Green tea catechins and their metabolites in human skin before and after exposure to ultraviolet radiation

Journal of Nutritional Biochemistry

Volumn 27, Issue , 2016, Pages 203-210

  Clarke, Kayleigh A ^a   Dew, Tristan P ^a   Watson, Rachel E B ^b   Farrar, Mark D ^b   Osman, Joanne E ^b   Nicolaou, Anna ^c   Rhodes, Lesley E ^b   Williamson, Gary ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Bioavailability; Green tea catechin conjugates; Polyphenols; Skin; Ultraviolet radiation

Indexed keywords

3 HYDROXYBENZOIC ACID O SULFATE; ASCORBIC ACID; BENZOIC ACID; BENZOIC ACID O SULFATE; CATECHIN; DRUG METABOLITE; EPICATECHIN; EPICATECHIN GALLATE; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; EPIGALLOCATECHIN O GLUCURONIDE; GALLIC ACID O GLUCURONIDE; HIPPURIC ACID; O METHYL M4 O SULFATE; SYRINGIC ACID O GLUCURONIDE; SYRINGIC ACID O SULFATE; UNCLASSIFIED DRUG; VALEROLACTONE; TEA;

ADULT; ARTICLE; BLISTER FLUID; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CONJUGATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MASS SPECTROMETRY; NORMAL HUMAN; SKIN; SKIN BIOPSY; SKIN PROTECTION; TEA; ULTRAVIOLET RADIATION; ADOLESCENT; BIOAVAILABILITY; BLOOD; CHEMISTRY; DRUG EFFECTS; LIMIT OF DETECTION; METABOLISM; MIDDLE AGED; RADIATION RESPONSE; YOUNG ADULT;

ADOLESCENT; ADULT; BIOLOGICAL AVAILABILITY; CATECHIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HUMANS; LIMIT OF DETECTION; MALE; MASS SPECTROMETRY; MIDDLE AGED; SKIN; TEA; ULTRAVIOLET RAYS; YOUNG ADULT;

EID: 84952865408     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2015.09.001     Document Type: Article

References (41)

1. Lambert J.D., Sang S., Yang C.S. Biotransformation of green tea polyphenols and the biological activities of those metabolites. Mol Pharm 2007, 4:819-825.
2. Wu C.H., Yeh C.T., Yeh G.C. Epigallocatechin gallate (EGCG) binds to low-density lipoproteins (LDL) and protects them from oxidation and glycation under high-glucose conditions mimicking diabetes. Food Chem 2010, 121:639-644.
3. Bogdanski P., Suliburska J., Szulinska M., Stepien M., Pupek-Musialik D., Jablecka A. Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients. Nutr Res 2012, 32:421-427.
4. Yuan J.M. Cancer prevention by green tea: evidence from epidemiologic studies. Am J Clin Nutr 2013, 98:1676S-1681S.
5. Singh T., Katiyar S.K. Green tea polyphenol, (-)-epigallocatechin-3-gallate, induces toxicity in human skin cancer cells by targeting beta-catenin signaling. Toxicol Appl Pharmacol 2013, 273:418-424.
6. Lambert J.D. Does tea prevent cancer? Evidence from laboratory and human intervention studies. Am J Clin Nutr 2013, 98:1667S-1675S.
7. Hartley L., Flowers N., Holmes J., Clarke A., Stranges S., Hooper L., et al. Green and black tea for the primary prevention of cardiovascular disease. Cochrane Database Syst Res 2013, 6:CD009934.
8. Afaq F., Syed D.N., Malik A., Hadi N., Sarfaraz S., Kweon M.H., et al. Delphinidin, an anthocyanidin in pigmented fruits and vegetables, protects human HaCaT keratinocytes and mouse skin against UVB-mediated oxidative stress and apoptosis. J Invest Dermatol 2007, 127:222-232.
9. Hwang Y.P., Oh K.N., Yun H.J., Jeong H.G. The flavonoids apigenin and luteolin suppress ultraviolet A-induced matrix metalloproteinase-1 expression via MAPKs and AP-1-dependent signaling in HaCaT cells. J Dermatol Sci 2011, 61:23-31.
10. Poquet L., Clifford M.N., Williamson G. Effect of dihydrocaffeic acid on UV irradiation of human keratinocyte HaCaT cells. Arch Biochem Biophys 2008, 476:196-204.
11. Heinrich U., Moore C.E., De Spirt S., Tronnier H., Stahl W. Green tea polyphenols provide photoprotection, increase microcirculation, and modulate skin properties of women. J Nutr 2011, 141:1202-1208.
12. Afaq F., Adhami V.M., Ahmad N., Mukhtar H. Inhibition of ultraviolet B-mediated activation of nuclear factor kappa B in normal human epidermal keratinocytes by green tea constituent (-)-epigallocatechin-3-gallate. Oncogene 2003, 22:1035-1044.
13. Song X.Z., Bi Z.G., Xu A.E. Green tea polyphenol epigallocatechin-3-gallate inhibits the expression of nitric oxide synthase and generation of nitric oxide induced by ultraviolet B in HaCaT cells. Chin Med J (Engl) 2006, 119:282-287.
14. Wu L.Y., Zheng X.Q., Lu J.L., Liang Y.R. Protective effect of green tea polyphenols against ultraviolet B-induced damage to HaCaT cells. Hum Cell 2009, 22:18-24.
15. Haake A., Scott G.A., Holbrook K.A. Structure and function of the skin: overview of the epidermis and dermis. The biology of the skin 2001, 19-46. Parthenon, New York. 1st edit. R.K. Freinkel, D.T. Woodley (Eds.).
16. Sies H., Stahl W. Carotenoids and UV protection. Photochem Photobiol Sci 2004, 3:749-752.
17. Trautinger F. Mechanisms of photodamage of the skin and its functional consequences for skin ageing. Clin Exp Dermatol 2001, 26:573-577.
18. Rhodes L.E., Gledhill K., Masoodi M., Haylett A.K., Brownrigg M., Thody A.J., et al. The sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases. FASEB J 2009, 23:3947-3956.
19. Huang M.T., Ghai G., Ho C.T. Inflammatory process and molecular targets for antiinflammatory nutraceuticals. Compr Rev Food Sci F 2004, 3:127-139.
20. Swindells K., Rhodes L.E. Influence of oral antioxidants on ultraviolet radiation-induced skin damage in humans. Photodermatol Photoimmunol Photomed 2004, 20:297-304.
21. Pfeifer G.P., You Y.H., Besaratinia A. Mutations induced by ultraviolet light. Mutat Res 2005, 571:19-31.
22. Sies H. Total antioxidant capacity: appraisal of a concept. J Nutr 2007, 137:1493-1495.
23. Cancer Research UK Skin cancer incidence statistics. Version current 22 April 2014 Internet:, [accessed 1 October 2014]. http://www.cancerresearchuk.org/cancer-info/cancerstats/types/skin/incidence.
24. Del Rio D., Calani L., Cordero C., Salvatore S., Pellegrini N., Brighenti F. Bioavailability and catabolism of green tea flavan-3-ols in humans. Nutrition 2010, 26:1110-1116.
25. Fung S.T., Ho C.K., Choi S.W., Chung W.Y., Benzie I.F.F. Comparison of catechin profiles in human plasma and urine after single dosing and regular intake of green tea (Camellia sinensis). Br J Nutr 2013, 109:2199-2207.
26. Stalmach A., Troufflard S., Serafini M., Crozier A. Absorption, metabolism and excretion of Choladi green tea flavan-3-ols by humans. Mol Nutr Food Res 2009, 53:S44-S53.
27. Del Rio D., Calani L., Scazzina F., Jechiu L., Cordero C., Brighenti F. Bioavailability of catechins from ready-to-drink tea. Nutrition 2010, 26:528-533.
28. Mullen W., Borges G., Lean M.E., Roberts S.A., Crozier A. Identification of metabolites in human plasma and urine after consumption of a polyphenol-rich juice drink. J Agric Food Chem 2010, 58:2586-2595.
29. Wang P.W., Aronson W.J., Huang M., Zhang Y.J., Lee R.P., Heber D., et al. Green tea polyphenols and metabolites in prostatectomy tissue: implications for cancer prevention. Cancer Prev Res (Phila) 2010, 3:985-993.
30. Kohri T., Matsumoto N., Yamakawa M., Suzuki M., Nanjo F., Hara Y., et al. Metabolic fate of (-)-4-H-3 epigallocatechin gallate in rats after oral administration. J Agric Food Chem 2001, 49:4102-4112.
31. Rhodes L.E., Darby G., Massey K.A., Clarke K.A., Dew T.P., Farrar M.D., et al. Oral green tea catechin metabolites are incorporated into human skin and protect against UV radiation-induced cutaneous inflammation in association with reduced production of pro-inflammatory eicosanoid 12-hydroxyeicosatetraenoic acid. Br J Nutr 2013, 110:891-900.
32. 2 dual extraction method for identification of green tea catechin metabolites excreted in human urine. J Chromatogr B Analyt Technol Biomed Life Sci 2014, 972:29-37.
33. Chen Z.Y., Zhu Q.Y., Wong Y.F., Zhang Z.S., Chung H.Y. Stabilizing effect of ascorbic acid on green tea catechins. J Agric Food Chem 1998, 46:2512-2516.
34. McArdle F., Rhodes L.E., Parslew R., Jack C.I.A., Friedmann P.S., Jackson M.J. UVR-induced oxidative stress in human skin in vivo: effects of oral vitamin C supplementation. Free Radic Biol Med 2002, 33:1355-1362.
35. Wong C.C., Meinl W., Glatt H.R., Barron D., Stalmach A., Steiling H., et al. In vitro and in vivo conjugation of dietary hydroxycinnamic acids by UDP-glucuronosyltransferases and sulfotransferases in humans. J Nutr Biochem 2010, 21:1060-1068.
36. Lee M.J., Maliakal P., Chen L.S., Meng X.F., Bondoc F.Y., Prabhu S., et al. Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability. Cancer Epidemiol Biomarkers Prev 2002, 11:1025-1032.
37. Hong Y.J., Barrett D.M., Mitchell A.E. Liquid chromatography/mass spectrometry investigation of the impact of thermal processing and storage on peach procyanidins. J Agric Food Chem 2004, 52:2366-2371.
38. Sang S., Lee M.J., Yang I., Buckley B., Yang C.S. Human urinary metabolite profile of tea polyphenols analyzed by liquid chromatography/electrospray ionization tandem mass spectrometry with data-dependent acquisition. Rapid Commun Mass Spectrom 2008, 22:1567-1578.
39. Williamson G., Dionisi F., Renouf M. Flavanols from green tea and phenolic acids from coffee: critical quantitative evaluation of the pharmacokinetic data in humans after consumption of single doses of beverages. Mol Nutr Food Res 2011, 55:864-873.
40. Hollman P.C., Van Het Hof K.H., Tijburg L.B., Katan M.B. Addition of milk does not affect the absorption of flavonols from tea in man. Free Radic Res 2001, 34:297-300.
41. Jin D., Hakamata H., Takahashi K., Kotani A., Kusu F. Determination of quercetin in human plasma after ingestion of commercial canned green tea by semi-micro HPLC with electrochemical detection. Biomed Chromatogr 2004, 18:662-666.