Identification of distinct monocyte phenotypes and correlation with circulating cytokine profiles in acute response to spinal cord injury: A pilot study

PM and R

Volumn 6, Issue 4, 2014, Pages 332-341

  Huang, Wan ^a,b   Vodovotz, Yoram ^c,d   Kusturiss, Mary B ^a   Barclay, Derek ^d,e   Greenwald, Karen ^a   Boninger, Michael L ^a,f   Coen, Paul M ^g   Brienza, David ^f,g   Sowa, Gwendolyn ^a,b,f  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b Ferguson Laboratory for Orthopaedic Research   (United States)

^c Department of Surgery ^*  (United States)

^d MCGOWAN INSTITUTE FOR REGENERATIVE MEDICINE   (United States)

^e UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^f University of Pittsburgh   (United States)

^g UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2 INTERFERON; CD14 ANTIGEN; CD16 ANTIGEN; CHEMOKINE; CXCL9 CHEMOKINE; CYTOKINE; EOTAXIN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; AUTACOID;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; INJURY SCALE; INJURY SEVERITY; MALE; MONOCYTE; OBSERVATIONAL STUDY; PHENOTYPE; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SPINAL CORD INJURY; ADOLESCENT; BLOOD; COMPARATIVE STUDY; MIDDLE AGED;

ADOLESCENT; ADULT; AGED; CYTOKINES; FEMALE; FLOW CYTOMETRY; HUMANS; INFLAMMATION MEDIATORS; MALE; MIDDLE AGED; MONOCYTES; PHENOTYPE; PILOT PROJECTS; PROSPECTIVE STUDIES; SPINAL CORD INJURIES;

EID: 84899059223     PISSN: 19341482     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pmrj.2013.10.006     Document Type: Article

References (30)

1. Tator C.H. Experimental and clinical studies of the pathophysiology and management of acute spinal cord injury. JSpinal Cord Med 1996, 19:206-214.
2. Dusart I., Schwab M.E. Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord. Eur J Neurosci 1994, 6:712-724.
3. Chang H.T. Subacute human spinal cord contusion: Few lymphocytes and many macrophages. Spinal Cord 2007, 45:174-182.
4. Fleming J.C., Norenberg M.D., Ramsay D.A., et al. The cellular inflammatory response in human spinal cords after injury. Brain 2006, 129:3249-3269.
5. Popovich P.G., Guan Z., Wei P., Huitinga I., van Rooijen N., Stokes B.T. Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury. Exp Neurol 1999, 158:351-365.
6. Blight A.R. Effects of silica on the outcome from experimental spinal cord injury: Implication of macrophages in secondary tissue damage. Neuroscience 1994, 60:263-273.
7. Shechter R., London A., Varol C., et al. Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role inrecovery from spinal cord injury in mice. PLoS Med 2009, 6:e1000113.
8. Kigerl K.A., Gensel J.C., Ankeny D.P., Alexander J.K., Donnelly D.J., Popovich P.G. Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. JNeurosci 2009, 29:13435-13444.
9. Yin Y., Cui Q., Li Y., et al. Macrophage-derived factors stimulate optic nerve regeneration. JNeurosci 2003, 23:2284-2293.
10. Rapalino O., Lazarov-Spiegler O., Agranov E., et al. Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats. Nat Med 1998, 4:814-821.
11. Knoller N., Auerbach G., Fulga V., et al. Clinical experience using incubated autologous macrophages as a treatment for complete spinalcord injury: Phase I study results. JNeurosurg Spine 2005, 3:173-181.
12. Shechter R., Raposo C., London A., Sagi I., Schwartz M. The glial scar-monocyte interplay: A pivotal resolution phase in spinal cord repair. PLoS One 2011, 6:e27969.
13. Martinez F.O., Gordon S., Locati M., Mantovani A. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: New molecules and patterns of gene expression. JImmunol 2006, 177:7303-7311.
14. Passlick B., Flieger D., Ziegler-Heitbrock H.W. Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood 1989, 74:2527-2534.
15. Ziegler-Heitbrock L. The CD14+ CD16+ blood monocytes: Their role in infection and inflammation. JLeukoc Biol 2007, 81:584-592.
16. Frankenberger M., Sternsdorf T., Pechumer H., Pforte A., Ziegler-Heitbrock H.W. Differential cytokine expression in human blood monocyte subpopulations: A polymerase chain reaction analysis. Blood 1996, 87:373-377.
17. Belge K.U., Dayyani F., Horelt A., et al. The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF. JImmunol 2002, 168:3536-3542.
18. Skrzeczynska-Moncznik J., Bzowska M., Loseke S., Grage-Griebenow E., Zembala M., Pryjma J. Peripheral blood CD14high CD16+ monocytes are main producers of IL-10. Scand J Immunol 2008, 67:152-159.
19. Baker S.P., O'Neill B., Haddon W., Long W.B. The injury severity score: A method for describing patients with multiple injuries and evaluating emergency care. JTrauma 1974, 14:187-196.
20. Coen P.M., Goodpaster B.H. Circulating inflammatory monocytes (CD14+CD16+) are elevated in severe obesity. Diabetes 2010, 59. A356-A356.
21. Kim J., Hematti P. Mesenchymal stem cell-educated macrophages: A novel type of alternatively activated macrophages. Exp Hematol 2009, 37:1445-1453.
22. Bomstein Y., Marder J.B., Vitner K., et al. Features of skin-coincubated macrophages that promote recovery from spinal cord injury. JNeuroimmunol 2003, 142:10-16.
23. Lazarov-Spiegler O., Solomon A.S., Zeev-Brann A.B., Hirschberg D.L., Lavie V., Schwartz M. Transplantation of activated macrophages overcomes central nervous system regrowth failure. FASEB J 1996, 10:1296-1302.
24. Lammertse D.P., Jones L.A., Charlifue S.B., et al. Autologous incubated macrophage therapy in acute, complete spinal cord injury: Results of the phase 2 randomized controlled multicenter trial. Spinal Cord 2012, 50:661-671.
25. De Serres S.A., Vadivel N., Mfarrej B.G., et al. Monocyte-secreted inflammatory cytokines are associated with transplant glomerulopathy in renal allograft recipients. Transplantation 2011, 91:552-559.
26. Moore K.W., de Waal Malefyt R., Coffman R.L., O'Garra A. Interleukin-10and the interleukin-10 receptor. Annu Rev Immunol 2001, 19:683-765.
27. Zhou Z., Peng X., Insolera R., Fink D.J., Mata M. IL-10 promotes neuronalsurvival following spinal cord injury. Exp Neurol 2009, 220:183-190.
28. Bethea J.R., Nagashima H., Acosta M.C., et al. Systemically administered interleukin-10 reduces tumor necrosis factor-alpha production and significantly improves functional recovery following traumatic spinal cord injury in rats. JNeurotrauma 1999, 16:851-863.
29. Kwon B.K., Stammers A.M., Belanger L.M., et al. Cerebrospinal fluid inflammatory cytokines and biomarkers of injury severity in acute human spinal cord injury. JNeurotrauma 2010, 27:669-682.
30. Lammertse D.P. Clinical trials in spinal cord injury: Lessons learned on the path to translation. The 2011 International Spinal Cord Society Sir Ludwig Guttmann Lecture. Spinal Cord 2013, 51:2-9.