Genetic Variants That Predispose to DNA Double-Strand Breaks in Lymphocytes from a Subset of Patients with Familial Colorectal Carcinomas

Gastroenterology

Volumn 149, Issue 7, 2015, Pages 1872-1883.e9

  Arora, Sanjeevani ^a   Yan, Hong ^a   Cho, Iltaeg ^b   Fan, Hua Ying ^b   Luo, Biao ^a   Gai, Xiaowu ^c   Bodian, Dale L ^d   Vockley, Joseph G ^d   Zhou, Yan ^a   Handorf, Elizabeth A ^a   Egleston, Brian L ^a   Andrake, Mark D ^a   Nicolas, Emmanuelle ^a   Serebriiskii, Ilya G ^a,e   Yen, Timothy J ^a   Hall, Michael J ^a   Golemis, Erica A ^a   Enders, Greg H ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BETTY AND GUY BEATTY CENTER FOR INTEGRATED RESEARCH   (United States)

^e KAZAN FEDERAL UNIVERSITY   (Russian Federation)

Author keywords

Colon Cancer; Genomic Instability; Hereditary Cancer; Tumorigenesis

Indexed keywords

DNA; DOUBLE STRANDED DNA; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 6; GLUTAMINE; HISTONE H2AX; ISOLEUCINE; PROTEIN VARIANT; RECQ HELICASE; THREONINE; TRANSCRIPTION FACTOR; TYROSINE; UNCLASSIFIED DRUG; DNA HELICASE; DNA LIGASE; ERCC6 PROTEIN, HUMAN; EXODEOXYRIBONUCLEASE; H2AFX PROTEIN, HUMAN; HISTONE; MUTAGENIC AGENT; TUMOR MARKER; WERNER SYNDROME ATP DEPENDENT HELICASE; WRN PROTEIN, HUMAN;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CANCER PATIENT; CELL IMMORTALIZATION; CLINICAL ARTICLE; COLON POLYPOSIS; COLORECTAL CANCER; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVITY; EXOME; FAMILIAL COLORECTAL CARCINOMA OF AN UNDEFINED GENETIC BASIS; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC VARIABILITY; GENOTYPE; GERM LINE; HCT116 CELL LINE; HEREDITARY COLORECTAL CANCER; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MIDDLE AGED; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SEQUENCE ANALYSIS; T LYMPHOCYTE; WERNER SYNDROME; AGED; BIOLOGY; CASE CONTROL STUDY; COLORECTAL TUMOR; DNA REPAIR; DNA SEQUENCE; DRUG EFFECTS; FEMALE; GENE FREQUENCY; GENE SILENCING; GENETIC DATABASE; GENETIC PREDISPOSITION; GENETIC TRANSFECTION; GENETIC VARIATION; GENETICS; GENOMIC INSTABILITY; HCT 116 CELL LINE; HEREDITY; IMMUNOLOGY; MALE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; UPREGULATION; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BIOMARKERS, TUMOR; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; COMPUTATIONAL BIOLOGY; DATABASES, GENETIC; DNA BREAKS, DOUBLE-STRANDED; DNA HELICASES; DNA REPAIR; DNA REPAIR ENZYMES; EXODEOXYRIBONUCLEASES; EXOME; FEMALE; GENE FREQUENCY; GENE KNOCKDOWN TECHNIQUES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOMIC INSTABILITY; HCT116 CELLS; HEREDITY; HISTONES; HUMANS; MALE; MIDDLE AGED; MUTAGENS; PHENOTYPE; PHOSPHORYLATION; RECQ HELICASES; SEQUENCE ANALYSIS, DNA; T-LYMPHOCYTES; TRANSFECTION; UP-REGULATION; WERNER SYNDROME HELICASE;

EID: 84952979819     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.08.052     Document Type: Article

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