MicroRNA-203 Modulates the Radiation Sensitivity of Human Malignant Glioma Cells

International Journal of Radiation Oncology Biology Physics

Volumn 94, Issue 2, 2016, Pages 412-420

  Chang, Ji Hyun ^a   Hwang, Yeo Hyun ^b   Lee, David J ^b   Kim, Dan Hyo ^b   Park, Ji Min ^b   Wu, Hong Gyun ^a   Kim, In Ah ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BIOINFORMATICS; CELL CULTURE; CELLS; CYTOLOGY; DNA; ELECTROPHORESIS; POLYMERASE CHAIN REACTION; RADIATION; REPAIR; RNA; TUMORS;

BIOINFORMATICS ANALYSIS; METHODS AND MATERIALS; MODULATION OF RADIATION; POST-TRANSCRIPTIONAL; RADIATION RESISTANCE; RADIATION SENSITIVITY; SIGNALING PATHWAYS; WESTERN-BLOT ANALYSIS;

CELL SIGNALING;

ATM PROTEIN; CLAUDIN 1; GAMMA HISTONE H2AX; GELATINASE A; HISTONE H2AX; HYPOXIA INDUCIBLE FACTOR 1ALPHA; JANUS KINASE; JANUS KINASE 1; MICRORNA; MICRORNA 203; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; PROTEIN ZO1; RAD51 PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR SLUG; UNCLASSIFIED DRUG; VASCULOTROPIN; VIMENTIN; MIRN203 MICRORNA, HUMAN; PROTEIN; PSMF1 PROTEIN, HUMAN; SNAIL FAMILY TRANSCRIPTION FACTORS; STAT3 PROTEIN, HUMAN; TJP1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ALGORITHM; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE OVEREXPRESSION; GENE TARGETING; GLIOBLASTOMA; GLIOBLASTOMA CELL LINE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; PRIORITY JOURNAL; RADIOSENSITIVITY; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR INVASION; UPREGULATION; WESTERN BLOTTING; BRAIN NEOPLASMS; CELL MOTION; GENETICS; GLIOMA; METABOLISM; PATHOLOGY; PHYSIOLOGY; RADIATION TOLERANCE; TUMOR CELL LINE;

BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CLAUDIN-1; DNA REPAIR; DOWN-REGULATION; GLIOMA; HUMANS; JANUS KINASES; MICRORNAS; NEOPLASM INVASIVENESS; PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RADIATION TOLERANCE; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; UP-REGULATION; VIMENTIN; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84953635501     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2015.10.001     Document Type: Article

References (31)

1. M.E. Hegi, L. Liu, J.G. Herman, and et al. Correlation of o6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity J Clin Oncol 26 2008 4189 4199
2. M.T. Milano, P. Okunieff, R.S. Donatello, and et al. Patterns and timing of recurrence after temozolomide-based chemoradiation for glioblastoma Int J Radiat Oncol Biol Phys 78 2010 1147 1155
3. J.V. Brower, P.A. Clark, W. Lyon, and et al. MicroRNAs in cancer: Glioblastoma and glioblastoma cancer stem cells Neurochem Int 77 2014 68 77
4. P. Guo, J. Lan, J. Ge, and et al. Mir-26a enhances the radiosensitivity of glioblastoma multiforme cells through targeting of ataxia-telangiectasia mutated Exp Cell Res 320 2014 200 208
5. X. Deng, L. Ma, M. Wu, and et al. Mir-124 radiosensitizes human glioma cells by targeting CDK4 J Neurooncol 114 2013 263 274
6. S. Asuthkar, K.K. Velpula, C. Chetty, and et al. Epigenetic regulation of mirna-211 by mmp-9 governs glioma cell apoptosis, chemosensitivity and radiosensitivity Oncotarget 3 2012 1439 1454
7. J.H. He, Y.M. Li, Y.G. Li, and et al. Hsa-mir-203 enhances the sensitivity of leukemia cells to arsenic trioxide Exp Ther Med 5 2013 1315 1321
8. Z. Chen, D. Li, Q. Cheng, and et al. Microrna-203 inhibits the proliferation and invasion of u251 glioblastoma cells by directly targeting pld2 Mol Med Rep 9 2014 503 508
9. R. Dontula, A. Dinasarapu, C. Chetty, and et al. Microrna 203 modulates glioma cell migration via robo1/erk/mmp-9 signaling Genes Cancer 4 2013 285 296
10. K.M. Lee, E.J. Choi, and I.A. Kim Microrna-7 increases radiosensitivity of human cancer cells with activated EGFR-associated signaling Radiother Oncol 101 2011 171 176
11. E.J. Choi, B.J. Cho, D.J. Lee, and et al. Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: Targeting PI3K-AKT-MTOR signaling, HSP90 and histone deacetylases BMC Cancer 14 2014 17
12. T.M. Witkos, E. Koscianska, and W.J. Krzyzosiak Practical aspects of microRNA target prediction Curr Mol Med 11 2011 93 109
13. Y. Zhou, G. Wan, R. Spizzo, and et al. Mir-203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating atm kinase Mol Oncol 8 2014 83 92
14. E. Chautard, G. Loubeau, A. Tchirkov, and et al. Akt signaling pathway: A target for radiosensitizing human malignant glioma Neuro Oncol 12 2010 434 443
15. S.O. Rahaman, P.C. Harbor, O. Chernova, and et al. Inhibition of constitutively active stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells Oncogene 21 2002 8404 8413
16. B. Mukherjee, B. McEllin, C.V. Camacho, and et al. EGFRVIII and DNA double-strand break repair: A molecular mechanism for radioresistance in glioblastoma Cancer Res 69 2009 4252 4259
17. I.A. Kim, S.S. Bae, A. Fernandes, and et al. Selective inhibition of ras, phosphoinositide 3 kinase, and akt isoforms increases the radiosensitivity of human carcinoma cell lines Cancer Res 65 2005 7902 7910
18. M.C. O'Reilly, S.A. Scott, K.A. Brown, and et al. Development of dual pld1/2 and pld2 selective inhibitors from a common 1,3,8-triazaspiro[4.5]decane core: Discovery of ml298 and ml299 that decrease invasive migration in u87-mg glioblastoma cells J Med Chem 56 2013 2695 2699
19. M.S. Carro, W.K. Lim, M.J. Alvarez, and et al. The transcriptional network for mesenchymal transformation of brain tumours Nature 463 2010 318 325
20. H. Zhou, R. Miki, M. Eeva, and et al. Reciprocal regulation of Socs1 and Socs3 enhances resistance to ionizing radiation in glioblastoma multiforme Clin Cancer Res 13 2007 2344 2353
21. L. Gao, F. Li, B. Dong, and et al. Inhibition of stat3 and erbb2 suppresses tumor growth, enhances radiosensitivity, and induces mitochondria-dependent apoptosis in glioma cells Int J Radiat Oncol Biol Phys 77 2010 1223 1231
22. Y.P. Yang, Y.L. Chang, P.I. Huang, and et al. Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the stat3 axis J Cell Physiol 227 2012 976 993
23. J. Theys, B. Jutten, R. Habets, and et al. E-cadherin loss associated with emt promotes radioresistance in human tumor cells Radiother Oncol 99 2011 392 397
24. J. Meng, P. Li, Q. Zhang, and et al. A radiosensitivity gene signature in predicting glioma prognostic via emt pathway Oncotarget 5 2014 4683 4693
25. J. Du, B. Sun, X. Zhao, and et al. Hypoxia promotes vasculogenic mimicry formation by inducing epithelial-mesenchymal transition in ovarian carcinoma Gynecol Oncol 133 2014 575 583
26. Y. Piao, J. Liang, L. Holmes, and et al. Acquired resistance to anti-vegf therapy in glioblastoma is associated with a mesenchymal transition Clin Cancer Res 19 2013 4392 4403
27. O. Kargiotis, C. Chetty, C.S. Gondi, and et al. Adenovirus-mediated transfer of siRNA against mmp-2 mRNA results in impaired invasion and tumor-induced angiogenesis, induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma Oncogene 27 2008 4830 4840
28. B. Kaur, F.W. Khwaja, E.A. Severson, and et al. Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis Neuro Oncol 7 2005 134 153
29. G. Niu, K.L. Wright, M. Huang, and et al. Constitutive stat3 activity up-regulates vegf expression and tumor angiogenesis Oncogene 21 2002 2000 2008
30. Q. Xu, J. Briggs, S. Park, and et al. Targeting stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways Oncogene 24 2005 5552 5560
31. M.E. Peter Targeting of mRNAs by multiple miRNAs: The next step Oncogene 29 2010 2161 2164