Simultaneous quantification of cefpodoxime proxetil and clavulanic acid in human plasma by LC-MS using solid phase extraction with application to pharmacokinetic studies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 921-922, Issue , 2013, Pages 49-55

  Dubala, Anil ^a   Nagarajan, Janaki Sankarachari Krishnan ^a   Vimal, Chandran Sathish ^a   George, Renjith ^a  

^a JSS COLLEGE OF PHARMACY   (India)

Author keywords

APCI; Cefpodoxime proxetil; Clavulanic acid; LC MS; Pharmacokinetics

Indexed keywords

AMMONIUM ACETATE; APCI; CALIBRATION CURVES; CEFPODOXIME PROXETIL; CHROMATOGRAPHIC SEPARATIONS; CLAVULANIC ACID; CONCENTRATION RANGES; ELIMINATION RATE; HPLC-APCI-MS; HUMAN PLASMAS; INTERNAL STANDARDS; LC-MS; PHARMACOKINETIC PARAMETERS; PHARMACOKINETIC STUDIES; QUADRUPOLES; REVERSE PHASE; SELECTED ION MONITORING; SIMULTANEOUS ESTIMATION; SOLID PHASE EXTRACTION TECHNIQUES; SOLID-PHASE EXTRACTION;

ACETONITRILE; AMMONIUM COMPOUNDS; ATMOSPHERIC PRESSURE; CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHANOL; PHARMACOKINETICS; PLASMA (HUMAN); RATE CONSTANTS;

CARBOXYLIC ACIDS;

CEFPODOXIME PROXETIL; CHLORAMPHENICOL; CLAVULANIC ACID;

AREA UNDER THE CURVE; ARTICLE; ATMOSPHERIC PRESSURE; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MONITORING; FLOW RATE; FREEZE THAWING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SOLID PHASE EXTRACTION; TABLET; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANTI-BACTERIAL AGENTS; CEFTIZOXIME; CHROMATOGRAPHY, LIQUID; CLAVULANIC ACID; HUMANS; MASS SPECTROMETRY; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION;

EID: 84874561307     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2013.01.018     Document Type: Article

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