-
1
-
-
0024425887
-
Checkpoints: Controls that ensure the order of cell cycle events
-
Hartwell, L. H., and Weinert, T. A. (1989) Checkpoints: controls that ensure the order of cell cycle events. Science. 246, 629-634
-
(1989)
Science
, vol.246
, pp. 629-634
-
-
Hartwell, L.H.1
Weinert, T.A.2
-
2
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist, C. J., and Kastan, M. B. (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
3
-
-
0035989348
-
Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes
-
Craven, R. J., Greenwell, P. W., Dominska, M., and Petes, T. D. (2002) Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes. Genetics 161, 493-507
-
(2002)
Genetics
, vol.161
, pp. 493-507
-
-
Craven, R.J.1
Greenwell, P.W.2
Dominska, M.3
Petes, T.D.4
-
4
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.[see comment]
-
Zou, L., and Elledge, S. J. (2003) Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.[see comment]. Science 300, 1542-1548
-
(2003)
Science
, vol.300
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
-
5
-
-
3042798440
-
Minichromosome maintenance proteins are direct targets of theATMandATRcheckpoint kinases
-
Cortez, D., Glick, G., and Elledge, S. J. (2004) Minichromosome maintenance proteins are direct targets of theATMandATRcheckpoint kinases. Proc. Natl. Acad. Sci. U.S.A. 101, 10078-10083
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 10078-10083
-
-
Cortez, D.1
Glick, G.2
Elledge, S.J.3
-
6
-
-
33845607102
-
The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint
-
Majka, J., Niedziela-Majka, A., and Burgers, P. M. (2006) The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint. Mol. Cell 24, 891-901
-
(2006)
Mol. Cell
, vol.24
, pp. 891-901
-
-
Majka, J.1
Niedziela-Majka, A.2
Burgers, P.M.3
-
7
-
-
0345564858
-
Replication protein A-mediated recruitment and activation of Rad17 complexes
-
Zou, L., Liu, D., and Elledge, S. J. (2003) Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc. Natl. Acad. Sci. U.S.A. 100, 13827-13832
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 13827-13832
-
-
Zou, L.1
Liu, D.2
Elledge, S.J.3
-
8
-
-
0035955398
-
Recruitment of Mec1 and Ddc1 checkpoint proteins to doublestrand breaks through distinct mechanisms
-
Kondo, T., Wakayama, T., Naiki, T., Matsumoto, K., and Sugimoto, K. (2001) Recruitment of Mec1 and Ddc1 checkpoint proteins to doublestrand breaks through distinct mechanisms. Science 294, 867-870
-
(2001)
Science
, vol.294
, pp. 867-870
-
-
Kondo, T.1
Wakayama, T.2
Naiki, T.3
Matsumoto, K.4
Sugimoto, K.5
-
9
-
-
0035498938
-
Two checkpoint complexes are independently recruited to sites of DNA damage in vivo
-
Melo, J. A., Cohen, J., and Toczyski, D. P. (2001) Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev. 15, 2809-2821
-
(2001)
Genes Dev
, vol.15
, pp. 2809-2821
-
-
Melo, J.A.1
Cohen, J.2
Toczyski, D.P.3
-
10
-
-
33644757806
-
TopBP1 activates the ATR-ATRIP complex
-
Kumagai, A., Lee, J., Yoo, H. Y., and Dunphy, W. G. (2006) TopBP1 activates the ATR-ATRIP complex. Cell 124, 943-955
-
(2006)
Cell
, vol.124
, pp. 943-955
-
-
Kumagai, A.1
Lee, J.2
Yoo, H.Y.3
Dunphy, W.G.4
-
11
-
-
44849093460
-
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
-
Mordes, D. A., Glick, G. G., Zhao, R., and Cortez, D. (2008) TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev. 22, 1478-1489
-
(2008)
Genes Dev
, vol.22
, pp. 1478-1489
-
-
Mordes, D.A.1
Glick, G.G.2
Zhao, R.3
Cortez, D.4
-
12
-
-
57749099248
-
Dpb11 activates the Mec1-Ddc2 complex
-
Mordes, D. A., Nam, E. A., and Cortez, D. (2008) Dpb11 activates the Mec1-Ddc2 complex. Proc. Natl. Acad. Sci. U.S.A. 105, 18730-18734
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 18730-18734
-
-
Mordes, D.A.1
Nam, E.A.2
Cortez, D.3
-
13
-
-
58149102035
-
Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase
-
Navadgi-Patil, V. M., and Burgers, P. M. (2008) Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase. J. Biol. Chem. 283, 35853-35859
-
(2008)
J. Biol. Chem
, vol.283
, pp. 35853-35859
-
-
Navadgi-Patil, V.M.1
Burgers, P.M.2
-
14
-
-
81755189059
-
The unstructured C-terminal tail of yeast Dpb11 (human TopBP1) protein is dispensable for DNA replication and the S phase checkpoint but required for the G2/M checkpoint
-
Navadgi-Patil, V. M., Kumar, S., and Burgers, P. M. (2011) The unstructured C-terminal tail of yeast Dpb11 (human TopBP1) protein is dispensable for DNA replication and the S phase checkpoint but required for the G2/M checkpoint. J. Biol. Chem. 286, 40999-41007
-
(2011)
J. Biol. Chem
, vol.286
, pp. 40999-41007
-
-
Navadgi-Patil, V.M.1
Kumar, S.2
Burgers, P.M.3
-
15
-
-
34250705797
-
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1
-
Delacroix, S., Wagner, J. M., Kobayashi, M., Yamamoto, K., and Karnitz, L. M. (2007) The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev. 21, 1472-1477
-
(2007)
Genes Dev
, vol.21
, pp. 1472-1477
-
-
Delacroix, S.1
Wagner, J.M.2
Kobayashi, M.3
Yamamoto, K.4
Karnitz, L.M.5
-
16
-
-
2442646547
-
Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1
-
Furuya, K., Poitelea, M., Guo, L., Caspari, T., and Carr, A. M. (2004) Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1. Genes Dev. 18, 1154-1164
-
(2004)
Genes Dev
, vol.18
, pp. 1154-1164
-
-
Furuya, K.1
Poitelea, M.2
Guo, L.3
Caspari, T.4
Carr, A.M.5
-
17
-
-
33748780358
-
Replication protein A directs loading of the DNA damage checkpoint clamp to 5'- DNA junctions
-
Majka, J., Binz, S. K., Wold, M. S., and Burgers, P. M. (2006) Replication protein A directs loading of the DNA damage checkpoint clamp to 5'- DNA junctions. J. Biol. Chem. 281, 27855-27861
-
(2006)
J. Biol. Chem
, vol.281
, pp. 27855-27861
-
-
Majka, J.1
Binz, S.K.2
Wold, M.S.3
Burgers, P.M.4
-
18
-
-
71149093704
-
The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms
-
Navadgi-Patil, V. M., and Burgers, P. M. (2009) The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms. Mol Cell 36, 743-753
-
(2009)
Mol Cell
, vol.36
, pp. 743-753
-
-
Navadgi-Patil, V.M.1
Burgers, P.M.2
-
19
-
-
84884614941
-
An essential function for the ATR-activationdomain (AAD) of TopBP1 in mouse development and cellular senescence
-
Zhou, Z. W., Liu, C., Li, T. L., Bruhn, C., Krueger, A., Min, W., Wang, Z. Q., and Carr, A. M. (2013) An essential function for the ATR-activationdomain (AAD) of TopBP1 in mouse development and cellular senescence. PLoS Genet 9, e1003702
-
(2013)
PLoS Genet
, vol.9
-
-
Zhou, Z.W.1
Liu, C.2
Li, T.L.3
Bruhn, C.4
Krueger, A.5
Min, W.6
Wang, Z.Q.7
Carr, A.M.8
-
20
-
-
84873521523
-
Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery
-
Kumar, S., and Burgers, P. M. (2013) Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery. Genes Dev. 27, 313-321
-
(2013)
Genes Dev
, vol.27
, pp. 313-321
-
-
Kumar, S.1
Burgers, P.M.2
-
21
-
-
83555168211
-
Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment
-
Pfander, B., and Diffley, J. F. (2011) Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment. EMBO J. 30, 4897-4907
-
(2011)
EMBO J
, vol.30
, pp. 4897-4907
-
-
Pfander, B.1
Diffley, J.F.2
-
22
-
-
33747856166
-
The MPI Bioinformatics Toolkit for protein sequence analysis
-
Biegert, A., Mayer, C., Remmert, M., Söding, J., and Lupas, A. N. (2006) The MPI Bioinformatics Toolkit for protein sequence analysis. Nucleic Acids Res. 34, W335-339
-
(2006)
Nucleic Acids Res
, vol.34
-
-
Biegert, A.1
Mayer, C.2
Remmert, M.3
Söding, J.4
Lupas, A.N.5
-
23
-
-
2142738304
-
WebLogo: A sequence logo generator
-
Crooks, G. E., Hon, G., Chandonia, J. M., and Brenner, S. E. (2004) WebLogo: a sequence logo generator. Genome Res. 14, 1188-1190
-
(2004)
Genome Res
, vol.14
, pp. 1188-1190
-
-
Crooks, G.E.1
Hon, G.2
Chandonia, J.M.3
Brenner, S.E.4
-
24
-
-
0037418195
-
Yeast Rad17/Mec3/Ddc1: A sliding clamp for the DNA damage checkpoint
-
Majka, J., and Burgers, P. M. (2003) Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint. Proc. Natl. Acad. Sci. U.S.A. 100, 2249-2254
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 2249-2254
-
-
Majka, J.1
Burgers, P.M.2
-
25
-
-
33645212498
-
Activation of the checkpoint kinase Rad53 by the phosphatidyl inositol kinase-like kinase Mec1
-
Ma, J. L., Lee, S. J., Duong, J. K., and Stern, D. F. (2006) Activation of the checkpoint kinase Rad53 by the phosphatidyl inositol kinase-like kinase Mec1. J. Biol. Chem. 281, 3954-3963
-
(2006)
J. Biol. Chem
, vol.281
, pp. 3954-3963
-
-
Ma, J.L.1
Lee, S.J.2
Duong, J.K.3
Stern, D.F.4
-
26
-
-
67649111979
-
Crystal Structure of the Rad9-Rad1-Hus1 DNA Damage Checkpoint Complex- Implications for Clamp Loading and Regulation
-
Doré, A. S., Kilkenny, M. L., Rzechorzek, N. J., and Pearl, L. H. (2009) Crystal Structure of the Rad9-Rad1-Hus1 DNA Damage Checkpoint Complex- Implications for Clamp Loading and Regulation. Mol. Cell 34, 735-745
-
(2009)
Mol. Cell
, vol.34
, pp. 735-745
-
-
Doré, A.S.1
Kilkenny, M.L.2
Rzechorzek, N.J.3
Pearl, L.H.4
-
27
-
-
67449103064
-
Crystal Structure of the Human Rad9- Hus1-Rad1 Clamp
-
Sohn, S. Y., and Cho, Y. (2009) Crystal Structure of the Human Rad9- Hus1-Rad1 Clamp. J. Mol. Biol. 390, 490-502
-
(2009)
J. Mol. Biol
, vol.390
, pp. 490-502
-
-
Sohn, S.Y.1
Cho, Y.2
-
28
-
-
68949137117
-
Structure and functional implications of the human rad9-hus1-rad1 cell cycle checkpoint complex
-
Xu, M., Bai, L., Gong, Y., Xie, W., Hang, H., and Jiang, T. (2009) Structure and functional implications of the human rad9-hus1-rad1 cell cycle checkpoint complex. J. Biol. Chem. 284, 20457-20461
-
(2009)
J. Biol. Chem
, vol.284
, pp. 20457-20461
-
-
Xu, M.1
Bai, L.2
Gong, Y.3
Xie, W.4
Hang, H.5
Jiang, T.6
-
29
-
-
84938485356
-
Yet another job for Dna2: Checkpoint activation
-
Wanrooij, P. H., and Burgers, P. M. (2015) Yet another job for Dna2: Checkpoint activation. DNA Repair 32, 17-23
-
(2015)
DNA Repair
, vol.32
, pp. 17-23
-
-
Wanrooij, P.H.1
Burgers, P.M.2
-
30
-
-
0030593033
-
Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways
-
Sanchez, Y., Desany, B. A., Jones, W. J., Liu, Q., Wang, B., and Elledge, S. J. (1996) Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271, 357-360
-
(1996)
Science
, vol.271
, pp. 357-360
-
-
Sanchez, Y.1
Desany, B.A.2
Jones, W.J.3
Liu, Q.4
Wang, B.5
Elledge, S.J.6
-
31
-
-
84925235571
-
Phosphoproteomics reveals distinct modes of Mec1/ATR signaling during DNA replication
-
Bastos de Oliveira, F. M., Kim, D., Cussiol, J. R., Das, J., Jeong, M. C., Doerfler, L., Schmidt, K. H., Yu, H., and Smolka, M. B. (2015) Phosphoproteomics reveals distinct modes of Mec1/ATR signaling during DNA replication. Mol. Cell 57, 1124-1132
-
(2015)
Mol. Cell
, vol.57
, pp. 1124-1132
-
-
Bastos De Oliveira, F.M.1
Kim, D.2
Cussiol, J.R.3
Das, J.4
Jeong, M.C.5
Doerfler, L.6
Schmidt, K.H.7
Yu, H.8
Smolka, M.B.9
-
32
-
-
0029057336
-
A single ataxia telangiectasia gene with a product similar to PI-3 kinase
-
Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., Ashkenazi, M., Pecker, I., Frydman, M., Harnik, R., Patanjali, S. R., Simmons, A., Clines, G. A., Sartiel, A., Gatti, R. A., Chessa, L., Sanal, O., Lavin, M. F., Jaspers, N. G., Taylor, A. M., Arlett, C. F., Miki, T., Weissman, S. M., Lovett, M., Collins, F. S., and Shiloh, Y. (1995) A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268, 1749-1753
-
(1995)
Science
, vol.268
, pp. 1749-1753
-
-
Savitsky, K.1
Bar-Shira, A.2
Gilad, S.3
Rotman, G.4
Ziv, Y.5
Vanagaite, L.6
Tagle, D.A.7
Smith, S.8
Uziel, T.9
Sfez, S.10
Ashkenazi, M.11
Pecker, I.12
Frydman, M.13
Harnik, R.14
Patanjali, S.R.15
Simmons, A.16
Clines, G.A.17
Sartiel, A.18
Gatti, R.A.19
Chessa, L.20
Sanal, O.21
Lavin, M.F.22
Jaspers, N.G.23
Taylor, A.M.24
Arlett, C.F.25
Miki, T.26
Weissman, S.M.27
Lovett, M.28
Collins, F.S.29
Shiloh, Y.30
more..
-
33
-
-
0034102337
-
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
-
Brown, E. J., and Baltimore, D. (2000) ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev. 14, 397-402
-
(2000)
Genes Dev
, vol.14
, pp. 397-402
-
-
Brown, E.J.1
Baltimore, D.2
-
34
-
-
0034177408
-
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
-
de Klein, A., Muijtjens, M., van Os, R., Verhoeven, Y., Smit, B., Carr, A. M., Lehmann, A. R., and Hoeijmakers, J. H. (2000) Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice. Curr. Biol. 10, 479-482
-
(2000)
Curr. Biol
, vol.10
, pp. 479-482
-
-
De Klein, A.1
Muijtjens, M.2
Van Os, R.3
Verhoeven, Y.4
Smit, B.5
Carr, A.M.6
Lehmann, A.R.7
Hoeijmakers, J.H.8
-
35
-
-
0035941021
-
ATR and ATRIP: Partners in checkpoint signaling
-
Cortez, D., Guntuku, S., Qin, J., and Elledge, S. J. (2001) ATR and ATRIP: partners in checkpoint signaling. Science 294, 1713-1716
-
(2001)
Science
, vol.294
, pp. 1713-1716
-
-
Cortez, D.1
Guntuku, S.2
Qin, J.3
Elledge, S.J.4
-
36
-
-
0345073699
-
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
-
O'Driscoll, M., Ruiz-Perez, V. L., Woods, C. G., Jeggo, P. A., and Goodship, J. A. (2003) A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat. Genet. 33, 497-501
-
(2003)
Nat. Genet
, vol.33
, pp. 497-501
-
-
O'Driscoll, M.1
Ruiz-Perez, V.L.2
Woods, C.G.3
Jeggo, P.A.4
Goodship, J.A.5
-
37
-
-
33745171123
-
How cells activate ATR
-
Kumagai, A., and Dunphy, W. G. (2006) How cells activate ATR. Cell Cycle 5, 1265-1268
-
(2006)
Cell Cycle
, vol.5
, pp. 1265-1268
-
-
Kumagai, A.1
Dunphy, W.G.2
-
38
-
-
34548060929
-
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
-
Choi, J. H., Lindsey-Boltz, L. A., and Sancar, A. (2007) Reconstitution of a human ATR-mediated checkpoint response to damaged DNA. Proc. Natl. Acad. Sci. U.S.A. 104, 13301-13306
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 13301-13306
-
-
Choi, J.H.1
Lindsey-Boltz, L.A.2
Sancar, A.3
-
39
-
-
20744452365
-
GOR v server for protein secondary structure prediction
-
Sen, T. Z., Jernigan, R. L., Garnier, J., and Kloczkowski, A. (2005) GOR V server for protein secondary structure prediction. Bioinformatics 21, 2787-2788
-
(2005)
Bioinformatics
, vol.21
, pp. 2787-2788
-
-
Sen, T.Z.1
Jernigan, R.L.2
Garnier, J.3
Kloczkowski, A.4
-
40
-
-
24044538903
-
IUPred: Web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content
-
Dosztányi, Z., Csizmok, V., Tompa, P., and Simon, I. (2005) IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content. Bioinformatics 21, 3433-3434
-
(2005)
Bioinformatics
, vol.21
, pp. 3433-3434
-
-
Dosztányi, Z.1
Csizmok, V.2
Tompa, P.3
Simon, I.4
|