Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines

Journal of Neuroinflammation

Volumn 13, Issue 1, 2016, Pages

  Ghosh, Mousumi ^a   Xu, Yong ^a   Pearse, Damien D ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Alternative activation; Arginase; Inflammation; Innate immunity; Inos; Interleukin; M1; M2; Phenotype; Repair

Indexed keywords

ARGINASE 1; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; REACTIVE OXYGEN METABOLITE; RELM ALPHA; RESISTIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; AIF1 PROTEIN, MOUSE; ARG1 PROTEIN, MOUSE; ARGINASE; CALCIUM BINDING PROTEIN; CYCLOOXYGENASE 2; CYTOKINE; NITRITE; PTGS2 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EXPERIMENTAL SPINAL CORD INJURY; FEMALE; GENE EXPRESSION REGULATION; IMMUNOREACTIVITY; M2A MACROPHAGE; MACROPHAGE; MACROPHAGE ACTIVATION; MICROGLIA; MICROGLIAL CELL CULTURE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PHENOTYPE; POLARIZATION; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TH2 CELL; THORACIC SPINAL CORD; ANIMAL; BRAIN CORTEX; C57BL MOUSE; CELL CULTURE; CLASSIFICATION; CYTOLOGY; METABOLISM; NEWBORN; PATHOLOGY; SPINAL CORD INJURY;

ANIMALS; ANIMALS, NEWBORN; ARGINASE; CALCIUM-BINDING PROTEINS; CELLS, CULTURED; CEREBRAL CORTEX; CYCLIC AMP; CYCLOOXYGENASE 2; CYTOKINES; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICROFILAMENT PROTEINS; MICROGLIA; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; RATS; REACTIVE OXYGEN SPECIES; SPINAL CORD INJURIES; TH2 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84953792158     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-015-0463-9     Document Type: Article

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