Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Reddon, Hudson ^a   Gerstein, Hertzel C ^a,b   Engert, James C ^c   Mohan, Viswanathan ^d   Bosch, Jackie ^b   Desai, Dipika ^a,b   Bailey, Swneke D ^c   Diaz, Rafael ^e   Yusuf, Salim ^a,b   Anand, Sonia S ^a,b   Meyre, David ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b HAMILTON GENERAL HOSPITAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d MADRAS DIABETES RESEARCH FOUNDATION   (India)

^e ECLA   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALLELE; BODY MASS; CLINICAL TRIAL; ETHNIC GROUP; FEMALE; FOLLOW UP; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HUMAN; LONGITUDINAL STUDY; MALE; MIDDLE AGED; MOTOR ACTIVITY; MULTICENTER STUDY; OBESITY; OUTCOME ASSESSMENT; RISK; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ALLELES; BODY MASS INDEX; ETHNIC GROUPS; FEMALE; FOLLOW-UP STUDIES; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MOTOR ACTIVITY; OBESITY; PATIENT OUTCOME ASSESSMENT; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK;

EID: 84952917641     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep18672     Document Type: Article

References (53)

1. Finucane, M. M. et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet 377, 557-567, doi: 10.1016/S0140-6736(10)62037-5 (2011).
2. Dixon, J. B. The effect of obesity on health outcomes. Mol Cell Endocrinol 316, 104-108, doi: 10.1016/j.mce.2009.07.008 (2010).
3. Fontaine, K. R., Redden, D. T., Wang, C., Westfall, A. O. & Allison, D. B. Years of life lost due to obesity. Jama 289, 187-193 (2003).
4. McAllister, E. J. et al. Ten putative contributors to the obesity epidemic. Crit Rev Food Sci Nutr 49, 868-913, doi: 10.1080/10408390903372599 (2009).
5. Birch, L. L. & Ventura, A. K. Preventing childhood obesity: what works? Int J Obes (Lond) 33 Suppl 1, S74-81, doi: 10.1038/ijo.2009.22 (2009).
6. Wardle, J., Carnell, S., Haworth, C. M. & Plomin, R. Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment. Am J Clin Nutr 87, 398-404 (2008).
7. Mustelin, L., Silventoinen, K., Pietilainen, K., Rissanen, A. & Kaprio, J. Physical activity reduces the influence of genetic effects on BMI and waist circumference: A study in young adult twins. Int J Obes (Lond) 33, 29-36, doi: 10.1038/ijo.2008.258 (2009).
8. Andreasen, C. H. et al. Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 57, 95-101 (2008).
9. Xi, B. et al. [Impact on the risk of obesity due to interactions between fat mass-And obesity-Associated gene rs9939609 variants and behavioral factors, in the Chinese school-Aged children]. Zhonghua Liu Xing Bing Xue Za Zhi 31, 737-741 (2010).
10. Demerath, E. W. et al. Interaction of FTO and physical activity level on adiposity in African-American and European-American adults: The ARIC study. Obesity (Silver Spring) 19, 1866-1872, doi: 10.1038/oby.2011.131 (2011).
11. Ahmad, S. et al. Gene x physical activity interactions in obesity: combined analysis of 111, 421 individuals of European ancestry. PLoS Genet 9, e1003607, doi: 10.1371/journal.pgen.1003607 (2013).
12. Mitchell, J. A. et al. FTO genotype and the weight loss benefits of moderate intensity exercise. Obesity (Silver Spring) 18, 641-643, doi: 10.1038/oby.2009.311 (2010).
13. Manolio, T. A., Bailey-Wilson, J. E. & Collins, F. S. Genes, environment and the value of prospective cohort studies. Nat Rev Genet 7, 812-820, doi: 10.1038/nrg1919 (2006).
14. Grimes, D. A. & Schulz, K. F. Cohort studies: marching towards outcomes. Lancet 359, 341-345, doi: 10.1016/S0140-6736(02)07500-1 (2002).
15. Hein, R., Beckmann, L. & Chang-Claude, J. Sample size requirements for indirect association studies of gene-environment interactions (G x E). Genet Epidemiol 32, 235-245 (2008).
16. Ahmad, T. et al. Lifestyle interaction with fat mass and obesity-Associated (FTO) genotype and risk of obesity in apparently healthy U.S. women. Diabetes Care 34, 675-680, doi: 10.2337/dc10-0948 (2011).
17. Muller, M. J., Bosy-Westphal, A. & Krawczak, M. Genetic studies of common types of obesity: A critique of the current use of phenotypes. Obesity reviews : An official journal of the International Association for the Study of Obesity 11, 612-618 (2010).
18. Kilpelainen, T. O. et al. Physical activity attenuates the influence of FTO variants on obesity risk: A meta-Analysis of 218, 166 adults and 19, 268 children. PLoS Med 8, e1001116, doi: 10.1371/journal.pmed.1001116 (2011).
19. Li, S. et al. Physical activity attenuates the genetic predisposition to obesity in 20, 000 men and women from EPIC-Norfolk prospective population study. PLoS Med 7, doi: 10.1371/journal.pmed.1000332 (2010).
20. Ainsworth, B. E. et al. 2011 Compendium of Physical Activities: A second update of codes and MET values. Med Sci Sports Exerc 43, 1575-1581, doi: 10.1249/MSS.0b013e31821ece12 (2011).
21. Bergman, R. N. et al. A better index of body adiposity. Obesity (Silver Spring) 19, 1083-1089, doi: 10.1038/oby.2011.38 (2011).
22. Gerstein, H. C., Yusuf, S., Holman, R., Bosch, J. & Pogue, J. Rationale, design and recruitment characteristics of a large, simple international trial of diabetes prevention: The DREAM trial. Diabetologia 47, 1519-1527, doi: 10.1007/s00125-004-1485-5 (2004).
23. Anand, S. S. et al. Glucose levels are associated with cardiovascular disease and death in an international cohort of normal glycaemic and dysglycaemic men and women: The EpiDREAM cohort study. Eur J Prev Cardiol 19, 755-764, doi: 10.1177/1741826711409327 (2012).
24. Keating, B. J. et al. Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One 3, e3583 (2008).
25. Bergman, R. N. et al. A better index of body adiposity. Obesity (Silver Spring) 19, 1083-1089, doi: 10.1038/oby.2011.38 (2011).
26. Genuth, S. et al. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26, 3160-3167 (2003).
27. Vanderweele, T. J., Ko, Y.-A. & Mukherjee, B. Environmental confounding in gene-environment interaction studies. Am J Epidemiol 178, 144-152 (2013).
28. Thorgeirsson, T. E. et al. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 452, 638-642, doi: 10.1038/nature06846 (2008).
29. Janssens, A. C. et al. The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases. Genet Med 9, 528-535, doi: 10.1097GIM.0b013e31812eece0 (2007).
30. Robiou-du-Pont, S. et al. Contribution of 24 obesity-Associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population. Int J Obes (Lond) 37, 980-985, doi: 10.1038/ijo.2012.175 (2013).
31. Shi, Q., Pavey, E. S. & Carter, R. E. Bonferroni-based correction factor for multiple, correlated endpoints. Pharm Stat 11, 300-309, doi: 10.1002/pst.1514 (2012).
32. Yang, J. et al. FTO genotype is associated with phenotypic variability of body mass index. Nature 490, 267-272, doi: 10.1038/nature11401 (2012).
33. Bell, C. G. et al. Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. PLoS One 5, e14040, doi: 10.1371/journal.pone.0014040 (2010).
34. Ronn, T. et al. A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue. PLoS Genet 9, e1003572, doi: 10.1371/journal.pgen.1003572 (2013).
35. Sonestedt, E. et al. Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity. Am J Clin Nutr 90, 1418-1425, doi: 10.3945/ajcn.2009.27958 (2009).
36. Nitert, M. D. et al. Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes. Diabetes 61, 3322-3332, doi: 10.2337/db11-1653 (2012).
37. Claussnitzer, M. et al. FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. N Engl J Med 373, 895-907, doi: 10.1056/NEJMoa1502214 (2015).
38. Stanford, K. I., Middelbeek, R. J. & Goodyear, L. J. Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations. Diabetes 64, 2361-2368, doi: 10.2337/db15-0227 (2015).
39. Ioannidis, J. P. Why most published research findings are false. PLoS Med 2, e124, doi: 10.1371/journal.pmed.0020124 (2005).
40. Speakman, J. R. & ORahilly, S. Fat: An evolving issue. Dis Model Mech 5, 569-573, doi: 10.1242/dmm.010553 (2012).
41. Ladabaum, U., Mannalithara, A., Myer, P. A. & Singh, G. Obesity, Abdominal Obesity, Physical Activity, and Caloric Intake in U.S. Adults: 1988-2010. Am J Med, doi: 10.1016/j.amjmed.2014.02.026 (2014).
42. Wong, M. Y., Day, N. E., Luan, J. A., Chan, K. P. & Wareham, N. J. The detection of gene-environment interaction for continuous traits: should we deal with measurement error by bigger studies or better measurement? Int J Epidemiol 32, 51-57 (2003).
43. Franks, P. W., Pearson, E. & Florez, J. C. Gene-environment and gene-Treatment interactions in type 2 diabetes: progress, pitfalls, and prospects. Diabetes Care 36, 1413-1421, doi: 10.2337/dc12-2211 (2013).
44. Peters, T. et al. Validity of a short questionnaire to assess physical activity in 10 European countries. Eur J Epidemiol 27, 15-25, doi: 10.1007/S10654-011-9625-Y (2012).
45. Rankinen, T., Rice, T., Teran-Garcia, M., Rao, D. C. & Bouchard, C. FTO genotype is associated with exercise training-induced changes in body composition. Obesity (Silver Spring) 18, 322-326, doi: 10.1038/oby.2009.205 (2010).
46. Rampersaud, E. et al. Physical activity and the association of common FTO gene variants with body mass index and obesity. Arch Intern Med 168, 1791-1797, doi: 10.1001/archinte.168.16.1791 (2008).
47. Gray, J. et al. Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene. Diabetes 55, 3366-3371, doi: 10.2337/db06-0550 (2006).
48. Kernie, S. G., Liebl, D. J. & Parada, L. F. BDNF regulates eating behavior and locomotor activity in mice. Embo J 19, 1290-1300, doi: 10.1093/emboj/19.6.1290 (2000).
49. Jonsson A & F. P. Obesity, FTO gene variant, and energy intake in children. N Engl J Med 360, 1571-1572; author reply 1572 (2009).
50. Neel, J. V. Diabetes mellitus: A "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet 14, 353-362 (1962).
51. Pelleymounter, M. A. et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269, 540-543 (1995).
52. Southam, L. et al. Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes-And obesitysusceptibility variants? Diabetologia 52, 1846-1851, doi: 10.1007/s00125-009-1419-3 (2009).
53. Belcher, B. R. et al. Physical activity in US youth: effect of race/ethnicity, age, gender, and weight status. Med Sci Sports Exerc 42, 2211-2221, doi: 10.1249/MSS.0b013e3181e1fba9 (2010).