Hidden Selection of Bacterial Resistance to Fluoroquinolones In Vivo: The Case of Legionella pneumophila and Humans

EBioMedicine

Volumn 2, Issue 9, 2015, Pages 1179-1185

  Shadoud, Lubana ^a,b,c   Almahmoud, Iyad ^a,b,c   Jarraud, Sophie ^d,e,f   Etienne, Jérôme ^d,e,f   Larrat, Sylvie ^a   Schwebel, Carole ^c   Timsit, Jean François ^c,g   Schneider, Dominique ^a,b   Maurin, Max ^a,b,c  

^a UNIV GRENOBLE ALPES   (France)

^b CNRS   (France)

^c GRENOBLE UNIVERSITY HOSPITAL   (France)

^d CENTRE INTERNATIONAL DE RECHERCHE EN INFECTIOLOGIE   (France)

^e INSERM   (France)

^f HOSPICES CIVILS DE LYON   (France)

^g INSTITUT ALBERT BONNIOT   (France)

Author keywords

Fluoroquinolone resistance; In vivo selection; Legionella pneumophila; Legionellosis; Next generation sequencing; Resistance detection

Indexed keywords

AZITHROMYCIN; CEFTAZIDIME; CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING) A; ERYTHROMYCIN; LEVOFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TEICOPLANIN; BACTERIAL DNA; QUINOLONE DERIVATIVE;

ADULT; AGED; ANTIBIOTIC RESISTANCE; APLASIA; ARTICLE; DNA EXTRACTION; FEMALE; GENE SEQUENCE; GENETIC SELECTION; HOSPITALIZATION; HUMAN; LEGIONELLA PNEUMOPHILA; LEGIONNAIRE DISEASE; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MICROBIOLOGICAL EXAMINATION; MIDDLE AGED; MINIMUM INHIBITORY CONCENTRATION; MUTATION; MUTATION RATE; PNEUMONIA; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RELAPSE; SENSITIVITY AND SPECIFICITY; TREATMENT FAILURE; BACTERIAL GENE; BACTERIAL LOAD; COHORT ANALYSIS; DRUG EFFECTS; GENETICS; PHYSIOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BACTERIAL LOAD; COHORT STUDIES; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; FEMALE; FLUOROQUINOLONES; GENES, BACTERIAL; HUMANS; LEGIONELLA PNEUMOPHILA; MALE; MIDDLE AGED; MUTATION;

EID: 84953751476     PISSN: None     EISSN: 23523964     Source Type: Journal    
DOI: 10.1016/j.ebiom.2015.07.018     Document Type: Article

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