1,25D3 prevents CD8 + Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter

Nature Communications

Volumn 7, Issue , 2016, Pages

  Schedel, Michaela ^a   Jia, Yi ^a,f   Michel, Sven ^b,c   Takeda, Katsuyuki ^a   Domenico, Joanne ^a   Joetham, Anthony ^a   Ning, Fangkun ^a   Strand, Matthew ^a   Han, Junyan ^a   Wang, Meiqin ^a   Lucas, Joseph J ^a   Vogelberg, Christian ^d   Kabesch, Michael ^b,c   O'Connor, Brian P ^a,e   Gelfand, Erwin W ^a  

^a DEPARTMENT OF MEDICINE   (United States)

^b UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^e UNIVERSITY OF COLORADO   (United States)

^f ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); INTERLEUKIN 4; VITAMIN D RECEPTOR; ALLERGEN; CALCITRIOL RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 13; OVALBUMIN; PREGNENOLONE;

ALLERGY; ASTHMA; CELL ORGANELLE; ENZYME ACTIVITY; MOLECULAR ANALYSIS; POLYMORPHISM; PROTEIN; VITAMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE COURSE; DISEASE PREDISPOSITION; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PROMOTER REGION; STEROIDOGENESIS; T LYMPHOCYTE; ADOLESCENT; ADOPTIVE TRANSFER; ANIMAL; CASE CONTROL STUDY; CHILD; CHROMATIN IMMUNOPRECIPITATION; COMPUTER SIMULATION; CYTOTOXIC T LYMPHOCYTE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENETIC PREDISPOSITION; GENETICS; HUMAN; IMMUNOBLOTTING; IMMUNOLOGY; LUNG; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADOPTIVE TRANSFER; ALLERGENS; ANIMALS; ASTHMA; CALCITRIOL; CASE-CONTROL STUDIES; CD8-POSITIVE T-LYMPHOCYTES; CHILD; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CHROMATIN IMMUNOPRECIPITATION; COMPUTER SIMULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOBLOTTING; INTERFERON-GAMMA; INTERLEUKIN-13; LUNG; MICE; OVALBUMIN; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNENOLONE; RECEPTORS, CALCITRIOL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84954148684     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10213     Document Type: Article

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