Serum KL-6 differentiates neuroendocrine cell hyperplasia of infancy from the inborn errors of surfactant metabolism

Thorax

Volumn 64, Issue 8, 2009, Pages 677-681

  Doan, M L ^a   Elidemir, O ^a   Dishop, M K ^a   Zhang, H ^a   Smith, E O ^b   Black, P G ^c   Deterding, R R ^d   Roberts, D M ^e   Al Salmi, Q A ^f   Fan, L L ^a  

^a TEXAS CHILDREN S HOSPITAL   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^d CHILDREN S HOSPITAL   (United States)

^e Pediatric Breathing Disorders   (United States)

^f ROYAL HOSPITAL   (Oman)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; GLYCOPROTEIN; GLYCOPROTEIN KL6; SURFACTANT; UNCLASSIFIED DRUG;

ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; HUMAN; HYPERPLASIA; INBORN ERROR OF METABOLISM; INFANT; NEUROENDOCRINE CELL HYPERPLASIA OF INFANCY; NEUROSECRETORY CELL; NEWBORN; PRIORITY JOURNAL;

EID: 68049091001     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thx.2008.107979     Document Type: Article

References (34)

1. Nogee LM, Dunbar AE, Wert SE, et al. A mutation in the surfactant protein C gene associated with familial interstitial lung disease. N Engl J Med 2001;344:573-9.
2. Shulenin S, Nogee LM, Annilo T, et al. ABCA3 gene mutations in newborns with fatal surfactant deficiency. N Engl J Med 2004;350:1296-303.
3. Deterding RR, Pye C, Fan LL, et al. Persistent tachypnea of infancy is associated with neuroendocrine cell hyperplasia. Pediatr Pulmonol 2005;40:157-65.
4. Brody AS, Crotty EJ. Neuroendocrine cell hyperplasia of infancy (NEHI). Pediatr Radiol 2006;36:1328.
5. Hamvas A. Inherited surfactant protein-B deficiency and surfactant protein-C associated disease: clinical features and evaluation. Semin Perinatol 2006;30:316-26.
6. Brasch F, Griese M, Tredano M, et al. Interstitial lung disease in a baby with a de novo mutation in the SFTPC gene. Eur Respir J 2004;24:30-9.
7. Tredano M, Griese M, Brasch F, et al. Mutation of SFTPC in infantile pulmonary alveolar proteinosis with or without fibrosing lung disease. Am J Med Genet 2004;126A:18-26.
8. Hamvas A, Nogee LM, White FV, et al. Progressive lung disease and surfactant dysfunction with a deletion in surfactant protein C gene. Am J Respir Cell Mol Biol 2004;30:771-6.
9. Chibbar R, Shih F, Baga M, et al. Nonspecific interstitial pneumonia and usual interstitial pneumonia with mutation in surfactant protein C in familial pulmonary fibrosis. Mod Pathol 2004;17:973-80.
10. Soraisham AS, Tierney AJ, Amin HJ. Neonatal respiratory failure associated with mutation in the surfactant protein C gene. J Perinatol 2006;26:67-70.
11. Saugstad OD, Hansen TWR, Ronnestad A, et al. Novel mutations in the gene encoding ATP binding cassette protein member A3 (ABCA3) resulting in fatal neonatal lung disease. Acta Paediatr 2007;96:185-90.
12. Doan ML, Guillerman RP, Dishop MK, et al. Clinical, radiological and pathological features of ABCA3 mutations in children. Thorax 2008;63:366-73.
13. Prestridge A, Wooldridge J, Deutsch G, et al. Persistent tachypnea and hypoxia in a 3-month-old term infant. J Pediatr 2006;149:702-6.
14. Bullard JE, Wert SE, Whitsett JA, et al. ABCA3 mutations associated with pediatric interstitial lung disease. Am J Respir Crit Care Med 2005;172:1026-31.
15. Kohno N, Akiyama M, Kyoizumi S, et al. Detection of soluble tumor-associated antigens in sera and effusion using novel monoclonal antibodies, KL-3 and KL-6, against lung adenocarcinoma. Jpn J Clin Oncol 1988;18:203-16.
16. Kohno N, Kyoizumi S, Awaya Y, et al. New serum indicator of interstitial pneumonia activity, sialyated carbohydrate antigen KL-6. Chest 1989;96:68-73.
17. Kobayashi J, Kitamura S. KL-6: a serum marker for interstitial pneumonia. Chest 1995;108:311-.
18. Al-Salmi QA, Walter JN, Colasurdo GN, et al. Serum KL-6 and surfactant proteins A and D in pediatric interstitial lung disease. Chest 2005;127:403-7.
19. Imai T, Takase M, Takeda S, et al. Serum KL-6 levels in pediatric patients: reference values for children and levels in pneumonia, asthma, and measles patients. Pediatr Pulmonol 2002;33:135-41.
20. Kubota M, Haruta T. The role of serum KL-6 measurement in common pediatric respiratory infections. J Infect Chemother 2006;12:22-4.
21. Daimon T, Tajima S, Oshikawa K, et al. KL-6 and surfactant proteins A and D in serum and bronchoalveolar lavage fluid in patients with acute eosinophilic pneumonia. Intern Med 2005;44:811-7.
22. Takahashi T, Munakata M, Suzuki I, et al. Serum and bronchoalveolar fluid KL-6 levels in patients with pulmonary alveolar proteinosis. Am J Respir Crit Care Med 1998;158:1294-8.
23. Fan LL, Kozinetz CA. Factors influencing survival in children with chronic interstitial lung disease. Am J Respir Crit Care Med 1997;156:939-42.
24. Doan ML, Zhang H, Elidemir O, et al. Serum KL-6 levels in children with inborn errors of surfactant metabolism and neuroendocrine cell hyperplasia of infancy [abstract]. Chest 2006;130:156S.
25. Edwards V, Cutz E, Viero S, et al. Ultrastructure of lamellar bodies in congenital surfactant deficiency. Ultrastruct Pathol 2005;29:503-9.
26. Kohno N, Awaya Y, Oyama T, et al. KL-6, a mucin-like glycoprotein, in bronchoalveolar lavage fluid from patients with interstitial lung disease. Am Rev Respir Dis 1993;148:637-42.
27. Inoue Y, Barker E, Daniloff E, et al. Pulmonary epithelial cell injury and alveolar-capillary permeability in berylliosis. Am J Respir Crit Care Med 1997;156:109-15.
28. Imai T, Takase M, Takeda S, et al. Serum KL-6 levels in pediatric patients: reference values for children and levels in pneumonia, asthma, and measles patients. Pediatr Pulmonol 2002;33:135-41.
29. Kunitake R, Kuwano K, Yoshida K, et al. KL-6, surfactant protein A and D in bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis. Respiration 2001;68:488-95.
30. Ishizaka A, Matsuda T, Albertine KH, et al. Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol 2004;286:L1088-94.
31. Suzuki R, Suzuki Y, Itoh K, et al. A study of reference intervals for a serum KL-6 in normal children without respiratory disease and a serum marker for interstitial pneumonia. J Jpn Pediatr Soc 2001;105:703-10.
32. Kurotobi S, Maekawa S, Hara T, et al. Serum KL-6 level in newborns with meconium aspiration syndrome. Pediatr Int 2003;45:517-21.
33. Ogihara T, Hirano K, Morinobu T, et al. KL-6, a mucinous glycoprotein, as an indicator of chronic lung disease of the newborn. J Pediatr 2000;137:280-2.
34. Yamane M, Yokoyama. Serum KL-6 level and pulmonary function in preterm infants with chronic lung disease. Kobe J Med Sci 2004;50:131-40.