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Volumn 33, Issue , 2015, Pages 29-33

Novel glucocorticoids: Where are we now and where do we want to go?

Author keywords

Benefit:risk ratio; Glucocorticoid therapy; Liposomal glucocorticoids; Modified release prednisone; Selective glucocorticoid receptor agonists

Indexed keywords

DIPYRIDAMOLE; DISEASE MODIFYING ANTIRHEUMATIC DRUG; FOSDAGROCORAT; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; LIPOSOMAL GLUCOCORTICOID; MEMBRANE BOUND GLUCOCORTICOID RECEPTOR; NCX 1015; NITROSTEROID; PLACEBO; PREDNISOLONE; PREDNISONE; SELECTIVE GLUCOCORTICOID RECEPTOR AGONIST; TRIPTERYGIUM WILFORDII EXTRACT; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; DRUG COMBINATION; LIGAND; LIPOSOME;

EID: 84953342215     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (28)

References (35)
  • 1
    • 80053566904 scopus 로고    scopus 로고
    • Do the treatment with glucocorticoids and/or the disease itself drive the impairment in glucose metabolism in patients with rheumatoid arthritis?
    • BUTTGEREIT F: Do the treatment with glucocorticoids and/or the disease itself drive the impairment in glucose metabolism in patients with rheumatoid arthritis? Ann Rheum Dis 2011; 70: 1881-3.
    • (2011) Ann Rheum Dis , vol.70 , pp. 1881-1883
    • Buttgereit, F.1
  • 2
    • 78650768326 scopus 로고    scopus 로고
    • Exogenous and endogenous glucocorticoids in rheumatic diseases
    • BUTTGEREIT F, BURMESTER GR, STRAUB RH et al.: Exogenous and endogenous glucocorticoids in rheumatic diseases. Arthritis Rheum 2011; 63: 1-9.
    • (2011) Arthritis Rheum , vol.63 , pp. 1-9
    • Buttgereit, F.1    Burmester, G.R.2    Straub, R.H.3
  • 3
    • 26844433194 scopus 로고    scopus 로고
    • Antiinflammatory action of glucocorticoids-new mechanisms for old drugs
    • RHEN T, CIDLOWSKI JA: Antiinflammatory action of glucocorticoids-new mechanisms for old drugs. N Engl J Med 2005; 353: 1711-23.
    • (2005) N Engl J Med , vol.353 , pp. 1711-1723
    • Rhen, T.1    Cidlowski, J.A.2
  • 4
    • 84884534217 scopus 로고    scopus 로고
    • Optimized glucocorticoid therapy: Teaching old drugs new tricks
    • STREHL C, BUTTGEREIT F: Optimized glucocorticoid therapy: Teaching old drugs new tricks. Mol Cell Endocrinol 2013; 380: 32-40.
    • (2013) Mol Cell Endocrinol , vol.380 , pp. 32-40
    • Strehl, C.1    Buttgereit, F.2
  • 5
    • 0035997486 scopus 로고    scopus 로고
    • Standardised nomenclature for glucocorticoid dosages and glucocorticoid treatment regimens: current questions and tentative answers in rheumatology
    • BUTTGEREIT F, da SILVA JA, BOERS M et al.: Standardised nomenclature for glucocorticoid dosages and glucocorticoid treatment regimens: current questions and tentative answers in rheumatology. Ann Rheum Dis 2002; 61: 718-22.
    • (2002) Ann Rheum Dis , vol.61 , pp. 718-722
    • Buttgereit, F.1    Da Silva, J.A.2    Boers, M.3
  • 6
    • 33144484825 scopus 로고    scopus 로고
    • Safety of low dose glucocorticoid treatment in rheumatoid arthritis: published evidence and prospective trial data
    • Dda SILVA JA, JACOBS JW, KIRWAN JR et al.: Safety of low dose glucocorticoid treatment in rheumatoid arthritis: published evidence and prospective trial data. Ann Rheum Dis 2006; 65: 285-93.
    • (2006) Ann Rheum Dis , vol.65 , pp. 285-293
    • Dda Silva, J.A.1    Jacobs, J.W.2    Kirwan, J.R.3
  • 7
    • 36749001123 scopus 로고    scopus 로고
    • EULAR evidence-based recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases
    • HOES JN, JACOBS JW, BOERS M et al.: EULAR evidence-based recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases. Ann Rheum Dis 2007; 66: 1560-7.
    • (2007) Ann Rheum Dis , vol.66 , pp. 1560-1567
    • Hoes, J.N.1    Jacobs, J.W.2    Boers, M.3
  • 8
    • 77953717225 scopus 로고    scopus 로고
    • Patient and rheumatologist perspectives on glucocorticoids: an exercise to improve the implementation of the European League Against Rheumatism (EULAR) recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases
    • van der GOES MC, JACOBS JW, BOERS M et al.: Patient and rheumatologist perspectives on glucocorticoids: an exercise to improve the implementation of the European League Against Rheumatism (EULAR) recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases. Ann Rheum Dis 2010; 69: 1015-21.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1015-1021
    • Van Der Goes, M.C.1    Jacobs, J.W.2    Boers, M.3
  • 9
    • 77953703402 scopus 로고    scopus 로고
    • Current evidence for the management of rheumatoid arthritis with glucocorticoids: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis
    • GORTER SL, BIJLSMA JW, CUTOLO M et al.: Current evidence for the management of rheumatoid arthritis with glucocorticoids: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis. Ann Rheum Dis 2010; 69: 1010-4.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1010-1014
    • Gorter, S.L.1    Bijlsma, J.W.2    Cutolo, M.3
  • 10
    • 77955455011 scopus 로고    scopus 로고
    • Monitoring adverse events of low-dose glucocorticoid therapy: EULAR recommendations for clinical trials and daily practice
    • van der GOES MC, JACOBS JW, BOERS M et al.: Monitoring adverse events of low-dose glucocorticoid therapy: EULAR recommendations for clinical trials and daily practice. Ann Rheum Dis 2010; 69: 1913-9.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1913-1919
    • Van Der Goes, M.C.1    Jacobs, J.W.2    Boers, M.3
  • 11
    • 84887495327 scopus 로고    scopus 로고
    • EULAR evidence-based and consensus-based recommendations on the management of medium to high-dose glucocorticoid therapy in rheumatic diseases
    • DURU N, van der GOES MC, JACOBS JW et al.: EULAR evidence-based and consensus-based recommendations on the management of medium to high-dose glucocorticoid therapy in rheumatic diseases. Ann Rheum Dis 2013; 72: 1905-13.
    • (2013) Ann Rheum Dis , vol.72 , pp. 1905-1913
    • Duru, N.1    Van Der Goes, M.C.2    Jacobs, J.W.3
  • 12
    • 84958201876 scopus 로고    scopus 로고
    • Glucocorticoids in the treatment of rheumatoid arthritis
    • (in press)
    • BIJLSMA JW, JACOBS JW, BUTTGEREIT F: Glucocorticoids in the treatment of rheumatoid arthritis. Rheumatology 2013 (in press).
    • (2013) Rheumatology
    • Bijlsma, J.W.1    Jacobs, J.W.2    Buttgereit, F.3
  • 13
    • 38149067809 scopus 로고    scopus 로고
    • Efficacy of modified-release versus stan-dard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial
    • BUTTGEREIT F, DOERING G, SCHAEFFLER A et al.: Efficacy of modified-release versus stan-dard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial. Lancet 2008; 371: 205-14.
    • (2008) Lancet , vol.371 , pp. 205-214
    • Buttgereit, F.1    Doering, G.2    Schaeffler, A.3
  • 14
    • 77954979202 scopus 로고    scopus 로고
    • Targeting pathophysiological rhythms: prednisone chronotherapy shows sustained efficacy in rheumatoid arthritis
    • BUTTGEREIT F, DOERING G, SCHAEFFLER A et al.: Targeting pathophysiological rhythms: prednisone chronotherapy shows sustained efficacy in rheumatoid arthritis. Ann Rheum Dis 2010; 69: 1275-80.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1275-1280
    • Buttgereit, F.1    Doering, G.2    Schaeffler, A.3
  • 15
    • 84872061599 scopus 로고    scopus 로고
    • Low-dose prednisone chronotherapy for rheumatoid arthritis: a randomised clinical trial (CAPRA-2)
    • BUTTGEREIT F, MEHTA D, KIRWAN J et al.: Low-dose prednisone chronotherapy for rheumatoid arthritis: a randomised clinical trial (CAPRA-2). Ann Rheum Dis 2013; 72: 204-10.
    • (2013) Ann Rheum Dis , vol.72 , pp. 204-210
    • Buttgereit, F.1    Mehta, D.2    Kirwan, J.3
  • 16
    • 84867559755 scopus 로고    scopus 로고
    • Selective glucocorticoid receptor modulation maintains bone mineral density in mice
    • THIELE S, ZIEGLER N, TSOURDI E et al.: Selective glucocorticoid receptor modulation maintains bone mineral density in mice. J Bone Miner Res 2012; 27: 2242-50.
    • (2012) J Bone Miner Res , vol.27 , pp. 2242-2250
    • Thiele, S.1    Ziegler, N.2    Tsourdi, E.3
  • 17
    • 82755190623 scopus 로고    scopus 로고
    • Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells
    • BASCHANT U, FRAPPART L, RAUCHHAUS U et al.: Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells. Proc Natl Acad Sci USA 2011; 108: 19317-22.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 19317-19322
    • Baschant, U.1    Frappart, L.2    Rauchhaus, U.3
  • 18
    • 84856544361 scopus 로고    scopus 로고
    • Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages
    • KLEIMAN A, HüBNER S, RODRIGUEZ PARKITNA JM et al.: Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages. FASEB J 2012; 26: 722-9.
    • (2012) FASEB J , vol.26 , pp. 722-729
    • Kleiman, A.1    Hübner, S.2    Rodriguez Parkitna, J.M.3
  • 19
    • 84861822417 scopus 로고    scopus 로고
    • Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation
    • VANDEVYVER S, DEJAGER L, Vvan BOGAERT T et al.: Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation. J Clin Invest 2012; 122: 2130-40.
    • (2012) J Clin Invest , vol.122 , pp. 2130-2140
    • Vandevyver, S.1    Dejager, L.2    Vvan Bogaert, T.3
  • 20
    • 84874585409 scopus 로고    scopus 로고
    • New insights into the anti-inflammatory mechanisms of glucocorticoids: an emerging role for glucocorticoid-receptor-mediated transactivation
    • VANDEVYVER S, DEJAGER L, TUCKERMANN J, LIBERT C: New insights into the anti-inflammatory mechanisms of glucocorticoids: an emerging role for glucocorticoid-receptor-mediated transactivation. Endocrinology 2013; 154: 993-1007.
    • (2013) Endocrinology , vol.154 , pp. 993-1007
    • Vandevyver, S.1    Dejager, L.2    Tuckermann, J.3    Libert, C.4
  • 21
    • 77952539277 scopus 로고    scopus 로고
    • Separating therapeutic efficacy from glucocorticoid side-effects in rodent arthritis using novel, liposomal delivery of dexamethasone phosphate: long-term suppression of arthritis facilitates interval treatment
    • RAUCHHAUS U, SCHWAIGER FW, PANZNER S: Separating therapeutic efficacy from glucocorticoid side-effects in rodent arthritis using novel, liposomal delivery of dexamethasone phosphate: long-term suppression of arthritis facilitates interval treatment, Arthritis Res Ther 2009; 11: R190.
    • (2009) Arthritis Res Ther , vol.11
    • Rauchhaus, U.1    Schwaiger, F.W.2    Panzner, S.3
  • 22
    • 72249101465 scopus 로고    scopus 로고
    • Targeted delivery of liposomal dexamethasone phosphate to the spleen provides a persistent therapeutic effect in rat antigen-induced arthritis
    • RAUCHHAUS U, KINNE RW, POHLERS D et al.: Targeted delivery of liposomal dexamethasone phosphate to the spleen provides a persistent therapeutic effect in rat antigen-induced arthritis. Ann Rheum Dis 2009; 68: 1933-4.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1933-1934
    • Rauchhaus, U.1    Kinne, R.W.2    Pohlers, D.3
  • 23
    • 84958201877 scopus 로고    scopus 로고
    • Long-circulating Liposomal Prednisolone versus Pulse Intramuscular Methylprednisolone in Patients with Active Rheumatoid Arthritis
    • BARRERA P, MULDER S, SMETSERS AI et al.: Long-circulating Liposomal Prednisolone versus Pulse Intramuscular Methylprednisolone in Patients with Active Rheumatoid Arthritis. ACR 2008. Abstract L10.
    • (2008) ACR
    • Barrera, P.1    Mulder, S.2    Smetsers, A.I.3
  • 24
    • 0038002438 scopus 로고    scopus 로고
    • Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes
    • METSELAAR JM, WAUBEN MH, WAGENAAR-HILBERS JP, BOERMAN OC, STORM G: Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes. Arthritis Rheum 2003; 48: 2059-66.
    • (2003) Arthritis Rheum , vol.48 , pp. 2059-2066
    • Metselaar, J.M.1    Wauben, M.H.2    Wagenaar-Hilbers, J.P.3    Boerman, O.C.4    Storm, G.5
  • 25
    • 1842505688 scopus 로고    scopus 로고
    • Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritis
    • METSELAAR JM, van den BERG WB, HOLTHUYSEN AE, WAUBEN MH, STORM G, van LENT PL: Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritis. Ann Rheum Dis 2004; 63: 348-53.
    • (2004) Ann Rheum Dis , vol.63 , pp. 348-353
    • Metselaar, J.M.1    Van Den Berg, W.B.2    Holthuysen, A.E.3    Wauben, M.H.4    Storm, G.5    Van Lent, P.L.6
  • 27
    • 60849108323 scopus 로고    scopus 로고
    • Selective amplification of glucocorticoid anti-inflammatory activity through synergistic multi-target action of a combination drug
    • ZIMMERMANN GR, AVERY W, FINELLI AL, FARWELL M, FRASER CC, BORISY AA: Selective amplification of glucocorticoid anti-inflammatory activity through synergistic multi-target action of a combination drug. Arthritis Res Ther 2009; 11: R12.
    • (2009) Arthritis Res Ther , vol.11
    • Zimmermann, G.R.1    Avery, W.2    Finelli, A.L.3    Farwell, M.4    Fraser, C.C.5    Borisy, A.A.6
  • 28
    • 0037022343 scopus 로고    scopus 로고
    • Potent antiarthritic properties of a glucocorticoid derivative, NCX-1015, in an experimental model of arthritis
    • PAUL-CLARK MJ, MANCINI L, Ddel SOLDATO P, FLOWER RJ, PERRETTI M: Potent antiarthritic properties of a glucocorticoid derivative, NCX-1015, in an experimental model of arthritis, Proc Natl Acad Sci USA 2002; 99: 1677-82.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 1677-1682
    • Paul-Clark, M.J.1    Mancini, L.2    Ddel Soldato, P.3    Flower, R.J.4    Perretti, M.5
  • 29
    • 33846660210 scopus 로고    scopus 로고
    • Membrane glucocorticoid receptors (mGCR) on monocytes are up-regulated after vaccination
    • SPIES CM, BARTHOLOME B, BERKI T et al.: Membrane glucocorticoid receptors (mGCR) on monocytes are up-regulated after vaccination. Rheumatology 2007; 46: 364-5.
    • (2007) Rheumatology , vol.46 , pp. 364-365
    • Spies, C.M.1    Bartholome, B.2    Berki, T.3
  • 30
    • 9144249937 scopus 로고    scopus 로고
    • Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis
    • BARTHOLOME B, SPIES CM, GABER T et al.: Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis. FASEB J 2004; 18: 70-80.
    • (2004) FASEB J , vol.18 , pp. 70-80
    • Bartholome, B.1    Spies, C.M.2    Gaber, T.3
  • 31
    • 33750990494 scopus 로고    scopus 로고
    • Membrane glucocorticoid receptor expression on peripheral blood mononuclear cells in patients with ankylosing spondylitis
    • TRYC AB, SPIES CM, SCHNEIDER U et al.: Membrane glucocorticoid receptor expression on peripheral blood mononuclear cells in patients with ankylosing spondylitis. J Rheumatol 2006; 33: 2249-53.
    • (2006) J Rheumatol , vol.33 , pp. 2249-2253
    • Tryc, A.B.1    Spies, C.M.2    Schneider, U.3
  • 32
    • 33747807968 scopus 로고    scopus 로고
    • Membrane glucocorticoid receptors are down regulated by glucocorticoids in patients with systemic lupus erythematosus and use a caveolin-1-independent expression pathway
    • SPIES CM, SCHAUMANN DH, BERKI T et al.: Membrane glucocorticoid receptors are down regulated by glucocorticoids in patients with systemic lupus erythematosus and use a caveolin-1-independent expression pathway. Ann Rheum Dis 2006; 65: 1139-46.
    • (2006) Ann Rheum Dis , vol.65 , pp. 1139-1146
    • Spies, C.M.1    Schaumann, D.H.2    Berki, T.3
  • 33
    • 82455212460 scopus 로고    scopus 로고
    • Origin and functional activity of the membrane-bound glucocorticoid receptor
    • STREHL C, GABER T, LöWENBERG M et al.: Origin and functional activity of the membrane-bound glucocorticoid receptor. Arthritis Rheum 2011; 63: 3779-88.
    • (2011) Arthritis Rheum , vol.63 , pp. 3779-3788
    • Strehl, C.1    Gaber, T.2    Löwenberg, M.3
  • 34
    • 33847278423 scopus 로고    scopus 로고
    • Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)
    • BRINKER AM, MA J, LIPSKY PE, RASKIN I: Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae). Phytochemistry 2007;68:732-66.
    • (2007) Phytochemistry , vol.68 , pp. 732-766
    • Brinker, A.M.1    Ma, J.2    Lipsky, P.E.3    Raskin, I.4
  • 35
    • 69149101082 scopus 로고    scopus 로고
    • Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial
    • GOLDBACH-MANSKY R, WILSON M, FLEISCHMANN R et al.: Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial. Ann Intern Med 2009; 151: 229-40.
    • (2009) Ann Intern Med , vol.151 , pp. 229-240
    • Goldbach-Mansky, R.1    Wilson, M.2    Fleischmann, R.3


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