Evaluation of an adaptive maximizing design study based on clinical utility versus morphine for TRV130 proof-of- concept and dose-regimen finding in patients with postoperative pain after bunionectomy

Therapeutic Innovation and Regulatory Science

Volumn 49, Issue 5, 2015, Pages 756-766

  Bolognese, James A ^a   Subach, Ruth Ann ^b   Skobieranda, Franck ^b  

^a Cytel Incorporated   (United States)

^b TREVENA INC   (United States)

Author keywords

Adaptive design; Bunionectomy; Clinical utility; PoC + dose finding; TRV130

Indexed keywords

MORPHINE; OLICERIDINE;

ADAPTIVE MAXIMIZING DESIGN; ARTICLE; DRUG EFFICACY; DRUG TOLERABILITY; DRUG USE; HEALTH CARE UTILIZATION; HUMAN; MAJOR CLINICAL STUDY; PHASE 2 CLINICAL TRIAL; POSTOPERATIVE PAIN; PRIORITY JOURNAL; SIMULATION; STUDY DESIGN; TREATMENT OUTCOME;

EID: 84953719070     PISSN: 21684790     EISSN: 21684804     Source Type: Journal    
DOI: 10.1177/2168479015577866     Document Type: Article

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