Exogenous protein Hsp70/Hsc70 can penetrate into brain structures and attenuate the severity of chemically-induced seizures

Journal of Neurochemistry

Volumn 115, Issue 4, 2010, Pages 1035-1044

  Ekimova, Irina V ^a   Nitsinskaya, Larisa E ^a   Romanova, Irina V ^a   Pastukhov, Yuri F ^a   Margulis, Boris A ^b   Guzhova, Irina V ^b  

^a SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

^b INSTITUTE OF CYTOLOGY   (Russian Federation)

Author keywords

Brain; Chemically induced seizures; GAD67; Hsp70; Rat; Synaptophysin

Indexed keywords

4 AMINOBUTYRIC ACID; ANTICONVULSIVE AGENT; CHAPERONE; GLUTAMATE DECARBOXYLASE; HEAT SHOCK PROTEIN 70 HEAT SHOCK COGNATE PROTEIN 70; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PENTETRAZOLE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN NERVE CELL; CLONUS; COMPLEX PARTIAL SEIZURE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; GLIA; GRAND MAL SEIZURE; HIPPOCAMPUS; IMMUNOPRECIPITATION; LEPTOMENINX; MALE; MOTOR CORTEX; MUSCLE TONE; NERVE ENDING; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; RAT; SEIZURE; TONIC CLONIC SEIZURE;

ANIMALS; ANTICONVULSANTS; BRAIN; CATTLE; HSC70 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MALE; N-METHYLASPARTATE; PENTYLENETETRAZOLE; PROSPECTIVE STUDIES; PROTEIN TRANSPORT; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; SEIZURES; SEVERITY OF ILLNESS INDEX;

ANIMALIA; RATTUS;

EID: 77958554541     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06989.x     Document Type: Article

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