An improved HPLC-DAD method for clavulanic acid quantification in fermentation broths of Streptomyces clavuligerus

Journal of Pharmaceutical and Biomedical Analysis

Volumn 120, Issue , 2016, Pages 241-247

  Ramirez Malule, Howard ^a   Junne, Stefan ^b   López, Carlos ^a   Zapata, Julian ^a   Sáez, Alex ^c   Neubauer, Peter ^b   Rios Estepa, Rigoberto ^a  

^a UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^b TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSIDAD EAFIT   (Colombia)

Author keywords

Clavulanate imidazole; Clavulanic acid; Fermentation processes; High performance liquid chromatography method; Streptomyces clavuligerus

Indexed keywords

CLAVULANIC ACID; CULTURE MEDIUM;

ANALYTIC METHOD; ANALYTICAL EQUIPMENT; ARTICLE; CONCENTRATION (PARAMETERS); DIODE ARRAY DETECTION; DIODE ARRAY DETECTOR; ELUTION; FERMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MEASUREMENT ACCURACY; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES CLAVULIGERUS; VALIDATION STUDY; ANALYSIS; CHEMISTRY; CULTURE MEDIUM; METABOLISM; PHYSIOLOGY; PROCEDURES; STREPTOMYCES;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLAVULANIC ACID; CULTURE MEDIA; FERMENTATION; STREPTOMYCES;

EID: 84952837330     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2015.12.035     Document Type: Article

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