Diabetes increases cryoinjury size with associated effects on Cx43 gap junction function and phosphorylation in the mouse heart

Journal of Diabetes Research

Volumn 2016, Issue , 2016, Pages

  Palatinus, Joseph A ^a   Gourdie, Robert G ^b,c  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b VIRGINIA TECH CARILION SCHOOL OF MEDICINE   (United States)

^c VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 43; INSULIN; SERINE; ANTIDIABETIC AGENT; GJA1 PROTEIN, MOUSE; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COMMUNICATION; COLD INJURY; CONDUCTANCE; CONTROLLED STUDY; DIABETES MELLITUS; GAP JUNCTION; HEART MUSCLE INJURY; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PERICARDIUM; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SKIN INJURY; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CARDIAC MUSCLE; CHEMICALLY INDUCED; COLD; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; METABOLISM; MYOCARDIAL INFARCTION; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; COLD TEMPERATURE; CONNEXIN 43; DIABETES MELLITUS, EXPERIMENTAL; GAP JUNCTIONS; HYPOGLYCEMIC AGENTS; INSULIN; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; MYOCARDIUM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STREPTOZOCIN;

EID: 84953931844     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2016/8789617     Document Type: Article

References (32)

1. K. Tamita, M. Katayama, T. Takagi et al., "Impact of newly diagnosed abnormal glucose tolerance on long-term prognosis in patients with acute myocardial infarction," Circulation Journal, vol. 71, no. 6, pp. 834-841, 2007.
2. S. L. Woodfield, C. F. Lundergan, J. S. Reiner et al., "Angiographic findings and outcome in diabetic patients treated with thrombolytic therapy for acute myocardial infarction: the GUSTO-I experience," Journal of the American College of Cardiology, vol. 28, no. 7, pp. 1661-1669, 1997.
3. A. N. Mather, A. Crean, N. Abidin et al., "Relationship of dysglycemia to acutemyocardial infarct size and cardiovascular outcome as determined by cardiovascular magnetic resonance," Journal of CardiovascularMagnetic Resonance, vol. 12, article 61, 2010.
4. T. D. Miller, T. F. Christian, D. O. Hodge, M. R. Hopfenspirger, B. J. Gersh, and R. J. Gibbons, "Comparison of acutemyocardial infarct size to two-year mortality in patients <65 to those >65 years of age,The American Journal of Cardiology, vol. 84,no. 10, pp. 1170-1175, 1999.
5. R. Marfella, M. DAmico, C. Di Filippo et al., "Myocardial infarction in diabetic rats: role of hyperglycaemia on infarct size and early expression of hypoxia-inducible factor 1," Diabetologia, vol. 45, no. 8, pp. 1172-1181, 2002.
6. P. Coutinho, C. Qiu, S. Frank et al., "Limiting burn extension by transient inhibition of Connexin43 expression at the site of injury," British Journal of Plastic Surgery, vol. 58, no. 5, pp. 658-667, 2005.
7. C. M. Wang, J. Lincoln, J. E. Cook, and D. L. Becker, "Abnormal connexin expression underlies delayed wound healing in diabetic skin," Diabetes, vol. 56, no. 11, pp. 2809-2817, 2007.
8. C. L. Grek, G. Prasad, V. Viswanathan, D. G. Armstrong, R. G. Gourdie, and G. S. Ghatnekar, "Topical administration of a connexin43-based peptide augments healing of chronic neuropathic diabetic foot ulcers: a multicenter, randomized trial," Wound Repair and Regeneration, vol. 23, no. 2, pp. 203-212, 2015.
9. M. P. OQuinn, J. A. Palatinus, B. S. Harris, K. W. Hewett, and R. G. Gourdie, "A peptide mimetic of the connexin43 carboxyl terminus reduces gap junction remodeling and induced arrhythmia following ventricular injury," Circulation Research, vol. 108, no. 6, pp. 704-715, 2011.
10. V. Akoyev and D. J. Takemoto, "ZO-1 is required for protein kinase C gamma-driven disassembly of connexin 43," Cellular Signalling, vol. 19, no. 5, pp. 958-967, 2007.
11. P. D. Lampe and A. F. Lau, "Regulation of gap junctions by phosphorylation of connexins," Archives of Biochemistry and Biophysics, vol. 384, no. 2, pp. 205-215, 2000.
12. W. Srisakuldee, M. M. Jeyaraman, B. E. Nickel, S. Tanguy, Z.-S. Jiang, and E. Kardami, "Phosphorylation of connexin-at serine 262 promotes a cardiac injury-resistant state," Cardiovascular Research, vol. 83, no. 4, pp. 672-681, 2009.
13. O. Bian, H. Zhang, Q. Guan, Y. Sun, and D. Zeng, "High-dose insulin inhibits gap junction intercellular communication in vascular smooth muscle cells,"MolecularMedicine Reports, vol. 12, no. 1, pp. 331-336, 2015.
14. R. Marfella, C. Di Filippo, K. Esposito et al., "Absence of inducible nitric oxide synthase reduces myocardial damage during ischemia reperfusion in streptozotocin-induced hyperglycemic mice," Diabetes, vol. 53, no. 2, pp. 454-462, 2004.
15. G. Hadour, R. Ferrera, L. Sebbag, R. Forrat, J. Delaye, and M. De Lorgeril, "Improved myocardial tolerance to ischaemia in the diabetic rabbit," Journal of Molecular and Cellular Cardiology, vol. 30, no. 9, pp. 1869-1875, 1998.
16. D. J. Paulson, "The diabetic heart is more sensitive to ischemic injury," Cardiovascular Research, vol. 34, no. 1, pp. 104-112, 1997.
17. A. Tosaki, D. T. Engelman, R. M. Engelman, and D. K. Das, "The evolution of diabetic response to ischemia/reperfusion and preconditioning in isolated working rat hearts," Cardiovascular Research, vol. 31, no. 4, pp. 526-536, 1996.
18. S. E. Capes, D. Hunt, K. Malmberg, and H. C. Gerstein, "Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview," The Lancet, vol. 355, no. 9206, pp. 773-778, 2000.
19. R. G. Gourdie, C. R. Green, N. J. Severs, and R. P. Thompson, "Immunolabelling patterns of gap junction connexins in the developing and mature rat heart," Anatomy and Embryology, vol. 185, no. 4, pp. 363-378, 1992.
20. R. G. Gourdie, E. Harfst, N. J. Severs, and C. R. Green, "Cardiac gap junctions in rat ventricle: localization using sitedirected antibodies and laser scanning confocal microscopy," Cardioscience, vol. 1, no. 1, pp. 75-82, 1990.
21. C. R. Green, N. S. Peters, R. G. Gourdie, S. Rothery, and N. J. Severs, "Validation of immunohistochemical quantification in confocal scanning laser microscopy: a comparative assessment of gap junction size with confocal and ultrastructural techniques," Journal of Histochemistry and Cytochemistry, vol. 41, no. 9, pp. 1339-1349, 1993.
22. N. J. Severs, "Microscopy of the gap junction: a historical perspective," in Microscopy Research and Technique, R. G. Gourdie, Ed., vol. 31, pp. 338-346, Wiley-Liss, New York, NY, USA, 1995.
23. A. Nygren, M. L. Olson, K. Y. Chen, T. Emmett, G. Kargacin, and Y. Shimoni, "Propagation of the cardiac impulse in the diabetic rat heart: reduced conduction reserve," Journal of Physiology, vol. 580, no. 2, pp. 543-560, 2007.
24. N. Homma, J. L. Alvarado, W. Coombs et al., "A particlereceptor model for the insulin-induced closure of connexin43 channels," Circulation Research, vol. 83, no. 1, pp. 27-32, 1998.
25. B. W. Doble, X. Dang, P. Ping et al., "Phosphorylation of serine in the gap junction protein connexin-43 regulates DNA synthesis in cell-cell contact forming cardiomyocytes," Journal of Cell Science, vol. 117, no. 3, pp. 507-514, 2004.
26. H. Lin, K. Ogawa, I. Imanaga, and N. Tribulova, "Remodeling of connexin 43 in the diabetic rat heart,"Molecular and Cellular Biochemistry, vol. 290, no. 1-2, pp. 69-78, 2006.
27. M. L. Standaert, A. Avignon, T. Arnold et al., "Insulin translocates PKC-ε and phorbol esters induce and persistently translocate PKC-β2 in BC3H-1 myocytes," Cellular Signalling, vol. 8, no. 4, pp. 313-316, 1996.
28. T. S. Richards, C. A. Dunn, W. G. Carter, M. L. Usui, J. E. Olerud, and P. D. Lampe, "Protein kinase C spatially and temporally regulates gap junctional communication during human wound repair via phosphorylation of connexin43 on serine368," Journal of Cell Biology, vol. 167, no. 3, pp. 555-562, 2004.
29. J. F. Ek-Vitorin, T. J. King, N. S. Heyman, P. D. Lampe, and J. M. Burt, "Selectivity of connexin 43 channels is regulated through protein kinase C-dependent phosphorylation," Circulation Research, vol. 98, no. 12, pp. 1498-1505, 2006.
30. T. J. Schulz, D. Westermann, F. Isken et al., "Activation of mitochondrial energy metabolism protects against cardiac failure," Aging, vol. 2, no. 11, pp. 843-853, 2010.
31. H. V. M. van Rijen, D. Eckardt, J. Degen et al., "Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43," Circulation, vol. 109, no. 8, pp. 1048-1055, 2004.
32. W. Srisakuldee, B. E. Nickel, R. R. Fandrich, Z.-S. Jiang, and E. Kardami, "Administration of FGF-2 to the heart stimulates connexin-43 phosphorylation at protein kinase C target sites," Cell Communication and Adhesion, vol. 13, no. 1-2, pp. 13-19, 2006.