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84907982178
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Prognostic value of fractional flow reserve: linking physiologic severity to clinical outcomes
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From a large database establishes statistically the severity-risk-benefit continuum of CAD having profound implications for the imaging standard of quantifying severity and personalized management
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Johnson NP, Tóth GG, Lai D, Zhu H, Açar G, Agostoni P, et al. Prognostic value of fractional flow reserve: linking physiologic severity to clinical outcomes. J Am Coll Cardiol. 2014;64:1641–54. From a large database establishes statistically the severity-risk-benefit continuum of CAD having profound implications for the imaging standard of quantifying severity and personalized management.
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Johnson, N.P.1
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Documents CFR thresholds for high, intermediate and low risk global diffuse CAD.
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Taqueti, V.R.1
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Patient selection for elective revascularization to reduce myocardial infarction and mortality: new lessons from randomized trials, coronary physiology, and statistics
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Establishes basic concepts and clinical implications of the severity-risk-benefit continuum to explain failure of randomized intervention trials to reduce risk of MI or mortality and criteria for patient selection clinically and for future trials to demonstrate improved event free survival.
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Gould KL, Johnson NP, Kaul S, Kirkeeide RL, Mintz GS, Rentrop KP, et al. Patient selection for elective revascularization to reduce myocardial infarction and mortality: new lessons from randomized trials, coronary physiology, and statistics. Circ Cardiovasc Imaging. 2015;8, e003099. doi:10.1161/CIRCIMAGING.114.003099. Establishes basic concepts and clinical implications of the severity-risk-benefit continuum to explain failure of randomized intervention trials to reduce risk of MI or mortality and criteria for patient selection clinically and for future trials to demonstrate improved event free survival.
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Gould, K.L.1
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Johnson NP, Gould KL. Physiologic basis for angina and ST change: PET-verified thresholds of quantitative stress myocardial perfusion and coronary flow reserve. J Am Coll Cardiol Img. 2011;4:990–8.
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Integrating noninvasive absolute flow, coronary flow reserve, and ischemic thresholds into a comprehensive map of physiologic severity
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Reports the concept of Coronary Flow Capacity to define physiologic severity of CAD that incorporates stress flow in cc/min/gm and CFR thereby accounting for the great heterogeneity of continuous values into a simple color coded evidences based schema for interventional and management decisions
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Johnson NP, Gould KL. Integrating noninvasive absolute flow, coronary flow reserve, and ischemic thresholds into a comprehensive map of physiologic severity. J Am Coll Cardiol Img. 2012;5:430–40. Reports the concept of Coronary Flow Capacity to define physiologic severity of CAD that incorporates stress flow in cc/min/gm and CFR thereby accounting for the great heterogeneity of continuous values into a simple color coded evidences based schema for interventional and management decisions.
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Johnson, N.P.1
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Anatomic versus physiologic assessment of coronary artery disease: role of CFR, FFR, and PET imaging in revascularization decision-making
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Overview of physiologic severity of focal and global diffuse CAD with review of the world’s literature on quantitative myocardial perfusion
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Gould KL, Johnson NP, Bateman TM, Beanlands RS, Bengel FM, Bober R, et al. Anatomic versus physiologic assessment of coronary artery disease: role of CFR, FFR, and PET imaging in revascularization decision-making. J Am Coll Cardiol. 2013;62:1639–53. Overview of physiologic severity of focal and global diffuse CAD with review of the world’s literature on quantitative myocardial perfusion.
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Documents common invalid informed consent for PCI “to prevent heart attack or death” based on absence of improved event free survival after PCI in randomized trials.
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Rothberg MB, Scherer L, Kashef MA, Coylewright M, Ting HHT, Hu B, et al. The effect of information presentation on beliefs about the benefits of elective percutaneous coronary intervention. JAMA Intern Med. 2014;174:1623–9. Documents common invalid informed consent for PCI “to prevent heart attack or death” based on absence of improved event free survival after PCI in randomized trials.
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Rothberg, M.B.1
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Documents frequent discordant between low FFR and absence of significant angiogram stenosis
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Toth G, Hamilos M, Pyxaras S, Mangiacapra F, Nelis O, De Vroey F, et al. Evolving concepts of angiogram: fractional flow reserve discordances in 4000 coronary stenosis. Eur Heart J. 2014;35:2831–8. Documents frequent discordant between low FFR and absence of significant angiogram stenosis.
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Clinical evaluation of a new concept: resting myocardial perfusion heterogeneity quantified by Markovian analysis of P.E.T. identifies coronary microvascular dysfunction and early atherosclerosis in 1,034 subjects
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Johnson NP, Gould KL. Clinical evaluation of a new concept: resting myocardial perfusion heterogeneity quantified by Markovian analysis of P.E.T. identifies coronary microvascular dysfunction and early atherosclerosis in 1,034 subjects. J Nucl Med. 2005;46:1427–37.
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Does coronary vasodilation after adenosine override endothelin-1 induced coronary vasoconstriction? Experimental validation of a new concept in myocardial perfusion imaging: resting perfusion defects that improve after adenosine are markers of coronary endothelial dysfunction
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Loghin C, Sdringola S, Gould KL. Does coronary vasodilation after adenosine override endothelin-1 induced coronary vasoconstriction? Experimental validation of a new concept in myocardial perfusion imaging: resting perfusion defects that improve after adenosine are markers of coronary endothelial dysfunction. Am J Physiol Heart Circ Physiol. 2007;292:496–502.
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Physiology of endothelin in producing myocardial perfusion heterogeneity: a mechanistic study using darusentan and positron emission tomography
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Johnson NP, Gould KL. Physiology of endothelin in producing myocardial perfusion heterogeneity: a mechanistic study using darusentan and positron emission tomography. J Nucl Cardiol. 2013;20:835–44.
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Coronary branch steal—experimental validation and clinical implications of interacting stenosis in branching coronary arteries
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Gould KL, Kirkeeide R, Johnson NP. Coronary branch steal—experimental validation and clinical implications of interacting stenosis in branching coronary arteries. Circ Cardiovasc Imaging. 2010;3:701–9.
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Common artifacts in PET myocardial perfusion images due to attenuation-emission misregistration: clinical significance, causes and solutions in 1177 patients
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Loghin C, Sdringola S, Gould KL. Common artifacts in PET myocardial perfusion images due to attenuation-emission misregistration: clinical significance, causes and solutions in 1177 patients. J Nucl Med. 2004;45:1029–39.
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Frequent diagnostic errors in cardiac PET-CT due to misregistration of CT attenuation and emission PET images: a definitive analysis of causes, consequences and corrections
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Gould KL, Pan T, Loghin C, Johnson N, Guha A, Sdringola S. Frequent diagnostic errors in cardiac PET-CT due to misregistration of CT attenuation and emission PET images: a definitive analysis of causes, consequences and corrections. J Nucl Med. 2007;48:1112–21.
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Shifted helical CT to optimize cardiac PET-CT co-registration: quantitative improvement and limitations
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Johnson NP, Pan T, Gould KL. Shifted helical CT to optimize cardiac PET-CT co-registration: quantitative improvement and limitations. J Mol Imaging. 2010;9:256–67.
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Quantification of myocardial blood flow and flow reserve: technical aspects
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Klein R, Beanlands RSB, deKemp RA. Quantification of myocardial blood flow and flow reserve: technical aspects. J Nucl Cardiol. 2010;17:555–70.
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deKemp RA, Yoshinaga KY, Beanlands RSB. Will 30dimensional PET-CT enable the routine quantification of myocardial blood flow. J Nucl Cardiol. 2007;14:380–97.
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Reducing radiation dose in rest stress cardiac PET-CT by single post stress cine CT for attenuation correction—quantitative validation
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Gould KL, Pan T, Loghin C, Johnson NP, Sdringola. Reducing radiation dose in rest stress cardiac PET-CT by single post stress cine CT for attenuation correction—quantitative validation. J Nucl Med. 2008;49:738–45.
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Single low-dose CT scan optimized for rest-stress PET attenuation correction and quantification of coronary artery calcium
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Kaster TS, Dwivedi G, Susser L, Renaud JM, Beanlands RS, Chow BJ, et al. Single low-dose CT scan optimized for rest-stress PET attenuation correction and quantification of coronary artery calcium. J Nucl Cardiol. 2015;22:419–28.
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Variation in quantitative myocardial perfusion due to arterial input selection
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Vasquez AF, Johnson NP, Gould KL. Variation in quantitative myocardial perfusion due to arterial input selection. J Am Coll Cardiol Img. 2013;6:559–68.
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Coronary flow and flow reserve by positron emission tomography simplified for clinical application using Rb-82 or N-13 ammonia
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Yoshida K, Mullani N, Gould KL. Coronary flow and flow reserve by positron emission tomography simplified for clinical application using Rb-82 or N-13 ammonia. J Nucl Med. 1996;37:1701–12.
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Characterizing the normal range of myocardial blood flow with rubidium-82 and N-13 ammonia PET imaging
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Renaud JM, DaSilva JN, Beanlands RSB, deKemp RA. Characterizing the normal range of myocardial blood flow with rubidium-82 and N-13 ammonia PET imaging. J Nucl Cardiol. 2013;20:578–91.
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