Aldosterone induces renal fibrosis and inflammatory M1-macrophage subtype via mineralocorticoid receptor in rats

PLoS ONE

Volumn 11, Issue 1, 2016, Pages

  Martín Fernández, Beatriz ^a   Rubio Navarro, Alfonso ^b   Cortegano, Isabel ^c   Ballesteros, Sandra ^a   Alía, Mario ^c   Cannata Ortiz, Pablo ^b   Olivares Álvaro, Elena ^a   Egido, Jesús ^b   De Andrés, Belén ^c   Gaspar, María Luisa ^c   De Las Heras, Natalia ^a   Lahera, Vicente ^a   Moreno, Juan Antonio ^b  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ARG2 PROTEIN; CD163 ANTIGEN; CD45 ANTIGEN; CD68 ANTIGEN; CD86 ANTIGEN; CLODRONIC ACID; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; CREATININE; ED2 PROTEIN; FIBRONECTIN; GAMMA INTERFERON; GELATINASE A; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; MARKER; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; NITROGEN; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SPIRONOLACTONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UREA; MINERALOCORTICOID ANTAGONIST; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE CLEARANCE; ELEVATED BLOOD PRESSURE; GENE EXPRESSION; KIDNEY FIBROSIS; KIDNEY HYPERTROPHY; KIDNEY MASS; MACROPHAGE; MACROPHAGE MIGRATION; MALE; NONHUMAN; RAT; UREA NITROGEN BLOOD LEVEL; ANIMAL; DRUG EFFECTS; FIBROSIS; IMMUNOLOGY; INFLAMMATION; KIDNEY; KIDNEY DISEASES; PATHOLOGY; WISTAR RAT;

ALDOSTERONE; ANIMALS; FIBROSIS; INFLAMMATION; KIDNEY; KIDNEY DISEASES; MACROPHAGES; MALE; MINERALOCORTICOID RECEPTOR ANTAGONISTS; RATS; RATS, WISTAR; RECEPTORS, MINERALOCORTICOID; SODIUM CHLORIDE; SPIRONOLACTONE;

EID: 84954057718     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0145946     Document Type: Article

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