Five-year follow-up study of hyperechogenicity of the substantia nigra in Parkinson's disease

Movement Disorders

Volumn 20, Issue 3, 2005, Pages 383-385

  Berg, Daniela ^a,b   Merz, Berthold ^c   Reiners, Karlheinz ^c   Naumann, Markus ^c   Becker, Georg ^d  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d SAARLAND UNIVERSITY   (Germany)

Author keywords

Hyperechogenicity of the substantia nigra; Nigrostriatal vulnerability; Parkinson's disease; Trait marker; Transcranial sonography

Indexed keywords

ADOLESCENCE; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE MARKER; DISEASE PREDISPOSITION; DOPPLER ECHOGRAPHY; EVIDENCE BASED MEDICINE; FEMALE; FOLLOW UP; HUMAN; LONGITUDINAL STUDY; MALE; NIGRONEOSTRIATAL SYSTEM; PARKINSON DISEASE; PRIORITY JOURNAL; SUBSTANTIA NIGRA;

EID: 18144397394     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: 10.1002/mds.20311     Document Type: Article

References (10)

1. Becker G, Seufert J, Bogdahn U, Reichmann H, Reiners K. Degeneration of substantia nigra in chronic Parkinson's disease visualized by transcranial color-coded real-time sonography. Neurology 1995;45:182-184.
2. Berg D, Siefker C, Becker G. Echogenicity of the substantia nigra in Parkinson's disease and its relation to clinical findings. J Neurol 2001;248:684-689.
3. Walter U, Wittstock M, Benecke R, Dressler D. Substantia nigra echogenicity is normal in non-extrapyramidal cerebral disorders but increased in Parkinson's disease. J Neural Transm 2002;109:191-196.
4. Berg D, Becker G, Zeiler B, et al. Vulnerability of the nigrostriatal system as detected by transcranial ultrasound. Neurology 1999;53: 1026-1031.
5. Berg D, Roggendorf W, Schröder U, et al. Echogenicity of the substantia nigra - association with increased iron content and marker for susceptibility to nigrostriatal injury. Arch Neurol 2002; 59:999-1005.
6. Berg D, Grote C, Rausch W-D, et al. Iron accumulation of the substantia nigra in rats visualized by ultrasound. Ultrasound Med Biol 1999;25:901-904.
7. Gerlach M, Ben-Shachar D, Riederer P, Youdim MB. Altered brain metabolism of iron as a cause of neurodegenerative diseases? J Neurochem 1994;63:793-807.
8. Iova A, Garmashov A, Andruchtchenko N, et al. Postnatal decrease in substantia nigra echogenicity - implications for the pathogenesis of Parkinson's disease. submitted.
9. Ruprecht-Dörfler P, Berg D, Tucha O, et al. Echogenicity of the substantia nigra in relatives of patients with sporadic Parkinson's disease. Neuroimage 2003;18:416-422.
10. Hochstrasser H, Felletschin B, Schöbel K, et al. Sequence variations in genes involved in iron metabolism in Parkinson's disease. Medgen 2003;15:240.