메뉴 건너뛰기




Volumn 17, Issue 1, 2016, Pages

Cells of renin lineage express hypoxia inducible factor 2α following experimental ureteral obstruction

Author keywords

Fibrosis; HIF 2 ; Hypoxia; Microvascular rarefaction; PDGF R; Pericytes; progenitor; Tubulointerstitial; UUO

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; HYPOXIA INDUCIBLE FACTOR 2ALPHA; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; RENIN; ACTIN; ALPHA-SMOOTH MUSCLE ACTIN, MOUSE; ANTIGEN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CHONDROITIN SULFATE PROTEOGLYCAN 4; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; PROTEOGLYCAN;

EID: 84954114504     PISSN: None     EISSN: 14712369     Source Type: Journal    
DOI: 10.1186/s12882-015-0216-0     Document Type: Article
Times cited : (19)

References (52)
  • 1
    • 67349203391 scopus 로고    scopus 로고
    • Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy
    • 19340094
    • Chevalier R, Forbes M, Thornhill B. Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy. Kidney Int. 2009;75:1145-52
    • (2009) Kidney Int , vol.75 , pp. 1145-1152
    • Chevalier, R.1    Forbes, M.2    Thornhill, B.3
  • 3
    • 0016735753 scopus 로고
    • Relationship between renal blood flow and ureteral pressure during 18 hours of total unilateral uretheral occlusion. Implications for changing sites of increased renal resistance
    • 1193822
    • Moody TE, Vaughn ED, Gillenwater JY. Relationship between renal blood flow and ureteral pressure during 18 hours of total unilateral uretheral occlusion. Implications for changing sites of increased renal resistance. Invest Urol. 1975;13:246-51
    • (1975) Invest Urol , vol.13 , pp. 246-251
    • Moody, T.E.1    Vaughn, E.D.2    Gillenwater, J.Y.3
  • 5
    • 80052667572 scopus 로고    scopus 로고
    • Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression
    • 21778339 3172806
    • Franco M, Roswall P, Cortez E, Hanahan D, Pietras K. Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression. Blood. 2011;118:2906-17
    • (2011) Blood , vol.118 , pp. 2906-2917
    • Franco, M.1    Roswall, P.2    Cortez, E.3    Hanahan, D.4    Pietras, K.5
  • 6
    • 79953886254 scopus 로고    scopus 로고
    • Capillary rarefaction, hypoxia, VEGF and angiogenesis in chronic renal disease
    • Mayer G. Capillary rarefaction, hypoxia, VEGF and angiogenesis in chronic renal disease. Nephrol Dial Transpl. 2011;26:1132-7
    • (2011) Nephrol Dial Transpl , vol.26 , pp. 1132-1137
    • Mayer, G.1
  • 7
    • 57149113728 scopus 로고    scopus 로고
    • Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney
    • 19008372 2626374
    • Lin S-L, Kisseleva T, Brenner DA, Duffield JS. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol. 2008;173:1617-27
    • (2008) Am J Pathol , vol.173 , pp. 1617-1627
    • Lin, S.-L.1    Kisseleva, T.2    Brenner, D.A.3    Duffield, J.S.4
  • 8
    • 73949096744 scopus 로고    scopus 로고
    • Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis
    • 20008127 2797872
    • Humphreys BD, Lin S-L, Kobayashi A, Hudson TE, Nowlin BT, Bonventre JV, et al. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol. 2010;176:85-97
    • (2010) Am J Pathol , vol.176 , pp. 85-97
    • Humphreys, B.D.1    Lin, S.-L.2    Kobayashi, A.3    Hudson, T.E.4    Nowlin, B.T.5    Bonventre, J.V.6
  • 9
    • 2342512100 scopus 로고    scopus 로고
    • Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened
    • 15130496
    • Sequeira López MLS, Pentz EE, Nomasa T, Smithies O, Gomez RA. Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened. Dev Cell. 2004;6:719-28
    • (2004) Dev Cell , vol.6 , pp. 719-728
    • Sequeira López, M.L.S.1    Pentz, E.E.2    Nomasa, T.3    Smithies, O.4    Gomez, R.A.5
  • 11
    • 84943334128 scopus 로고    scopus 로고
    • Physiology of the renal interstitium
    • Zeisberg M, Kalluri R. Physiology of the renal interstitium. Clin J Am Soc Nephrol. 2015;10(10):1831-40. doi: 10.2215/CJN.00640114
    • (2015) Clin J Am Soc Nephrol , vol.10 , Issue.10 , pp. 1831-1840
    • Zeisberg, M.1    Kalluri, R.2
  • 12
    • 0030752624 scopus 로고    scopus 로고
    • Extraglomerular origin of the mesangial cell after injury. A new role of the juxtaglomerular apparatus
    • 9259576 508249
    • Hugo C, Shankland S, Bowen-Pope D, Couser W, Johnson R. Extraglomerular origin of the mesangial cell after injury. A new role of the juxtaglomerular apparatus. J Clin Invest. 1997;100:786-94
    • (1997) J Clin Invest , vol.100 , pp. 786-794
    • Hugo, C.1    Shankland, S.2    Bowen-Pope, D.3    Couser, W.4    Johnson, R.5
  • 14
    • 84880580891 scopus 로고    scopus 로고
    • Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease
    • 23769837 3730767
    • Pippin JW, Sparks MA, Glenn ST, Buitrago S, Coffman TM, Duffield JS, et al. Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease. Am J Pathol. 2013;183:542-57
    • (2013) Am J Pathol , vol.183 , pp. 542-557
    • Pippin, J.W.1    Sparks, M.A.2    Glenn, S.T.3    Buitrago, S.4    Coffman, T.M.5    Duffield, J.S.6
  • 15
    • 84874583754 scopus 로고    scopus 로고
    • Deletion of von Hippel-Lindau protein converts renin-producing cells into erythropoietin-producing cells
    • 23393316 3582205
    • Kurt B, Paliege A, Willam C, Schwarzensteiner I, Schucht K, Neymeyer H, et al. Deletion of von Hippel-Lindau protein converts renin-producing cells into erythropoietin-producing cells. J Am Soc Nephrol. 2013;24:433-44
    • (2013) J Am Soc Nephrol , vol.24 , pp. 433-444
    • Kurt, B.1    Paliege, A.2    Willam, C.3    Schwarzensteiner, I.4    Schucht, K.5    Neymeyer, H.6
  • 17
    • 84947618982 scopus 로고    scopus 로고
    • Glomerular parietal epithelial cells contribute to adult podocyte regeneration in experimental focal segmental glomerulosclerosis
    • Eng DG, Sunseri MW, Kaverina NV, Roeder SS, Pippin JW, Shankland SJ. Glomerular parietal epithelial cells contribute to adult podocyte regeneration in experimental focal segmental glomerulosclerosis. Kidney Int. 2015;88(5):999-1012. doi: 10.1038/ki.2015.152
    • (2015) Kidney Int , vol.88 , Issue.5 , pp. 999-1012
    • Eng, D.G.1    Sunseri, M.W.2    Kaverina, N.V.3    Roeder, S.S.4    Pippin, J.W.5    Shankland, S.J.6
  • 18
    • 0033392921 scopus 로고    scopus 로고
    • Cyclin kinase inhibitor p21CIP1/WAF1 limits interstitial cell proliferation following ureteric obstruction
    • 10600942
    • Hughes J, Brown P, Shankland S. Cyclin kinase inhibitor p21CIP1/WAF1 limits interstitial cell proliferation following ureteric obstruction. Am J Physiol. 1999;277(6 Pt 2):F948-56
    • (1999) Am J Physiol , vol.277 , Issue.6 , pp. F948-F956
    • Hughes, J.1    Brown, P.2    Shankland, S.3
  • 19
    • 79951816985 scopus 로고    scopus 로고
    • Targeting endothelium-pericyte cross talk by inhibiting VEGF receptor signaling attenuates kidney microvascular rarefaction and fibrosis
    • 21281822 3070546
    • Lin S-L, Chang F-C, Schrimpf C, Chen Y-T, Wu C-F, Wu V-C, et al. Targeting endothelium-pericyte cross talk by inhibiting VEGF receptor signaling attenuates kidney microvascular rarefaction and fibrosis. Am J Pathol. 2011;178:911-23
    • (2011) Am J Pathol , vol.178 , pp. 911-923
    • Lin, S.-L.1    Chang, F.-C.2    Schrimpf, C.3    Chen, Y.-T.4    Wu, C.-F.5    Wu, V.-C.6
  • 21
    • 84930904241 scopus 로고    scopus 로고
    • ACE-inhibition increases podocyte number in experimental glomerular disease independent of proliferation
    • Zhang J, Yanez D, Floege A, Lichtnekert J, Krofft RD, Liu Z-H, et al. ACE-inhibition increases podocyte number in experimental glomerular disease independent of proliferation. J Renin Angiotensin Aldosterone Syst. 2014;16(2):234-48. doi: 10.1177/1470320314543910
    • (2014) J Renin Angiotensin Aldosterone Syst , vol.16 , Issue.2 , pp. 234-248
    • Zhang, J.1    Yanez, D.2    Floege, A.3    Lichtnekert, J.4    Krofft, R.D.5    Liu, Z.-H.6
  • 22
    • 84879979598 scopus 로고    scopus 로고
    • Reversibility of structural and functional damage in a model of advanced diabetic nephropathy
    • 23641056 3699819
    • Pichaiwong W, Hudkins KL, Wietecha T, Nguyen TQ, Tachaudomdach C, Li W, et al. Reversibility of structural and functional damage in a model of advanced diabetic nephropathy. J Am Soc Nephrol. 2013;24:1088-102
    • (2013) J Am Soc Nephrol , vol.24 , pp. 1088-1102
    • Pichaiwong, W.1    Hudkins, K.L.2    Wietecha, T.3    Nguyen, T.Q.4    Tachaudomdach, C.5    Li, W.6
  • 23
    • 84879289564 scopus 로고    scopus 로고
    • Renal vascular structure and rarefaction
    • 23720331 3936257
    • Chade AR. Renal vascular structure and rarefaction. Compr Physiol. 2013;3:817-31
    • (2013) Compr Physiol , vol.3 , pp. 817-831
    • Chade, A.R.1
  • 24
    • 0036287669 scopus 로고    scopus 로고
    • Peritubular capillary regression during the progression of experimental obstructive nephropathy
    • 12089375
    • Ohashi R. Peritubular capillary regression during the progression of experimental obstructive nephropathy. J Am Soc Nephrol. 2002;13:1795-805
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1795-1805
    • Ohashi, R.1
  • 26
    • 83455198258 scopus 로고    scopus 로고
    • Two microRNAs, MIR-330 and MIR-125b-5p, mark the juxtaglomerular cell and balance its smooth muscle phenotype
    • 21993888 3251334
    • Medrano S, Monteagudo MC, Sequeira-Lopez MLS, Pentz ES, Gomez RA. Two microRNAs, miR-330 and miR-125b-5p, mark the juxtaglomerular cell and balance its smooth muscle phenotype. Am J Physiol Renal Physiol. 2012;302:F29-37
    • (2012) Am J Physiol Renal Physiol , vol.302 , pp. F29-37
    • Medrano, S.1    Monteagudo, M.C.2    Sequeira-Lopez, M.L.S.3    Pentz, E.S.4    Gomez, R.A.5
  • 28
    • 84878651323 scopus 로고    scopus 로고
    • Renal pericytes: Multifunctional cells of the kidneys
    • 23588377
    • Stefańska A, Péault B, Mullins JJ. Renal pericytes: multifunctional cells of the kidneys. Pflugers Arch. 2013;465:767-73
    • (2013) Pflugers Arch , vol.465 , pp. 767-773
    • Stefańska, A.1    Péault, B.2    Mullins, J.J.3
  • 29
    • 84857111725 scopus 로고    scopus 로고
    • The origin of interstitial myofibroblasts in chronic kidney disease
    • 21311912 3116994
    • Grgic I, Duffield JS, Humphreys BD. The origin of interstitial myofibroblasts in chronic kidney disease. Pediatr Nephrol. 2012;27:183-93
    • (2012) Pediatr Nephrol , vol.27 , pp. 183-193
    • Grgic, I.1    Duffield, J.S.2    Humphreys, B.D.3
  • 30
  • 31
    • 75749150800 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2alpha-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization
    • 20016470
    • Paliege A, Rosenberger C, Bondke A, Sciesielski L, Shina A, Heyman SN, et al. Hypoxia-inducible factor-2alpha-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization. Kidney Int. 2010;77:312-8
    • (2010) Kidney Int , vol.77 , pp. 312-318
    • Paliege, A.1    Rosenberger, C.2    Bondke, A.3    Sciesielski, L.4    Shina, A.5    Heyman, S.N.6
  • 33
    • 0037315337 scopus 로고    scopus 로고
    • Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs
    • 12490539
    • Wiesener MS, Jürgensen JS, Rosenberger C, Scholze CK, Hörstrup JH, Warnecke C, et al. Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. FASEB J. 2003;17:271-3
    • (2003) FASEB J , vol.17 , pp. 271-273
    • Wiesener, M.S.1    Jürgensen, J.S.2    Rosenberger, C.3    Scholze, C.K.4    Hörstrup, J.H.5    Warnecke, C.6
  • 34
    • 0038788826 scopus 로고    scopus 로고
    • Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): Role of cytoplasmic trapping of HIF-2alpha
    • 12832481 162224
    • Park S-K, Dadak AM, Haase VH, Fontana L, Giaccia AJ, Johnson RS. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol Cell Biol. 2003;23:4959-71
    • (2003) Mol Cell Biol , vol.23 , pp. 4959-4971
    • Park, S.-K.1    Dadak, A.M.2    Haase, V.H.3    Fontana, L.4    Giaccia, A.J.5    Johnson, R.S.6
  • 35
    • 79951678325 scopus 로고    scopus 로고
    • Origin of new cells in the adult kidney: Results from genetic labeling techniques
    • 20861816
    • Duffield JS, Humphreys BD. Origin of new cells in the adult kidney: results from genetic labeling techniques. Kidney Int. 2011;79:494-501
    • (2011) Kidney Int , vol.79 , pp. 494-501
    • Duffield, J.S.1    Humphreys, B.D.2
  • 36
    • 0034037110 scopus 로고    scopus 로고
    • Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia
    • Fine LG, Bandyopadhay D, Norman JT. Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia. Kidney Int. 2000;57:22-6
    • (2000) Kidney Int , vol.57 , pp. 22-26
    • Fine, L.G.1    Bandyopadhay, D.2    Norman, J.T.3
  • 37
    • 51849094304 scopus 로고    scopus 로고
    • Chronic hypoxia as a mechanism of progression of chronic kidney diseases: From hypothesis to novel therapeutics
    • 18633339
    • Fine LG, Norman JT. Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics. Kidney Int. 2008;74:867-72
    • (2008) Kidney Int , vol.74 , pp. 867-872
    • Fine, L.G.1    Norman, J.T.2
  • 38
    • 8644251822 scopus 로고    scopus 로고
    • Pathophysiology of unilateral ureteral obstruction: Studies from Charlottesville to New York
    • 15538209
    • Vaughan ED, Marion D, Poppas DP, Felsen D. Pathophysiology of unilateral ureteral obstruction: studies from Charlottesville to New York. J Urol. 2004;172(6 Pt 2):2563-9
    • (2004) J Urol , vol.172 , Issue.6 , pp. 2563-2569
    • Vaughan, E.D.1    Marion, D.2    Poppas, D.P.3    Felsen, D.4
  • 39
    • 33645452371 scopus 로고    scopus 로고
    • Chronic hypoxia and tubulointerstitial injury: A final common pathway to end-stage renal failure
    • 16291837
    • Nangaku M. Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J Am Soc Nephrol. 2006;17:17-25
    • (2006) J Am Soc Nephrol , vol.17 , pp. 17-25
    • Nangaku, M.1
  • 40
    • 33750630119 scopus 로고    scopus 로고
    • Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype
    • 17097563
    • Holmquist-Mengelbier L, Fredlund E, Löfstedt T, Noguera R, Navarro S, Nilsson H, et al. Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype. Cancer Cell. 2006;10:413-23
    • (2006) Cancer Cell , vol.10 , pp. 413-423
    • Holmquist-Mengelbier, L.1    Fredlund, E.2    Löfstedt, T.3    Noguera, R.4    Navarro, S.5    Nilsson, H.6
  • 42
    • 51649090078 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice
    • 18490920 2575082
    • Rankin EB, Rha J, Unger TL, Wu CH, Shutt HP, Johnson RS, et al. Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene. 2008;27:5354-8
    • (2008) Oncogene , vol.27 , pp. 5354-5358
    • Rankin, E.B.1    Rha, J.2    Unger, T.L.3    Wu, C.H.4    Shutt, H.P.5    Johnson, R.S.6
  • 43
    • 34047156190 scopus 로고    scopus 로고
    • HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
    • 17418410 3145406
    • Gordan JD, Bertout JA, Hu C-J, Diehl JA, Simon MC. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell. 2007;11:335-47
    • (2007) Cancer Cell , vol.11 , pp. 335-347
    • Gordan, J.D.1    Bertout, J.A.2    Hu, C.-J.3    Diehl, J.A.4    Simon, M.C.5
  • 44
    • 67651098992 scopus 로고    scopus 로고
    • Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis
    • 19439736 2714217
    • Skuli N, Liu L, Runge A, Wang T, Yuan L, Patel S, et al. Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood. 2009;114:469-77
    • (2009) Blood , vol.114 , pp. 469-477
    • Skuli, N.1    Liu, L.2    Runge, A.3    Wang, T.4    Yuan, L.5    Patel, S.6
  • 45
    • 84859700702 scopus 로고    scopus 로고
    • Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes
    • 22426208 3314446
    • Skuli N, Majmundar AJ, Krock BL, Mesquita RC, Mathew LK, Quinn ZL, et al. Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes. J Clin Invest. 2012;122:1427-43
    • (2012) J Clin Invest , vol.122 , pp. 1427-1443
    • Skuli, N.1    Majmundar, A.J.2    Krock, B.L.3    Mesquita, R.C.4    Mathew, L.K.5    Quinn, Z.L.6
  • 46
    • 75149117810 scopus 로고    scopus 로고
    • Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions
    • 19755485 2791494
    • Forristal CE, Wright KL, Hanley NA, Oreffo ROC, Houghton FD. Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions. Reproduction. 2010;139:85-97
    • (2010) Reproduction , vol.139 , pp. 85-97
    • Forristal, C.E.1    Wright, K.L.2    Hanley, N.A.3    Oreffo, R.O.C.4    Houghton, F.D.5
  • 47
    • 84924036219 scopus 로고    scopus 로고
    • Chronic hypoxia-inducible transcription factor-2 activation stably transforms juxtaglomerular renin cells into fibroblast-like cells in vivo
    • 25071089
    • Kurt B, Gerl K, Karger C, Schwarzensteiner I, Kurtz A. Chronic hypoxia-inducible transcription factor-2 activation stably transforms juxtaglomerular renin cells into fibroblast-like cells in vivo. J Am Soc Nephrol. 2015;26:587-96
    • (2015) J Am Soc Nephrol , vol.26 , pp. 587-596
    • Kurt, B.1    Gerl, K.2    Karger, C.3    Schwarzensteiner, I.4    Kurtz, A.5
  • 48
    • 0031834239 scopus 로고    scopus 로고
    • A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
    • 9521897
    • Benjamin LE, Hemo I, Keshet E. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development. 1998;125:1591-8
    • (1998) Development , vol.125 , pp. 1591-1598
    • Benjamin, L.E.1    Hemo, I.2    Keshet, E.3
  • 50
    • 84884956652 scopus 로고    scopus 로고
    • Animal models of chronic kidney disease: Useful but not perfect
    • Becker G, Hewiston T. Animal models of chronic kidney disease: useful but not perfect. Nephrol Dial Transpl. 2013;28:2432-8
    • (2013) Nephrol Dial Transpl , vol.28 , pp. 2432-2438
    • Becker, G.1    Hewiston, T.2
  • 51
    • 0034773379 scopus 로고    scopus 로고
    • Contribution of androgens to chronic allograft nephropathy is mediated by dihydrotestosterone
    • 11703615
    • Antus B, Yao Y, Liu S, Song E, Lutz J, Heemann U. Contribution of androgens to chronic allograft nephropathy is mediated by dihydrotestosterone. Kidney Int. 2001;60:1955-63
    • (2001) Kidney Int , vol.60 , pp. 1955-1963
    • Antus, B.1    Yao, Y.2    Liu, S.3    Song, E.4    Lutz, J.5    Heemann, U.6
  • 52
    • 38949122729 scopus 로고    scopus 로고
    • Testosterone exacerbates obstructive renal injury by stimulating TNF-alpha production and increasing proapoptotic and profibrotic signaling
    • 18073317
    • Metcalfe P, Leslie J, Campbell M, Meldrum D, Hile K, Meldrum K. Testosterone exacerbates obstructive renal injury by stimulating TNF-alpha production and increasing proapoptotic and profibrotic signaling. Am J Physiol Endocrinol Metab. 2008;294:E435-43
    • (2008) Am J Physiol Endocrinol Metab , vol.294 , pp. E435-E443
    • Metcalfe, P.1    Leslie, J.2    Campbell, M.3    Meldrum, D.4    Hile, K.5    Meldrum, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.