Exogenous Hsp70 delays senescence and improves cognitive function in aging mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 52, 2015, Pages 16006-16011

  Bobkova, Natalia V ^a   Evgen'ev, Mikhail ^a,b   Garbuz, David G ^b   Kulikov, Alexei M ^c   Morozov, Alexei ^b   Samokhin, Alexander ^a   Velmeshev, Dmitri ^a   Medvinskaya, Natalia ^a   Nesterova, Inna ^a   Pollock, Andrew ^d   Nudler, Evgeny ^d  

^a INSTITUTE OF CELL BIOPHYSICS   (Russian Federation)

^b ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^c KOL TSOV INSTITUTE OF DEVELOPMENTAL BIOLOGY   (Russian Federation)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Hsp70; Memory; Proteasome; Therapy

Indexed keywords

HEAT SHOCK PROTEIN 70; LIPOFUSCIN; PROTEASOME; RECOMBINANT HUMAN HEAT SHOCK PROTEIN 70; RECOMBINANT PROTEIN; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; PROTEIN SUBUNIT;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR ASSESSMENT; CELL DENSITY; COGNITION; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; EXPLORATORY BEHAVIOR; GROUPS BY AGE; LEARNING; LIFE EXTENSION; LOCOMOTION; LONG TERM CARE; MALE; MEMORY; MEMORY DISORDER; MORRIS WATER MAZE TEST; MOUSE; NERVE CELL; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; SENESCENCE; SPATIAL MEMORY; SYNAPSE; ANIMAL; BRAIN; CYTOLOGY; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; GENETICS; HUMAN; INBRED MOUSE STRAIN; LONGEVITY; MAZE TEST; METABOLISM; MOTOR ACTIVITY; PROTEIN SUBUNIT; WESTERN BLOTTING;

AGING; ANIMALS; BLOTTING, WESTERN; BRAIN; COGNITION; EXPLORATORY BEHAVIOR; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LIPOFUSCIN; LONGEVITY; MALE; MAZE LEARNING; MEMORY; MICE, INBRED STRAINS; MICROSCOPY, FLUORESCENCE; MOTOR ACTIVITY; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; SYNAPTOPHYSIN;

EID: 84952690383     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1516131112     Document Type: Article

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