, M.1    Ziemann, K.2    Lammert, H.3    Pileri, S.4    Sabattini, E.5    Stein, H.6
  • 9
    • 0028943804 scopus 로고
    • Biopathologic features of Hodgkin's disease
    • Chilosi M, Pizzolo G. Biopathologic features of Hodgkin's disease. Leuk Lymphoma 1995;16:385-95.
    • (1995) Leuk Lymphoma , vol.16 , pp. 385-395
    • Chilosi, M.1    Pizzolo, G.2
  • 10
    • 57749171165 scopus 로고    scopus 로고
    • The biology of Hodgkin's lymphoma
    • Kuppers R. The biology of Hodgkin's lymphoma. Nat Rev Cancer 2009; 9:15-27.
    • (2009) Nat Rev Cancer , vol.9 , pp. 15-27
    • Kuppers, R.1
  • 11
    • 0025884829 scopus 로고
    • Immunohistochemical evidence of abnormal expression of the antioncogene-encoded p53 phosphoprotein in Hodgkin's disease and CD30 anaplastic lymphomas
    • Doglioni C, Pelosio P, Mombello A, Scarpa A, Chilosi M. Immunohistochemical evidence of abnormal expression of the antioncogene-encoded p53 phosphoprotein in Hodgkin's disease and CD30 anaplastic lymphomas. Hematol Pathol 1991;5:67-73.
    • (1991) Hematol Pathol , vol.5 , pp. 67-73
    • Doglioni, C.1    Pelosio, P.2    Mombello, A.3    Scarpa, A.4    Chilosi, M.5
  • 12
    • 10544225750 scopus 로고    scopus 로고
    • P21/WAF1 cyclin-kinase inhibitor expression in non-Hodgkin's lymphomas: A potential marker of p53 tumor-suppressor gene function
    • Chilosi M, Doglioni C, Magalini A, Inghirami G, Krampera M, Nadali G, et al. p21/WAF1 cyclin-kinase inhibitor expression in non-Hodgkin's lymphomas: A potential marker of p53 tumor-suppressor gene function. Blood 1996;88:4012-20.
    • (1996) Blood , vol.88 , pp. 4012-4020
    • Chilosi, M.1    Doglioni, C.2    Magalini, A.3    Inghirami, G.4    Krampera, M.5    Nadali, G.6
  • 13
    • 0032589956 scopus 로고    scopus 로고
    • P16INK4A is regularly expressed in Hodgkin's disease: Comparison with retinoblastoma, p53 and MDM2 protein status, and the presence of Epstein-Barr virus
    • Guenova M, Rassidakis GZ, Gorgoulis VG, Angelopoulou MK, Siakantaris MR, Kanavaros P, et al. p16INK4A is regularly expressed in Hodgkin's disease: Comparison with retinoblastoma, p53 and MDM2 protein status, and the presence of Epstein-Barr virus. Mod Pathol 1999;12:1062-71.
    • (1999) Mod Pathol , vol.12 , pp. 1062-1071
    • Guenova, M.1    Rassidakis, G.Z.2    Gorgoulis, V.G.3    Angelopoulou, M.K.4    Siakantaris, M.R.5    Kanavaros, P.6
  • 14
    • 29044442501 scopus 로고    scopus 로고
    • Expression of retinoblastoma protein and P16 proteins in classic Hodgkin lymphoma: Relationship with expression of p53 and presence of Epstein-Barr virus in the regulation of cell growth and death
    • Kim LH, Peh SC, Poppema S. Expression of retinoblastoma protein and P16 proteins in classic Hodgkin lymphoma: Relationship with expression of p53 and presence of Epstein-Barr virus in the regulation of cell growth and death. Hum Pathol 2006;37:92-100.
    • (2006) Hum Pathol , vol.37 , pp. 92-100
    • Kim, L.H.1    Peh, S.C.2    Poppema, S.3
  • 16
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
    • Campisi J. Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors. Cell 2005;120:513-22.
    • (2005) Cell , vol.120 , pp. 513-522
    • Campisi, J.1
  • 17
    • 68249096784 scopus 로고    scopus 로고
    • Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
    • Rodier F, Coppe JP, Patil CK, Hoeijmakers WA, Munoz DP, Raza SR, et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol 2009;11:973-9.
    • (2009) Nat Cell Biol , vol.11 , pp. 973-979
    • Rodier, F.1    Coppe, J.P.2    Patil, C.K.3    Hoeijmakers, W.A.4    Munoz, D.P.5    Raza, S.R.6
  • 18
  • 19
    • 84856209016 scopus 로고    scopus 로고
    • Emerging role of NF-kappaB signaling in the induction of senescence-associated secretory phenotype (SASP)
    • Salminen A, Kauppinen A, Kaarniranta K. Emerging role of NF-kappaB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell Signal 2012;24:835-45.
    • (2012) Cell Signal , vol.24 , pp. 835-845
    • Salminen, A.1    Kauppinen, A.2    Kaarniranta, K.3
  • 20
    • 0037086268 scopus 로고    scopus 로고
    • DNA damage is able to induce senescence in tumor cells in vitro and in vivo
    • te Poele RH, Okorokov AL, Jardine L, Cummings J, Joel SP. DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res 2002;62:1876-83.
    • (2002) Cancer Res , vol.62 , pp. 1876-1883
    • Te Poele, R.H.1    Okorokov, A.L.2    Jardine, L.3    Cummings, J.4    Joel, S.P.5
  • 21
    • 0038277105 scopus 로고    scopus 로고
    • Tumor cell senescence in cancer treatment
    • Roninson IB. Tumor cell senescence in cancer treatment. Cancer Res 2003;63:2705-15.
    • (2003) Cancer Res , vol.63 , pp. 2705-2715
    • Roninson, I.B.1
  • 22
    • 84859492402 scopus 로고    scopus 로고
    • Molecular links between cellular senescence, longevity and age-related diseases-A systems biology perspective
    • Tacutu R, Budovsky A, Yanai H, Fraifeld VE. Molecular links between cellular senescence, longevity and age-related diseases-a systems biology perspective. Aging 2011;3:1178-91.
    • (2011) Aging , vol.3 , pp. 1178-1191
    • Tacutu, R.1    Budovsky, A.2    Yanai, H.3    Fraifeld, V.E.4
  • 24
    • 0024422603 scopus 로고
    • Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin's disease: Cotswolds meeting
    • Lister TA, Crowther D, Sutcliffe SB, Glatstein E, Canellos GP, Young RC, et al. Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin's disease: Cotswolds meeting. J Clin Oncol 1989;7:1630-6.
    • (1989) J Clin Oncol , vol.7 , pp. 1630-1636
    • Lister, T.A.1    Crowther, D.2    Sutcliffe, S.B.3    Glatstein, E.4    Canellos, G.P.5    Young, R.C.6
  • 25
    • 0025685210 scopus 로고
    • Radiation therapy in the management of Hodgkin's disease
    • Hoppe RT. Radiation therapy in the management of Hodgkin's disease. Semin Oncol 1990;17:704-15.
    • (1990) Semin Oncol , vol.17 , pp. 704-715
    • Hoppe, R.T.1
  • 26
    • 0025663096 scopus 로고
    • The use of chemotherapy in the treatment of Hodgkin's disease
    • Longo DL. The use of chemotherapy in the treatment of Hodgkin's disease. Semin Oncol 1990;17:716-35.
    • (1990) Semin Oncol , vol.17 , pp. 716-735
    • Longo, D.L.1
  • 27
    • 77957763759 scopus 로고    scopus 로고
    • Disturbed expression of the T-cell receptor/CD3 complex and associated signaling molecules in CD30 T-cell lymphoproliferations
    • Geissinger E, Sadler P, Roth S, Grieb T, Puppe B, Muller N, et al. Disturbed expression of the T-cell receptor/CD3 complex and associated signaling molecules in CD30 T-cell lymphoproliferations. Haematologica 2010; 95:1697-704.
    • (2010) Haematologica , vol.95 , pp. 1697-1704
    • Geissinger, E.1    Sadler, P.2    Roth, S.3    Grieb, T.4    Puppe, B.5    Muller, N.6
  • 28
    • 77954267751 scopus 로고    scopus 로고
    • MARQ: An online tool to mine GEO for experiments with similar or opposite gene expression signatures
    • Vazquez M, Nogales-Cadenas R, Arroyo J, Botias P, Garcia R, Carazo JM, et al. MARQ: An online tool to mine GEO for experiments with similar or opposite gene expression signatures. Nucleic Acids Res 2010;38:W228-32.
    • (2010) Nucleic Acids Res , vol.38 , pp. 228-232
    • Vazquez, M.1    Nogales-Cadenas, R.2    Arroyo, J.3    Botias, P.4    Garcia, R.5    Carazo, J.M.6
  • 30
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observation
    • Kaplan EL, Meier P. Nonparametric estimation from incomplete observation. J Am Stat Assoc 1958;53:457-81.
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 32
    • 7344228961 scopus 로고    scopus 로고
    • Serum levels of p55 and p75 soluble TNF receptors in adult acute leukaemia at diagnosis: Correlationwith clinical and biological features and outcome
    • Vinante F, Rigo A, Tecchio C, Morosato L, Nadali G, RicettiMM, et al. Serum levels of p55 and p75 soluble TNF receptors in adult acute leukaemia at diagnosis: Correlationwith clinical and biological features and outcome. Br J Haematol 1998;102:1025-34.
    • (1998) Br J Haematol , vol.102 , pp. 1025-1034
    • Vinante, F.1    Rigo, A.2    Tecchio, C.3    Morosato, L.4    Nadali, G.5    Ricetti, M.M.6
  • 33
    • 0030069896 scopus 로고    scopus 로고
    • Multivariable prognostic models: Issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors
    • Harrell FE Jr, Lee KL, Mark DB. Multivariable prognostic models: Issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med 1996;15:361-87.
    • (1996) Stat Med , vol.15 , pp. 361-387
    • Harrell, F.E.1    Lee, K.L.2    Mark, D.B.3
  • 34
    • 33745712849 scopus 로고    scopus 로고
    • The power and the promise of oncogene-induced senescence markers
    • Collado M, Serrano M. The power and the promise of oncogene-induced senescence markers. Nat Rev Cancer 2006;6:472-6.
    • (2006) Nat Rev Cancer , vol.6 , pp. 472-476
    • Collado, M.1    Serrano, M.2
  • 35
    • 80054682555 scopus 로고    scopus 로고
    • Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype
    • Coppe JP, Rodier F, Patil CK, Freund A, Desprez PY, Campisi J. Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype. J Biol Chem 2011;286:36396-403.
    • (2011) J Biol Chem , vol.286 , pp. 36396-36403
    • Coppe, J.P.1    Rodier, F.2    Patil, C.K.3    Freund, A.4    Desprez, P.Y.5    Campisi, J.6
  • 36
    • 0032510327 scopus 로고    scopus 로고
    • Inhibitors of cyclindependent kinases induce features of replicative senescence in early passage human diploid fibroblasts
    • McConnell BB, Starborg M, Brookes S, Peters G. Inhibitors of cyclindependent kinases induce features of replicative senescence in early passage human diploid fibroblasts. Curr Biol 1998;8:351-4.
    • (1998) Curr Biol , vol.8 , pp. 351-354
    • McConnell, B.B.1    Starborg, M.2    Brookes, S.3    Peters, G.4
  • 37
    • 2342570379 scopus 로고    scopus 로고
    • Hallmarks of senescence in carcinogenesis and cancer therapy
    • Shay JW, Roninson IB. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 2004;23:2919-33.
    • (2004) Oncogene , vol.23 , pp. 2919-2933
    • Shay, J.W.1    Roninson, I.B.2
  • 38
  • 39
    • 62549094378 scopus 로고    scopus 로고
    • The3D nuclear organization of telomeres marks the transition from Hodgkin to Reed-Sternberg cells
    • Knecht H, Sawan B, Lichtensztejn D, Lemieux B, Wellinger RJ, Mai S. The3D nuclear organization of telomeres marks the transition from Hodgkin to Reed-Sternberg cells. Leukemia 2009;23:565-73.
    • (2009) Leukemia , vol.23 , pp. 565-573
    • Knecht, H.1    Sawan, B.2    Lichtensztejn, D.3    Lemieux, B.4    Wellinger, R.J.5    Mai, S.6
  • 41
    • 84905657472 scopus 로고    scopus 로고
    • Oncogene-induced senescence distinguishes indolent from aggressive forms of pulmonary and non-pulmonary Langerhans cell histiocytosis
    • Chilosi M, Facchetti F, Cali-o A, Zam-o A, Brunelli M, Martignoni G, et al. Oncogene-induced senescence distinguishes indolent from aggressive forms of pulmonary and non-pulmonary Langerhans cell histiocytosis. Leuk Lymphoma 2014;55:2620-6.
    • (2014) Leuk Lymphoma , vol.55 , pp. 2620-2626
    • Chilosi, M.1    Facchetti, F.2    Cali-O, A.3    Zam-O, A.4    Brunelli, M.5    Martignoni, G.6
  • 42
    • 79959231353 scopus 로고    scopus 로고
    • The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway
    • Martinelli P, Bonetti P, Sironi C, Pruneri G, Fumagalli C, Raviele PR, et al. The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway. Blood 2011; 117:6617-26.
    • (2011) Blood , vol.117 , pp. 6617-6626
    • Martinelli, P.1    Bonetti, P.2    Sironi, C.3    Pruneri, G.4    Fumagalli, C.5    Raviele, P.R.6
  • 43
    • 33744496006 scopus 로고    scopus 로고
    • The impact of P53 and P21(waf1) expression on the survival of patients with the germinal center phenotype of diffuse large B-cell lymphoma
    • Visco C, Canal F, Parolini C, Andreoli A, Ambrosetti A, Krampera M, et al. The impact of P53 and P21(waf1) expression on the survival of patients with the germinal center phenotype of diffuse large B-cell lymphoma. Haematologica 2006;91:687-90.
    • (2006) Haematologica , vol.91 , pp. 687-690
    • Visco, C.1    Canal, F.2    Parolini, C.3    Andreoli, A.4    Ambrosetti, A.5    Krampera, M.6
  • 44
    • 0037438584 scopus 로고    scopus 로고
    • Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: Analyses using tissue microarrays
    • Garcia JF, Camacho FI, Morente M, Fraga M, Montalban C, Alvaro T, et al. Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: Analyses using tissue microarrays. Blood 2003;101:681-9.
    • (2003) Blood , vol.101 , pp. 681-689
    • Garcia, J.F.1    Camacho, F.I.2    Morente, M.3    Fraga, M.4    Montalban, C.5    Alvaro, T.6
  • 45
    • 0033391985 scopus 로고    scopus 로고
    • Loss of p16 protein expression associated with methylation of the p16INK4A gene is a frequent finding in Hodgkin's disease
    • Garcia JF, Villuendas R, Algara P, Saez AI, Sanchez-Verde L, Martinez-Montero JC, et al. Loss of p16 protein expression associated with methylation of the p16INK4A gene is a frequent finding in Hodgkin's disease. Lab Invest 1999;79:1453-9.
    • (1999) Lab Invest , vol.79 , pp. 1453-1459
    • Garcia, J.F.1    Villuendas, R.2    Algara, P.3    Saez, A.I.4    Sanchez-Verde, L.5    Martinez-Montero, J.C.6
  • 46
    • 34447543913 scopus 로고    scopus 로고
    • Cellular senescence in cancer and aging
    • ColladoM, Blasco MA, SerranoM. Cellular senescence in cancer and aging. Cell 2007;130:223-33.
    • (2007) Cell , vol.130 , pp. 223-233
    • Collado, M.1    Blasco, M.A.2    Serrano, M.3
  • 47
    • 84874772161 scopus 로고    scopus 로고
    • Induction of p16(INK4a) is the major barrier to proliferation when Epstein-Barr virus (EBV) transforms primary B cells into lymphoblastoid cell lines
    • Skalska L, White RE, Parker GA, Turro E, Sinclair AJ, Paschos K, et al. Induction of p16(INK4a) is the major barrier to proliferation when Epstein-Barr virus (EBV) transforms primary B cells into lymphoblastoid cell lines. PLoS Pathog 2013;9:e1003187.
    • (2013) PLoS Pathog , vol.9 , pp. e1003187
    • Skalska, L.1    White, R.E.2    Parker, G.A.3    Turro, E.4    Sinclair, A.J.5    Paschos, K.6
  • 48
    • 0042467687 scopus 로고    scopus 로고
    • Epstein-Barr virus and oncogenesis: From latent genes to tumours
    • Young LS, Murray PG. Epstein-Barr virus and oncogenesis: From latent genes to tumours. Oncogene 2003;22:5108-21.
    • (2003) Oncogene , vol.22 , pp. 5108-5121
    • Young, L.S.1    Murray, P.G.2
  • 49
    • 0034643382 scopus 로고    scopus 로고
    • LMP1 of Epstein-Barr virus suppresses cellular senescence associated with the inhibition of p16INK4a expression
    • Yang X, He Z, Xin B, Cao L. LMP1 of Epstein-Barr virus suppresses cellular senescence associated with the inhibition of p16INK4a expression. Oncogene 2000;19:2002-13.
    • (2000) Oncogene , vol.19 , pp. 2002-2013
    • Yang, X.1    He, Z.2    Xin, B.3    Cao, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.