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Volumn 16, Issue 1, 2016, Pages 1-8

Advances in Biomarker Research in Parkinson’s Disease

Author keywords

Biomarkers; Dopaminergic imaging; Parkinson s disease; Transcranial ultrasound; synuclein

Indexed keywords

6 FLUORODOPA F 18; ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN[1-42]; BIOLOGICAL MARKER; DIHYDROTETRABENAZINE C 13; DJ 1 PROTEIN; IOMETOPANE I 123; RADIOPHARMACEUTICAL AGENT; TAU 181 PROTEIN; TAU PROTEIN; UNCLASSIFIED DRUG; URIC ACID; [2 [[2 [[[3 (4 CHLOROPHENYL) 8 METHYL 8 AZABICYCLO[3.2.1]OCT 2 YL]METHYL](2 MERCAPTOETHYL)AMINO]ETHYL]AMINO]ETHANETHIOLATO]OXOTECHNETIUM TC 99M;

EID: 84952039556     PISSN: 15284042     EISSN: 15346293     Source Type: Journal    
DOI: 10.1007/s11910-015-0607-4     Document Type: Review
Times cited : (42)

References (57)
  • 1
    • 0026514953 scopus 로고
    • Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases
    • PID: 1564476, COI: 1:STN:280:DyaK383is1Omsg%3D%3D
    • Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry. 1992;55(3):181–4.
    • (1992) J Neurol Neurosurg Psychiatry , vol.55 , Issue.3 , pp. 181-184
    • Hughes, A.J.1    Daniel, S.E.2    Kilford, L.3    Lees, A.J.4
  • 2
    • 0036209085 scopus 로고    scopus 로고
    • The accuracy of diagnosis of Parkinsonian syndromes in a specialist movement disorder service
    • PID: 11912118
    • Hughes AJ, Daniel SE, Ben-Shlomo Y, Lees AJ. The accuracy of diagnosis of Parkinsonian syndromes in a specialist movement disorder service. Brain. 2002;125(Pt 4):861–70.
    • (2002) Brain , vol.125 , pp. 861-870
    • Hughes, A.J.1    Daniel, S.E.2    Ben-Shlomo, Y.3    Lees, A.J.4
  • 3
    • 84905822184 scopus 로고    scopus 로고
    • Low clinical diagnostic accuracy of early vs advanced Parkinson disease: clinicopathologic study
    • PID: 24975862
    • Adler CH, Beach TG, Hentz JG, et al. Low clinical diagnostic accuracy of early vs advanced Parkinson disease: clinicopathologic study. Neurology. 2014;83(5):406–12.
    • (2014) Neurology , vol.83 , Issue.5 , pp. 406-412
    • Adler, C.H.1    Beach, T.G.2    Hentz, J.G.3
  • 4
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: preferred definitions and conceptual framework.
    • Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 2001;69(3):89–95.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 89-95
  • 5
    • 16344390099 scopus 로고    scopus 로고
    • Biomarkers and surrogates
    • Fox N, Growdon JH. Biomarkers and surrogates. NeuroRx. 2004;1(2):181.
    • (2004) NeuroRx , vol.1 , Issue.2 , pp. 181
    • Fox, N.1    Growdon, J.H.2
  • 7
    • 33846572874 scopus 로고    scopus 로고
    • Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030
    • PID: 17082464, COI: 1:STN:280:DC%2BD2s%2FlsFOmug%3D%3D
    • Dorsey ER, Constantinescu R, Thompson JP, et al. Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology. 2007;68(5):384–6.
    • (2007) Neurology , vol.68 , Issue.5 , pp. 384-386
    • Dorsey, E.R.1    Constantinescu, R.2    Thompson, J.P.3
  • 8
    • 82755161902 scopus 로고    scopus 로고
    • The Parkinson Progression Marker Initiative (PPMI). Prog Neurobiol 2011;95(4):629–635.
    • (2011) Prog Neurobiol , vol.95 , Issue.4 , pp. 629-635
  • 9
    • 77953390617 scopus 로고    scopus 로고
    • Parkinson’s at risk syndrome: can Parkinson’s disease be predicted?
    • PID: 20187248
    • Stern MB, Siderowf A. Parkinson’s at risk syndrome: can Parkinson’s disease be predicted? Mov Disord. 2010;25 Suppl 1:S89–93.
    • (2010) Mov Disord , vol.25 , pp. S89-S93
    • Stern, M.B.1    Siderowf, A.2
  • 10
    • 84871665722 scopus 로고    scopus 로고
    • The PRIPS study: screening battery for subjects at risk for Parkinson’s disease
    • PID: 22852790, COI: 1:STN:280:DC%2BC38fkslektA%3D%3D
    • Berg D, Godau J, Seppi K, et al. The PRIPS study: screening battery for subjects at risk for Parkinson’s disease. Eur J Neurol. 2013;20(1):102–8.
    • (2013) Eur J Neurol , vol.20 , Issue.1 , pp. 102-108
    • Berg, D.1    Godau, J.2    Seppi, K.3
  • 12
    • 84908594084 scopus 로고    scopus 로고
    • Olfactory dysfunction in incidental Lewy body disease and Parkinson’s disease
    • PID: 25172126
    • Driver-Dunckley E, Adler CH, Hentz JG, et al. Olfactory dysfunction in incidental Lewy body disease and Parkinson’s disease. Parkinsonism Relat Disord. 2014;20(11):1260–2.
    • (2014) Parkinsonism Relat Disord , vol.20 , Issue.11 , pp. 1260-1262
    • Driver-Dunckley, E.1    Adler, C.H.2    Hentz, J.G.3
  • 13
    • 77951216731 scopus 로고    scopus 로고
    • Incidental Lewy body disease: clinical comparison to a control cohort
    • PID: 20175211
    • Adler CH, Connor DJ, Hentz JG, et al. Incidental Lewy body disease: clinical comparison to a control cohort. Mov Disord. 2010;25(5):642–6.
    • (2010) Mov Disord , vol.25 , Issue.5 , pp. 642-646
    • Adler, C.H.1    Connor, D.J.2    Hentz, J.G.3
  • 14
    • 4043098888 scopus 로고    scopus 로고
    • Olfaction and Parkinson’s syndromes: its role in differential diagnosis
    • PID: 15247536
    • Katzenschlager R, Lees AJ. Olfaction and Parkinson’s syndromes: its role in differential diagnosis. Curr Opin Neurol. 2004;17(4):417–23.
    • (2004) Curr Opin Neurol , vol.17 , Issue.4 , pp. 417-423
    • Katzenschlager, R.1    Lees, A.J.2
  • 16
    • 74949133175 scopus 로고    scopus 로고
    • Severity of REM atonia loss in idiopathic REM sleep behavior disorder predicts Parkinson disease
    • PID: 20083800, COI: 1:STN:280:DC%2BC3c%2Fjtlerug%3D%3D
    • Postuma RB, Gagnon JF, Rompre S, Montplaisir JY. Severity of REM atonia loss in idiopathic REM sleep behavior disorder predicts Parkinson disease. Neurology. 2010;74(3):239–44.
    • (2010) Neurology , vol.74 , Issue.3 , pp. 239-244
    • Postuma, R.B.1    Gagnon, J.F.2    Rompre, S.3    Montplaisir, J.Y.4
  • 17
    • 84925308554 scopus 로고    scopus 로고
    • Parkinson risk in idiopathic REM sleep behavior disorder: preparing for neuroprotective trials
    • PID: 25681454, This paper presents data on conversion rates of a prospective cohort of RBD patients and other clinical risk factors to neurodegenerative disease over a 10 year follow-up period
    • Postuma RB, Gagnon J-F, Bertrand J-A, Génier Marchand D, Montplaisir JY. Parkinson risk in idiopathic REM sleep behavior disorder: preparing for neuroprotective trials. Neurology. 2015;84(11):1104–13. This paper presents data on conversion rates of a prospective cohort of RBD patients and other clinical risk factors to neurodegenerative disease over a 10 year follow-up period.
    • (2015) Neurology , vol.84 , Issue.11 , pp. 1104-1113
    • Postuma, R.B.1    Gagnon, J.-F.2    Bertrand, J.-A.3    Génier Marchand, D.4    Montplaisir, J.Y.5
  • 18
    • 84941309181 scopus 로고    scopus 로고
    • Sleep disorders in Parkinsonian and nonparkinsonian LRRK2 mutation carriers
    • PID: 26177462
    • Pont-Sunyer C, Iranzo A, Gaig C, et al. Sleep disorders in Parkinsonian and nonparkinsonian LRRK2 mutation carriers. PLoS One. 2015;10(7), e0132368.
    • (2015) PLoS One , vol.10 , Issue.7
    • Pont-Sunyer, C.1    Iranzo, A.2    Gaig, C.3
  • 19
    • 79960843923 scopus 로고    scopus 로고
    • Diagnostic markers for Parkinson’s disease
    • PID: 21464716, COI: 1:CAS:528:DC%2BC3MXos1arsbw%3D
    • Chahine LM, Stern MB. Diagnostic markers for Parkinson’s disease. Curr Opin Neurol. 2011;24(4):309–17.
    • (2011) Curr Opin Neurol , vol.24 , Issue.4 , pp. 309-317
    • Chahine, L.M.1    Stern, M.B.2
  • 20
    • 84880759951 scopus 로고    scopus 로고
    • Recent developments in biomarkers in Parkinson disease
    • PID: 23823465, COI: 1:CAS:528:DC%2BC3sXhtVyksrzK
    • Schapira AH. Recent developments in biomarkers in Parkinson disease. Curr Opin Neurol. 2013;26(4):395–400.
    • (2013) Curr Opin Neurol , vol.26 , Issue.4 , pp. 395-400
    • Schapira, A.H.1
  • 21
    • 78049293738 scopus 로고    scopus 로고
    • Biomarkers in Parkinson’s disease
    • PID: 20809400, COI: 1:CAS:528:DC%2BC3cXht1CjsLjE
    • Morgan JC, Mehta SH, Sethi KD. Biomarkers in Parkinson’s disease. Curr Neurol Neurosci Rep. 2010;10(6):423–30.
    • (2010) Curr Neurol Neurosci Rep , vol.10 , Issue.6 , pp. 423-430
    • Morgan, J.C.1    Mehta, S.H.2    Sethi, K.D.3
  • 22
    • 0037785449 scopus 로고    scopus 로고
    • Slower progression of Parkinson’s disease with Ropinirole versus levodopa: the REAL-PET study
    • PID: 12838524, COI: 1:CAS:528:DC%2BD3sXlvVWisrw%3D
    • Whone AL, Watts RL, Stoessl AJ, et al. Slower progression of Parkinson’s disease with Ropinirole versus levodopa: the REAL-PET study. Ann Neurol. 2003;54(1):93–101.
    • (2003) Ann Neurol , vol.54 , Issue.1 , pp. 93-101
    • Whone, A.L.1    Watts, R.L.2    Stoessl, A.J.3
  • 23
    • 33644833272 scopus 로고    scopus 로고
    • Randomized controlled trial of intraputamenal glial cell line-derived Neurotrophic factor infusion in Parkinson disease
    • PID: 16429411, COI: 1:CAS:528:DC%2BD28XjtV2lsbY%3D
    • Lang AE, Gill S, Patel NK, et al. Randomized controlled trial of intraputamenal glial cell line-derived Neurotrophic factor infusion in Parkinson disease. Ann Neurol. 2006;59(3):459–66.
    • (2006) Ann Neurol , vol.59 , Issue.3 , pp. 459-466
    • Lang, A.E.1    Gill, S.2    Patel, N.K.3
  • 24
    • 84913582942 scopus 로고    scopus 로고
    • Neuroimaging biomarkers for Parkinson disease: facts and fantasy
    • PID: 25363872, This is a very elegant review and discussion of state of radiotracer imaging in Parkinson's disease both from a clinical and research perspective
    • Perlmutter JS, Norris SA. Neuroimaging biomarkers for Parkinson disease: facts and fantasy. Ann Neurol. 2014;76(6):769–83. This is a very elegant review and discussion of state of radiotracer imaging in Parkinson's disease both from a clinical and research perspective.
    • (2014) Ann Neurol , vol.76 , Issue.6 , pp. 769-783
    • Perlmutter, J.S.1    Norris, S.A.2
  • 25
    • 19744378296 scopus 로고    scopus 로고
    • Levodopa and the progression of Parkinson’s disease
    • PID: 15590952, COI: 1:CAS:528:DC%2BD2cXhtVGksbnE
    • Fahn S, Oakes D, Shoulson I, et al. Levodopa and the progression of Parkinson’s disease. N Engl J Med. 2004;351(24):2498–508.
    • (2004) N Engl J Med , vol.351 , Issue.24 , pp. 2498-2508
    • Fahn, S.1    Oakes, D.2    Shoulson, I.3
  • 26
    • 0028869760 scopus 로고
    • Degeneration of substantia nigra in chronic Parkinson’s disease visualized by transcranial color-coded real-time sonography
    • PID: 7824114, COI: 1:STN:280:DyaK2M7isVGguw%3D%3D
    • Becker G, Seufert J, Bogdahn U, Reichmann H, Reiners K. Degeneration of substantia nigra in chronic Parkinson’s disease visualized by transcranial color-coded real-time sonography. Neurology. 1995;45(1):182–4.
    • (1995) Neurology , vol.45 , Issue.1 , pp. 182-184
    • Becker, G.1    Seufert, J.2    Bogdahn, U.3    Reichmann, H.4    Reiners, K.5
  • 27
    • 18144397394 scopus 로고    scopus 로고
    • Five-year follow-up study of hyperechogenicity of the substantia nigra in Parkinson’s disease
    • PID: 15486999
    • Berg D, Merz B, Reiners K, Naumann M, Becker G. Five-year follow-up study of hyperechogenicity of the substantia nigra in Parkinson’s disease. Mov Disord. 2005;20(3):383–5.
    • (2005) Mov Disord , vol.20 , Issue.3 , pp. 383-385
    • Berg, D.1    Merz, B.2    Reiners, K.3    Naumann, M.4    Becker, G.5
  • 28
    • 79960173762 scopus 로고    scopus 로고
    • Enlarged substantia nigra hyperechogenicity and risk for Parkinson disease: a 37-month 3-center study of 1847 older persons
    • PID: 21747034
    • Berg D, Seppi K, Behnke S, et al. Enlarged substantia nigra hyperechogenicity and risk for Parkinson disease: a 37-month 3-center study of 1847 older persons. Arch Neurol. 2011;68(7):932–7.
    • (2011) Arch Neurol , vol.68 , Issue.7 , pp. 932-937
    • Berg, D.1    Seppi, K.2    Behnke, S.3
  • 29
    • 67649908520 scopus 로고    scopus 로고
    • Midbrain hyperechogenicity in idiopathic REM sleep behavior disorder
    • PID: 19645057
    • Stockner H, Iranzo A, Seppi K, et al. Midbrain hyperechogenicity in idiopathic REM sleep behavior disorder. Mov Disord. 2009;24(13):1906–9.
    • (2009) Mov Disord , vol.24 , Issue.13 , pp. 1906-1909
    • Stockner, H.1    Iranzo, A.2    Seppi, K.3
  • 30
    • 77949911937 scopus 로고    scopus 로고
    • Relevance of substantia nigra hyperechogenicity and reduced odor identification in idiopathic REM sleep behavior disorder
    • PID: 20223708
    • Iwanami M, Miyamoto T, Miyamoto M, Hirata K, Takada E. Relevance of substantia nigra hyperechogenicity and reduced odor identification in idiopathic REM sleep behavior disorder. Sleep Med. 2010;11(4):361–5.
    • (2010) Sleep Med , vol.11 , Issue.4 , pp. 361-365
    • Iwanami, M.1    Miyamoto, T.2    Miyamoto, M.3    Hirata, K.4    Takada, E.5
  • 31
    • 84930193605 scopus 로고    scopus 로고
    • Developments in the role of transcranial sonography for the differential diagnosis of parkinsonism
    • PID: 26008814, This paper reviews the growing evidence of TCUS studies in patients with parkinsonism and their ability to distinguish PD from atypical parkinsonism
    • Pilotto A, Yilmaz R, Berg D. Developments in the role of transcranial sonography for the differential diagnosis of parkinsonism. Curr Neurol Neurosci Rep. 2015;15(7):43. This paper reviews the growing evidence of TCUS studies in patients with parkinsonism and their ability to distinguish PD from atypical parkinsonism.
    • (2015) Curr Neurol Neurosci Rep , vol.15 , Issue.7 , pp. 43
    • Pilotto, A.1    Yilmaz, R.2    Berg, D.3
  • 32
    • 77958125674 scopus 로고    scopus 로고
    • Reproducibility and diagnostic accuracy of substantia nigra sonography for the diagnosis of Parkinson’s disease
    • PID: 20543186
    • van de Loo S, Walter U, Behnke S, et al. Reproducibility and diagnostic accuracy of substantia nigra sonography for the diagnosis of Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2010;81(10):1087–92.
    • (2010) J Neurol Neurosurg Psychiatry , vol.81 , Issue.10 , pp. 1087-1092
    • van de Loo, S.1    Walter, U.2    Behnke, S.3
  • 33
    • 84871664204 scopus 로고    scopus 로고
    • EFNS/MDS-ES/ENS [corrected] recommendations for the diagnosis of Parkinson’s disease
    • PID: 23279440, COI: 1:STN:280:DC%2BC3s3lvVarsA%3D%3D
    • Berardelli A, Wenning GK, Antonini A, et al. EFNS/MDS-ES/ENS [corrected] recommendations for the diagnosis of Parkinson’s disease. Eur J Neurol. 2013;20(1):16–34.
    • (2013) Eur J Neurol , vol.20 , Issue.1 , pp. 16-34
    • Berardelli, A.1    Wenning, G.K.2    Antonini, A.3
  • 34
    • 77954384099 scopus 로고    scopus 로고
    • Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson’s disease
    • PID: 20540987, COI: 1:CAS:528:DC%2BC3cXos1ymtr4%3D
    • Shi M, Zabetian CP, Hancock AM, et al. Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson’s disease. Neurosci Lett. 2010;480(1):78–82.
    • (2010) Neurosci Lett , vol.480 , Issue.1 , pp. 78-82
    • Shi, M.1    Zabetian, C.P.2    Hancock, A.M.3
  • 35
    • 84871820127 scopus 로고    scopus 로고
    • DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease
    • PID: 23233873
    • Lin X, Cook TJ, Zabetian CP, et al. DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease. Sci Rep. 2012;2:954.
    • (2012) Sci Rep , vol.2 , pp. 954
    • Lin, X.1    Cook, T.J.2    Zabetian, C.P.3
  • 36
    • 0029795479 scopus 로고    scopus 로고
    • Observations on serum uric acid levels and the risk of idiopathic Parkinson’s disease
    • PID: 8781463, COI: 1:STN:280:DyaK28znsFSrsA%3D%3D
    • Davis JW, Grandinetti A, Waslien CI, Ross GW, White LR, Morens DM. Observations on serum uric acid levels and the risk of idiopathic Parkinson’s disease. Am J Epidemiol. 1996;144(5):480–4.
    • (1996) Am J Epidemiol , vol.144 , Issue.5 , pp. 480-484
    • Davis, J.W.1    Grandinetti, A.2    Waslien, C.I.3    Ross, G.W.4    White, L.R.5    Morens, D.M.6
  • 37
    • 27644540928 scopus 로고    scopus 로고
    • Serum uric acid levels and the risk of Parkinson disease
    • PID: 16240356
    • de Lau LM, Koudstaal PJ, Hofman A, Breteler MM. Serum uric acid levels and the risk of Parkinson disease. Ann Neurol. 2005;58(5):797–800.
    • (2005) Ann Neurol , vol.58 , Issue.5 , pp. 797-800
    • de Lau, L.M.1    Koudstaal, P.J.2    Hofman, A.3    Breteler, M.M.4
  • 38
    • 45149122797 scopus 로고    scopus 로고
    • Serum urate as a predictor of clinical and radiographic progression in Parkinson disease
    • PID: 18413464
    • Schwarzschild MA, Schwid SR, Marek K, et al. Serum urate as a predictor of clinical and radiographic progression in Parkinson disease. Arch Neurol. 2008;65(6):716–23.
    • (2008) Arch Neurol , vol.65 , Issue.6 , pp. 716-723
    • Schwarzschild, M.A.1    Schwid, S.R.2    Marek, K.3
  • 39
    • 84913533374 scopus 로고    scopus 로고
    • Mendelian randomization of serum urate and Parkinson disease progression
    • PID: 25257975, COI: 1:CAS:528:DC%2BC2cXitVCjt7%2FF
    • Simon KC, Eberly S, Gao X, et al. Mendelian randomization of serum urate and Parkinson disease progression. Ann Neurol. 2014;76(6):862–8.
    • (2014) Ann Neurol , vol.76 , Issue.6 , pp. 862-868
    • Simon, K.C.1    Eberly, S.2    Gao, X.3
  • 40
    • 84893841038 scopus 로고    scopus 로고
    • Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial
    • PID: 24366103, A large safety study showing the ability of inosine to raise urate levels in patients with PD. This has led to a larger study to assess the disease modifying potential of inosine
    • Schwarzschild MA, Ascherio A, Beal MF, et al. Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial. JAMA Neurol. 2014;71(2):141–50. A large safety study showing the ability of inosine to raise urate levels in patients with PD. This has led to a larger study to assess the disease modifying potential of inosine.
    • (2014) JAMA Neurol , vol.71 , Issue.2 , pp. 141-150
    • Schwarzschild, M.A.1    Ascherio, A.2    Beal, M.F.3
  • 41
    • 84882450447 scopus 로고    scopus 로고
    • Omics technologies and the study of human ageing
    • PID: 23938363
    • Valdes AM, Glass D, Spector TD. Omics technologies and the study of human ageing. Nat Rev Genet. 2013;14(9):601–7.
    • (2013) Nat Rev Genet , vol.14 , Issue.9 , pp. 601-607
    • Valdes, A.M.1    Glass, D.2    Spector, T.D.3
  • 42
    • 84951927396 scopus 로고    scopus 로고
    • Mohney RP: Hattori N. Identification of novel biomarkers for Parkinson’s disease by metabolomic technologies. J Neurol Neurosurg Psychiatry
    • Hatano T, Saiki S, Okuzumi A, Mohney RP, Hattori N. Identification of novel biomarkers for Parkinson’s disease by metabolomic technologies. J Neurol Neurosurg Psychiatry. 2015.
    • (2015) Okuzumi A
    • Hatano, T.1    Saiki, S.2
  • 43
    • 84886413067 scopus 로고    scopus 로고
    • 3-hydroxykynurenine and other Parkinson’s disease biomarkers discovered by metabolomic analysis
    • PID: 23873789, COI: 1:CAS:528:DC%2BC3sXhslWjsLzN
    • Lewitt PA, Li J, Lu M, Beach TG, Adler CH, Guo L. 3-hydroxykynurenine and other Parkinson’s disease biomarkers discovered by metabolomic analysis. Mov Disord. 2013;28(12):1653–60.
    • (2013) Mov Disord , vol.28 , Issue.12 , pp. 1653-1660
    • Lewitt, P.A.1    Li, J.2    Lu, M.3    Beach, T.G.4    Adler, C.H.5    Guo, L.6
  • 44
    • 84893834001 scopus 로고    scopus 로고
    • Cerebrospinal fluid alpha-synuclein levels in Parkinson's disease—changed or unchanged?
    • PID: 24330157, COI: 1:STN:280:DC%2BC2c3lvFCqsw%3D%3D
    • Zetterberg H, Petzold M, Magdalinou N. Cerebrospinal fluid alpha-synuclein levels in Parkinson's disease—changed or unchanged? Eur J Neurol. 2014;21(3):365–7.
    • (2014) Eur J Neurol , vol.21 , Issue.3 , pp. 365-367
    • Zetterberg, H.1    Petzold, M.2    Magdalinou, N.3
  • 45
    • 84885699313 scopus 로고    scopus 로고
    • Association of cerebrospinal fluid beta-amyloid 1-42, T-tau, P-tau181, and alpha-synuclein levels with clinical features of drug-naive patients with early Parkinson disease
    • PID: 23979011
    • Kang JH, Irwin DJ, Chen-Plotkin AS, et al. Association of cerebrospinal fluid beta-amyloid 1-42, T-tau, P-tau181, and alpha-synuclein levels with clinical features of drug-naive patients with early Parkinson disease. JAMA Neurol. 2013;70(10):1277–87.
    • (2013) JAMA Neurol , vol.70 , Issue.10 , pp. 1277-1287
    • Kang, J.H.1    Irwin, D.J.2    Chen-Plotkin, A.S.3
  • 46
    • 79951720856 scopus 로고    scopus 로고
    • Alpha-synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study
    • PID: 21317042, COI: 1:CAS:528:DC%2BC3MXit1Wksbc%3D
    • Mollenhauer B, Locascio JJ, Schulz-Schaeffer W, Sixel-Doring F, Trenkwalder C, Schlossmacher MG. Alpha-synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study. Lancet Neurol. 2011;10(3):230–40.
    • (2011) Lancet Neurol , vol.10 , Issue.3 , pp. 230-240
    • Mollenhauer, B.1    Locascio, J.J.2    Schulz-Schaeffer, W.3    Sixel-Doring, F.4    Trenkwalder, C.5    Schlossmacher, M.G.6
  • 47
    • 84925950008 scopus 로고    scopus 로고
    • CSF biomarkers and clinical progression of Parkinson disease
    • PID: 25411441, COI: 1:CAS:528:DC%2BC2MXislWnuw%3D%3D, This is a unique propspective study of CSF biomarkers which showed higher CSF α-synuclein levels were associated with a faster progression of motor symptoms and cognitive decline over 2 years
    • Hall S, Surova Y, Ohrfelt A, Zetterberg H, Lindqvist D, Hansson O. CSF biomarkers and clinical progression of Parkinson disease. Neurology. 2015;84(1):57–63. This is a unique propspective study of CSF biomarkers which showed higher CSF α-synuclein levels were associated with a faster progression of motor symptoms and cognitive decline over 2 years.
    • (2015) Neurology , vol.84 , Issue.1 , pp. 57-63
    • Hall, S.1    Surova, Y.2    Ohrfelt, A.3    Zetterberg, H.4    Lindqvist, D.5    Hansson, O.6
  • 48
    • 84902173245 scopus 로고    scopus 로고
    • CSF Abeta42 predicts early-onset dementia in Parkinson disease
    • PID: 24748671, COI: 1:CAS:528:DC%2BC2cXosVOns74%3D
    • Alves G, Lange J, Blennow K, et al. CSF Abeta42 predicts early-onset dementia in Parkinson disease. Neurology. 2014;82(20):1784–90.
    • (2014) Neurology , vol.82 , Issue.20 , pp. 1784-1790
    • Alves, G.1    Lange, J.2    Blennow, K.3
  • 49
    • 77957220702 scopus 로고    scopus 로고
    • CSF amyloid {beta} 1-42 predicts cognitive decline in Parkinson disease
    • PID: 20720189, COI: 1:CAS:528:DC%2BC3cXhtFOrsbjI
    • Siderowf A, Xie SX, Hurtig H, et al. CSF amyloid {beta} 1-42 predicts cognitive decline in Parkinson disease. Neurology. 2010;75(12):1055–61.
    • (2010) Neurology , vol.75 , Issue.12 , pp. 1055-1061
    • Siderowf, A.1    Xie, S.X.2    Hurtig, H.3
  • 51
    • 84929308938 scopus 로고    scopus 로고
    • Gastrointestinal dysfunction in Parkinson’s disease
    • PID: 25987282, COI: 1:CAS:528:DC%2BC2MXosVGjtbo%3D
    • Fasano A, Visanji NP, Liu LW, Lang AE, Pfeiffer RF. Gastrointestinal dysfunction in Parkinson’s disease. Lancet Neurol. 2015;14(6):625–39.
    • (2015) Lancet Neurol , vol.14 , Issue.6 , pp. 625-639
    • Fasano, A.1    Visanji, N.P.2    Liu, L.W.3    Lang, A.E.4    Pfeiffer, R.F.5
  • 52
    • 77953021942 scopus 로고    scopus 로고
    • Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders
    • PID: 20306269, COI: 1:CAS:528:DC%2BC3cXlslWgtL0%3D, This paper describes the distribution of phos-α-synuclein in the different organs in the body and led to the finding of submandibular gland having higher concentrations of phos-α-synuclein in Lewy body diseases
    • Beach TG, Adler CH, Sue LI, et al. Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders. Acta Neuropathol. 2010;119(6):689–702. This paper describes the distribution of phos-α-synuclein in the different organs in the body and led to the finding of submandibular gland having higher concentrations of phos-α-synuclein in Lewy body diseases.
    • (2010) Acta Neuropathol , vol.119 , Issue.6 , pp. 689-702
    • Beach, T.G.1    Adler, C.H.2    Sue, L.I.3
  • 53
    • 84872870323 scopus 로고    scopus 로고
    • Submandibular gland biopsy for the diagnosis of Parkinson disease
    • PID: 23334596, COI: 1:CAS:528:DC%2BC3sXhsFSisr8%3D
    • Beach TG, Adler CH, Dugger BN, et al. Submandibular gland biopsy for the diagnosis of Parkinson disease. J Neuropathol Exp Neurol. 2013;72(2):130–6.
    • (2013) J Neuropathol Exp Neurol , vol.72 , Issue.2 , pp. 130-136
    • Beach, T.G.1    Adler, C.H.2    Dugger, B.N.3
  • 54
    • 84898714555 scopus 로고    scopus 로고
    • Submandibular gland needle biopsy for the diagnosis of Parkinson disease
    • PID: 24500652, COI: 1:CAS:528:DC%2BC2cXktlSqu7Y%3D
    • Adler CH, Dugger BN, Hinni ML, et al. Submandibular gland needle biopsy for the diagnosis of Parkinson disease. Neurology. 2014;82(10):858–64.
    • (2014) Neurology , vol.82 , Issue.10 , pp. 858-864
    • Adler, C.H.1    Dugger, B.N.2    Hinni, M.L.3
  • 55
    • 59249083870 scopus 로고    scopus 로고
    • Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders
    • PID: 18982334, COI: 1:CAS:528:DC%2BD1MXhtVCltLg%3D
    • Beach TG, White 3rd CL, Hladik CL, et al. Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders. Acta Neuropathol. 2009;117(2):169–74.
    • (2009) Acta Neuropathol , vol.117 , Issue.2 , pp. 169-174
    • Beach, T.G.1    White, C.L.2    Hladik, C.L.3
  • 56
    • 77953022918 scopus 로고    scopus 로고
    • Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson’s disease
    • PID: 20229352
    • Del Tredici K, Hawkes CH, Ghebremedhin E, Braak H. Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson’s disease. Acta Neuropathol. 2010;119(6):703–13.
    • (2010) Acta Neuropathol , vol.119 , Issue.6 , pp. 703-713
    • Del Tredici, K.1    Hawkes, C.H.2    Ghebremedhin, E.3    Braak, H.4
  • 57
    • 84931082558 scopus 로고    scopus 로고
    • CSF proteins and resting-state functional connectivity in Parkinson disease
    • PID: 25979701, COI: 1:CAS:528:DC%2BC2MXhtVais7%2FM
    • Campbell MC, Koller JM, Snyder AZ, Buddhala C, Kotzbauer PT, Perlmutter JS. CSF proteins and resting-state functional connectivity in Parkinson disease. Neurology. 2015;84(24):2413–21.
    • (2015) Neurology , vol.84 , Issue.24 , pp. 2413-2421
    • Campbell, M.C.1    Koller, J.M.2    Snyder, A.Z.3    Buddhala, C.4    Kotzbauer, P.T.5    Perlmutter, J.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.