-
2
-
-
77249098331
-
Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden
-
Rabinovici, G. D. et al. Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden. Brain 133, 512-528 (2010).
-
(2010)
Brain
, vol.133
, pp. 512-528
-
-
Rabinovici, G.D.1
-
3
-
-
84865544952
-
Mitochondrial Fission, Fusion, and Stress
-
Youle, R. J. & van der Bliek, A. M. Mitochondrial Fission, Fusion, and Stress. Science 337, 1062-1065 (2012).
-
(2012)
Science
, vol.337
, pp. 1062-1065
-
-
Youle, R.J.1
Van Der Bliek, A.M.2
-
4
-
-
84869030015
-
Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health
-
Chan, D. C. Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health. Ann. Rev. Genet. 46, 265-287 (2012).
-
(2012)
Ann. Rev. Genet.
, vol.46
, pp. 265-287
-
-
Chan, D.C.1
-
5
-
-
34547601410
-
Mitochondrial Fusion Protects against Neurodegeneration in the Cerebellum
-
Chen, H., McCaffery, J. M. & Chan, D. C. Mitochondrial Fusion Protects against Neurodegeneration in the Cerebellum. Cell 130, 548-562 (2007).
-
(2007)
Cell
, vol.130
, pp. 548-562
-
-
Chen, H.1
McCaffery, J.M.2
Chan, D.C.3
-
6
-
-
27544466847
-
Mitochondrial Morphology And Dynamics In Yeast And Multicellular Eukaryotes
-
Okamoto, K. & Shaw, J. M. Mitochondrial Morphology And Dynamics In Yeast And Multicellular Eukaryotes. Ann. Rev. Genet. 39, 503-536 (2005).
-
(2005)
Ann. Rev. Genet.
, vol.39
, pp. 503-536
-
-
Okamoto, K.1
Shaw, J.M.2
-
7
-
-
56349103980
-
The molecular mechanism of mitochondrial fusion
-
Hoppins, S. & Nunnari, J. The molecular mechanism of mitochondrial fusion. BBA 1793, 20-26 (2009).
-
(2009)
BBA
, vol.1793
, pp. 20-26
-
-
Hoppins, S.1
Nunnari, J.2
-
8
-
-
77955298543
-
Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1
-
Chang, C.-R. & Blackstone, C. Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1. Ann. NY Acad. Sci. 1201, 34-39 (2010).
-
(2010)
Ann. NY Acad. Sci.
, vol.1201
, pp. 34-39
-
-
Chang, C.-R.1
Blackstone, C.2
-
9
-
-
84875213589
-
Regulation of mitochondrial dynamics: Convergences and divergences between yeast and vertebrates
-
Zhao, J., Lendahl, U. & Nister, M. Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates. Cell. Mol. Life Sci. 70, 951-976 (2013).
-
(2013)
Cell. Mol. Life Sci.
, vol.70
, pp. 951-976
-
-
Zhao, J.1
Lendahl, U.2
Nister, M.3
-
10
-
-
79959655354
-
Mitochondrial Division: Molecular Machinery and Physiological Functions
-
Kageyama, Y., Zhang, Z. & Sesaki, H. Mitochondrial Division: Molecular Machinery and Physiological Functions. Curr. Opinion Cell Biol. 23, 427-434 (2011).
-
(2011)
Curr. Opinion Cell Biol.
, vol.23
, pp. 427-434
-
-
Kageyama, Y.1
Zhang, Z.2
Sesaki, H.3
-
11
-
-
84926258887
-
Disturbed mitochondrial dynamics and neurodegenerative disorders
-
Burte, F., Carelli, V., Chinnery, P. F. & Yu-Wai-Man, P. Disturbed mitochondrial dynamics and neurodegenerative disorders. Nat. Rev. Neurol. 11, 11-24 (2015).
-
(2015)
Nat. Rev. Neurol.
, vol.11
, pp. 11-24
-
-
Burte, F.1
Carelli, V.2
Chinnery, P.F.3
Yu-Wai-Man, P.4
-
12
-
-
84884909413
-
Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency
-
Cogliati, S. et al. Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency. Cell 155, 160-171 (2013).
-
(2013)
Cell
, vol.155
, pp. 160-171
-
-
Cogliati, S.1
-
13
-
-
10944269186
-
The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
-
Li, Z., Okamoto, K., Hayashi, Y. & Sheng, M. The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Cell 119, 873-887 (2004).
-
(2004)
Cell
, vol.119
, pp. 873-887
-
-
Li, Z.1
Okamoto, K.2
Hayashi, Y.3
Sheng, M.4
-
14
-
-
79958721260
-
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: Implications for neuronal damage
-
Manczak, M., Calkins, M. J. & Reddy, P. H. Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. Hum. Mol. Genet. 20, 2495-2509 (2011).
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 2495-2509
-
-
Manczak, M.1
Calkins, M.J.2
Reddy, P.H.3
-
15
-
-
84863245760
-
Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease
-
Trushina, E. et al. Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease. PLoS One 7 (2012).
-
(2012)
PLoS One
, vol.7
-
-
Trushina, E.1
-
16
-
-
77952549255
-
Pathological role of hypoxia in Alzheimer's disease
-
Zhang, X. & Le, W. Pathological role of hypoxia in Alzheimer's disease. Exper. Neurol. 223, 299-303 (2010).
-
(2010)
Exper. Neurol.
, vol.223
, pp. 299-303
-
-
Zhang, X.1
Le, W.2
-
17
-
-
84878864199
-
The hallmarks of aging
-
Lopez-Otin, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. The hallmarks of aging. Cell 153, 1194-1217 (2013).
-
(2013)
Cell
, vol.153
, pp. 1194-1217
-
-
Lopez-Otin, C.1
Blasco, M.A.2
Partridge, L.3
Serrano, M.4
Kroemer, G.5
-
18
-
-
77951905953
-
Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Δ12,14-prostaglandin J2
-
Mishra, N. et al. Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Δ12,14-prostaglandin J2. Biochem. Biophys. Res. Comm. 395, 17-24 (2010).
-
(2010)
Biochem. Biophys. Res. Comm.
, vol.395
, pp. 17-24
-
-
Mishra, N.1
-
19
-
-
84872532360
-
Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease
-
Zhu, X., Perry, G., Smith, M. A. & Wang, X. Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. J. Alzheimers Dis. 33 Suppl 1 (2013).
-
(2013)
J. Alzheimers Dis.
, vol.33
-
-
Zhu, X.1
Perry, G.2
Smith, M.A.3
Wang, X.4
-
20
-
-
78649413837
-
Mitochondrial fusion and fission in cell life and death
-
Westermann, B. Mitochondrial fusion and fission in cell life and death. Nat. Rev. Mol. Cell. Biol. 11, 872-884 (2010).
-
(2010)
Nat. Rev. Mol. Cell. Biol.
, vol.11
, pp. 872-884
-
-
Westermann, B.1
-
21
-
-
80155137546
-
PKA/AKAP1 and PP2A/Bβ2 Regulate Neuronal Morphogenesis via Drp1 Phosphorylation and Mitochondrial Bioenergetics
-
Dickey, A. S. & Strack, S. PKA/AKAP1 and PP2A/Bβ2 Regulate Neuronal Morphogenesis via Drp1 Phosphorylation and Mitochondrial Bioenergetics. J. Neurosci. 31, 15716-15726 (2011).
-
(2011)
J. Neurosci.
, vol.31
, pp. 15716-15726
-
-
Dickey, A.S.1
Strack, S.2
-
22
-
-
38849099158
-
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization
-
Cassidy-Stone, A. et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Developm. cell 14, 193-204 (2008).
-
(2008)
Developm. Cell
, vol.14
, pp. 193-204
-
-
Cassidy-Stone, A.1
-
23
-
-
0033231549
-
C. elegans Dynamin-Related Protein DRP-1 Controls Severing of the Mitochondrial Outer Membrane
-
Labrousse, A. M., Zappaterra, M. D., Rube, D. A. & van der Bliek, A. M. C. elegans Dynamin-Related Protein DRP-1 Controls Severing of the Mitochondrial Outer Membrane. Molec. Cell 4, 815-826 (1999).
-
(1999)
Molec. Cell
, vol.4
, pp. 815-826
-
-
Labrousse, A.M.1
Zappaterra, M.D.2
Rube, D.A.3
Van Der Bliek, A.M.4
-
24
-
-
79957988402
-
MiD49 and MiD51, new components of the mitochondrial fission machinery
-
Palmer, C. S. et al. MiD49 and MiD51, new components of the mitochondrial fission machinery. EMBO Reports 12, 565-573 (2011).
-
(2011)
EMBO Reports
, vol.12
, pp. 565-573
-
-
Palmer, C.S.1
-
25
-
-
34347398050
-
The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division
-
Karbowski, M., Neutzner, A. & Youle, R. J. The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. J. Cell Biol. 178, 71-84 (2007).
-
(2007)
J. Cell Biol.
, vol.178
, pp. 71-84
-
-
Karbowski, M.1
Neutzner, A.2
Youle, R.J.3
-
26
-
-
84920933634
-
Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission
-
Li, S. et al. Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission. J. Cell Biol. 208, 109-123 (2015).
-
(2015)
J. Cell Biol.
, vol.208
, pp. 109-123
-
-
Li, S.1
-
27
-
-
78650987611
-
Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission
-
Mears, J. A. et al. Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission. Nat. Struct. Mol. Biol. 18, 20-26 (2011).
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 20-26
-
-
Mears, J.A.1
-
28
-
-
84906993286
-
Optimized two-color super resolution imaging of Drp1 during mitochondrial fission with a slow-switching Dronpa variant
-
Rosenbloom, A. B. et al. Optimized two-color super resolution imaging of Drp1 during mitochondrial fission with a slow-switching Dronpa variant. Proc. Natl. Acad. Sci. USA 111, 13093-13098 (2014).
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 13093-13098
-
-
Rosenbloom, A.B.1
-
29
-
-
0033551134
-
Cyclopentenone prostaglandins suppress activation of microglia: Down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2
-
Petrova, T. V., Akama, K. T. & Van Eldik, L. J. Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2. Proc. Natl. Acad. Sci. USA 96, 4668-4673 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 4668-4673
-
-
Petrova, T.V.1
Akama, K.T.2
Van Eldik, L.J.3
-
30
-
-
84877781381
-
Mechanics of dynamin-mediated membrane fission
-
Morlot, S. & Roux, A. Mechanics of dynamin-mediated membrane fission. Ann. Rev. Biophys. 42, 629-649 (2013).
-
(2013)
Ann. Rev. Biophys.
, vol.42
, pp. 629-649
-
-
Morlot, S.1
Roux, A.2
-
31
-
-
33745026786
-
GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission
-
Roux, A., Uyhazi, K., Frost, A. & De Camilli, P. GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission. Nature 441, 528-531 (2006).
-
(2006)
Nature
, vol.441
, pp. 528-531
-
-
Roux, A.1
Uyhazi, K.2
Frost, A.3
De Camilli, P.4
-
32
-
-
57649238675
-
Real-time visualization of dynamin-catalyzed membrane fission and vesicle release
-
Pucadyil, T. J. & Schmid, S. L. Real-time visualization of dynamin-catalyzed membrane fission and vesicle release. Cell 135, 1263-1275 (2008).
-
(2008)
Cell
, vol.135
, pp. 1263-1275
-
-
Pucadyil, T.J.1
Schmid, S.L.2
-
33
-
-
25844496169
-
Lipid alterations in the earliest clinically recognizable stage of Alzheimer's disease: Implication of the role of lipids in the pathogenesis of Alzheimer's disease
-
Han, X. Lipid alterations in the earliest clinically recognizable stage of Alzheimer's disease: implication of the role of lipids in the pathogenesis of Alzheimer's disease. Cur.r Alzheimer Res. 2, 65-77 (2005).
-
(2005)
Cur.r Alzheimer Res.
, vol.2
, pp. 65-77
-
-
Han, X.1
-
34
-
-
0037032099
-
Impaired axonal transport of cortical neurons in Alzheimer's disease is associated with neuropathological changes
-
Dai, J., Buijs, R. M., Kamphorst, W. & Swaab, D. F. Impaired axonal transport of cortical neurons in Alzheimer's disease is associated with neuropathological changes. Brain Res. 948, 138-144 (2002).
-
(2002)
Brain Res.
, vol.948
, pp. 138-144
-
-
Dai, J.1
Buijs, R.M.2
Kamphorst, W.3
Swaab, D.F.4
-
35
-
-
79955481136
-
Quantitative in vivo measurement of early axonal transport deficits in a triple transgenic mouse model of Alzheimer's disease using manganese-enhanced MRI
-
Kim, J., Choi, I. Y., Michaelis, M. L. & Lee, P. Quantitative in vivo measurement of early axonal transport deficits in a triple transgenic mouse model of Alzheimer's disease using manganese-enhanced MRI. Neuroimage 56, 1286-1292 (2011).
-
(2011)
Neuroimage
, vol.56
, pp. 1286-1292
-
-
Kim, J.1
Choi, I.Y.2
Michaelis, M.L.3
Lee, P.4
-
36
-
-
84873323723
-
Vesicular glycolysis provides on-board energy for fast axonal transport
-
Zala, D. et al. Vesicular glycolysis provides on-board energy for fast axonal transport. Cell 152, 479-491 (2013).
-
(2013)
Cell
, vol.152
, pp. 479-491
-
-
Zala, D.1
-
37
-
-
84861130196
-
Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: Implications for mitochondrial dysfunction and neuronal damage
-
Manczak, M. & Reddy, P. H. Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage. Hum. Mol. Genet. 21, 2538-2547 (2012).
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 2538-2547
-
-
Manczak, M.1
Reddy, P.H.2
-
38
-
-
84864669289
-
Bioenergetic role of mitochondrial fusion and fission
-
Westermann, B. Bioenergetic role of mitochondrial fusion and fission. Biochim Biophys. Acta 1817, 1833-1838 (2012).
-
(2012)
Biochim Biophys. Acta
, vol.1817
, pp. 1833-1838
-
-
Westermann, B.1
-
39
-
-
79959987510
-
Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation
-
Rambold, A. S., Kostelecky, B., Elia, N. & Lippincott-Schwartz, J. Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation. Proc. Natl. Acad. Sci. USA 108, 10190-10195 (2011).
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 10190-10195
-
-
Rambold, A.S.1
Kostelecky, B.2
Elia, N.3
Lippincott-Schwartz, J.4
-
40
-
-
79955623510
-
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability
-
Gomes, L. C., Di Benedetto, G. & Scorrano, L. During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat. Cell. Biol. 13, 589-598 (2011).
-
(2011)
Nat. Cell. Biol.
, vol.13
, pp. 589-598
-
-
Gomes, L.C.1
Di Benedetto, G.2
Scorrano, L.3
-
41
-
-
0029742199
-
Correlative memory deficits, A beta elevation, and amyloid plaques in transgenic mice
-
Hsiao, K. et al. Correlative memory deficits, A beta elevation, and amyloid plaques in transgenic mice. Science 274, 99-102 (1996).
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
-
42
-
-
16044366039
-
Increased amyloid-[beta]42(43) in brains of mice expressing mutant presenilin 1
-
Duff, K. et al. Increased amyloid-[beta]42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710-713 (1996).
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
-
43
-
-
0031914718
-
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
-
Holcomb, L. et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat. Medicine 4, 97-100 (1998).
-
(1998)
Nat. Medicine
, vol.4
, pp. 97-100
-
-
Holcomb, L.1
-
44
-
-
0042697305
-
Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles: Intracellular Aβ and Synaptic Dysfunction
-
Oddo, S. et al. Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles: Intracellular Aβ and Synaptic Dysfunction. Neuron 39, 409-421 (2003).
-
(2003)
Neuron
, vol.39
, pp. 409-421
-
-
Oddo, S.1
-
45
-
-
33846538660
-
Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
-
Yoshiyama, Y. et al. Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model. Neuron 53, 337-351 (2007).
-
(2007)
Neuron
, vol.53
, pp. 337-351
-
-
Yoshiyama, Y.1
-
46
-
-
40449090190
-
Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice
-
Eckert, A. et al. Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice. Neurodegen. Dis. 5, 157-159 (2008).
-
(2008)
Neurodegen. Dis.
, vol.5
, pp. 157-159
-
-
Eckert, A.1
-
47
-
-
70149093436
-
Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
-
Yao, J. et al. Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 106, 14670-14675 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 14670-14675
-
-
Yao, J.1
-
48
-
-
33646152108
-
Mitochondria are a direct site of Abeta accumulation in Alzheimer's disease neurons: Implications for free radical generation and oxidative damage in disease progression
-
Manczak, M. et al. Mitochondria are a direct site of Abeta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. Hum. Mol. Genet. 15, 1437-1449 (2006).
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 1437-1449
-
-
Manczak, M.1
-
49
-
-
78649815388
-
Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
-
Du, H. et al. Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model. Proc. Natl. Acad. Sci. USA 107, 18670-18675 (2010).
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 18670-18675
-
-
Du, H.1
-
50
-
-
80051665640
-
Neuroprotective strategies involving ROS in Alzheimer disease
-
Dumont, M. & Beal, M. F. Neuroprotective strategies involving ROS in Alzheimer disease. Free Radic. Biol. Med. 51, 1014-1026 (2011).
-
(2011)
Free Radic. Biol. Med.
, vol.51
, pp. 1014-1026
-
-
Dumont, M.1
Beal, M.F.2
-
51
-
-
17144363197
-
Reconstruct: A free editor for serial section microscopy
-
Fiala, J. C. Reconstruct: a free editor for serial section microscopy. J. Microscopy 218, 52-61 (2005).
-
(2005)
J. Microscopy
, vol.218
, pp. 52-61
-
-
Fiala, J.C.1
-
52
-
-
0036068212
-
Intracellular distribution of the fluorescent dye nonyl acridine orange responds to the mitochondrial membrane potential: Implications for assays of cardiolipin and mitochondrial mass
-
Jacobson, J., Duchen, M. R. & Heales, S. J. R. Intracellular distribution of the fluorescent dye nonyl acridine orange responds to the mitochondrial membrane potential: implications for assays of cardiolipin and mitochondrial mass. J. Neurochem. 82, 224-233 (2002).
-
(2002)
J. Neurochem.
, vol.82
, pp. 224-233
-
-
Jacobson, J.1
Duchen, M.R.2
Heales, S.J.R.3
|