The deployment of adenovirus-containing gene activated matrices onto severed axons after central nervous system injury leads to transgene expression in target neuronal cell bodies

Journal of Gene Medicine

Volumn 11, Issue 8, 2009, Pages 679-688

  Gonzalez, Ana Maria ^a   Berlanga, Oscar ^a   Leadbeater, Wendy E ^a   Cooper Charles, Lisa ^a   Sims, Karen ^a   Logan, Ann ^a   Eliceiri, Brian ^b   Berry, Martin ^a   Baird, Andrew ^a,b  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Adenoviral vectors; CNS; Collagen; Gene therapy; Matrix; Optic nerve injury; Retinal ganglion cells; Retrograde axonal transport

Indexed keywords

ADENOVIRUS VECTOR; COLLAGEN IMPLANT; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; FREEZE DRYING; GENE EXPRESSION; HUMAN; HUMAN CELL; NERVE CELL; NERVE FIBER; NONHUMAN; OPTIC NERVE INJURY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RETINA GANGLION CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRAL GENE DELIVERY SYSTEM; VIRUS PARTICLE;

ADENOVIRIDAE; ANIMALS; AXONS; BIOCOMPATIBLE MATERIALS; CELL LINE; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; DNA, VIRAL; GENE THERAPY; GREEN FLUORESCENT PROTEINS; HUMANS; OPTIC NERVE; RATS; RATS, WISTAR; RETINAL GANGLION CELLS; RNA, MESSENGER; TRANSCRIPTIONAL ACTIVATION; TRANSGENES;

ADENOVIRIDAE; RATTUS;

EID: 70349480713     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1354     Document Type: Article

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