Modeling the Blood-Brain Barrier in a 3D triple co-culture microfluidic system

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

Volumn 2015-November, Issue , 2015, Pages 338-341

  Adriani, G ^a   Ma, D ^c   Pavesi, A ^a   Goh, E L K ^c   Kamm, R D ^a,b  

^a SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^b USA   (United States)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRAN;

ANIMAL; ASTROCYTE; BLOOD BRAIN BARRIER; CHEMISTRY; COCULTURE; CYTOLOGY; DEVICES; DRUG EFFECTS; HUMAN; LAB ON A CHIP; LONG EVANS RAT; MOLECULAR WEIGHT; NERVE CELL; PERMEABILITY; PROCEDURES; TRANSPORT AT THE CELLULAR LEVEL; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; ASTROCYTES; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; COCULTURE TECHNIQUES; DEXTRANS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LAB-ON-A-CHIP DEVICES; MOLECULAR WEIGHT; NEURONS; PERMEABILITY; RATS, LONG-EVANS;

EID: 84953257102     PISSN: 1557170X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/EMBC.2015.7318368     Document Type: Conference Paper

References (14)

1. N. J. Abbott, A. A. K. Patabendige, D. E. M. Dolman, S. R. Yusof, and D. J. Begley, "Structure and function of the blood-brain barrier, " Neurobiology of Disease, vol. 37, no. 1, pp. 13-25, Jan. 2010.
2. J. T. Henderson and M. Piquette-Miller, "Blood-brain barrier: An impediment to neuropharmaceuticals., " Clin. Pharmacol. Ther., vol. 97, no. 4, pp. 308-313, Apr. 2015.
3. R. Cabezas, M. Avila, J. Gonzalez, R. S. El-Bachá, E. Báez, L. M. García-Segura, J. C. Jurado Coronel, F. Capani, G. P. Cardona-Gomez, and G. E. Barreto, "Astrocytic modulation of blood brain barrier: Perspectives on Parkinson's disease., " Front Cell Neurosci, vol. 8, p. 211, 2014.
4. J.-C. Li, L. Han, Y.-X. Wen, Y.-X. Yang, S. Li, X.-S. Li, C.-J. Zhao, T.-Y. Wang, H. Chen, Y. Liu, C.-L. Qi, X.-D. He, Q.-L. Gu, Y.-X. Ye, Y. Zhang, R. Huang, Y.-E. Wu, R.-R. He, H. Kurihara, X.-Y. Song, L. Cao, and L.-J. Wang, "Increased permeability of the blood-brain barrier and Alzheimer's disease-like alterations in slit-2 transgenic mice., " J. Alzheimers Dis., vol. 43, no. 2, pp. 535-548, 2015.
5. M. C. Grieshaber and J. Flammer, "Does the Blood-brain Barrier Play a Role in Glaucoma?, " Survey of Ophthalmology, vol. 52, no. 6, pp. S115-S121, Nov. 2007.
6. L. M. Griep, F. Wolbers, B. de Wagenaar, P. M. Ter Braak, B. B. Weksler, I. A. Romero, P. O. Couraud, I. Vermes, A. D. van der Meer, and A. van den Berg, "BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function, " Biomed Microdevices, vol. 15, no. 1, pp. 145-150, Sep. 2012.
7. R. Booth and H. Kim, "Characterization of a microfluidic in vitro model of the blood-brain barrier (?BBB), " Lab Chip, vol. 12, no. 10, p. 1784, 2012.
8. J. H. Yeon, D. Na, K. Choi, S.-W. Ryu, C. Choi, and J.-K. Park, "Reliable permeability assay system in a microfluidic device mimicking cerebral vasculatures., " Biomed Microdevices, vol. 14, no. 6, pp. 1141-1148, Dec. 2012.
9. S. Kaech and G. Banker, "Culturing hippocampal neurons, " Nat Protoc, vol. 1, no. 5, pp. 2406-2415, Jan. 2007.
10. D. Ma, S.-I. Yoon, C.-H. Yang, G. Marcy, N. Zhao, W.-Y. Leong, V. Ganapathy, J. Han, A. M. J. Van Dongen, K.-S. Hsu, G.-L. Ming, G. J. Augustine, and E. L. K. Goh, "Rescue of Methyl-CpG Binding Protein 2 Dysfunction-induced Defects in Newborn Neurons by Pentobarbital, " Neurotherapeutics, vol. 12, no. 2, pp. 477-90, Mar. 2015.
11. V. Vickerman and R. D. Kamm, "Mechanism of a flow-gated angiogenesis switch: early signaling events at cell-matrix and cell-cell junctions, " Integr. Biol., vol. 4, no. 8, p. 863, 2012.
12. Y. S. Chang, L. L. Munn, M. V. Hillsley, R. O. Dull, J. Yuan, S. Lakshminarayanan, T. W. Gardner, R. K. Jain, and J. M. Tarbell, "Effect of Vascular Endothelial Growth Factor on Cultured Endothelial Cell Monolayer Transport Properties, " Microvascular Research, vol. 59, no. 2, pp. 265-277, Mar. 2000.
13. I. K. Zervantonakis, S. K. Hughes-Alford, J. L. Charest, J. S. Condeelis, F. B. Gertler, and R. D. Kamm, "Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function, " Proceedings of the National Academy of Sciences, vol. 109, no. 34, pp. 13515-13520, Aug. 2012.
14. W. Yuan, Y. Lv, M. Zeng, and B. M. Fu, "Non-invasive measurement of solute permeability in cerebral microvessels of the rat., " Microvascular Research, vol. 77, no. 2, pp. 166-173, Mar. 2009.