Generation of redox imbalance mediates the cytotoxic effect of malabaricone-A in a multidrug resistant cell line

Anti-Cancer Agents in Medicinal Chemistry

Volumn 15, Issue 9, 2015, Pages 1156-1163

  Manna, Alak ^a   Bauri, Ajay K ^b   Chattopadhyay, Subrata ^b   Chatterjee, Mitali ^a  

^a INSTITUTE OF POST GRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

^b BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

Apoptosis; Drug resistance; Malabaricone A; Oxidative stress; Pro oxidant

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MALABARICONE A; PHOSPHATIDYLSERINE; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; REACTIVE OXYGEN METABOLITE; RESORCINOL DERIVATIVE;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE PROGRESSION; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHATIC LEUKEMIA; MITOCHONDRIAL MEMBRANE POTENTIAL; MULTIDRUG RESISTANCE; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; DRUG EFFECTS; DRUG POTENTIATION; DRUG RESISTANCE; METABOLISM; OXIDATION REDUCTION REACTION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; RESORCINOLS;

EID: 84952881328     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/1871520615666150602093004     Document Type: Article

References (25)

1. Gottesman, M.M.; Fojo, T.; Bates, S.E. Multidrug resistance in cancer: Role of ATP-dependent transporters. Nat. Rev. Cancer, 2002, 2(1), 48-58.
2. Fox, E.; Bates, S.E. Tariquidar (XR9576): A P-glycoprotein drug efflux pump inhibitor. Exp. Rev. Anticancer Ther, 2007, 7(4), 447-459.
3. Hall, M.D.; Salam, N.K.; Hellawell, J.L.; Fales, H.M.; Kensler, C.B.; Ludwig, J.A.; Szakacs, G.; Hibbs, D.E.; Gottesman, M.M. Synthesis, activity and pharmacophore development for isatin-beta- thiosemicarbazones with selective activity toward multidrug- resistant cells. J. Med. Chem, 2009, 52(10), 3191-3204.
4. Kelly, R.J.; Draper, D.; Chen, C.C.; Robey, R.W.; Figg, W.D.; Piekarz, R.L.; Chen, X.; Gardner, E.R.; Balis, F.M.; Venkatesan, A.M.; Steinberg, S.M.; Fojo, T.; Bates, S.E. A pharmacodynamic study of docetaxel in combination with the P-glycoprotein antagonist tariquidar (XR9576) in patients with lung, ovarian, and cervical cancer. Clin. Cancer Res., 2011, 7(3), 569-580.
5. Nobili, S.; Landini, I.; Mazzei, T.; Mini, E. Overcoming tumor multidrug resistance using drugs able to evade P-glycoprotein or to exploit its expression. Med. Res. Rev., 2012, 52(6), 1220-1262.
6. Hall, M.D.; Marshall, T.S.; Kwit, A.D.; Miller-Jenkins, L.M.; Dulcey, A.E.; Madigan, J.P.; Pluchino, K.M.; Goldsborough, A.S.; Brimacombe, K.R.; Griffiths, G.L.; Gottesman, M.M. Inhibition of glutathione peroxidase mediates the collateral sensitivity of multidrug-resistant cells to tiopronin. J. Biol. Chem., 2014, 289 (31), 21473-21489.
7. Hall, M.D.; Handley, M.D.; Gottesman, M.M. Is resistance useless? Multidrug resistance and collateral sensitivity. Trends Pharmacol. Sci., 2009, 50(10), 546-556.
8. Pluchino, K.M.; Hall, M.D.; Goldsborough, A.S.; Callaghan, R.; Gottesman, M.M. Collateral sensitivity as a strategy against cancer multidrug resistance. Drug Resist. Updat., 2012, 75(1-2), 98-105.
9. Ganguly, A.; Basu, S.; Chakraborty, P.; Chatterjee, S.; Sarkar, A.; Chatterjee, M.; Choudhuri, S.K. Targeting mitochondrial cell death pathway to overcome drug resistance with a newly developed iron chelate. PLoS One, 2010, 5(6), e11253.
10. Manna, A.; Saha, P.; Sarkar, A.; Mukhopadhyay, D.; Bauri, A.K.; Kumar, D.; Das, P.; Chattopadhyay, S.; Chatterjee, M. Malabaricone-A induces apoptosis in U937 cells via increased generation of reactive oxygen species. PLoS One, 2012, 7(5), e36938.
11. Manna, A.; De Sarkar, S.; De, S.; Bauri, A.K.; Chattopadhyay, S.; Chatterjee, M. The variable chemotherapeutic response of Malabaricone-A in leukemic and solid tumor cell lines depends on the degree of redox imbalance. Phytomedicine, 2015, 22(7-8), 713723.
12. Gillet, J.P.; Efferth, T.; Steinbach, D.; Hamels, J.; De Longueville, F.; Bertholet, V.; Remacle J. Microarray-based detection of multidrug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes. Cancer Res., 2004, 64 (24), 8987-8993.
13. Efferth, T.; Sauerbrey, A.; Halatsch, M.E.; Ross, D.D.; Gebhart, E. Molecular modes of action of cephalotaxine and homoharringtonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell lines. Naunyn Schmiedebergs Arch. Pharmacol., 2003, 567(1), 56-67.
14. Kimmig, A.; Gekeler, V.; Neumann, M.; Frese, G.; Handgretinger, R.; Kardos, G.; Diddens, H.; Niethammer, D. Susceptibility of multidrug-resistant human leukemia cell lines to human interleukin 2-activated killer cells. Cancer Res., 1990, 50(21), 6793-6799.
15. Rahman, I.; Kode, A.; Biswas, S.K. Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat. Protoc., 2006, 7(6), 3159-3165.
16. Trachootham, D.; Alexandre, J.; Huang, P. Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach? Nat. Rev. Drug Discov., 2009, 8(7), 579-591.
17. Lo, Y.L.; Wang, W. Formononetin potentiates epirubicin-induced apoptosis via ROS production in HeLa cells in vitro. Chem. Biol. Interact, 2013, 205(3), 188-197.
18. Ganguly, A.; Chakraborty, P.; Banerjee, K.; Chatterjee, S.; Basu, S.; Sarkar, A.; Chatterjee, M.; Choudhuri, S.K. Iron N-(2-hydroxy acetophenone) glycinate (FeNG), a non-toxic glutathione depletor circumvents doxorubicin resistance in Ehrlich ascites carcinoma cells in vivo. Biometals, 2012, 25(1), 149-163.
19. Banerjee, K.; Ganguly, A.; Chakraborty, P.; Sarkar, A.; Singh, S.; Chatterjee, M.; Bhattacharya, S.; Choudhuri, S.K. ROS and RNS induced apoptosis through p53 and iNOS mediated pathway by a dibasic hydroxamic acid molecule in leukemia cells. Eur. J. Pharm. Sci, 2014, 52, 146-164.
20. Ganguly, A.; Banerjee, K.; Chakraborty, P.; Das, S.; Sarkar, A.; Hazra, A.; Banerjee, M.; Maity, A.; Chatterjee, M.; Mondal, N.B.; Choudhuri, S.K. Overcoming multidrug resistance (MDR) in cancer in vitro and in vivo by a quinoline derivative. Biomed. Pharmacother., 2011, 65(6), 387-394.
21. Chatterjee, S.; Chakraborty, P.; Banerjee, K.; Sinha, A.; Adhikary, A.; Das, T.; Choudhuri, S.K. Selective induction of apoptosis in various cancer cells irrespective of drug sensitivity through a copper chelate, copper N-(2 hydroxy acetophenone) glycinate: Crucial involvement of glutathione. Biometals, 2013, 26(3), 517-534.
22. Mari, M.; Morales, A.; Colell, A.; Garcfa-Ruiz, C.; Fernandez-Checa, J.C. Mitochondrial glutathione, a key survival antioxidant. Antioxid. Redox. Signal., 2009, 77(11), 2685-2700.
23. Orrenius, S.; Zhivotovsky, B.; Nicotera, P. Regulation of cell death: the calcium-apoptosis link. Nat. Rev. Mol. Cell Biol., 2003, 4 (7), 552-565.
24. Tyurina, Y.Y.; Kini, V.; Tyurin, V.A.; Vlasova, I.I.; Jiang, J.; Kapralov, A.A.; Belikova, N.A.; Yalowich, J.C.; Kurnikov, I.V.; Kagan, V.E. Mechanisms of cardiolipin oxidation by cytochrome c: relevance to pro- and antiapoptotic functions of etoposide. Mol. Pharmacol., 2006, 70(2), 706-717.
25. Zou, H.; Yang, R.; Hao, J.; Wang, J.; Sun, C.; Fesik, S.W.; Wu, J.C.; Tomaselli, K.J.; Armstrong, R.C. Regulation of the Apaf- 1/caspase-9 apoptosome by caspase-3 and XIAP. J. Biol. Chem., 2003, 278(10), 8091-8098.