In vivo depletion and genetic targeting of mouse intestinal CX3CR1+ mononuclear phagocytes

Journal of Immunological Methods

Volumn 432, Issue , 2016, Pages 13-23

  Koscsó, Balázs ^a   Gowda, Kavitha ^a   Bogunovic, Milena ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CX3CR1; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CSF1R; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; CHEMOKINE RECEPTOR; CRE RECOMBINASE; CSF1R PROTEIN, MOUSE; CX3CR1 PROTEIN, MOUSE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; INTEGRASE; LYSOZYME;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEPLETION; DRUG MEGADOSE; GENE TARGETING; IN VIVO STUDY; LOW DRUG DOSE; MACROPHAGE; MONONUCLEAR PHAGOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL LINEAGE; DEFICIENCY; DENDRITIC CELL; DOWN REGULATION; DRUG EFFECTS; GENETICS; GENOTYPE; HYBRIDOMA; IMMUNOLOGY; IMMUNOPHENOTYPING; INTESTINE; KNOCKOUT MOUSE; METABOLISM; MUCOSAL IMMUNITY; PHENOTYPE; PROCEDURES; PROMOTER REGION;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOMARKERS; CELL LINEAGE; DENDRITIC CELLS; DOWN-REGULATION; GENE TARGETING; GENOTYPE; HYBRIDOMAS; IMMUNITY, MUCOSAL; IMMUNOPHENOTYPING; INTEGRASES; INTESTINES; MACROPHAGES; MICE, INBRED C57BL; MICE, KNOCKOUT; MURAMIDASE; PHENOTYPE; PROMOTER REGIONS, GENETIC; RECEPTORS, CHEMOKINE; RECEPTORS, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR;

EID: 84953233387     PISSN: 00221759     EISSN: 18727905     Source Type: Journal    
DOI: 10.1016/j.jim.2015.12.009     Document Type: Article

References (40)

1. Bain C.C., Bravo-Blas A., Scott C.L., Gomez Perdiguero E., Geissmann F., Henri S., Malissen B., Osborne L.C., Artis D., Mowat A.M. Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice. Nat. Immunol. 2014, 15:929-937.
2. Bogunovic M., Ginhoux F., Helft J., Shang L., Hashimoto D., Greter M., Liu K., Jakubzick C., Ingersoll M.A., Leboeuf M., Stanley E.R., Nussenzweig M., Lira S.A., Randolph G.J., Merad M. Origin of the lamina propria dendritic cell network. Immunity 2009, 31:513-525.
3. Bogunovic M., Ginhoux F., Wagers A., Loubeau M., Isola L.M., Lubrano L., Najfeld V., Phelps R.G., Grosskreutz C., Scigliano E., Frenette P.S., Merad M. Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men. J. Exp. Med. 2006, 203:2627-2638.
4. Bogunovic M., Mortha A., Muller P.A., Merad M. Mononuclear phagocyte diversity in the intestine. Immunol. Res. 2012, 54:37-49.
5. Burnett S.H., Kershen E.J., Zhang J.Y., Zeng L., Straley S.C., Kaplan A.M., Cohen D.A. Conditional macrophage ablation in transgenic mice expressing a Fas-based suicide gene. J. Leukoc. Biol. 2004, 75:612-623.
6. Cecchini M.G., Dominguez M.G., Mocci S., Wetterwald A., Felix R., Fleisch H., Chisholm O., Hofstetter W., Pollard J.W., Stanley E.R. Role of colony-stimulating factor-I in the establishment and regulation of tissue macrophages during postnatal-development of the mouse. Development 1994, 120:1357-1372.
7. Cerovic V., Houston S.A., Scott C.L., Aumeunier A., Yrlid U., Mowat A.M., Milling S.W. Intestinal CD103(-) dendritic cells migrate in lymph and prime effector T cells. Mucosal Immunol. 2013, 6:104-113.
8. Denning T.L., Wang Y.C., Patel S.R., Williams I.R., Pulendran B. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat. Immunol. 2007, 8:1086-1094.
9. Diehl G.E., Longman R.S., Zhang J.X., Breart B., Galan C., Cuesta A., Schwab S.R., Littman D.R. Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells. Nature 2013, 494:116-120.
10. Fogg D.K., Sibon C., Miled C., Jung S., Aucouturier P., Littman D.R., Cumano A., Geissmann F. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science 2006, 311:83-87.
11. Gross M., Salame T.M., Jung S. Guardians of the gut - murine intestinal macrophages and dendritic cells. Front. Immunol. 2015, 6:254.
12. + regulatory T cells in the lamina propria. Immunity 2011, 34:237-246.
13. Hashimoto D., Chow A., Greter M., Saenger Y., Kwan W.H., Leboeuf M., Ginhoux F., Ochando J.C., Kunisaki Y., van Rooijen N., Liu C., Teshima T., Heeger P.S., Stanley E.R., Frenette P.S., Merad M. Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation. J. Exp. Med. 2011, 208:1069-1082.
14. Hoshi N., Schenten D., Nish S.A., Walther Z., Gagliani N., Flavell R.A., Reizis B., Shen Z., Fox J.G., Iwasaki A., Medzhitov R. MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nat. Commun. 2012, 3:1120.
15. + dendritic cells display unique functional properties that are conserved between mice and humans. J. Exp. Med. 2008, 205:2139-2149.
16. Jakubzick C., Bogunovic M., Bonito A.J., Kuan E.L., Merad M., Randolph G.J. Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes. J. Exp. Med. 2008, 205:2839-2850.
17. + dendritic cells in the regulation of tissue-selective T cell homing. J. Exp. Med. 2005, 202:1063-1073.
18. Jung S., Aliberti J., Graemmel P., Sunshine M.J., Kreutzberg G.W., Sher A., Littman D.R. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol. Cell. Biol. 2000, 20:4106-4114.
19. Kobayashi M., Kweon M.N., Kuwata H., Schreiber R.D., Kiyono H., Takeda K., Akira S. Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J. Clin. Invest. 2003, 111:1297-1308.
20. Koscso B., Gowda K., Schell T.D., Bogunovic M. Purification of dendritic cell and macrophage subsets from the normal mouse small intestine. J. Immunol. Methods 2015, 421:1-13.
21. Mazzini E., Massimiliano L., Penna G., Rescigno M. Oral tolerance can be established via gap junction transfer of fed antigens from CX3CR1(+) macrophages to CD103(+) dendritic cells. Immunity 2014, 40:248-261.
22. + dendritic cells in the small intestine. Nature 2012, 483:345-349.
23. Miller J.C., Brown B.D., Shay T., Gautier E.L., Jojic V., Cohain A., Pandey G., Leboeuf M., Elpek K.G., Helft J., Hashimoto D., Chow A., Price J., Greter M., Bogunovic M., Bellemare-Pelletier A., Frenette P.S., Randolph G.J., Turley S.J., Merad M. Deciphering the transcriptional network of the dendritic cell lineage. Nat. Immunol. 2012, 13:888-899.
24. Mortha A., Chudnovskiy A., Hashimoto D., Bogunovic M., Spencer S.P., Belkaid Y., Merad M. Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Science 2014, 343:1249288.
25. Mowat A.M., Agace W.W. Regional specialization within the intestinal immune system. Nat. Rev. Immunol. 2014, 14:667-685.
26. Muller P.A., Koscso B., Rajani G.M., Stevanovic K., Berres M.L., Hashimoto D., Mortha A., Leboeuf M., Li X.M., Mucida D., Stanley E.R., Dahan S., Margolis K.G., Gershon M.D., Merad M., Bogunovic M. Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility. Cell 2014, 158:300-313.
27. Naik S.H., Sathe P., Park H.Y., Metcalf D., Proietto A.I., Dakic A., Carotta S., O'Keeffe M., Bahlo M., Papenfuss A., Kwak J.Y., Wu L., Shortman K. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat. Immunol. 2007, 8:1217-1226.
28. Niess J.H., Brand S., Gu X., Landsman L., Jung S., McCormick B.A., Vyas J.M., Boes M., Ploegh H.L., Fox J.G., Littman D.R., Reinecker H.C. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 2005, 307:254-258.
29. Onai N., Kurabayashi K., Hosoi-Amaike M., Toyama-Sorimachi N., Matsushima K., Inaba K., Ohteki T. A clonogenic progenitor with prominent plasmacytoid dendritic cell developmental potential. Immunity 2013, 38:943-957.
30. + plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat. Immunol. 2007, 8:1207-1216.
31. Panea C., Farkas A.M., Goto Y., Abdollahi-Roodsaz S., Lee C., Koscso B., Gowda K., Hohl T.M., Bogunovic M., Ivanov I.I. Intestinal monocyte-derived macrophages control commensal-specific Th17 responses. Cell Rep. 2015, 12:1314-1324.
32. Rivollier A., He J., Kole A., Valatas V., Kelsall B.L. Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon. J. Exp. Med. 2012, 209:139-155.
33. Schlitzer A., Sivakamasundari V., Chen J., Sumatoh H.R., Schreuder J., Lum J., Malleret B., Zhang S., Larbi A., Zolezzi F., Renia L., Poidinger M., Naik S., Newell E.W., Robson P., Ginhoux F. Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow. Nat. Immunol. 2015, 16:718-728.
34. Schreiber H.A., Loschko J., Karssemeijer R.A., Escolano A., Meredith M.M., Mucida D., Guermonprez P., Nussenzweig M.C. Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium. J. Exp. Med. 2013, 210:2025-2039.
35. Schulz O., Jaensson E., Persson E.K., Liu X., Worbs T., Agace W.W., Pabst O. Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J. Exp. Med. 2009, 206:3101-3114.
36. Scott C.L., Bain C.C., Wright P.B., Sichien D., Kotarsky K., Persson E.K., Luda K., Guilliams M., Lambrecht B.N., Agace W.W., Milling S.W., Mowat A.M. CCR2(+)CD103(-) intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells. Mucosal Immunol. 2015, 8:327-339.
37. Sudo T., Nishikawa S., Ogawa M., Kataoka H., Ohno N., Izawa A., Hayashi S., Nishikawa S. Functional hierarchy of c-kit and c-fms in intramarrow production of CFU-M. Oncogene 1995, 11:2469-2476.
38. Varol C., Vallon-Eberhard A., Elinav E., Aychek T., Shapira Y., Luche H., Fehling H.J., Hardt W.D., Shakhar G., Jung S. Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity 2009, 31:502-512.
39. Varol C., Zigmond E., Jung S. Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria. Nat. Rev. Immunol. 2010, 10:415-426.
40. Zigmond E., Varol C., Farache J., Elmaliah E., Satpathy A.T., Friedlander G., Mack M., Shpigel N., Boneca I.G., Murphy K.M., Shakhar G., Halpern Z., Jung S. Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. Immunity 2012, 37:1076-1090.