Impaired myelination and reduced brain ferric iron in the mouse model of mucolipidosis IV

DMM Disease Models and Mechanisms

Volumn 8, Issue 12, 2015, Pages 1591-1601

  Grishchuk, Yulia ^a   Peña, Karina A ^b   Coblentz, Jessica ^b   King, Victoria E ^a   Humphrey, Daniel M ^a   L wang, Shirley ^a   Kiselyov, Kirill I ^b   Slaugenhaupt, Susan A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Lysosome; Myelination; Oligodendrocytes; Transient receptor potential channel mucolipin 1

Indexed keywords

APC PROTEIN; FERRIC ION; HEME OXYGENASE 1; LYSOSOMAL TRANSIENT RECEPTOR POTENTIAL ION CHANNEL MUCOLIPIN 1; MESSENGER RNA; MYELIN ASSOCIATED GLYCOPROTEIN; MYELIN BASIC PROTEIN; PROTEIN; PROTEOLIPID PROTEIN; RNA; UNCLASSIFIED DRUG; IRON; MCOLN1 PROTEIN, MOUSE; TRANSIENT RECEPTOR POTENTIAL CHANNEL;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN LEVEL; CELL COUNT; CELL DENSITY; CELL LOSS; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; CORPUS CALLOSUM; DISEASE COURSE; DISEASES; DOWN REGULATION; FERRIC IRON BRAIN LEVEL; GENOTYPE; GRAY MATTER; MICROENVIRONMENT; MOUSE; MUCOLIPIDOSIS TYPE 4; MYELIN DEFICIENCY; MYELINATION; NERVE CELL DIFFERENTIATION; NONHUMAN; OLIGODENDROGLIA; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; SURFACE AREA; TISSUE STRUCTURE; WHITE MATTER; WHITE MATTER LESION; ANIMAL; AXON; BRAIN; C57BL MOUSE; DEFICIENCY; DISEASE MODEL; GENETICS; KNOCKOUT MOUSE; METABOLISM; MUCOLIPIDOSIS; MYELIN SHEATH; OXIDATIVE STRESS; PATHOLOGY;

ANIMALS; AXONS; BRAIN; CELL COUNT; CORPUS CALLOSUM; DISEASE MODELS, ANIMAL; IRON; MICE, INBRED C57BL; MICE, KNOCKOUT; MUCOLIPIDOSES; MYELIN SHEATH; OLIGODENDROGLIA; OXIDATIVE STRESS; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84952772333     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.021154     Document Type: Article

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