Administration of Hsp70 in vivo inhibits motor and sensory neuron degeneration

Cell Stress and Chaperones

Volumn 9, Issue 1, 2004, Pages 88-98

  Tidwell, J Lille ^a   Houenou, Lucien J ^b   Tytell, Michael ^a,b  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b Prosperon Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN 70;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INJURY; MOTONEURON; MOTOR NEURON DISEASE; MOUSE; NERVE FIBER TRANSECTION; NERVOUS SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; SCIATIC NERVE; SENSORY NERVE CELL; SENSORY NEUROPATHY; SPINAL GANGLION; STRESS; WESTERN BLOTTING;

ABSORBABLE IMPLANTS; ANIMALS; ANIMALS, NEWBORN; AXOTOMY; BLOTTING, WESTERN; CELL SURVIVAL; GANGLIA, SPINAL; HSC70 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED BALB C; MOTOR NEURONS; NERVE DEGENERATION; NEURONS, AFFERENT; RECOMBINANT PROTEINS; SCIATIC NERVE;

ANIMALIA;

EID: 1842562325     PISSN: 13558145     EISSN: None     Source Type: Journal    
DOI: 10.1379/1466-1268(2004)009<0088:AOHIVI>2.0.CO;2     Document Type: Article

References (53)

1. Alder GM, Austen BM, Bashford CL, Mehlert A, Pasternak CA. 1990. Heat shock proteins induce pores in membranes. Biosci Rep 10: 509-518.
2. Arispe N, De Maio A. 2000. ATP and ADP modulate a cation channel formed by Hsc70 in acidic phospholipid membranes. J Biol Chem 275: 30839-30843.
3. Arispe N, Doh M, De Maio A. 2002. Lipid interaction differentiates the constitutive and stress-induced heat shock proteins Hsc70 and Hsp70. Cell Stress Chaperones 7: 330-338.
4. Asea A, Kraeft S-K, Kurt-Jones EA, Stevenson MA, Chen LB, Finberg RW, Koo GC, Calderwood SK. 2000. Hsp70 stimulates cytokine production through a CD14-dependent pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med 6: 435-442.
5. Asea A, Rehli M, Kabingu E, Boch JA, Baré O, Auron PE, Stevenson MA, Calderwood SK. 2002. Novel signal transduction pathway utilized by extracellular Hsp70. J Biol Chem 277: 15028-15034.
6. Batulan Z, Shinder GA, Minotti S, He BP, Doroudchi MM, Nalbantoglu J, Strong MJ, Durham HD. 2003. High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1. J Neurosci 23: 5789-5798.
7. Bechtold DA, Brown, IR. 2000. Heat shock proteins Hsp27 and Hsp32 localize to synaptic sites in the rat cerebellum following hyperthermia. Brain Res Mol Brain Res 75: 309-320.
8. Benn S, Perrelet D, Kato A, Scholz J, Decosterd I, Mannion R, Bakowska J, Woolf C. 2002. Hsp27 upregulation and phosphorylation is required for injured sensory and motor neuron survival. Neuron 36: 45-56.
9. + cells. J Immunol 165: 2582-2587.
10. Brown IR. 1991. Expression of heat shock genes (hsp70) in the mammalian nervous system. Results Probl Cell Diff 17: 217-229.
11. Brown IR. 1994. Chapter 2. Induction of heat shock genes in the mammalian brain by hyperthermia and tissue injury. In: Heat Shock Proteins in the Nervous System, ed Brown IR. Academic Press, Inc., San Diego, CA, 31-53.
12. Edbladh M, Ekstrom PAR, Edstrom A. 1994. Retrograde axonal transport of locally synthesized proteins, e.g. actin and heat shock protein 70, in regenerating adult frog sciatic sensory axons. J Neurosci Res 38: 424-432.
13. Edgington SM. 1995. Therapeutic applications of heat shock proteins. Biotechnology (NY) 13: 1442-1444.
14. Frydman J, Hohfeld J. 1997. Chaperones get in touch: the Hip-Hop connection. Trends Biochem Sci 22: 87-92.
15. Fujihara SM, Nadler SG. 1999. Intranuclear targeted delivery of functional NF-kB by 70 kDa heat shock protein. EMBO 18: 411-419.
16. Greenberg SC, Lasek RJ. 1985. Comparison of labelled heat shock proteins in neuronal and nonneuronal cells of Aplysia californica. Neuroscience 5: 1239-1245.
17. Guzhova I, Kislyakova K, Moskaliova O, Fridlanskaya I, Tytell M, Cheetham M, Margulis B. 2001. In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance. Brain. Res 914: 66-73.
18. Guzhova IV, Arnholdt ACV, Darieva ZA, et al 1998. Effects of exogenous stress protein 70 on the functional properties of human promonocytes through binding to cell surface and internalization. Cell Stress Chaperones 3: 67-77.
19. Hartl FU. 1996. Molecular chaperones in cellular protein folding. Nature 381: 571-580.
20. Hightower LE, Guidon PT. 1989. Selective release from cultured mammalian cells of heat-shock (stress) proteins that resemble glia-axon transfer proteins. J Cell Physiol 138: 257-266.
21. Hoogeveen JF, Van Der Kracht AHW, Wondergem J, Haveman J. 1993. Heat shock proteins (HSP-72kd) in thermotolerant rat sciatic nerves. Int J Hyperthermia 9: 361-368.
22. Houenou LJ, Li L, Lei M, Kent CR, Tytell M. 1996. Exogenous heat shock cognate protein Hsc70 prevents axotomy-induced death of spinal sensory neurons. Cell Stress Chaperones 1: 161-166.
23. Johnson AD, Berberian PA, Bond MG. 1990. Effect of heat shock proteins on survival of isolated aortic cells from normal and atherosclerotic cynomologous macaques. Atherosclerosis 84: 111-119.
24. Johnson AD, Berberian PA, Tytell M. 1995. Differential distribution of 70-kD heat shock protein in atherosclerosis: its potential role in arterial SMC survival. Arterioscler Thromb Vasc Biol 15: 27-36.
25. Kalmar B, Burnstock G, Vrbova G, Greensmith L. 2002a. The effect of neonatal nerve injury on the expression of heat shock proteins in developing rat motoneurones. J Neurotrauma 19: 667-679.
26. Kalmar B, Burnstock G, Vrbova G, Urbanics R, Csermely P, Greensmith L. 2002b. Upregulation of heat shock proteins rescues motoneurones from axotomy-induced cell death in neonatal rats. Exp Neurol 176: 87-97.
27. Kelty J, Noseworthy P, Feder M, Robertson R, Ramirez J. 2002. Thermal preconditioning and heat-shock protein preserve synaptic transmission during thermal stress. J Neurosci 22: 193.
28. Kiang JG, Tsokos GC. 1998. Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology. Pharmacol Ther 80: 183-201.
29. Lasek RJ, Gainer H, Barker JL. 1977. Cell-to-cell transfer of glial proteins to the squid giant axon: The glia-neuron protein transfer hypothesis. J Cell Biol 74: 501-523.
30. Li L, Houenou LJ, Wu W, Lei M, Prevette DM, Oppenheim RW. 1998. Characterization of spinal motoneuron degeneration following different types of peripheral nerve injury in neonatal and adult mice. J Comp Neurol 396: 158-168.
31. Li L, Oppenheim RW, Lei M, Houenou LJ. 1994. Neurotrophic agents prevent motoneuron death following sciatic nerve section in the neonatal mouse. J Neurobiol 25: 759-766.
32. Lindquist S, Craig EA. 1988. The heat-shock proteins. Annu Rev Genet 22: 631-677.
33. Mattson M. 2000. Neuroprotective signaling and the aging brain: take away my food and let me run. Brain Res 886: 47-53.
34. Mitchell D, Ibrahim S, Gusterson BA. 1985. Improved immunohistochemical localization of tissue antigens using methacarn fixation. J Histochem Cytochem 33: 491-495.
35. Moreno-Flores MT, Olazabal UE, Kreutzberg GW. 1997. Axotomy increases the expression of glucose-related protein 78 kDa in rat facial nucleus. Exp Neurol 146: 10-16.
36. Morimoto RI, Kline MP, Bimston DN, Cotto JJ. 1997. The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones. Essays Biochem 32: 17-29.
37. Muchowski P, Schaffar G, Sittler A, Wanker E, Hayer-Hartl M, Hartl F. 2000. Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils. PNAS 97: 7841-7846.
38. Negulyaev YA, Vedernikova EA, Kinev AV, Voronin AP. 1996. Exogenous heat shock protein hsp70 activates potassium channels in U937 cells. Biochim Biophys Acta 1282: 156-162.
39. New GA, Hendrickson BR, Jones KJ. 1989. Induction of heat shock protein 70 mRNA in adult hamster facial nuclear groups following axotomy of the facial nerve. Metab Brain Dis 4: 273-279.
40. Newfry GA, Jones KJ. 1998. Differential effects of facial nerve transection on heat shock protein 70 expression in the developing and adult hamster facial nucleus. Metab Brain Dis 13: 253-257.
41. Ohtsuka K, Suzuki T. 2000. Roles of molecular chaperones in the nervous system. Brain Res Bull 53: 141-146.
42. Puchtler H, Waldrop FS, Meloan SN, Terry MS, Conner HM. 1970. Methacarn (methanol-Carnoy) fixation: practical and theoretical considerations. Histochemie 21: 97-116.
43. Rajdev S, Sharp FR. 2000. Stress proteins as molelcular markers of neurotoxicity. Toxicol Pathol 28: 105-112.
44. Schumacher RJ, Hansen WJ, Freeman BC, Alnemri E, Litwak G, Toft DO. 1996. Cooperative action of Hsp70, Hsp90, and DnaJ proteins in protein renaturation. Biochemistry 35: 14889-14898.
45. Sheller RA, Smyers ME, Grossfeld RM, Ballinger ML, Bittner GD. 1998. Heat-shock proteins in axoplasm: high constitutive levels and transfer of inducible isoforms from glia. J Comp Neurol 396: 1-11.
46. Smith PJS, Hammar K, Tytell M. 1995. Effects of exogenous heat shock protein (hsp70) on neuronal calcium flux. Biol Bull 189: 209-210.
47. Snider WD, Elliott JL, Yan Q. 1992. Axotomy-induced neuronal death during development. J Neurobiol 23: 1231-1246.
48. Tytell M, Greenberg SG, Lasek RJ. 1986. Heat shock-like protein is transferred from glia to axon. Brain Res 363: 161-164.
49. Tytell M, Hooper PL. 2001. Heat shock proteins: new keys to the development of cytoprotective therapies. Emerging Therapeutic Targets 5: 267-287.
50. Vigh L, Literati PN, Horvath I, et al 1997. Bimoclomol: a nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects. Nat Med 3: 1150-1154.
51. Welch WJ, Suhan JP. 1986. Cellular and biochemical events in mammalian cells during and after recovery from physiological stress. J Cell Biol 103: 2035-2052.
52. Yenari MA, Giffard RG, Sapolsky RM, Steinberg GK. 1999. The neuroportective potential of heat shock protein 70 (HSP70). Mol Med Today 5: 525-531.
53. Yu Q, Kent CR, Tytell M. 2001. Retinal uptake of intravitreally injected Hsc/Hsp70 and its effect on susceptibility to light damage. Mol Vis 7: 48-56.