Neurogenomics: An opportunity to integrate neuroscience, genomics and bioinformatics research in Africa

Applied and Translational Genomics

Volumn 5, Issue , 2015, Pages 3-10

  Karikari, Thomas K ^a,b   Aleksic, Jelena ^c  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Africa; Bioinformatics; Genomics; Neurogenomics; Neuroscience; Scientific capacity

Indexed keywords

AFRICA; BEHAVIOR; BIOINFORMATICS; CLINICAL PRACTICE; DATA PROCESSING; EDUCATION PROGRAM; FUNDING; GENE MUTATION; GENETIC VARIABILITY; GENOMICS; HEALTH CARE SYSTEM; HUMAN; MEDICAL EDUCATION; MEDICAL ETHICS; MEDICAL RESEARCH; MOLECULAR DIAGNOSIS; NERVOUS SYSTEM DEVELOPMENT; NEUROGENOMICS; NEUROLOGIC DISEASE; NEUROSCIENCE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRADITIONAL MEDICINE;

EID: 84952631870     PISSN: 22120661     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atg.2015.06.004     Document Type: Review

References (87)

1. Abdullahi A.A. Trends and challenges of traditional medicine in Africa. Afr. J. Tradit. Complement. Altern. Med. 2011, 8:115-123. 10.4314/ajtcam.v8i5S.5.
2. Adoga M.P., Fatumo S.A., Agwale S.M. H3Africa: a tipping point for a revolution in bioinformatics, genomics and health research in Africa. Source Code Biol. Med. 2014, 9:10. 10.1186/1751-0473-9-10.
3. Adusi-Poku Y., Okine L.K.-N., Hlortsi-Akakpo F.K., Fleischer T.C., Mensah M.L.K., Arhin P., Agyemfra G., Dabra T., Mensah E.N. Assesssing herbal medical practitioners in professional qualifying examination in Ghana, a model. Afr. J. Tradit. Complement. Altern. Med. 2009, 7:85-87.
4. Aleksic J., Ferrero E., Fischer B., Shen S.P., Russell S. The role of Dichaete in transcriptional regulation during Drosophila embryonic development. BMC Genomics 2013, 14:861. 10.1186/1471-2164-14-861.
5. Allen M.J., Drummond J.A., Moffat K.G. Development of the giant fiber neuron of Drosophila melanogaster. J. Comp. Neurol. 1998, 397:519-531. 10.1002/(SICI)1096-9861(19980810)397:4<519::AID-CNE5>3.0.CO;2-4.
6. Ashraf Q., Galor O. The "out of Africa" hypothesis, human genetic diversity, and comparative economic development. Working Paper No. 17216 2011, National Bureau of Economic Research.
7. Baden T., Chagas A.M., Gage G., Marzullo T., Prieto-Godino L.L., Euler T. Open labware: 3-D printing your own lab equipment. PLoS Biol. 2015, 13:e1002086. 10.1371/journal.pbio.1002086.
8. Bakare M.O., Munir K.M. Autism spectrum disorders (ASD) in Africa: a perspective. Afr. J. Psychiatry 2011, 14:208-210. 10.4314/ajpsy.v14i3.3.
9. Bangirana P., Musisi S., Boivin M.J., Ehnvall A., John C.C., Bergemann T.L., Allebeck P. Malaria with neurological involvement in Ugandan children: effect on cognitive ability, academic achievement and behaviour. Malar. J. 2011, 10:334. 10.1186/1475-2875-10-334.
10. Bergen D.C., Good D. Neurology training programs worldwide: a world federation of neurology survey. J. Neurol. Sci. 2006, 246:59-64. 10.1016/j.jns.2006.02.003.
11. Bishop Ö.T., Adebiyi E.F., Alzohairy A.M., Everett D., Ghedira K., Ghouila A., Kumuthini J., Mulder N.J., Panji S., Patterton H.-G. Bioinformatics education-perspectives and challenges out of Africa. Brief. Bioinform. 2015, 16(2):355-364. 10.1093/bib/bbu022.
12. Blanckenberg J., Bardien S., Glanzmann B., Okubadejo N.U., Carr J.A. The prevalence and genetics of Parkinson's disease in sub-Saharan Africans. J. Neurol. Sci. 2013, 335:22-25. 10.1016/j.jns.2013.09.010.
13. Boguski M.S., Jones A.R. Neurogenomics: at the intersection of neurobiology and genome sciences. Nat. Neurosci. 2004, 7:429-433. 10.1038/nn1232.
14. Bower J.H., Zenebe G. Neurologic services in the nations of Africa. Neurology 2005, 64:412-415. 10.1212/01.WNL.0000150894.53961.E2.
15. Campbell M.C., Tishkoff S.A. African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping. Annu. Rev. Genomics Hum. Genet. 2008, 9:403-433. 10.1146/annurev.genom.9.081307.164258.
16. Carhan A., Reeve S., Dee C.T., Baines R.A., Moffat K.G. Mutation in slowmo causes defects in Drosophila larval locomotor behaviour. Invertebr. Neurosci. 2003, 5:65-75. 10.1007/s10158-003-0028-y.
17. Caron L., Karkazis K., Raffin T.A., Swan G., Koenig B.A. Nicotine addiction through a neurogenomic prism. Nicotine Tob. Res. 2005, 7:181-197. 10.1080/14622200500055251.
18. Chandrasekaran S., Ament S.A., Eddy J.A., Rodriguez-Zas S.L., Schatz B.R., Price N.D., Robinson G.E. Behavior-specific changes in transcriptional modules lead to distinct and predictable neurogenomic states. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:18020-18025. 10.1073/pnas.1114093108.
19. Cherian A., Thomas S. Central nervous system tuberculosis. Afr. Health Sci. 2011, 11:116-127.
20. Cilia R. Neurology training for non-neurologists in West Africa: focus on Parkinson's disease and other neurodegenerative disorders [WWW document] URL, (accessed 4.28.15). http://www.movementdisorders.org/MDS/Regional-Sections/Sub-SaharanAfrica/Neurology-Training-for-Non-Neurologists-in-West-Africa.htm.
21. Cilia R., Sironi F., Akpalu A., Cham M., Sarfo F.S., Brambilla T., Bonetti A., Amboni M., Goldwurm S., Pezzoli G. Screening LRRK2 gene mutations in patients with Parkinson's disease in Ghana. J. Neurol. 2012, 259:569-570. 10.1007/s00415-011-6210-y.
22. De Vries J., Tindana P., Littler K., Ramsay M., Rotimi C., Abayomi A., Mulder N., Mayosi B.M. The H3Africa policy framework: negotiating fairness in genomics. Trends Genet. 2015, 31:117-119. 10.1016/j.tig.2014.11.004.
23. De Vries J., Williams T.N., Bojang K., Kwiatkowski D.P., Fitzpatrick R., Parker M. Knowing who to trust: exploring the role of "ethical metadata" in mediating risk of harm in collaborative genomics research in Africa. BMC Med. Ethics 2014, 15:62. 10.1186/1472-6939-15-62.
24. Deriziotis P., Fisher S.E. Neurogenomics of speech and language disorders: the road ahead. Genome Biol. 2013, 14:1-12. 10.1186/gb-2013-14-4-204.
25. Drislane F.W., Akpalu A., Wegdam H.H.J. The medical system in Ghana. Yale J. Biol. Med. 2014, 87:321-326.
26. Drislane F.W., Akpalu A., Wegdam H.H.J. Establishment of a general medicine residency training program in rural West Africa. Yale J. Biol. Med. 2014, 87:327-339.
27. Dua T., Cumbrera M.G., Mathers C., Saxena S. Global Burden of Neurological Disorders: Estimates and Projections, in: Neurological Diseases: Public Health Challenges 2006, World Health Organization.
28. Easter J., Stephen S., Nicola G.N. The development of vision in the zebrafish (Danio rerio). Dev. Biol. 1996, 180:646-663. 10.1006/dbio.1996.0335.
29. Eddison M., Guarnieri D.J., Cheng L., Liu C.-H., Moffat K.G., Davis G., Heberlein U. Arouser reveals a role for synapse number in the regulation of ethanol sensitivity. Neuron 2011, 70:979-990. 10.1016/j.neuron.2011.03.030.
30. Edelenbosch R., Kupper F., Broerse J.E.W. The application of neurogenomics to education: analyzing guiding visions. New Genet. Soc. 2013, 32:285-301. 10.1080/14636778.2013.808033.
31. Fatumo S.A., Adoga M.P., Ojo O.O., Oluwagbemi O., Adeoye T., Ewejobi I., Adebiyi M., Adebiyi E., Bewaji C., Nashiru O. Computational biology and bioinformatics in Nigeria. PLoS Comput. Biol. 2014, 10:e1003516. 10.1371/journal.pcbi.1003516.
32. Gerstein M.B., Lu Z.J., Nostrand E.L.V., Cheng C., Arshinoff B.I., Liu T., Yip K.Y., Robilotto R., Rechtsteiner A., Ikegami K., Alves P., Chateigner A., Perry M., Morris M., Auerbach R.K., Feng X., Leng J., Vielle A., Niu W., Rhrissorrakrai K., Agarwal A., Alexander R.P., Barber G., Brdlik C.M., Brennan J., Brouillet J.J., Carr A., Cheung M.-S., Clawson H., Contrino S., Dannenberg L.O., Dernburg A.F., Desai A., Dick L., Dosé A.C., Du J., Egelhofer T., Ercan S., Euskirchen G., Ewing B., Feingold E.A., Gassmann R., Good P.J., Green P., Gullier F., Gutwein M., Guyer M.S., Habegger L., Han T., Henikoff J.G., Henz S.R., Hinrichs A., Holster H., Hyman T., Iniguez A.L., Janette J., Jensen M., Kato M., Kent W.J., Kephart E., Khivansara V., Khurana E., Kim J.K., Kolasinska-Zwierz P., Lai E.C., Latorre I., Leahey A., Lewis S., Lloyd P., Lochovsky L., Lowdon R.F., Lubling Y., Lyne R., MacCoss M., Mackowiak S.D., Mangone M., McKay S., Mecenas D., Merrihew G., Miller D.M., Muroyama A., Murray J.I., Ooi S.-L., Pham H., Phippen T., Preston E.A., Rajewsky N., Rätsch G., Rosenbaum H., Rozowsky J., Rutherford K., Ruzanov P., Sarov M., Sasidharan R., Sboner A., Scheid P., Segal E., Shin H., Shou C., Slack F.J., Slightam C., Smith R., Spencer W.C., Stinson E.O., Taing S., Takasaki T., Vafeados D., Voronina K., Wang G., Washington N.L., Whittle C.M., Wu B., Yan K.-K., Zeller G., Zha Z., Zhong M., Zhou X., Ahringer J., Strome S., Gunsalus K.C., Micklem G., Liu X.S., Reinke V., Kim S.K., Hillier L.W., Henikoff S., Piano F., Snyder M., Stein L., Lieb J.D., Waterston R.H. Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science 2010, 330:1775-1787. 10.1126/science.1196914.
33. Gire S.K., Goba A., Andersen K.G., Sealfon R.S.G., Park D.J., Kanneh L., Jalloh S., Momoh M., Fullah M., Dudas G., Wohl S., Moses L.M., Yozwiak N.L., Winnicki S., Matranga C.B., Malboeuf C.M., Qu J., Gladden A.D., Schaffner S.F., Yang X., Jiang P.-P., Nekoui M., Colubri A., Coomber M.R., Fonnie M., Moigboi A., Gbakie M., Kamara F.K., Tucker V., Konuwa E., Saffa S., Sellu J., Jalloh A.A., Kovoma A., Koninga J., Mustapha I., Kargbo K., Foday M., Yillah M., Kanneh F., Robert W., Massally J.L.B., Chapman S.B., Bochicchio J., Murphy C., Nusbaum C., Young S., Birren B.W., Grant D.S., Scheiffelin J.S., Lander E.S., Happi C., Gevao S.M., Gnirke A., Rambaut A., Garry R.F., Khan S.H., Sabeti P.C. Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak. Science 2014, 345:1369-1372. 10.1126/science.1259657.
34. Gomez F., Hirbo J., Tishkoff S.A. Genetic variation and adaptation in Africa: implications for human evolution and disease. Cold Spring Harb. Perspect. Biol. 2014, 6:a008524. 10.1101/cshperspect.a008524.
35. Gurdasani D., Carstensen T., Tekola-Ayele F., Pagani L., Tachmazidou I., Hatzikotoulas K., Karthikeyan S., Iles L., Pollard M.O., Choudhury A., Ritchie G.R.S., Xue Y., Asimit J., Nsubuga R.N., Young E.H., Pomilla C., Kivinen K., Rockett K., Kamali A., Doumatey A.P., Asiki G., Seeley J., Sisay-Joof F., Jallow M., Tollman S., Mekonnen E., Ekong R., Oljira T., Bradman N., Bojang K., Ramsay M., Adeyemo A., Bekele E., Motala A., Norris S.A., Pirie F., Kaleebu P., Kwiatkowski D., Tyler-Smith C., Rotimi C., Zeggini E., Sandhu M.S. The African genome variation project shapes medical genetics in Africa. Nature 2015, 517:327-332. 10.1038/nature13997.
36. H3Africa Consortium, Rotimi C., Abayomi A., Abimiku A., Adabayeri V.M., Adebamowo C., Adebiyi E., Ademola A.D., Adeyemo A., Adu D., Affolabi D., Agongo G., Ajayi S., Akarolo-Anthony S., Akinyemi R., Akpalu A., Alberts M., Alonso Betancourt O., Alzohairy A.M., Ameni G., Amodu O., Anabwani G., Andersen K., Arogundade F., Arulogun O., Asogun D., Bakare R., Balde N., Baniecki M.L., Beiswanger C., Benkahla A., Bethke L., Boehnke M., Boima V., Brandful J., Brooks A.I., Brosius F.C., Brown C., Bucheton B., Burke D.T., Burnett B.G., Carrington-Lawrence S., Carstens N., Chisi J., Christoffels A., Cooper R., Cordell H., Crowther N., Croxton T., de Vries J., Derr L., Donkor P., Doumbia S., Duncanson A., Ekem I., El Sayed A., Engel M.E., Enyaru J.C.K., Everett D., Fadlelmola F.M., Fakunle E., Fischbeck K.H., Fischer A., Folarin O., Gamieldien J., Garry R.F., Gaseitsiwe S., Gbadegesin R., Ghansah A., Giovanni M., Goesbeck P., Gomez-Olive F.X., Grant D.S., Grewal R., Guyer M., Hanchard N.A., Happi C.T., Hazelhurst S., Hennig B.J., Hertz- C., Fowler, Hide W., Hilderbrandt F., Hugo-Hamman C., Ibrahim M.E., James R., Jaufeerally-Fakim Y., Jenkins C., Jentsch U., Jiang P.-P., Joloba M., Jongeneel V., Joubert F., Kader M., Kahn K., Kaleebu P., Kapiga S.H., Kassim S.K., Kasvosve I., Kayondo J., Keavney B., Kekitiinwa A., Khan S.H., Kimmel P., King M.-C., Kleta R., Koffi M., Kopp J., Kretzler M., Kumuthini J., Kyobe S., Kyobutungi C., Lackland D.T., Lacourciere K.A., Landouré G., Lawlor R., Lehner T., Lesosky M., Levitt N., Littler K., Lombard Z., Loring J.F., Lyantagaye S., Macleod A., Madden E.B., Mahomva C.R., Makani J., Mamven M., Marape M., Mardon G., Marshall P., Martin D.P., Masiga D., Mason R., Mate-Kole M., Matovu E., Mayige M., Mayosi B.M., Mbanya J.C., McCurdy S.A., McCarthy M.I., McIlleron H., Mc'Ligeyo S.O., Merle C., Mocumbi A.O., Mondo C., Moran J.V., Motala A., Moxey-Mims M., Mpoloka W.S., Msefula C.L., Mthiyane T., Mulder N., Mulugeta G.h., Mumba D., Musuku J., Nagdee M., Nash O., Ndiaye D., Nguyen A.Q., Nicol M., Nkomazana O., Norris S., Nsangi B., Nyarko A., Nyirenda M., Obe E., Obiakor R., Oduro A., Ofori-Acquah S.F., Ogah O., Ogendo S., Ohene-Frempong K., Ojo A., Olanrewaju T., Oli J., Osafo C., Ouwe Missi Oukem-Boyer O., Ovbiagele B., Owen A., Owolabi M.O., Owolabi L., Owusu-Dabo E., Pare G., Parekh R., Patterton H.G., Penno M.B., Peterson J., Pieper R., Plange-Rhule J., Pollak M., Puzak J., Ramesar R.S., Ramsay M., Rasooly R., Reddy S., Sabeti P.C., Sagoe K., Salako T., Samassékou O., Sandhu M.S., Sankoh O., Sarfo F.S., Sarr M., Shaboodien G., Sidibe I., Simo G., Simuunza M., Smeeth L., Sobngwi E., Soodyall H., Sorgho H., Sow Bah O., Srinivasan S., Stein D.J., Susser E.S., Swanepoel C., Tangwa G., Tareila A., Tastan Bishop O., Tayo B., Tiffin N., Tinto H., Tobin E., Tollman S.M., Traoré M., Treadwell M.J., Troyer J., Tsimako-Johnstone M., Tukei V., Ulasi I., Ulenga N., van Rooyen B., Wachinou A.P., Waddy S.P., Wade A., Wayengera M., Whitworth J., Wideroff L., Winkler C.A., Winnicki S., Wonkam A., Yewondwos M., Sen T., Yozwiak N., Zar H. Research capacity. Enabling the genomic revolution in Africa. Science 2014, 344:1346-1348. 10.1126/science.1251546.
37. Harris R.M., Hofmann H.A. Neurogenomics of behavioral plasticity. Adv. Exp. Med. Biol. 2014, 781:149-168. 10.1007/978-94-007-7347-9_8.
38. Heberlein U., Tsai L.T.-Y., Kapfhamer D., Lasek A.W. Drosophila, a genetic model system to study cocaine-related behaviors: a review with focus on LIM-only proteins. Neuropharmacology 2009, 56:97. 10.1016/j.neuropharm.2008.07.023.
39. Human Development Network - The World Bank, Institute for Health Metrics and Evaluation - University of Washington The Global Burden of Disease: Generating Evidence, Guiding Policy - Sub-Saharan Africa Regional Edition (No. 80852) 2013, The World Bank.
40. Insel T.R., Volkow N.D., Landis S.C., Li T.-K., Battey J.F., Sieving P. Limits to growth: why neuroscience needs large-scale science. Nat. Neurosci. 2004, 7:426-427. 10.1038/nn0504-426.
41. International Glossina Genome Initiative Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis. Science 2014, 344:380-386. 10.1126/science.1249656.
42. Karikari T.K. Bioinformatics in Africa: the rise of Ghana?. PLoS Comput. Biol. 2015, (in press). 10.1371/journal.pcbi.1004308.
43. Karikari T.K. Neuroscience for kids: online resources that promote student engagement, teaching and learning about the brain. J. Undergrad. Neurosci. Educ. 2015, 13(2):R14-R15.
44. Karikari T.K. Letter to the editor. J. Microbiol. Biol. Educ. 2015, 16(1):3-4. 10.1128/jmbe.v16i1.801.
45. Karikari T.K., Cobham A.E., Ndams I.S. Building sustainable neuroscience capacity in Africa: the role of non-profit organisations. Metab. Brain Dis. 2015, (in press). 10.1007/s11011-015-9687-8.
46. Karikari T.K., Crighton S., Osgood R., Moffat K.G. Phosphorylated Tau affects sundowning sleep behaviour in a Drosophila tauopathy model. Neurodegener Dis 2015, 15(Suppl. 1):1630. 10.1159/000381736.
47. Karikari T.K., Yawson N.A., Amankwaa A.O. Bridging the gap: introducing neuroscience to Ghana. The Biochemist 2015, 37(1):46-47.
48. Kimmel C.B., Ballard W.W., Kimmel S.R., Ullmann B., Schilling T.F. Stages of embryonic development of the zebrafish. Dev. Dyn. 1995, 203:253-310. 10.1002/aja.1002030302.
49. Lekoubou A., Echouffo-Tcheugui J.B., Kengne A.P. Epidemiology of neurodegenerative diseases in sub-Saharan Africa: a systematic review. BMC Public Health 2014, 14:653. 10.1186/1471-2458-14-653.
50. Lesage S., Condroyer C., Lannuzel A., Lohmann E., Troiano A., Tison F., Damier P., Thobois S., Ouvrard-Hernandez A.-M., Rivaud-Péchoux S., Brefel-Courbon C., Destée A., Tranchant C., Romana M., Leclere L., Dürr A., Brice A. Molecular analyses of the LRRK2 gene in European and North African autosomal dominant Parkinson's disease. J. Med. Genet. 2009, 46:458-464. 10.1136/jmg.2008.062612.
51. Logue M.W., Schu M., Vardarajan B.N., Buros J., Green R.C., Go R.C.P., Griffith P., Obisesan T.O., Shatz R., Borenstein A., Cupples L.A., Lunetta K.L., Fallin M.D., Baldwin C.T., Farrer L.A., Multi-Institutional Research on Alzheimer Genetic Epidemiology (MIRAGE) Study Group A comprehensive genetic association study of Alzheimer disease in African Americans. Arch. Neurol. 2011, 68:1569-1579. 10.1001/archneurol.2011.646.
52. Mahomoodally M.F. Traditional medicines in Africa: an appraisal of ten potent African medicinal plants. Evid. Based Complement. Alternat. Med. 2013, 2013:e617459. 10.1155/2013/617459.
53. Martín-Araguz A., Bustamante-Martínez C., Emam-Mansour M.T., Moreno-Martínez J.M. Neuroscience in ancient Egypt and in the school of Alexandria. Rev. Neurol. 2002, 34:1183-1194.
54. Ministry of Health, Republic of Ghana The Ghana health sector: 2008 programme of work.
55. Mireku M.O., Boivin M.J., Davidson L.L., Ouédraogo S., Koura G.K., Alao M.J., Massougbodji A., Cot M., Bodeau-Livinec F. Impact of helminth infection during pregnancy on cognitive and motor functions of one-year-old children. PLoS Negl. Trop. Dis. 2015, 9:e0003463. 10.1371/journal.pntd.0003463.
56. Moffat K.G. Drosophila genetics for the analysis of neurobiological disease. SEB Exp. Biol. Ser. 2008, 60:9-24.
57. Mohamed W.M.Y. Neurogenomics: an Egyptian perspective. Appl. Transl. Genomics 2015, 10.1016/j.atg.2015.04.003.
58. Oers K.v., Mueller J.C. Evolutionary genomics of animal personality. Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci. 2010, 365:3991-4000. 10.1098/rstb.2010.0178.
59. Muindi F., Keller J. Developing world: build neuroscience capacity in Africa. Nature 2015, 518:35. 10.1038/518035e.
60. Mulligan M.K., Rhodes J.S., Crabbe J.C., Mayfield R.D., Harris R.A., Ponomarev I. Molecular profiles of drinking alcohol to intoxication in C57BL/6J mice. Alcohol. Clin. Exp. Res. 2011, 35:659-670. 10.1111/j.1530-0277.2010.01384.x.
61. Ndung'u R., Kinyua M. Cultural perspectives in language and speech disorders. Disabil. Stud. Q. 2009, 29.
62. Nüsslein-Volhard C., Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 1980, 287:795-801. 10.1038/287795a0.
63. O'Connell L.A., Hofmann H.A. The vertebrate mesolimbic reward system and social behavior network: a comparative synthesis. J. Comp. Neurol. 2011, 519:3599-3639. 10.1002/cne.22735.
64. Osuntokun B.O. The traditional basis of neuropsychiatric practice among the Yorubas of Nigeria. Trop. Geogr. Med. 1975, 27:422-430.
65. Owolabi M., Bower J., Ogunniyi A. Mapping Africa's way into prominence in the field of neurology. Arch. Neurol. 2007, 64:1696-1700. 10.1001/archneur.64.12.1696.
66. Peprah E., Xu H., Tekola-Ayele F., Royal C.D. Genome-wide association studies in Africans and African Americans: expanding the framework of the genomics of human traits and disease. Public Health Genomics 2015, 18:40-51. 10.1159/000367962.
67. Quansah E., Karikari T.K. Motor neuron diseases in sub-Saharan Africa: the need for more population-based studies. Biomed. Res. Int. 2015, (in press).
68. Reeve S., Carhan A., Dee C.T., Moffat K.G. Slowmo is required for Drosophila germline proliferation. Genesis 2007, 45:66-75. 10.1002/dvg.20265.
69. Rickards H. Depression in neurological disorders: Parkinson's disease, multiple sclerosis, and stroke. J. Neurol. Neurosurg. Psychiatry 2005, 76:i48-i52. 10.1136/jnnp.2004.060426.
70. Robertson K., Liner J., Hakim J., Sankalé J.-L., Grant I., Letendre S., Clifford D., Diop A.G., Jaye A., Kanmogne G., Njamnshi A., Langford T.D., Weyessa T.G., Wood C., Banda M., Hosseinipour M., Sacktor N., Nakasuja N., Bangirana P., Paul R., Joska J., Wong J., Boivin M., Holding P., Kammerer B., Van Rie A., Ive P., Nath A., Lawler K., Adebamowo C., Royal W., Joseph J., NeuroAIDS in Africa Conference Participants NeuroAIDS in Africa. J. Neurovirol. 2010, 16:189-202. 10.3109/13550284.2010.489597.
71. Roy S., Ernst J., Kharchenko P.V., Kheradpour P., Negre N., Eaton M.L., Landolin J.M., Bristow C.A., Ma L., Lin M.F., Washietl S., Arshinoff B.I., Ay F., Meyer P.E., Robine N., Washington N.L., Stefano L.D., Berezikov E., Brown C.D., Candeias R., Carlson J.W., Carr A., Jungreis I., Marbach D., Sealfon R., Tolstorukov M.Y., Will S., Alekseyenko A.A., Artieri C., Booth B.W., Brooks A.N., Dai Q., Davis C.A., Duff M.O., Feng X., Gorchakov A.A., Gu T., Henikoff J.G., Kapranov P., Li R., MacAlpine H.K., Malone J., Minoda A., Nordman J., Okamura K., Perry M., Powell S.K., Riddle N.C., Sakai A., Samsonova A., Sandler J.E., Schwartz Y.B., Sher N., Spokony R., Sturgill D., van Baren M., Wan K.H., Yang L., Yu C., Feingold E., Good P., Guyer M., Lowdon R., Ahmad K., Andrews J., Berger B., Brenner S.E., Brent M.R., Cherbas L., Elgin S.C.R., Gingeras T.R., Grossman R., Hoskins R.A., Kaufman T.C., Kent W., Kuroda M.I., Orr-Weaver T., Perrimon N., Pirrotta V., Posakony J.W., Ren B., Russell S., Cherbas P., Graveley B.R., Lewis S., Micklem G., Oliver B., Park P.J., Celniker S.E., Henikoff S., Karpen G.H., Lai E.C., MacAlpine D.M., Stein L.D., White K.P., Kellis M., Acevedo D., Auburn R., Barber G., Bellen H.J., Bishop E.P., Bryson T.D., Chateigner A., Chen J., Clawson H., Comstock C.L.G., Contrino S., DeNapoli L.C., Ding Q., Dobin A., Domanus M.H., Drenkow J., Dudoit S., Dumais J., Eng T., Fagegaltier D., Gadel S.E., Ghosh S., Guillier F., Hanley D., Hannon G.J., Hansen K.D., Heinz E., Hinrichs A.S., Hirst M., Jha S., Jiang L., Jung Y.L., Kashevsky H., Kennedy C.D., Kephart E.T., Langton L., Lee O.-K., Li S., Li Z., Lin W., Linder-Basso D., Lloyd P., Lyne R., Marchetti S.E., Marra M., Mattiuzzo N.R., McKay S., Meyer F., Miller D., Miller S.W., Moore R.A., Morrison C.A., Prinz J.A., Rooks M., Moore R., Rutherford K.M., Ruzanov P., Scheftner D.A., Senderowicz L., Shah P.K., Shanower G., Smith R., Stinson E.O., Suchy S., Tenney A.E., Tian F., Venken K.J.T., Wang H., White R., Wilkening J., Willingham A.T., Zaleski C., Zha Z., Zhang D., Zhao Y., Zieba J. Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science 2010, 330:1787-1797. 10.1126/science.1198374.
72. Sharma M.K., Phillips J., Agarwal S., Wiggins W.S., Shrivastava S., Koul S.B., Bhattacharjee M., Houchins C.D., Kalakota R.R., George B., Meyer R.R., Spencer D.H., Lockwood C.M., Nguyen T.T., Duncavage E.J., Al-Kateb H., Cottrell C.E., Godala S., Lokineni R., Sawant S.M., Chatti V., Surampudi S., Sunkishala R.R., Darbha R., Macharla S., Milbrandt J.D., Virgin H.W., Mitra R.D., Head R.D., Kulkarni S., Bredemeyer A., Pfeifer J.D., Seibert K., Nagarajan R. Clinical genomicist workstation. AMIA Jt. Summits Transl. Sci. Proc. AMIA Summit Transl. Sci. 2013 2013, 156-157.
73. Shen S.P., Aleksic J., Russell S. Identifying targets of the Sox domain protein Dichaete in the Drosophila CNS via targeted expression of dominant negative proteins. BMC Dev. Biol. 2013, 13:1. 10.1186/1471-213X-13-1.
74. Singh A.P., Schach U., Nüsslein-Volhard C. Proliferation, dispersal and patterned aggregation of iridophores in the skin prefigure striped colouration of zebrafish. Nat. Cell Biol. 2014, 16:607-614. 10.1038/ncb2955.
75. Street R.A., Prinsloo G. Commercially important medicinal plants of South Africa: a review. J. Chem. 2012, 2013:e205048. 10.1155/2013/205048.
76. Sullivan J., Karra K., Moxon S.A.T., Vallejos A., Motenko H., Wong J.D., Aleksic J., Balakrishnan R., Binkley G., Harris T., Hitz B., Jayaraman P., Lyne R., Neuhauser S., Pich C., Smith R.N., Trinh Q., Cherry J.M., Richardson J., Stein L., Twigger S., Westerfield M., Worthey E., Micklem G. InterMOD: integrated data and tools for the unification of model organism research. Sci. Rep. 2013, 3:1802. 10.1038/srep01802.
77. The ENCODE Project Consortium The ENCODE (ENCyclopedia Of DNA Elements) project. Science 2004, 306:636-640. 10.1126/science.1105136.
78. The World Bank A decade of development in sub-Saharan African science, technology, engineering and mathematics research 2014.
79. Thye T., Owusu-Dabo E., Vannberg F.O., van Crevel R., Curtis J., Sahiratmadja E., Balabanova Y., Ehmen C., Muntau B., Ruge G., Sievertsen J., Gyapong J., Nikolayevskyy V., Hill P.C., Sirugo G., Drobniewski F., van de Vosse E., Newport M., Alisjahbana B., Nejentsev S., Ottenhoff T.H.M., Hill A.V.S., Horstmann R.D., Meyer C.G. Common variants at 11p13 are associated with susceptibility to tuberculosis. Nat. Genet. 2012, 44:257-259. 10.1038/ng.1080.
80. Timmann C., Thye T., Vens M., Evans J., May J., Ehmen C., Sievertsen J., Muntau B., Ruge G., Loag W., Ansong D., Antwi S., Asafo-Adjei E., Nguah S.B., Kwakye K.O., Akoto A.O.Y., Sylverken J., Brendel M., Schuldt K., Loley C., Franke A., Meyer C.G., Agbenyega T., Ziegler A., Horstmann R.D. Genome-wide association study indicates two novel resistance loci for severe malaria. Nature 2012, 489:443-446. 10.1038/nature11334.
81. Tsuji S. The neurogenomics view of neurological diseases. JAMA Neurol. 2013, 70:689-694. 10.1001/jamaneurol.2013.734.
82. Van Andel T., Myren B., van Onselen S. Ghana's herbal market. J. Ethnopharmacol. 2012, 140:368-378. 10.1016/j.jep.2012.01.028.
83. Wright G.E., Adeyemo A.A., Tiffin N. Informed consent and ethical re-use of African genomic data. Hum. Genomics 2014, 8:18. 10.1186/s40246-014-0018-7.
84. Yonova-Doing E., Atadzhanov M., Quadri M., Kelly P., Shawa N., Musonda S.T.S., Simons E.J., Breedveld G.J., Oostra B.A., Bonifati V. Analysis of LRRK2, SNCA, Parkin, PINK1, and DJ-1 in Zambian patients with Parkinson's disease. Parkinsonism Relat. Disord. 2012, 18:567-571. 10.1016/j.parkreldis.2012.02.018.
85. Yusuf S., Baden T., Prieto-Godino L.L. Bridging the gap: establishing the necessary infrastructure and knowledge for teaching and research in neuroscience in Africa. Metab. Brain Dis. 2014, 29:217-220. 10.1007/s11011-013-9443-x.
86. Zabetian C.P., Hutter C.M., Yearout D., Lopez A.N., Factor S.A., Griffith A., Leis B.C., Bird T.D., Nutt J.G., Higgins D.S., Roberts J.W., Kay D.M., Edwards K.L., Samii A., Payami H. LRRK2 G2019S in families with Parkinson disease who originated from Europe and the Middle East: evidence of two distinct founding events beginning two millennia ago. Am. J. Hum. Genet. 2006, 79:752-758.
87. Zhu X., Need A.C., Petrovski S., Goldstein D.B. One gene, many neuropsychiatric disorders: lessons from Mendelian diseases. Nat. Neurosci. 2014, 17:773-781. 10.1038/nn.3713.