Depression in mild cognitive impairment is associated with progression to alzheimer's disease: A longitudinal study

Journal of Alzheimer's Disease

Volumn 42, Issue 4, 2014, Pages 1239-1250

  Van Der Mussele, Stefan ^a,b   Fransen, Erik ^b   Struyfs, Hanne ^a   Luyckx, Jill ^a   Mariën, Peter ^c,d   Saerens, Jos ^c   Somers, Nore ^c   Goeman, Johan ^c   De Deyn, Peter P ^a,b,c,e   Engelborghs, Sebastiaan ^a,c  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c ZNA Hospital Network Antwerp   (Belgium)

^d VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Alzheimer's disease; association; BPSD; Cox proportional hazard; dementia; depression; depressive symptoms; mild cognitive impairment; predictor; prognostic value

Indexed keywords

BIOLOGICAL MARKER;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BEHAVE AD; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID ANALYSIS; CIRCADIAN RHYTHM; COHEN MANSFIELD AGITATION INVENTORY; CONTROLLED STUDY; CORNELL SCALE FOR DEPRESSION IN DEMENTIA; DEPRESSION; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; FOLLOW UP; GERIATRIC DEPRESSION SCALE; HUMAN; HUMAN TISSUE; LONGITUDINAL STUDY; LUMBAR PUNCTURE; MAJOR CLINICAL STUDY; MALE; MIDDELHEIM FRONTALITY SCORE; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; ONSET AGE; PREVALENCE; PROGNOSIS; PROSPECTIVE STUDY; SCORING SYSTEM; SEX DIFFERENCE; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; PROPORTIONAL HAZARDS MODEL; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; SURVIVAL; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; DEPRESSION; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHOLOGICAL TESTS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; PSYCHIATRIC STATUS RATING SCALES; SURVIVAL ANALYSIS;

EID: 84908006139     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-140405     Document Type: Article

References (70)

1. Petersen RC (2004) Mild cognitive impairmentasadiagnostic entity. J Intern Med 256, 183-194.
2. Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, Nordberg A, Backman L, Albert M, Almkvist O, Arai H, Basun H, Blennow K, de Leon M, DeCarli C, Erkinjuntti T, Giacobini E, Graff C, Hardy J, Jack C, Jorm A, Ritchie K, van Duijn C, Visser P, Petersen RC (2004) Mild cognitive impairment-beyond controversies, towards a consensus: Report of the International Working Group on Mild Cognitive Impairment. J Intern Med 256, 240-246.
3. Albert MS, Dekosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH (2011) The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7, 270-279.
4. Dierckx E, Engelborghs S, De Raedt R, DeDeyn PP, Ponjaert-Kristoffersen I (2007) Mild cognitive impairment: What's in a name? Gerontology 53, 28-35.
5. Mitchell AJ, Shiri-Feshki M (2009) Rate of progression of mild cognitive impairment to dementia-meta-analysis of 41 robust inception cohort studies. Acta Psychiatr Scand 119, 252-265.
6. Finkel SI, Costa e Silva, Cohen G, Miller S, Sartorius N (1996) Behavioral and psychological signs and symptoms of dementia: A consensus statement on current knowledge and implications for research and treatment. Int Psychogeriatr 8, 497-500.
7. Van der Mussele S, Le Bastard N, Vermeiren Y, Saerens J, Somers N, Marien P, Goeman J, De Deyn PP, Engelborghs S (2013) Behavioral symptoms in mild cognitive impairment as compared with Alzheimer's disease and healthy older adults. Int J Geriatr Psychiatry 28, 265-275.
8. Van der Mussele S, Marien P, Saerens J, Somers N, Goeman J, De Deyn PP, Engelborghs S (2014) Behavioral syndromes in mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis 38, 319-329.
9. Monastero R, Mangialasche F, Camarda C, Ercolani S, Camarda R (2009) A systematic review of neuropsychiatric symptoms in mild cognitive impairment. J Alzheimers Dis 18, 11-30.
10. Apostolova LG, Cummings JL (2008) Neuropsychiatric manifestations in mild cognitive impairment: A systematic review of the literature. Dement Geriatr Cogn Disord 25, 115-126.
11. Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198.
12. The Psychological Corporation (1998) WAIS-III-WMS-III Technical Manual, Harcourt Brace & Co, London.
13. Randolph C, Tierney MC, Mohr E, Chase TN (1998) The Repeatable Battery for the Assessment of Neuropsychologi-cal Status (RBANS): Preliminary clinical validity. J Clin Exp Neuropsychol 20, 310-319.
14. Cole MG, Dastoor DP (1987) A new hierarchic approach to the measurement of dementia. Accurate results within 15 to 30 minutes. Psychosomatics 28, 298-301, 304.
15. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944.
16. American Psychiatric Association (2000) DSM-IV-TR: Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (Revised Text). American Psychiatric Association, Washington, DC.
17. Le Bastard N, Coart E, Vanderstichele H, Vanmechelen E, Martin JJ, Engelborghs S (2013) Comparison of two analytical platforms for the clinical qualification of Alzheimer's disease biomarkers in pathologically-confirmed dementia. J Alzheimers Dis 33, 117-131.
18. Reisberg B, Ferris SH, de Leon MJ, Crook T (1982) The Global Deterioration Scale (GDS) for assessment of primary degenerative dementia. Am J Psychiatry 139, 1136-1139.
19. Aries MJ, Le Bastard N, Debruyne H, Van Buggenhout M, Nagels G, De Deyn PP, Engelborghs S (2010) Relation between frontal lobe symptoms and dementia severity within and across diagnostic dementia categories. Int J Geriatr Psychiatry 25, 1186-1195.
20. De Deyn PP, Engelborghs S, Saerens J, Goeman J, Marien P, Maertens K, Nagels G, Martin JJ, Pickut BA (2005) The Middelheim Frontality Score:Abehavioural assessment scale that discriminates frontotemporal dementia from Alzheimer's disease. Int J Geriatr Psychiatry 20, 70-79.
21. Reisberg B, Borenstein J, Salob SP, Ferris SH, Franssen E, Georgotas A (1987) Behavioral symptomsinAlzheimer's disease: Phenomenology and treatment. J Clin Psychiatry 48, 9-15.
22. Cohen-Mansfield J (1996) Conceptualization of agitation: Results based on the Cohen-Mansfield Agitation Inventory and the Agitation Behavior Mapping Instrument. Int Psy-chogeriatr 8, 309-315.
23. Choy CN, Lam LC, Chan WC, Li SW, Chiu HF (2001) Agitation in Chinese elderly: Validation of the Chinese version of the Cohen-Mansfield Agitation Inventory. Int Psychogeriatr 13, 325-335.
24. Cohen-Mansfield J, Marx MS, Rosenthal AS (1989) A description of agitation in a nursing home. J Gerontol 44, M77-M84.
25. Gruber-Baldini AL, Boustani M, Sloane PD, Zimmerman S (2004) Behavioral symptoms in residential care/assisted living facilities: Prevalence, risk factors, and medication management. J Am Geriatr Soc 52, 1610-1617.
26. Suh GH (2004) Agitated behaviours among the institutionalized elderly with dementia: Validation of the Korean version of the Cohen-Mansfield Agitation Inventory. Int J Geriatr Psychiatry 19, 378-385.
27. Testad I, Aasland AM, Aarsland D (2007) Prevalence and cor-relatesofdisruptive behaviorinpatientsinNorwegian nursing homes. Int J Geriatr Psychiatry 22, 916-921.
28. Zuidema SU, Derksen E, Verhey FR, Koopmans RT (2007) Prevalence of neuropsychiatric symptoms in a large sample of Dutch nursing home patients with dementia. Int J Geriatr Psychiatry 22, 632-638.
29. Zuidema SU, de Jonghe JF, Verhey FR, Koopmans RT (2010) Environmental correlates of neuropsychiatric symptoms in nursing home patients with dementia. Int J Geriatr Psychiatry 25, 14-22.
30. Alexopoulos GS, Abrams RC, Young RC, Shamoian CA (1988) Cornell Scale for Depression in Dementia. Biol Psychiatry 23, 271-284.
31. Burns A, Lawlor B, Craig S (2004) Assessment Scales in Old Age Psychiatry, Martin Dunitz, London.
32. Alexopoulos GS, Abrams RC, Young RC, Shamoian CA (1988) Use of the Cornell scale in nondemented patients. J Am Geriatr Soc 36, 230-236.
33. Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, Leirer VO (1982) Development and validation of a geriatric depression screening scale: A preliminary report. J Psychiatr Res 17, 37-49.
34. Debruyne H, Van Buggenhout M, Le Bastard N, Aries M, Audenaert K, De Deyn PP, Engelborghs S (2009) Is the geriatric depression scale a reliable screening tool for depressive symptoms in elderly patients with cognitive impairment? Int J Geriatr Psychiatry 24, 556-562.
35. Engelborghs S, De VK, Van de Casteele T, Vanderstichele H, Van EB, Cras P, Martin JJ, Vanmechelen E, De Deyn PP (2008) Diagnostic performance of a CSF-biomarker panel in autopsy-confirmed dementia. Neurobiol Aging 29, 1143-1159.
36. Gao Y, Huang C, Zhao K, Ma L, Qiu X, Zhang L, Xiu Y, Chen L, Lu W, Huang C, Tang Y, Xiao Q (2013) Depression as arisk factor for dementia and mild cognitive impairment: A meta-analysis oflongitudinal studies. Int J Geriatr Psychiatry 28, 441-449.
37. Simard M, Hudon C, van RR (2009) Psychological distress and risk for dementia. Curr Psychiatry Rep 11, 41-47.
38. Enache D, Winblad B, Aarsland D (2011) Depression in dementia: Epidemiology, mechanisms, and treatment. Curr Opin Psychiatry 24, 461-472.
39. Teng E, Lu PH, Cummings JL (2007) Neuropsychiatric symptoms are associated with progression from mild cognitive impairment to Alzheimer's disease. Dement Geriatr Cogn Disord 24, 253-259.
40. Steenland K, Karnes C, Seals R, Carnevale C, Hermida A, Levey A (2012) Late-life depression as a risk factor for mild cognitive impairment or Alzheimer's disease in 30 US Alzheimer's disease centers. J Alzheimers Dis 31, 265-275.
41. Rosenberg PB, Mielke MM, Appleby BS, Oh ES, Geda YE, Lyketsos CG (2013) The association of neuropsychiatric symptomsin MCI with incident dementia and Alzheimer disease. Am J Geriatr Psychiatry 21, 685-695.
42. Modrego PJ, Ferrandez J (2004) Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: A prospective cohort study. Arch Neurol 61, 1290-1293.
43. Lee GJ, Lu PH, Hua X, Lee S, Wu S, Nguyen K, Teng E, Leow AD, Jack CR, Jr., Toga AW, Weiner MW, Bartzokis G, Thompson PM (2012) Depressive symptomsinmild cognitive impairment predict greater atrophy in Alzheimer's disease-related regions. Biol Psychiatry 71, 814-821.
44. Devier DJ, Pelton GH, Tabert MH, Liu X, Cuasay K, Eisen-stadt R, Marder K, Stern Y, Devanand DP (2009) The impact of anxiety on conversion from mild cognitive impairment to Alzheimer's disease. Int J Geriatr Psychiatry 24, 1335-1342.
45. Gallagher D, Coen R, Kilroy D, Belinski K, Bruce I, Coakley D, Walsh B, Cunningham C, Lawlor BA (2011) Anxiety and behavioural disturbance as markers of prodromal Alzheimer's diseasein patients with mild cognitive impairment. Int J Geri-atr Psychiatry 26, 166-172.
46. Palmer K, Berger AK, Monastero R, Winblad B, Backman L, Fratiglioni L (2007) Predictors of progression from mild cognitive impairment to Alzheimer disease. Neurology 68, 1596-1602.
47. Palmer K, Di IF, Varsi AE, Gianni W, Sancesario G, Cal-tagirone C, Spalletta G (2010) Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer's disease: The role of depression and apathy. J Alzheimers Dis 20, 175-183.
48. Richard E, Schmand B, Eikelenboom P, Yang SC, Ligthart SA, Moll van Charante EP, van Gool WA (2012) Symptoms of apathy are associated with progression from mild cognitive impairmentto Alzheimer's disease in non-depressed subjects. Dement Geriatr Cogn Disord 33, 204-209.
49. Robert PH, Berr C, Volteau M, Bertogliati C, Benoit M, Sarazin M, Legrain S, Dubois B (2006) Apathy in patients with mild cognitive impairment and the risk of developing dementia ofAlzheimer's disease: Aone-year follow-up study. Clin Neurol Neurosurg 108, 733-736.
50. Robert PH, Berr C, Volteau M, Bertogliati-Fileau C, Benoit M, Guerin O, Sarazin M, Legrain S, Dubois B (2008) Importance of lack of interest in patients with mild cognitive impairment. Am J Geriatr Psychiatry 16, 770-776.
51. Ramakers IH, Visser PJ, Aalten P, Kester A, Jolles J, Verhey FR (2010) Affective symptoms as predictors of Alzheimer's diseasein subjects with mild cognitive impairment: A 10-year follow-up study. Psychol Med 40, 1193-1201.
52. Ju YE, McLeland JS, Toedebusch CD, Xiong C, Fagan AM, Duntley SP, Morris JC, Holtzman DM (2013) Sleep quality and preclinical Alzheimer disease. JAMA Neurol 70, 587-593.
53. Rothman SM, Mattson MP (2012) Sleep disturbances in Alzheimer's and Parkinson's diseases. Neuromolecular Med 14, 194-204.
54. Weldemichael DA, Grossberg GT (2010) Circadian rhythm disturbances in patients with Alzheimer's disease: A review. Int J Alzheimers Dis 2010, pii: 716453.
55. Somme J, Fernandez-Martinez M, Molano A, Zarranz JJ (2013) Neuropsychiatric symptoms in amnestic mild cognitive impairment: Increased risk and faster progression to dementia. Curr Alzheimer Res 10, 86-94.
56. Bombois S, Derambure P, Pasquier F, Monaca C (2010) Sleep disorders in aging and dementia. J Nutr Health Aging 14, 212-217.
57. Panza F, Frisardi V, Capurso C, D'Introno A, Colacicco AM, Imbimbo BP, Santamato A, Vendemiale G, Seripa D, Pilotto A, Capurso A, Solfrizzi V (2010) Late-life depression, mild cognitive impairment, and dementia: Possible continuum?Am J Geriatr Psychiatry 18, 98-116.
58. Son JH, Han DH, Min KJ, Kee BS (2013) Correlation between gray matter volumein the temporal lobe and depressive symptoms in patients with Alzheimer's disease. Neurosci Lett 548, 15-20.
59. Lee GJ, Lu PH, Hua X, Lee S, Wu S, Nguyen K, Teng E, Leow AD, Jack CR Jr, Toga AW, Weiner MW, Bartzokis G, Thompson PM (2012) Depressive symptomsinmild cognitive impairment predict greater atrophy in Alzheimer's disease-related regions. Biol Psychiatry 71, 814-821.
60. Tsai CF, Hung CW, Lirng JF, Wang SJ, Fuh JL (2013) Differences in brain metabolism associated with agitation and depression in Alzheimer's disease. East Asian Arch Psychiatry 23, 86-90.
61. Trzepacz PT, Yu P, Bhamidipati PK, Willis B, Forrester T, Tabas L, Schwarz AJ, Saykin AJ (2013) Frontolimbic atrophy is associated with agitation and aggression in mild cognitive impairment and Alzheimer's disease. Alzheimers Dement 9, S95-S104.
62. Coppen A (1967) The biochemistry of affective disorders. Br J Psychiatry 113, 1237-1264.
63. Di Giovanni G, Esposito E, Di Matteo V (2010) Role of serotonin in central dopamine dysfunction. CNS Neurosci Ther 16, 179-194.
64. Engelborghs S, Vloeberghs E, Le BN, Van BM, Marien P, Somers N, Nagels G, Pickut BA, De Deyn PP (2008) The dopaminergic neurotransmitter system is associated with aggression and agitation in frontotemporal dementia. Neu-rochem Int 52, 1052-1060.
65. Bonelli RM, Cummings JL (2007) Frontal-subcortical circuitry and behavior. Dialogues Clin Neurosci 9, 141-151.
66. Goldman-Rakic PS, Lidow MS, Gallager DW (1990) Overlap of dopaminergic, adrenergic, and serotoninergic receptors and complementarity of their subtypes in primate prefrontal cortex. J Neurosci 10, 2125-2138.
67. Hansson O, Zetterberg H, Buchhave P, Londos E, Blennow K, Minthon L (2006) Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: A follow-up study. Lancet Neurol 5, 228-234.
68. Shaw LM, Vanderstichele H, Knapik-Czajka M, Figurski M, Coart E, Blennow K, Soares H, Simon AJ, Lewczuk P, Dean RA, Siemers E, Potter W, Lee VM, Trojanowski JQ (2011) Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI. Acta Neuropathol 121, 597-609.
69. American Psychiatric Association (2013) DSM-5: Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. American Psychiatric Association, Washington, DC.
70. Dubois B (2014) Improving diagnostic criteria for Alzheimer's disease-An update from the International Working Group. Lancet Neurol, in press.