Ultrasound-mediated gene transfer (sonoporation) in fibrin-based matrices: Potential for use in tissue regeneration

Journal of Tissue Engineering and Regenerative Medicine

Volumn 10, Issue 1, 2016, Pages 29-39

  Nomikou, Nikolitsa ^a   Feichtinger, Georg A ^b   Redl, Heinz ^b   McHale, Anthony P ^c  

^a Sonidel Ltd   (Ireland)

^b LUDWIG BOLTZMANN INSTITUTE FOR EXPERIMENTAL AND CLINICAL TRAUMATOLOGY   (Austria)

^c UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

Collagen; Fibrin; Gene transfer; Microbubbles; Sonoporation; Tissue engineering

Indexed keywords

COLLAGEN; GENE EXPRESSION; GENE THERAPY; NUCLEIC ACIDS; TISSUE; TISSUE REGENERATION; ULTRASONICS;

CATIONICS; CELL/B.E; DONOR CELLS; FIBRIN; GEL MATRIX; GENES EXPRESSION; MATRIX; MICROBUBBLES; SONOPORATION; TISSUES ENGINEERINGS;

GENE TRANSFER;

COLLAGEN; FIBRIN; NUCLEIC ACID; PLASMID DNA; COLLAGEN TYPE 1; LUCIFERASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE TRANSFER; MICROBUBBLE; MOUSE; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; TISSUE ENGINEERING; TISSUE REGENERATION; ULTRASOUND; ANIMAL; BIOTINYLATION; BOVINE; CELL SURVIVAL; DRUG EFFECTS; ELECTROPORATION; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; METABOLISM; PROCEDURES; REGENERATION;

ANIMALS; BIOTINYLATION; CATTLE; CELL SURVIVAL; COLLAGEN TYPE I; ELECTROPORATION; EXTRACELLULAR MATRIX; FIBRIN; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; LUCIFERASES; MICE; MICROBUBBLES; REGENERATION; ULTRASONICS;

EID: 84954109994     PISSN: 19326254     EISSN: 19327005     Source Type: Journal    
DOI: 10.1002/term.1730     Document Type: Article

References (34)

1. Bouuaert CC, Chalmers RA. 2009; Gene therapy vectors: the prospects and potentials of the cut-and-paste transposons. Genetica 138(5): 473-484.
2. Bushman FD. 2007; Retroviral integration and human gene therapy. J. Clin. Invest. 117(8): 2083-2086.
3. Correa de Sampaio P, Auslaender D, Krubasik D, et al. 2012; A heterogeneous in vitro three-dimensional model of tumour-stroma interactions regulating sprouting angiogenesis. PLoS One 7: e30753, 1-14
4. Davalos RV, Otten DM, Mir LM, et al. 2004; Electrical impedance tomography for imaging tissue electroporation. IEEE Trans Biomed Eng 51: 761-767.
5. Feichtinger G, Redl H, van Griensven M. 2010; Fibrin as gene-activated matrix. In Biological Adhesive Systems: from Nature to Technical and Medical Application, von Byern J, Grunwald I (eds). Springer:, USA; 254-255.
6. Feng X, Shaker M, Clark R, et al. 2010; Fibrin and type I collagen 3-D matrix differentially regulate sprout angiogenesis of human dermal microvascular endothelial cells. EJC Suppl 8(5): 90-91.
7. Geiger F, Bertram H, Berger I, et al. 2005; Vascular endothelial growth factor gene-activated matrix (VEGF165-GAM) enhances osteogenesis and angiogenesis in large segmental bone defects. J. Bone Miner. Res. 20(11): 2028-2035.
8. Gonzalez AM, Berlanga O, Leadbeater WE, et al. 2009; The deployment of adenovirus-containing gene activated matrices onto severed axons after central nervous system injury leads to transgene expression in target neuronal cell bodies. J. Gene Med. 11(8): 679-688.
9. Judo N, Okada K, Yamamoto K. 2009; Sonoporation by single-shot pulsed ultrasound with microbubbles adjacent to cells. Biophys. J. 96: 4866-4876.
10. Katagiri T, Komaki YA, Abe E, et al. 1994; Bone morphogenic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J. Cell Biol. 127: 1755-1766.
11. Keeney M, van den Beucken JJP, van der Kraan PM, et al. 2010; The ability of a collagen/calcium phosphate scaffold to act as its own vector for gene delivery and to promote bone formation via transfection with VEGF 165. Biomaterials 31(10): 2893-2902.
12. Keibl C, Fügl A, Zanoni G, et al. 2011; Human adipose derived stem cells reduce callus volume upon BMP-2 administration in bone regeneration. Injury 42(8): 814-820.
13. Kimelman-Bleich N, Pelled G, Zilberman Y, et al. 2011; Targeted gene-and-host progenitor cell therapy for nonunion bone fracture repair. Mol. Ther. 19(1): 53-59.
14. Kofron MD, Laurencin CT. 2006; Bone tissue engineering by gene delivery. Adv. Drug Deliv. Rev. 58: 555-576.
15. Lee MH, Kim YJ, Kim HJ, et al. 2003; BMP-2-induced Runx2 expression is mediated by Dlx5 and TGF-β1 opposes the BMP-2-induced osteoblast differentiation by suppression of DLx5 expession. J. Biol. Chem. 280; 34387-34394.
16. Li YS, Davidson E, Reid CN, et al. 2009; Optimising ultrasound-mediated gene transfer (sonoporation) in vitro and prolonged expression of a transgene in vivo: potential applications for gene therapy of cancer. Cancer Lett. 273: 62-69.
17. Li YS, Reid CN, McHale AP. 2008; Enhancing ultrasound-mediated cell membrane permeabilisation (sonoporation) using a high frequency pulse regime and implications for ultrasound-aided cancer chemotherapy. Cancer Lett. 266(2): 156-162.
18. Liu H, Collins SF, Suggs LJ. 2006; Three-dimensional culture for expansion and differentiation of mouse embryonic stem cells. Biomaterials 27(36): 6004-6014.
19. Mulder G, Tallis A, Marshall T, et al. 2009; Treatment of nonhealing diabetic foot ulcers with a platelet-derived growth factor gene-activated matrix (GAM501): results of a phase 1/2 trial. Wound Repair Regen. 17(6): 772-779.
20. Nakashima A, Katagiri T, Tamura M, 2005; Crosstalk between Wnt and bone morphogenic protein 2 (BMP-2) signalling in differentiation pathway of C2C12 myoblasts. J. Biol. Chem. 280; 37660-37668.
21. Nomikou N, McHale AP. 2010; Exploiting ultrasound-mediated effects in delivering targeted, site-specific cancer therapy. Cancer Lett. 296:133-143.
22. Nomikou N, Tiwari P, Trehan T, et al. 2012; Studies on neutral, cationic and biotinylated cationic microbubbles in enhancing ultrasound-mediated gene delivery in vitro and in vivo. Acta Biomater. 8(3): 1273-1280.
23. Osawa K, Okubo Y, Nakao K, et al. 2009; Osteoinduction by microbubble-enhanced transcutaneous sonoporation of human bone morphogenetic protein-2. J. Gene Med. 11(7): 633-641.
24. Park JS, Shim M, Shim SH, et al. 2011; Chondrogenic potential of stem cells derived from amniotic fluid, adipose tissue, or bone marrow encapsulated in fibrin gels containing TGF-β3. Biomaterials 32(32): 8139-8149.
25. Pérez RA, Won J, Knowles JC, et al. 2013; Naturally and synthetic smart composite biomaterials for tissue regeneration. Adv. Drug Deliv. Rev. http://dx.doi.org/10.1016/j.addr.2012.03.009.
26. Powell HM, Armour AD, Boyce ST. 2011; Fluorescein diacetate for determination of cell viability in 3D fibroblast-collagen-GAG constructs. Mammalian cell viability: methods and protocols. Method Mol Biol 740(13): 115-126.
27. Schillinger U, Wexel G, Hacker C, et al. 2008; A fibrin glue composition as carrier for nucleic acid vectors. Pharm. Res. 25(12): 2946-2962.
28. Schneider RK, Puellen A, Kramann R, et al. 2010; The osteogenic differentiation of adult bone marrow and perinatal umbilical mesenchymal stem cells and matrix remodelling in three-dimensional collagen scaffolds. Biomaterials 31(3): 467-480.
29. Suzuki R, Oda Y, Utoguchi N, et al. 2011; Progress in the development of ultrasound-mediated gene delivery systems utilizing nano- and microbubbles. J Control Rel 149: 36-41.
30. ter Haar G. 2007; Turning up the power: high intensity focused ultrasound (HIFU) for the treatment of cancer. Ultrasound 15: 73-77.
31. Wang X, Jin L, Ji S, et al. 2011; Hepatocytic differentiation of rhesus monkey embryonic stem cells promoted by collagen gels and growth factors. Cell Biol. Int. 35(8): 775-781.
32. Yasuda H, Kuroda S, Shichinohe H, et al. 2010; Effect of biodegradable fibrin scaffold on survival, migration, and differentiation of transplanted bone marrow stromal cells after cortical injury in rats. J. Neurosurg. 112(2): 336-344.
33. Zhang L, Wang P, Mei S, et al. 2012; In vivo alveolar bone regeneration by bone marrow stem cells/fibrin glue composition. Arch. Oral Biol. 57(3): 238-244.
34. Zhao M, Zhao Z, Koh JT, et al. 2005; Combinatorial gene therapy for bone regeneration: cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4, and 7. J. Cell. Biochem. 95: 1-16.