Hyperplasia of pulmonary neuroendocrine cells in infancy and childhood

Seminars in Diagnostic Pathology

Volumn 32, Issue 6, 2015, Pages 420-437

  Cutz, Ernest ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Airway O2 CO2 sensors; Amine peptide mediators; Congenital and acquired lung disorders; Neuroepithelial bodies; Solitary pulmonary neuroendocrine cells

Indexed keywords

BIOGENIC AMINE; BOMBESIN; PEPTIDE; SEROTONIN; TUMOR MARKER;

ARTICLE; CELL DIFFERENTIATION; CELL HYPERPLASIA; CELLULAR DISTRIBUTION; CHILDHOOD; FETUS LUNG; HUMAN; INFANCY; LUNG ALVEOLUS CELL; LUNG DEVELOPMENT; LUNG DISEASE; LUNG FUNCTION; MAMMAL; NEUROEPITHELIAL BODY; NEUROSECRETORY CELL; NONHUMAN; PERINATAL MORBIDITY; PERINATAL PERIOD; PRIORITY JOURNAL; PULMONARY NEUROENDOCRINE CELL; RESPIRATORY TRACT MUCOSA; BIOPSY; CELL LINEAGE; CELL PROLIFERATION; CELL SHAPE; CHILD; FLUORESCENT ANTIBODY TECHNIQUE; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; INFANT; LUNG; METABOLISM; MORTALITY; ONSET AGE; PATHOLOGY; PHENOTYPE; PREDICTIVE VALUE; PRESCHOOL CHILD;

AGE OF ONSET; BIOMARKERS, TUMOR; BIOPSY; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELL SHAPE; CHILD; CHILD, PRESCHOOL; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; INFANT; LUNG; LUNG DISEASES; NEUROENDOCRINE CELLS; PHENOTYPE; PREDICTIVE VALUE OF TESTS;

EID: 84952876909     PISSN: 07402570     EISSN: 19301111     Source Type: Journal    
DOI: 10.1053/j.semdp.2015.08.001     Document Type: Article

References (109)

1. Feyerter F. Uber Diffuse Endocrine Epitheliale Organe 1938, JA Barth, Leipzig.
2. Frohlich F. Die hellezelle der bronchialschleimhaut und ihre beziehungen zum problem der chemoreceptoren. Frankfurter Z Pathol 1949, 60:517-559.
3. Sorokin SP, Hoyt RF, eds. Proceedings of workshop on pulmonary neuroendocrine cells in health and disease. Anat Rec 1993;236:1-256.
4. Van Lommel A., Bolle T., Fannes W., Lauweryns J.M. The pulmonary neuroendocrine system: the past decade. Arch Histol Cytol 1999, 62:1-16.
5. Linnoila R.I. Functional facets of the pulmonary neuroendocrine system. Lab Invest 2006, 86:425-444.
6. Cutz E., Yeger H., Pan J. Pulmonary neuroendocrine cell system in pediatric lung disease. Pediatr Dev Pathol 2007, 10:419-435.
7. Cutz E., Fu X.W., Yeger H., Peers C., Kemp P.J. Oxygen sensing in pulmonary neuroepithelial bodies and related tumour cell model. Oxygen Sensing: Responses and Adaptation to Hypoxia, Lung Biology in Health and Disease 2003, 567-602. Marcel Dekker, NY. S. Lahiri, H. Prabhakar, G. Semenza (Eds.).
8. Cutz E., Pan J., Yeger H., Domnik N.J., Fisher J. Recent advances and controversies on the role of pulmonary neuroepithelial bodies as airway sensors. Semin Cell Dev Biol 2013, 24(1):40-50.
9. Sunday M.E. Oxygen, gastrin-realeasing peptide, and pediatric lung disease:life in a balance. Front Pediatr 2014, 2:1-9.
10. Weichselbaum M., Sparow M.P., Hamilton E.J., Thompson P.J., Knight D.A. A confocal microscopic study of solitary pulmonary neuroendocrine cells in human airway epithelium. Respir Res 2005, 6:115.
11. Pan J., Yeger H., Cutz E. Innervation of pulmonary neuroendocrine cells and neuroepithelial bodies in developing rabbit lung. J Histochem Cytochem 2004, 52(3):379-389.
12. Pan J., Copland I., Post M., Yeger H., Cutz E. Mechanical stretch inducedserotonin release from pulmonary neuroendocrine cells: implications for lung development. Am J Physiol Lung Cell Mol Physiol 2006, 290:L185-L193.
13. Cutz E., Chan W., Sonstegard K. Identification of neuro-epithelial bodies in rabbit fetal lungs by scanning electron microscopy: a correlative light, transmission and scanning electron microscopic study. Anat Rec 1978, 192:459-466.
14. Cutz E., Gillan J.E., Bryan A.C. Neuroendocrine cells in the developing human lung-morphologic and functional considerations. Pediatr Pulmonol 1985, 1(Suppl 3):S21-S29.
15. Cutz E, Gillan JE, Perrin DG: Pulmonary neuroendocrine cell system: an overview of cell biology and pathology with emphasis on pediatric lung disease. In: Rosenberg HS, Bernstein J. et al. eds. Pulmonary Disease: Perspectives in Pediatric Pathology, Basel, Karger, vol. 18. 1995:32-70.
16. Lauweryns J.M., Van Lommel A.T., Dom R.J. Innervation of rabbit intrapulmonary neuroepithelial bodies. Quantitative and qualitative ultrastructural study after vagotomy. J Neurol Sci 1985, 67:81-92.
17. Adriaensen D., Timmermans J.P., Brouns L., Berthoud H.R., Neuhuber W.L., Scheuermann D.W. Pulmonary intraepithelial vagal nodose afferent nerve terminals are confined to neuroepithelial bodies: an anterograde tracing and confocal microscopy study in adult rats. Cell Tissue Res 1998, 293:395-405.
18. Brouns I., Van Genechten J., Hayashi H., et al. Dual sensory innervation of pulmonary neuroepithelial bodies. Am J Respir Cell Mol Biol 2003, 28:275-285.
19. Boers J.E., den Brok L.M., Koudstaal J, Arends J.W., Thunnissen F.B. Number and proliferation of neuroendocrine cells in normal human airway epithelium. Am J Respir Crit Care Med 1996, 154:758-763.
20. Bolle T., Van Lommel A., Lauweryns J.M. Sterological estimates of number and volume of pulmonary neuroepithelial bodies in neonatal hamster lung. Microsc Res Tech 1999, 44:190-194.
21. Cho T., Chan W., Cutz E. Distribution and frequency of neuroepithelial bodies in post-natal rabbit lung: quantitative study with monoclonal antibody against serotonin. Cell Tissue Res 1989, 255:353-362.
22. Gosney J.R. Neuroendocrine cell population in postnatal human lung: minimal variation from childhood to old age. Anat Rec 1993, 236:177-180.
23. Lauweryns J.M., Cokelaere M. Hypoxia sensitive neuroepithelial bodies intrapulmonary secretory neuroreceptors, modulated by the CNS. Z Zellforsch 1973, 145:521-540.
24. Youngson C., Nurse C., Yeger H., Cutz E. Oxygen sensing in airway chemoreceptors. Nature 1993, 365:153-155.
25. + channel may function as an oxygen sensor complex in airway chemoreceptors and small cell carcinoma cell lines. Proc Natl Acad Sci USA 1996, 93:13182-13187.
26. + current modulation in wild-type and oxidase-deficient mice. Proc Natl Acad Sci USA 2000, 97:4374-4379.
27. Weir K.E., Lopez-Barneo J., Buckler K.J., Archer S.L. Acute oxygen-sensing mechanisms. N Engl J Med 2005, 353:2042-2055.
28. Quin M.T., Gans K.A. Structure and regulation of neutrophil respiratory burst oxidase: comparison with physiologic oxidases. J Leukoc Biol 2004, 76:760-781.
29. Kemp P.J., Lewis A., Hartness M.E., et al. Airway chemotransduction. From oxygen sensor to cellular effector. Am J Respir Crit CareMed 2002, 166:S17-S24.
30. 2 sensor in a human airway chemoreceptor cell line: biochemical, molecular, and electrophysiological evidence. Am J Physiol Lung Cell Mol Physiol 2012, 103:L598-L607.
31. Semenza G. Oxygen sensing, hypoxia inducible factors and disease pathophysiology. Ann Rev Pathol Mech Dis 2014, 9:47-71.
32. Kaelin W.G., Ratcliffe P.J. Oxygen sensing by metazoans; the central role of the HIF hydroxylase pathway. Mol Cell 2008, 30:393-402.
33. Pan J., Yeger H., Radcliffe P., Bishop P., Cutz E. Hyperplasia of pulmonary neuroepithelial bodies in lungs of prolylhydroxylase-1 deficient mice. Adv Exp Med Biol 2012, 758:149-155.
34. + sensing. Am J Physiol Lung Cell Mol Physiol 2015, 308(8):L807-L815.
35. Sunday M.E., Shan L., Subramanian M. Immunomodulatory functions of the diffuse neuroendocrine system: implications for bronchopulmonary dysplasia. Endocr Pathol 2004, 15:91-106.
36. Brouns I., De Proost I., Pintelon I., Timmermans J.P., Adriaensen D. Sensory receptors in the airway: neurochemical coding of smooth muscle-associated airway receptors and pulmonary neuroepithelial body innervation. Auton Neurosci 2006, 126-127:307-319.
37. Borges M., Linnoila R.I., Van De Velde H.J.K., et al. An achete-scute homologue essential for neuroendocrine differentiation in the lung. Nature 1997, 386:852-855.
38. Dauger S., Renolleau S., Vardon G., et al. Ventilatory responses to hypercapnia and hypoxia in Mash-1 heterozygous newborn and adult mice. Pediatr Res 1999, 46:535-542.
39. Ito T., Ogura T., Ogawa N., et al. Basic helix-loop-helix transcription factors regulate the neuroendocrine cell differentiation of fetal mouse pulmonary epithelium. Development 2000, 127:3913-3921.
40. Ishibashi M., Ang S.L., Shiota K., et al. Targeted disruption of mammalian hairy and enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis and severe neural tube defects. Genes Dev 1995, 9:3136-3148.
41. Mc Govern S., Pan J., Oliver G., Cutz E., Yeger H. The role of hypoxia and neurogenic genes (Mash-1 and Prox-1) in the developmental programming and maturation of pulmonary neuroendocrine cels in fetal mouse lung. Lab Invest 2010, 90:180-195.
42. Hernandez-Vasquez A., Will J.A., Quay W.B. Quantitative characteristics of the Feyerter cells and neuroeithelial bodies of the fetal rabbit lung in normoxia and chronic short term hypoxia. Cell Tissue Res 1978, 189:179-186.
43. Cutz E., Yeger H., Wong V., Bienkowski E., Chan W. In vitro characteristics of pulmonary neuroendocrine cells isolated from rabbit fetal lung: I. Effects of culture media and nerve growth factor. Lab Invest 1985, 53:672-683.
44. Hoyt R.F., McNelly N.A., Sorokin S.P. Dynamics of neuroepithelial body(NEB) formation in developing hamster lung: light microscopic autoradiography after H3 thymidine labeling in vivo. Anat Rec 1990, 227:340-350.
45. Linnoila R.I. Effects of diethylnitrosamine on lung neuroendocrine cells. Exp Lung Res 1982, 3:225-236.
46. Stevens T.P., McBride J.T., Peake J.L., Pinkerton K.E., Stripp B.R. Cell proliferation contributes to PNEC hyperplasia after acute airway injury. Am J Physiol 1997, 272:L468-L493.
47. Ijsselstijn H., Gaillard J.L.J., deJongste J.C., Tibboel D., Cutz E. Abnormal expression of pulmonary bombesin-like peptide immunostaining cells in infants with congenital diaphragmatic hernia. Pediatr Res 1997, 42:715-720.
48. Asabe K., Tsui K., Handa N., Kajiwara M., Suita S. Immunohistochemical distribution of bombesin-positive pulmonary neuroendocrine cells in a congenital diaphragmatic hernia. Surg Today 1999, 29:407-412.
49. Ijsselstijn H., Hung N., deJongste J.C., Tibboel D., Cutz E. Calcitonin gene-related peptide expression is altered in pulmonary neuroendocrine cells in developing lungs of rats with diaphragmatic hernia. Am J Respir Cell Mol Biol 1998, 19:278-285.
50. Ito T., Nskatani Y., Nagahara N. Quantitative study of pulmonary endocrine cells in anencephaly. Lung 1987, 165:297-304.
51. Jarmillo M.A., Gutierrez J.A., Margraf L.R. Pulmonary gastrin-releasing peptide expression in anencephaly. Pediatr Pathol Lab Med 1995, 15:377-387.
52. Bonasoni M.P., Reyes J.A., Keating S., Cutz E., Taylor G. The distribution and frequency of pulmonary neuroendocrine cells in Down Syndrome fetal lungs. Fetal Pediatr Pathol 2014, 33:157-165.
53. Saad A.G., Heffelfinger S., Stanek J. Amniotic sac infection syndrome features fetal lung neuroendocrine cell hyperfunction. Pediatr Dev Pathol 2003, 6:484-494.
54. El Mazloum D., Moschino L., Bozzetto S., Baraldi E. Chronic lung disease of prematurity: long-term respiratory outcome. Neonatology 2014, 105:352-356.
55. Carraro S., Flippone M., Da Dalt L., et al. Bronchopulmonary dysplasia: the earliest and perhaps the longest lasting obstructive lung disease in humans. Early Hum Dev 2013, 89(Suppl 3):S3-S5.
56. Baraldi E., Flippone M. Chronic lung disease after premature birth. N Engl J Med 2007, 357:1946-1955.
57. Northway W.H., Rosan R.C., Porter D.Y. Pulmonary disease following respiratory therapy of hyaline membrane disease: bronchopulmonary dysplasia. N Engl J Med 1967, 276:357-368.
58. Husain A.N., Siddiqui N.H., Stocker J.T. Pathology of arrested acinar development in postsurfactant bronchopulmonary dysplasia. Hum Pathol 1998, 29:710-717.
59. Gillan Y.E., Cutz E. Abnormal pulmonary bombesin immunoreactive cells in Wilson-Mikity syndrome (pulmonary dysmaturity) and bronchopulmonary dysplasia. Pediatr Pathol 1993, 13:165-180.
60. Cullen A., Van Marter L.J., Allred E.N., Moore M., Parad R.B., Sunday M.E. Urine bombesin-like peptide elevation precedes clinical evidence of bronchopulmonary dysplasia. Am J Respir Crit Care Med 2002, 165:1093-1097.
61. Johnson D.E., Gregorieff M.K. Pulmonary neuroendocrine cells: their secretory products and their potential role in health and chronic lung disease in infancy. Am J Respir Dis 1989, 143:815-819.
62. Sunday M.E., Yoder B.A., Cuttitta F., Haley K.J., Emanuel R.L. Bombesin-like peptide mediates lung injury in a baboon model of bronchopulmonary dysplasia. J Clin Invest 1998, 102:584-594.
63. Subramanian M., Sugiyama K., Coy D.H., et al. Bombesin-like peptides and mast cell responses: relevance to bronchopulmonary dysplasia?. Am J Respir Crit Care Med 2003, 168:601-611.
64. Ashour K., Shan L., Lee J.H., et al. Bombesin inhibits alveolarization and promotes pulmonary fibrosis in newborn mice. Am J Respir Crit Care Med 2006, 173:1377-1385.
65. Subramaniam M., Bausch C., Twomey A., et al. Bombesin-like peptides modulate alveolarization and angiogenesis in bronchopulmonary dysplasia. Am J Respir Crit Care Med 2007, 176(9):902-912.
66. Chang L., Subramanian M., Yoder B.A., et al. A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasia. Am J Respir Cell Mol Biol 2003, 167:57-64.
67. Rand C.M., Patwari P.P., Carroll M.S., Weese-Mayer D.E. Congenital central hypoventilation syndrome and sudden infant death syndrome: disorders of autonomic regulation. Semin Pediatr Neurol 2013, 20:44-55.
68. Amiel J., Laudier B., Attie-Bitach T., et al. Polyamine expansion and frameshift mutations of thepaired-like homeobox gene PHOX 2B in congenital central hypoventilation syndrome. Nat Genet 2003, 33:459-461.
69. Cutz E., Ma T.K.F., Perrin D.G., Moore A.M., Becker L.E. Peripheral chemoreceptors in congenital central hypoventilation syndrome. Amer J Respir Crit Care Med 1997, 155:358-363.
70. Perrin D.G., McDonald T.J., Cutz E. Hyperplasia of bombesin immunoreactive pulmonary neuroendocrine cells and neuroepithelial bodies in sudden infant death syndrome. Pediatr Pathol 1992, 11:427-443.
71. Perrin D.G., Cutz E., Becker L.E., Bryan A.C., Madapallimatum A., Sole M. Sudden infant death syndrome: increased carotid body dopamine and norepinephrine content. Lancet 1984, 8402:535-537.
72. Sachis P.N., Armstrong D.L., Becker L.E., Bryan A.C. The vagus nerve and sudden infant death syndrome: a morphometric study. J Pediatr 1981, 98:278-280.
73. Cutz E., Perrin D.G., Pan J., Haas E.A., Krous H.F. Pulmonary neuroendocrine cells and neuroepithelial bodies in sudden infant death syndrome: potential markers of airway chemoreceptor dysfunction. Pediatr Dev Pathol 2007, 10:106-116.
74. Cutz E., Perrin D.G., Hackman G.R., Czegledy-Nagy E.N. Maternal smoking and pulmonary neuroendocrine cells in sudden infant death syndrome. J Pediatr 1996, 98:668-672.
75. Nylen E.S., Becker K.L., Snider R.H., Tabassian A.R., Cassidy M.M., Linnoila R.I. Cholinergic-nicotinic control of growth and secretion of cultured pulmonary neuroendocrine cells. Anat Rec 1993, 236:129-135.
76. Kinney H.C., Thach B.T. The sudden infant death syndrome. N Engl J Med 2009, 361(8):795-805.
77. Narita N., Narita M., Takashima S., Nakayama M., Nagai T., Okado N. Serotonin transporter gene variation is a risk factor for sudden infant death syndrome in Japanese population. Pediatrics 2001, 107:690-692.
78. Weese-Mayer D.E., Berry-Kravis E.M., Maher B., Silvestri J.M., CurranME, Marazita M.L. Sudden infant death syndrome: association with promoter polymorphysm of the serotonin transporter gene. Am J Med Genet A 2003, 117:268-274.
79. Cutz E., Jackson A. Airway inflammation and peripheral chemoreceptors. Sudden Infant Death Syndrome: Problems, Progress and Possibilities 2001, 156-181. Arnold, London. R.W. Byard, H.F. Krous (Eds.).
80. Deterding R.R., Pye C., Fan L.L., Langston C. Persistent tachypnea of infancy is associated with neuroendocrine cell hyperplasia. Pediatr Pulmonol 2005, 40:157-165.
81. Brody A.S., Guillerman R.P., Hay T.C., et al. Neuroendocrine cell hyperplasia of infancy: diagnosis with high-resolution CT. Am J Roentgenol 2010, 194:238-244.
82. Young L.R., Brody A.S., Inge T.H., et al. Neuroendocrine cell distribution and frequency distinguish neuroendocrine cell hyperplasia of infancy from other pulmonary disorders. Chest 2011, 139:1060-1071.
83. Yancheva S.G., Velani A., Rice A., et al. Bombesin staining in neuroendocrine cell hyperplasia if infancy (NEHI) and other childhood interstitial lung diseases (chILD). Histopathology 2015, 10.1111/his.12672.
84. Kerby G.S., Wagner B.D., Popler J., et al. Abnormal infant pulmonary function in young infants with neuroendocrine cell hyperplasia of infancy. Pediatr Pulmonol 2013, 48:1008-1015.
85. Doan M.L., Elidemir O., Dishop M.K., et al. SerumKL-6 differentiates neuroendocrine cell hyperplasia of infancy from the inborn errors of surfactant metabolism. Thorax 2009, 64:677-681.
86. Popler J., Wagner B.D., Luckey Tarro H., Accurso F.J., Deterding R.R. Bronchoalveolar lavage fluid cytokine profiles in neuroendocrine cell hyperplasia of infancy and follicular bronchiolitis. Orphanet J Rare Dis 2013, 8:175.
87. Deutsch G.H., Young L.R., Deterding R.R., et al. Diffuse lung disease in young children. Application of novel classification scheme. Am J Respr Crit Care Med 2007, 176:1120-1128.
88. Popler J., Gower W.A., Mogayzel P.J., et al. Familial neuroendocrine cell hyperplasia of infancy. Pediatr Pulmonol 2010, 45:749-755.
89. Young L.R., Deutsch G.H., Boculic R.E., Brody A.S., Nogee L.M. A mutation in TTF/NKX2.1 is associated with familial neuroendocrine cell hyperplasia of infancy. Chest 2013, 144:1199-1206.
90. Alshehri M., Cutz E., Banzhoff A., Canny G. Hyperplasia of pulmonary neuroendocrine cells in a case of childhood pulmonary emphysema. Chest 1997, 112:553-556.
91. Rowe S.M., Miller S., Sorscher E.J. Cystic fibrosis. N Engl J Med 2005, 352:1992-2002.
92. Boucher R.C. New concepts of the pathogenesis of cystic fibrosis lung disease. Eur Respir J 2004, 23:146-158.
93. Yeger H., Pan Y., Fu W., Bear C., Cutz E. Expression of CFTR and CI(-) conductances in cells of pulmonary neuroepithelial bodies. Am J Physiol Lung Cell Mol Physiol 2001, 281:L713-L721.
94. Johnson D.A., Wobken J.D., Landrum B.G. Changes in bombesin, calcitonin and serotonin immunoreactive pulmonary neuroendocrine cells in cystic fibrosis and after prolonged mechanical ventilation. Am Rev Respir Dis 1998, 137:123-131.
95. Du K., Karp P.H., Cameron A., et al. Aggregates of mutant CFTR fragments in airway epithelial cells of CF lungs: new pathological observations. J Cyst Fibros 2015, 14:182-193.
96. Pan J., Bear C., Farragher S., Cutz E., Yeger H. CFTR modulates neurosecretory function in pulmonary neuroendocrine cell related tumor cell line. Am J Resp Cell Mol Biol 2002, 27:553-560.
97. Pan J., Luk C., Kent G., Cutz E., Yeger H. Pulmonary neuroendocrine cells, airway innervation and smooth muscle are altered in Cftr null mice. Am J Respir Cell Mol Biol 2006, 35:320-326.
98. Bonora M., Bernaudin J.F., Guernier C., Brahimi-Horn M.C. Ventilatory responses to hypercapnia and hypoxia in conscious cystic fibrosis knock-out mice. Pediatr Res 2004, 55:738-746.
99. Mhana M.J., Ferkol T., Martin R.J., et al. Nitric oxide deficiency contributes to impairment of airway relaxation in cystic fibrosis mice. Am J Respir Cell Mol Biol 2001, 24:621-626.
100. Cazzola M., Matera M.G., D'Amato G., Rossi F. Effects of serotonin on airways: recent developments. Allergy 1995, 50:1-10.
101. Lechin F., van der Dijs B., Orozco B., Lechin M., Lechin A.E. Increased levels of free serotonin in plasma of symptomatic asthmatic patients. Ann Allergy Asthma Immunol 1996, 77:245-253.
102. Carlsen K.C.L., Carlsen K.H. Effects of maternal and early tobacco exposure on the development of asthma and airway reactivity. Curr Opin Allergy Clin Immunol 2001, 1:139-143.
103. Shekhon H.S., Jia Y., Raab R., et al. Prenatal nicotine increases pulmonary alpha 7 receptor expression and alters fetal lung development in monkeys. J Clin Invest 1999, 103:637-647.
104. Morecroft I., Heeley R.P., Prentice H.M., Kirk A., MacLean M.R. 5-hydroxytryptamine receptors mediating contraction in small muscular pulmonary arteries: importance of the 5-HT 1B receptor. Br J Pharmacol 1999, 28:730-734.
105. Adnot S., Cigarini I., Herigault R., Harf A. Effects of substance P and calcitonin gene-related peptide on the pulmonary circulation. J Appl Physiol 1990, 70:1707-1712.
106. Heath D., Yacoub M., Gosney J.R., Madden B., Caslin A.W., Smith P. Pulmonary endocrine cells in hypertensive pulmonary vascular disease. Histopathology 1990, 16:21-28.
107. Shindler M.B., Bohn D.J., Bryan A.C., Cutz E., Rabinovitch M. Increased respiratory system resistance and bronchial smooth muscle hypertophy in children with acute postoperative pulmonary hypertension. Am J Respir Crit Care Med 1995, 152:1347-1352.
108. Eddahibi S., Raffestin B., Hamon M., Adnot S. Is the serotonin transporter involved in the pathogenesis of pulmonary hypertension?. J Lab Clin Med 2002, 139:194-201.
109. Chambers C.D., Hernandez-Diaz S., Van Marter L.J., et al. Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn. N Engl J Med 2006, 354:579-587.