메뉴 건너뛰기




Volumn 11, Issue 12, 2015, Pages 1461-1469

C-terminal neurogranin is increased in cerebrospinal fluid but unchanged in plasma in Alzheimer's disease

Author keywords

Alzheimer's disease; Amyloid; CSF biomarker; ELISA; Mild cognitive impairment; Neurogranin; Plasma biomarker; Prognostic biomarker; Ratio amyloid ; tau; secretase

Indexed keywords

ALBUMIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN E4; NEUROGRANIN; PLASMA PROTEIN; TAU PROTEIN; AMYLOID BETA PROTEIN; BIOLOGICAL MARKER; PEPTIDE FRAGMENT;

EID: 84952317004     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2015.05.012     Document Type: Article
Times cited : (132)

References (44)
  • 1
    • 84927178751 scopus 로고    scopus 로고
    • The clinical use of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: A consensus paper from the Alzheimer's Biomarkers Standardization Initiative
    • J.L. Molinuevo, K. Blennow, B. Dubois, S. Engelborghs, P. Lewczuk, A. Perret-Liaudet, and et al. The clinical use of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: A consensus paper from the Alzheimer's Biomarkers Standardization Initiative Alzheimers Dement 10 2014 808 817
    • (2014) Alzheimers Dement , vol.10 , pp. 808-817
    • Molinuevo, J.L.1    Blennow, K.2    Dubois, B.3    Engelborghs, S.4    Lewczuk, P.5    Perret-Liaudet, A.6
  • 2
    • 64049098761 scopus 로고    scopus 로고
    • Neuropathology and cognitive impairment in Alzheimer disease: A complex but coherent relationship
    • P.T. Nelson, H. Braak, and W.R. Markesbery Neuropathology and cognitive impairment in Alzheimer disease: A complex but coherent relationship J Neuropathol Exp Neurol 68 2009 1 14
    • (2009) J Neuropathol Exp Neurol , vol.68 , pp. 1-14
    • Nelson, P.T.1    Braak, H.2    Markesbery, W.R.3
  • 3
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • R.D. Terry, E. Masliah, D.P. Salmon, N. Butters, R. DeTeresa, R. Hill, and et al. Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment Ann Neurol 30 1991 572 580
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    DeTeresa, R.5    Hill, R.6
  • 4
    • 0029801332 scopus 로고    scopus 로고
    • Synaptic pathology in Alzheimer's disease: Relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the ApoE4 allele
    • K. Blennow, N. Bogdanovic, I. Alafuzoff, R. Ekman, and P. Davidsson Synaptic pathology in Alzheimer's disease: Relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the ApoE4 allele J Neural Transm 103 1996 603 618
    • (1996) J Neural Transm , vol.103 , pp. 603-618
    • Blennow, K.1    Bogdanovic, N.2    Alafuzoff, I.3    Ekman, R.4    Davidsson, P.5
  • 5
    • 77955859268 scopus 로고    scopus 로고
    • Neurogranin, a link between calcium/calmodulin and protein kinase C signaling in synaptic plasticity
    • F.J. Díez-Guerra Neurogranin, a link between calcium/calmodulin and protein kinase C signaling in synaptic plasticity IUBMB Life 62 2010 597 606
    • (2010) IUBMB Life , vol.62 , pp. 597-606
    • Díez-Guerra, F.J.1
  • 6
    • 0032589031 scopus 로고    scopus 로고
    • Identification of synaptic vesicle, pre- and postsynaptic proteins in human cerebrospinal fluid using liquid-phase isoelectric focusing
    • P. Davidsson, M. Puchades, and K. Blennow Identification of synaptic vesicle, pre- and postsynaptic proteins in human cerebrospinal fluid using liquid-phase isoelectric focusing Electrophoresis 20 1999 431 437
    • (1999) Electrophoresis , vol.20 , pp. 431-437
    • Davidsson, P.1    Puchades, M.2    Blennow, K.3
  • 7
    • 76749115747 scopus 로고    scopus 로고
    • The morphology and biochemistry of nanostructures provide evidence for synthesis and signaling functions in human cerebrospinal fluid
    • M.G. Harrington, A.N. Fonteh, E. Oborina, P. Liao, R.P. Cowan, G. McComb, and et al. The morphology and biochemistry of nanostructures provide evidence for synthesis and signaling functions in human cerebrospinal fluid Cerebrospinal Fluid Res 6 2009 10
    • (2009) Cerebrospinal Fluid Res , vol.6 , pp. 10
    • Harrington, M.G.1    Fonteh, A.N.2    Oborina, E.3    Liao, P.4    Cowan, R.P.5    McComb, G.6
  • 9
    • 0031778614 scopus 로고    scopus 로고
    • Neurochemical dissection of synaptic pathology in Alzheimer's disease
    • P. Davidsson, and K. Blennow Neurochemical dissection of synaptic pathology in Alzheimer's disease Int Psychogeriatr 10 1998 11 23
    • (1998) Int Psychogeriatr , vol.10 , pp. 11-23
    • Davidsson, P.1    Blennow, K.2
  • 10
    • 17844378691 scopus 로고    scopus 로고
    • Differential loss of synaptic proteins in Alzheimer's disease: Implications for synaptic dysfunction
    • discussion 173-80
    • P.H. Reddy, G. Mani, B.S. Park, J. Jacques, G. Murdoch, W. Whetsell Jr., and et al. Differential loss of synaptic proteins in Alzheimer's disease: Implications for synaptic dysfunction J Alzheimers Dis 7 2005 103 117 discussion 173-80
    • (2005) J Alzheimers Dis , vol.7 , pp. 103-117
    • Reddy, P.H.1    Mani, G.2    Park, B.S.3    Jacques, J.4    Murdoch, G.5    Whetsell, W.6
  • 11
    • 78149362552 scopus 로고    scopus 로고
    • Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's disease
    • A. Thorsell, M. Bjerke, J. Gobom, E. Brunhage, E. Vanmechelen, N. Andreasen, and et al. Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's disease Brain Res 1362 2010 13 22
    • (2010) Brain Res , vol.1362 , pp. 13-22
    • Thorsell, A.1    Bjerke, M.2    Gobom, J.3    Brunhage, E.4    Vanmechelen, E.5    Andreasen, N.6
  • 12
    • 84945471565 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of the synaptic protein neurogranin predict cognitive decline in prodromal Alzheimer's disease
    • H. Kvartsberg, F.H. Duits, M. Ingelsson, N. Andreasen, A. Öhrfelt, K. Andersson, and et al. Cerebrospinal fluid levels of the synaptic protein neurogranin predict cognitive decline in prodromal Alzheimer's disease Alzheimers Dement 11 2015 1180 1190
    • (2015) Alzheimers Dement , vol.11 , pp. 1180-1190
    • Kvartsberg, H.1    Duits, F.H.2    Ingelsson, M.3    Andreasen, N.4    Öhrfelt, A.5    Andersson, K.6
  • 13
    • 79959499115 scopus 로고    scopus 로고
    • A high-confidence human plasma proteome reference set with estimated concentrations in PeptideAtlas
    • M110.006353
    • T. Farrah, E.W. Deutsch, G.S. Omenn, D.S. Campbell, Z. Sun, J.A. Bletz, and et al. A high-confidence human plasma proteome reference set with estimated concentrations in PeptideAtlas Mol Cell Proteomics 10 2011 M110.006353
    • (2011) Mol Cell Proteomics , vol.10
    • Farrah, T.1    Deutsch, E.W.2    Omenn, G.S.3    Campbell, D.S.4    Sun, Z.5    Bletz, J.A.6
  • 14
    • 84907062215 scopus 로고    scopus 로고
    • Evaluation of eight plasma proteins as candidate blood-based biomarkers for malignant gliomas
    • R.P. Lange, A. Everett, P. Dulloor, F.K. Korley, C. Bettegowda, C. Blair, and et al. Evaluation of eight plasma proteins as candidate blood-based biomarkers for malignant gliomas Cancer Invest 32 2014 423 429
    • (2014) Cancer Invest , vol.32 , pp. 423-429
    • Lange, R.P.1    Everett, A.2    Dulloor, P.3    Korley, F.K.4    Bettegowda, C.5    Blair, C.6
  • 17
    • 84908700565 scopus 로고    scopus 로고
    • Amyloid-β 42/40 cerebrospinal fluid concentration ratio in the diagnostics of Alzheimer's disease: Validation of two novel assays
    • P. Lewczuk, N. Lelental, P. Spitzer, J.M. Maler, and J. Kornhuber Amyloid-β 42/40 cerebrospinal fluid concentration ratio in the diagnostics of Alzheimer's disease: Validation of two novel assays J Alzheimers Dis 43 2015 183 191
    • (2015) J Alzheimers Dis , vol.43 , pp. 183-191
    • Lewczuk, P.1    Lelental, N.2    Spitzer, P.3    Maler, J.M.4    Kornhuber, J.5
  • 18
    • 79956084514 scopus 로고    scopus 로고
    • The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • M.S. Albert, S.T. DeKosky, D. Dickson, B. Dubois, H.H. Feldman, N.C. Fox, and et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease Alzheimers Dement 7 2011 270 279
    • (2011) Alzheimers Dement , vol.7 , pp. 270-279
    • Albert, M.S.1    DeKosky, S.T.2    Dickson, D.3    Dubois, B.4    Feldman, H.H.5    Fox, N.C.6
  • 19
    • 79956142378 scopus 로고    scopus 로고
    • The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • G.M. McKhann, D.S. Knopman, H. Chertkow, B.T. Hyman, C.R. Jack Jr., C.H. Kawas, and et al. The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease Alzheimers Dement 7 2011 263 269
    • (2011) Alzheimers Dement , vol.7 , pp. 263-269
    • McKhann, G.M.1    Knopman, D.S.2    Chertkow, H.3    Hyman, B.T.4    Jack, C.R.5    Kawas, C.H.6
  • 20
    • 84908006139 scopus 로고    scopus 로고
    • Depression in mild cognitive impairment is associated with progression to Alzheimer's disease: A longitudinal study
    • S. Van der Mussele, E. Fransen, H. Struyfs, J. Luyckx, P. Mariën, J. Saerens, and et al. Depression in mild cognitive impairment is associated with progression to Alzheimer's disease: A longitudinal study J Alzheimers Dis 42 2014 1239 1250
    • (2014) J Alzheimers Dis , vol.42 , pp. 1239-1250
    • Van Der Mussele, S.1    Fransen, E.2    Struyfs, H.3    Luyckx, J.4    Mariën, P.5    Saerens, J.6
  • 21
    • 0026759348 scopus 로고
    • Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: Diagnostic value and neuropsychological correlates
    • P. Scheltens, D. Leys, F. Barkhof, D. Huglo, H.C. Weinstein, P. Vermersch, and et al. Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates J Neurol Neurosurg Psychiatry 55 1992 967 972
    • (1992) J Neurol Neurosurg Psychiatry , vol.55 , pp. 967-972
    • Scheltens, P.1    Leys, D.2    Barkhof, F.3    Huglo, D.4    Weinstein, H.C.5    Vermersch, P.6
  • 22
    • 84862774264 scopus 로고    scopus 로고
    • Development and advanced validation of an optimized method for the quantitation of Aβ42 in human cerebrospinal fluid
    • V.C. Cullen, R.A. Fredenburg, C. Evans, P.R. Conliffe, and M.E. Solomon Development and advanced validation of an optimized method for the quantitation of Aβ42 in human cerebrospinal fluid AAPS J 14 2012 510 518
    • (2012) AAPS J , vol.14 , pp. 510-518
    • Cullen, V.C.1    Fredenburg, R.A.2    Evans, C.3    Conliffe, P.R.4    Solomon, M.E.5
  • 23
    • 12944289492 scopus 로고    scopus 로고
    • Aging is associated with increased collagen type IV accumulation in the basal lamina of human cerebral microvessels
    • O. Uspenskaia, M. Liebetrau, J. Herms, A. Danek, and G.F. Hamann Aging is associated with increased collagen type IV accumulation in the basal lamina of human cerebral microvessels BMC Neurosci 5 2004 37
    • (2004) BMC Neurosci , vol.5 , pp. 37
    • Uspenskaia, O.1    Liebetrau, M.2    Herms, J.3    Danek, A.4    Hamann, G.F.5
  • 24
    • 84874853349 scopus 로고    scopus 로고
    • Human brain arteriovenous malformations are associated with interruptions in elastic fibers and changes in collagen content
    • Y. Guo, S.W. Qumu, O.A. Nacar, J.Y. Yang, J. Du, D. Belen, and et al. Human brain arteriovenous malformations are associated with interruptions in elastic fibers and changes in collagen content Turk Neurosurg 23 2013 10 15
    • (2013) Turk Neurosurg , vol.23 , pp. 10-15
    • Guo, Y.1    Qumu, S.W.2    Nacar, O.A.3    Yang, J.Y.4    Du, J.5    Belen, D.6
  • 25
    • 84899920099 scopus 로고    scopus 로고
    • Extracellular matrix synthesis in vascular disease: Hypertension, and atherosclerosis
    • M. Ponticos, and B.D. Smith Extracellular matrix synthesis in vascular disease: Hypertension, and atherosclerosis J Biomed Res 28 2014 25 39
    • (2014) J Biomed Res , vol.28 , pp. 25-39
    • Ponticos, M.1    Smith, B.D.2
  • 26
    • 0028955485 scopus 로고
    • Antibodies to postsynaptic PKC substrate neurogranin prevent long-term potentiation in hippocampal CA1 neurons
    • N.B. Fedorov, P. Pasinelli, A.B. Oestreicher, P.N. DeGraan, and K.G. Reymann Antibodies to postsynaptic PKC substrate neurogranin prevent long-term potentiation in hippocampal CA1 neurons Eur J Neurosci 7 1995 819 822
    • (1995) Eur J Neurosci , vol.7 , pp. 819-822
    • Fedorov, N.B.1    Pasinelli, P.2    Oestreicher, A.B.3    DeGraan, P.N.4    Reymann, K.G.5
  • 27
    • 0029077622 scopus 로고
    • Temporal differences in the phosphorylation state of pre- and postsynaptic protein kinase C substrates B-50/GAP-43 and neurogranin during long-term potentiation
    • G.M. Ramakers, P.N. De Graan, I.J. Urban, D. Kraay, T. Tang, P. Pasinelli, and et al. Temporal differences in the phosphorylation state of pre- and postsynaptic protein kinase C substrates B-50/GAP-43 and neurogranin during long-term potentiation J Biol Chem 270 1995 13892 13898
    • (1995) J Biol Chem , vol.270 , pp. 13892-13898
    • Ramakers, G.M.1    De Graan, P.N.2    Urban, I.J.3    Kraay, D.4    Tang, T.5    Pasinelli, P.6
  • 28
    • 84883302060 scopus 로고    scopus 로고
    • Identification and characterization of citrulline-modified brain proteins by combining HCD and CID fragmentation
    • Z. Jin, Z. Fu, J. Yang, J. Troncosco, A.D. Everett, and J.E. Van Eyk Identification and characterization of citrulline-modified brain proteins by combining HCD and CID fragmentation Proteomics 13 2013 2682 2691
    • (2013) Proteomics , vol.13 , pp. 2682-2691
    • Jin, Z.1    Fu, Z.2    Yang, J.3    Troncosco, J.4    Everett, A.D.5    Van Eyk, J.E.6
  • 30
    • 0037443545 scopus 로고    scopus 로고
    • Transcript profiling of human platelets using microarray and serial analysis of gene expression
    • D.V. Gnatenko, J.J. Dunn, S.R. McCorkle, D. Weissmann, P.L. Perrotta, and W.F. Bahou Transcript profiling of human platelets using microarray and serial analysis of gene expression Blood 101 2003 2285 2293
    • (2003) Blood , vol.101 , pp. 2285-2293
    • Gnatenko, D.V.1    Dunn, J.J.2    McCorkle, S.R.3    Weissmann, D.4    Perrotta, P.L.5    Bahou, W.F.6
  • 31
    • 0038383027 scopus 로고    scopus 로고
    • Transcriptional program of apoptosis induction following interleukin 2 deprivation: Identification of RC3, a calcium/calmodulin binding protein, as a novel proapoptotic factor
    • L.R. Devireddy, and M.R. Green Transcriptional program of apoptosis induction following interleukin 2 deprivation: Identification of RC3, a calcium/calmodulin binding protein, as a novel proapoptotic factor Mol Cell Biol 23 2003 4532 4541
    • (2003) Mol Cell Biol , vol.23 , pp. 4532-4541
    • Devireddy, L.R.1    Green, M.R.2
  • 33
    • 84906830985 scopus 로고    scopus 로고
    • A SAGE based approach to human glomerular endothelium: Defining the transcriptome, finding a novel molecule and highlighting endothelial diversity
    • G. Sengoelge, W. Winnicki, A. Kupczok, A. von Haeseler, M. Schuster, W. Pfaller, and et al. A SAGE based approach to human glomerular endothelium: Defining the transcriptome, finding a novel molecule and highlighting endothelial diversity BMC Genomics 15 2014 725
    • (2014) BMC Genomics , vol.15 , pp. 725
    • Sengoelge, G.1    Winnicki, W.2    Kupczok, A.3    Von Haeseler, A.4    Schuster, M.5    Pfaller, W.6
  • 34
    • 84867571146 scopus 로고    scopus 로고
    • Extensive p-tau pathology and SDS-stable p-tau oligomers in Alzheimer's cortical synapses
    • K.M. Henkins, S. Sokolow, C.A. Miller, H.V. Vinters, W.W. Poon, L.B. Cornwell, and et al. Extensive p-tau pathology and SDS-stable p-tau oligomers in Alzheimer's cortical synapses Brain Pathol 22 2012 826 833
    • (2012) Brain Pathol , vol.22 , pp. 826-833
    • Henkins, K.M.1    Sokolow, S.2    Miller, C.A.3    Vinters, H.V.4    Poon, W.W.5    Cornwell, L.B.6
  • 35
    • 84866478442 scopus 로고    scopus 로고
    • The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system
    • H.C. Tai, A. Serrano-Pozo, T. Hashimoto, M.P. Frosch, T.L. Spires-Jones, and B.T. Hyman The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system Am J Pathol 181 2012 1426 1435
    • (2012) Am J Pathol , vol.181 , pp. 1426-1435
    • Tai, H.C.1    Serrano-Pozo, A.2    Hashimoto, T.3    Frosch, M.P.4    Spires-Jones, T.L.5    Hyman, B.T.6
  • 36
    • 84886509822 scopus 로고    scopus 로고
    • A role for tau at the synapse in Alzheimer's disease pathogenesis
    • A.M. Pooler, W. Noble, and D.P. Hanger A role for tau at the synapse in Alzheimer's disease pathogenesis Neuropharmacology 76 Pt A 2014 1 8
    • (2014) Neuropharmacology , vol.76 , pp. 1-8
    • Pooler, A.M.1    Noble, W.2    Hanger, D.P.3
  • 37
    • 84902808236 scopus 로고    scopus 로고
    • Identification of longitudinally dynamic biomarkers in Alzheimer's disease cerebrospinal fluid by targeted proteomics
    • K.R. Wildsmith, S.P. Schauer, A.M. Smith, D. Arnott, Y. Zhu, J. Haznedar, and et al. Identification of longitudinally dynamic biomarkers in Alzheimer's disease cerebrospinal fluid by targeted proteomics Mol Neurodegener 9 2014 22
    • (2014) Mol Neurodegener , vol.9 , pp. 22
    • Wildsmith, K.R.1    Schauer, S.P.2    Smith, A.M.3    Arnott, D.4    Zhu, Y.5    Haznedar, J.6
  • 40
    • 84859379937 scopus 로고    scopus 로고
    • Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease
    • N. Kakuda, M. Shoji, H. Arai, K. Furukawa, T. Ikeuchi, K. Akazawa, and et al. Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease EMBO Mol Med 4 2012 344 352
    • (2012) EMBO Mol Med , vol.4 , pp. 344-352
    • Kakuda, N.1    Shoji, M.2    Arai, H.3    Furukawa, K.4    Ikeuchi, T.5    Akazawa, K.6
  • 41
    • 34247581358 scopus 로고    scopus 로고
    • Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load
    • J. Wiltfang, H. Esselmann, M. Bibl, M. Hüll, H. Hampel, H. Kessler, and et al. Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load J Neurochem 101 2007 1053 1059
    • (2007) J Neurochem , vol.101 , pp. 1053-1059
    • Wiltfang, J.1    Esselmann, H.2    Bibl, M.3    Hüll, M.4    Hampel, H.5    Kessler, H.6
  • 43
    • 84873681445 scopus 로고    scopus 로고
    • A selected reaction monitoring (SRM)-based method for absolute quantification of Aβ38, Aβ40, and Aβ42 in cerebrospinal fluid of Alzheimer's disease patients and healthy controls
    • J. Pannee, E. Portelius, M. Oppermann, A. Atkins, M. Hornshaw, I. Zegers, and et al. A selected reaction monitoring (SRM)-based method for absolute quantification of Aβ38, Aβ40, and Aβ42 in cerebrospinal fluid of Alzheimer's disease patients and healthy controls J Alzheimers Dis 33 2013 1021 1032
    • (2013) J Alzheimers Dis , vol.33 , pp. 1021-1032
    • Pannee, J.1    Portelius, E.2    Oppermann, M.3    Atkins, A.4    Hornshaw, M.5    Zegers, I.6
  • 44
    • 84903703012 scopus 로고    scopus 로고
    • Mass spectrometry-based candidate reference measurement procedure for quantification of amyloid-β in cerebrospinal fluid
    • A. Leinenbach, J. Pannee, T. Dülffer, A. Huber, T. Bittner, U. Andreasson, and et al. Mass spectrometry-based candidate reference measurement procedure for quantification of amyloid-β in cerebrospinal fluid Clin Chem 60 2014 987 994
    • (2014) Clin Chem , vol.60 , pp. 987-994
    • Leinenbach, A.1    Pannee, J.2    Dülffer, T.3    Huber, A.4    Bittner, T.5    Andreasson, U.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.