Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF)

Pharmacological Research

Volumn 104, Issue , 2016, Pages 97-107

  Kailainathan, Sumangali ^a,e   Piers, Thomas M ^a,b,c   Yi, Jee Hyun ^a,b   Choi, Seongmin ^a,b,c   Fahey, Mark S ^a   Borger, Eva ^d   Gunn Moore, Frank J ^d   O'Neill, Laurie ^a,b   Lever, Michael ^a,b   Whitcomb, Daniel J ^a,b,c   Cho, Kwangwook ^a,b,c   Allen, Shelley J ^a,e  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c Chonnam National University Medical School   (South Korea)

^d UNIVERSITY OF ST ANDREWS   (United Kingdom)

^e SOUTHMEAD HOSPITAL   (United Kingdom)

Author keywords

Binding kinetics; Chemical compounds studied in this article; Long term depression (LTD); Neurotrophin receptors; Pro brain derived neurotrophic factor (proBDNF); Val66Met polymorphism

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN-DERIVED NEUROTROPHIC FACTOR PRECURSOR; GLYCOGEN SYNTHASE KINASE 3BETA; GSK3B PROTEIN, HUMAN; LACTATE DEHYDROGENASE; PROTEIN PRECURSOR; RECOMBINANT PROTEIN; TAU PROTEIN;

ANIMAL; CELL CULTURE; DRUG EFFECTS; GENETIC POLYMORPHISM; GENETICS; HIPPOCAMPUS; HUMAN; LONG TERM POTENTIATION; MALE; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NERVE CELL; NERVE CELL PLASTICITY; PHYSIOLOGY; SYNAPSE; WISTAR RAT;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; GLYCOGEN SYNTHASE KINASE 3 BETA; HIPPOCAMPUS; HUMANS; L-LACTATE DEHYDROGENASE; LONG-TERM POTENTIATION; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; NEURONAL PLASTICITY; NEURONS; POLYMORPHISM, GENETIC; PROTEIN PRECURSORS; RATS, WISTAR; RECOMBINANT PROTEINS; SYNAPSES; TAU PROTEINS;

EID: 84952886825     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2015.12.008     Document Type: Article

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