Intact mass analysis of monoclonal antibodies by capillary electrophoresis-Mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 1011, Issue , 2016, Pages 24-32

  Han, Mei ^a   Rock, Brooke M ^a   Pearson, Josh T ^a   Rock, Dan A ^a  

^a AMGEN INC   (United States)

Author keywords

Capillary electrophoresis; CE MS; Deamidation; Heavy chain; IdeS; Intact mass analysis; Light chain; Oxidation; PTMs

Indexed keywords

CAPILLARY ELECTROPHORESIS; CHAINS; CHARACTERIZATION; CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; IONIZATION POTENTIAL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; OXIDATION; PULSE TIME MODULATION; SEPARATION; SPECTROMETRY; SURFACE PLASMON RESONANCE;

DEAMIDATION; HEAVY CHAIN; IDES; LIGHT CHAIN; MASS ANALYSIS;

ANTIBODIES;

MONOCLONAL ANTIBODY;

ARTICLE; CAPILLARY ELECTROPHORESIS; ELECTROSPRAY MASS SPECTROMETRY; HEAVY CHAIN; LIGHT CHAIN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OPTICAL RESOLUTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROCESSING; TIME OF FLIGHT MASS SPECTROMETRY; CHEMISTRY; DEVICES; EQUIPMENT DESIGN; GLYCOSYLATION; ISOLATION AND PURIFICATION; PROCEDURES;

ANTIBODIES, MONOCLONAL; ELECTROPHORESIS, CAPILLARY; EQUIPMENT DESIGN; GLYCOSYLATION; MASS SPECTROMETRY;

EID: 84952761353     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2015.12.045     Document Type: Article

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