Simultaneous determination of amoxycillin and clavulanic acid in pharmaceutical products by HPLC with β-cyclodextrin stationary phase

Journal of Pharmaceutical and Biomedical Analysis

Volumn 15, Issue 8, 1997, Pages 1197-1205

  Tsou, Tai Li ^a   Wu, Jing Ran ^a   Young, Chung Daw ^a   Wang, Teen Meei ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Cyclodextrin; Amoxycillin; Clavulanic acid; HPLC assay

Indexed keywords

AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; BETA CYCLODEXTRIN; CLAVULANIC ACID;

ACCURACY; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; REPRODUCIBILITY;

AMOXICILLIN; AMOXICILLIN-POTASSIUM CLAVULANATE COMBINATION; BETA-CYCLODEXTRINS; BUFFERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLAVULANIC ACIDS; CYCLODEXTRINS; DOSAGE FORMS; DRUG THERAPY, COMBINATION; HYDROGEN-ION CONCENTRATION; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0030958682     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(96)01960-7     Document Type: Article

References (25)

1. Amoxycillin and clavulanate potassium, in G.K. McEvoy (Ed.), AHFS Drug Information 95®, American Society of Health-System Pharmacists, MD, USA, 1995, pp. 292-297.
2. R. Yogev, C. Melick and W.J. Kabat, In vitro and in vivo synergism between amoxicillin and clavulanic acid against ampicillin-resistant Haemophilus influenzae type b, Antimicrob. Agents Chemother., 19 (1981) 993-996.
3. A.P. Ball, P.G. Davey, A.M. Geddes, I.D. Farrel and G. Brookes, Clavulanic acid and amoxicillin: a clinical, bacteriological and pharmacological study, Lancet, i (1980) 620-623.
4. W. Cullmann and W. Dick, A simple enzymatic assay for the simultaneous determination of penicillin derivatives and clavulanic acid in biological fluids. Immun. Infect., 14(5) (1986) 188-190.
5. P. Izquierdo, A. Gomez-Hens and D. Perez-Bendito, Stopped-flow photometric determination of clavulanic acid in pharmaceutical and serum samples, J. Pharm. Biomed. Anal., 11(10) (1993) 927-931.
6. A.E. Bird, J.M. Bellis and B.C. Gasson, Spectrophotometric assay of clavulanic acid by reaction with imidazole, Analyst, 107 (1982) 1241-1245.
7. G.G. Perez, I.G. Martin and B.R.V. De Aldana, Polarographic determination of clavulanic acid, J. Pharm. Biomed. Anal., 9(5) (1991) 383-386.
8. M. Foulstone and C. Reading, Assay of amoxicillin and clavulanic acid, the components of Augmentin, in biological fluids with HPLC, Antimicrob. Agents Chemother., 22(5) (1982) 753-762.
9. J. Martin and R. Mendez, High-performance liquid chromatographic determination of clavulanic acid in human serum and urine using a pre-column reaction with 1,2,4-triazole, J. Liq. Chromatogr., 11(8) (1988) 1697-1705.
10. J. Haginaka, H. Yasuda, T. Uno and T. Nakagawa, Alkaline degradation of clavulanic acid and high performance liquid chromatographic determination by post-column alkaline degradation, Chem. Pharm. Bull., 31(12) (1983) 4436-4447.
11. J. Haginaka, J. Wakai, H. Yasuda, T. Uno and T. Nakagawa, Improved high-performance liquid chromatographic assay of clavulanic acid and sulbactam by post-column alkaline degradation, J. Liq. Chromatogr., 8(13) (1985) 2521-2534.
12. J. Haginaka, J. Wakai and H. Yasuda, Liquid Chromatographic assay of clavulanic acid using a hollow-fiber postcolumn reactor, Chem. Pharm. Bull., 34(4) (1986) 1850-1852.
13. J. Haginaka, J. Wakai and H. Yasuda, Liquid Chromatographic assay of β-lactamase inhibitors in human serum and urine using a hollow-fiber postcolumn reactor, Anal. Chem., 59(2) (1987) 324-333.
14. F. Salto and M.T. Alemany, Ion interaction chromatography of clavulanic acid on a poly(styrene-divinylbenzene) adsorbent in the presence of tertabutylammonium salts, J. Liq. Chromatogr., 7(7) (1984) 1477-1487.
15. M.A. Abounassif, E.M. Abdel-moety, M.E. Mohamed and E.A. Gad-kariem, Liquid chromatographic determination of amoxycillin and clavulanic acid in pharmaceutical preparations, J. Pharm. Biomed. Anal., 9(9) (1991) 731-735.
16. United States Pharmacopoeia, Vol. XXII, 1989, pp. 84-85.
17. D.W. Armstrong, Bonded phase materials for chromatographic separations, US Patent 4 539 399, 1985.
18. A.N. Ahmed and S.M. Ei-Gizawy, Chemically bonded cyclodextrin stationary phase for the high-performance liquid chromatographic separation and determination of sulphonamides, Analyst, 114(5) (1989) 571-573.
19. S.M. EI-Gizawy, A.N. Ahmed and N.A. EI-Rabbat, High performance liquid chromatographic determination of multivitamin preparations using a chemically bonded cyclodextrin stationary phase, Anal. Lett., 24(7) (1991) 1173-1181.
20. J.W. Ho, A study of the solvent composition effects on the separation of seven clinically important porphyrins on cyclodextrin bonded phases, J. Liq. Chromatogr., 13(11) (1990) 2193-2205.
21. S. Piperaki, M. Parissi-Poulou and M. Koupparis, A separation study of tricyclic antidepressant drugs by HPLC with β-cyclodextrin bonded stationary phase, J. Liq. Chromatogr., 16(16) (1993) 3487-3508.
22. D.W. Armstrong, G.L. Bertrand, K.D. Ward and T.J. Ward, Evaluation of the effect of organic modifier and pH on retention and selectivity in reversed-phase liquid chromatographic separation of alkaloids on a cyclodextrin bonded phase, Anal. Chem., 62 (1990) 332-338.
23. D.W. Armstrong, T.J. Ward, R.D. Armstrong and T.E. Beesley, Separation of drug stereoisomers by the formation of β-cyclodextrin inclusion complexes. Science, 232 (1986) 1132-1135.
24. T.L. Tsou, J.R. Wu and T.M. Wang, The effects on separation of cephalosporins by HPLC with β-cyclodextrin bonded stationary phase, J. Liq. Chromatogr., 19(7) (1996) 1081-1095.
25. M.L. Bender and M. Komiyama, Cyclodextrin Chemistry, Springer, New York, 1978.