Tissue Engineering of Cartilage on Ground-Based Facilities

Microgravity Science and Technology

Volumn 28, Issue 3, 2016, Pages 237-245

  Aleshcheva, Ganna ^a   Bauer, Johann ^b   Hemmersbach, Ruth ^c   Egli, Marcel ^d   Wehland, Markus ^a   Grimm, Daniela ^a,e  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c GERMAN AEROSPACE CENTER DLR   (Germany)

^d LUCERNE UNIVERSITY OF APPLIED SCIENCES AND ARTS   (Switzerland)

^e AARHUS UNIVERSITY   (Denmark)

Author keywords

Cartilage; Chondrocytes; Clinostat; Cytoskeleton; Microgravity; Random Positioning Machine; Rotating Wall Vessel; Tissue engineering

Indexed keywords

BODY FLUIDS; CARTILAGE; CLINOSTATS; MICROGRAVITY; MICROGRAVITY PROCESSING; PROTEINS; SPACE FLIGHT; SPACE STATIONS; TISSUE; TISSUE ENGINEERING;

CHONDROCYTES; CLINOSTAT; CYTOSKELETONS; RANDOM POSITIONING; ROTATING WALL VESSELS;

SCAFFOLDS (BIOLOGY);

EID: 84951983644     PISSN: 09380108     EISSN: 18750494     Source Type: Journal    
DOI: 10.1007/s12217-015-9479-0     Document Type: Article

References (46)

1. Akmal, M., Anand, A., Anand, B., Wiseman, M., Goodship, A.E, Bentley, G.: The culture of articular chondrocytes in hydrogel constructs within a bioreactor enhances cell proliferation and matrix synthesis. J. Bone Joint Surg. Br. 88, 544–553 (2006)
2. Aleshcheva, G., Sahana, J., Ma, X., Hauslage, J., Hemmersbach, R., Egli, M., Infanger, M., Bauer, J., Grimm, D.: Changes in morphology, gene expression and protein content in chondrocytes cultured on a random positioning machine. PLoS One 8, e6814 (2013)
3. Aleshcheva, G., Wehland, M., Sahana, J., Bauer, J., Corydon, T.J., Hemmersbach, R., Frett, T., Egli, M., Infanger, M., Grosse, J., Grimm, D.: Moderate alterations of the cytoskeleton in human chondrocytes after short-term microgravity produced by parabolic flight maneuvers could be prevented by up-regulation of BMP-2 and SOX-9. FASEB J. 29, 2303–2314 (2015)
4. Aubin, J.E., Liu, F., Malaval, L., Gupta, A.K.: Osteoblast and chondroblast differentiation. Bone 17, 77–83 (1995)
5. Benjamin, M., Archer, C. W., Ralphs, J. R.: Cytoskeleton of cartilage cells. Microsc. Res. Tech. 28, 372–377 (1994)
6. Borst, A.G., van Loon, J.J.: Technology and Developments for the Random Positioning Machine, RPM. Microgravity Sci. Technol. 21, 287–292 (2009)
7. Briegleb, W.: Some qualitative and quantitative aspects of the fast-rotating clinostat as a research tool. ASGSB Bull 5, 23–30 (1992)
8. Buckwalter, J.A., Mankin, H.J.: Articular cartilage. I. Tissue design and chondrocyte–matrix interactions. Instr. Course Lect. 47, 477–486 (1998)
9. Buravkova, L., Romanov, Y., Rykova, M., Grigorieva, O., Merzlikina, N.: Cell-to-cell interactions in changed gravity: ground-based and flight experiments. Acta Astronaut. 57, 67–74 (2005)
10. Cerwinka, W.H., Sharp, S.M., Boyan, B.D., Zhau, H.E, Chung, L.W., Yates, C.: Differentiation of human mesenchymal stem cell spheroids under microgravity conditions. Cell Regen. (Lond). 1, 2 (2012)
11. Cogoli, A., Cogoli-Greuter, M. In: Brinckmann, E (ed.): Cells of the immune system in space (lymphocytes), pp. 193–222. Wiley-VCH, Weinheim (2007)
12. Cogoli-Greuter, M., Lovis, P., Vadrucci, S.: Signal transduction in T cells: an overview. J. Gravit. Physiol. 11, 53–56 (2004)
13. Eiermann, P., Kopp, S., Hauslage, J., Hemmersbach, R., Gerzer, R., Ivanova, K.: Adaptation of a 2D clinostat for simulated microgravity experiments with adherent cells. Micrograv. Sci. Technol. 25, 153–159 (2013)
14. Freed, L.E, Langer, R., Martin, I., Pellis, N.R, Vunjak-Novakovic, G.: Tissue engineering of cartilage in space. Proc. Natl. Acad. Sci. U S A. 94, 13885–13890 (1997)
15. Grimm, D., Bauer, J., Kossmehl, P., Shakibaei, M., Schönberger, J., Pickenhahn, H., Schulze-Tanzil, G., Vetter, R., Eilles, C., Paul, M., Cogoli, A.: Simulated microgravity alters differentiation and increases apoptosis in human follicular thyroid carcinoma cells. FASEB J 16, 604–606 (2002)
16. Grimm, D., Infanger, M., Westphal, K., Ulbrich, C., Pietsch, J., Kossmehl, P., Vadrucci, S., Baatout, S., Flick, B., Paul, M., Bauer, J.: A delayed type of three-dimensional growth of human endothelial cells under simulated weightlessness. Tissue Eng Part A 15, 2267–2275 (2009)
17. Grimm, D., Bauer, J., Ulbrich, C., Westphal, K., Wehland, M., Infanger, M., Aleshcheva, G., Pietsch, J., Ghardi, M., Beck, M., El-Saghire, H., de Saint-Georges, L., Baatout, S.: Different responsiveness of endothelial cells to vascular endothelial growth factor and basic fibroblast growth factor added to culture media under gravity and simulated microgravity. Tissue Eng Part A 16, 1559–1573 (2010)
18. Grimm, D., Wise, P., Lebert, M., Richter, P., Baatout, S.: How and why does the proteome respond to microgravity. Expert Rev Proteomics 8, 13–27 (2011)
19. Grimm, D., Wehland, M., Pietsch, J., Aleshcheva, G., Wise, P., van Loon, J., Ulbrich, C., Magnusson, N.E., Infanger, M., Bauer, J.: Growing tissues in real and simulated microgravity: new methods for tissue engineering. Tissue Eng Part B Rev 20, 555–566 (2014)
20. Herranz, R., Anken, R., Boonstra, J., Braun, M., Christianen, P.C, de Geest, M., Hauslage, J., Hilbig, R., Hill, R.J., Lebert, M., Medina, F.J., Vagt, N., Ullrich, O., van Loon, J.J., Hemmersbach, R.: Ground-based facilities for simulation of microgravity: organism-specific recommendations for their use, and recommended terminology. Astrobiology 13, 1–17 (2013)
21. Infanger, M., Ulbrich, C., Baatout, S., Wehland, M., Kreutz, R., Bauer, J., Grosse, J., Vadrucci, S., Cogoli, A., Derradji, H., Neefs, M., Küsters, S., Spain, M., Paul, M., Grimm, D.: Modeled gravitational unloading induced downregulation of endothelin-1 in human endothelial cells. Cell Biochem 101, 1439–1455 (2007)
22. Johnstone, B., Hering, T.M., Caplan, A. I., Goldberg, V.M., Yoo, J.U.: In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp. Cell Res. 238, 265–272 (1998)
23. Koch, R.J., Gorti, G.K.: Tissue engineering with chondrocytes. Facial Plast. Surg. 18, 59–68 (2002)
24. Kuznetsov, S.A., Mankani, M.H., Gronthos, S., Satomura, K., Bianco, P., Robey, P.G.: Circulating skeletal stem cells. J. Cell. Biol. 153, 1133–1140 (2001)
25. Ma, X., Pietsch, J., Wehland, M., Schulz, H., Saar, K., Hübner, N., Bauer, J., Braun, M., Schwarzwälder, A., Segerer, J., Birlem, M., Horn, A., Hemmersbach, R., Waßer, K., Grosse, J., Infanger, M., Grimm, D.: Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space. FASEB J. 28, 813–35 (2014)
26. Marlovits, S., Tichy, B., Truppe, M., Gruber, D., Schlegel, W.: Collagen expression in tissue engineered cartilage of aged human articular chondrocytes in a rotating bioreactor. Int. J. Artif. Organs 26, 319–330 (2003a)
27. Marlovits, S., Tichy, B., Truppe, M., Gruber, D., Vécsei, V.: Chondrogenesis of aged human articular cartilage in a scaffold-free bioreactor. Tissue Eng 9, 1215–26 (2003b)
28. Mitteregger, R., Vogt, G., Rossmanith, E., Falkenhagenm, D.: Rotary cell culture system (RCCS): a new method for cultivating hepatocytes on microcarriers. Int. J. Artif. Organs 22, 816–822 (1999)
29. Nakamura, S., Arai, Y., Takahashi, K.A., Terauchi, R., Ohashi, S., Mazda, O., Imanishi, J., Inoue, A., Tonomura, H., Kubo, T.: Hydrostatic pressure induces apoptosis of chondrocytes cultured in alginate beads. J. Orthop. Res. 24, 733–739 (2006)
30. Ohgushi, H., Caplan, A. I.: Stem cell technology and bioceramics: from cell to gene engineering. J. Biomed. Mater. Res. 48, 913–927 (1999)
31. Pietsch, J., Sickmann, A., Weber, G., Bauer, J., Egli, M., Wildgruber, R., Infanger, M., Grimm, D.: A proteomic approach to analysing spheroid formation of two human thyroid cell lines cultured on a random positioning machine. Proteomics 11, 2095–2104 (2011a)
32. Pietsch, J., Bauer, J., Egli, M., Infanger, M., Wise, P., Ulbrich, C., Grimm, D.: The effects of weightlessness on the human organism and mammalian cells. Curr. Mol. Med 11, 350–364 (2011b)
33. Pietsch, J., Ma, X., Wehland, M., Aleshcheva, G., Schwarzwälder, A., Segerer, J., Birlem, M., Horn, A., Bauer, J., Infanger, M., Grimm, D.: Spheroid formation of human thyroid cancer cells in an automated culturing system during the Shenzhou-8 space mission. Biomaterials 34, 7694–7705 (2013)
34. Riwaldt, S., Pietsch, J., Sickmann, A., Bauer, J., Braun, M., Segerer, J., Schwarzwälder, A., Aleshcheva, G., Corydon, T.J., Infanger, M., Grimm, D.: Identification of proteins involved in inhibition of spheroid formation under microgravity. Proteomics 15, 2945–2952 (2015)
35. Svejgaard, B., Wehland, M., Ma, X., Kopp, S., Sahana, J., Warnke, E., Aleshcheva, G., Hemmersbach, R., Hauslage, J., Grosse, J., Bauer, J., Corydon, T.J., Islam, T., Infanger, M., Grimm, D.: Common effects on cancer cells exerted by a Random Positioning Machine and a 2D clinostat. PLoS One 10, e0135157 (2015)
36. Schwarz, R.P., Goodwin, T.J., Wolf, D.A.: Cell culture for three-dimensional modeling in rotating-wall vessels: an application of simulated microgravity. J. Tissue Cult. Methods 14, 51–57 (1992)
37. Stockwell, R.A.: The cell density of human articular and costal cartilage. J. Anat 101, 753–763 (1967)
38. Temenoff, J.S., Mikos, A.G: Review: tissue engineering for regeneration of articular cartilage. Biomaterials 21, 431–440 (2000)
39. Uva, B. M., Masini, M. A., Sturla, M., Prato, P., Passalacqua, M., Giuliani, M., Tagliafierro, G., Strollo, F.: Clinorotation-induced weightlessness influences the cytoskeleton of glial cells in culture. Brain Res 934, 132–139 (2002)
40. van Loon, J.: Some history and use of the random positioning machine, RPM, in gravity related research. Adv. Space Res. 39, 1161–1165 (2007)
41. Vorselen, D., Roos, W.H., MacKintosh, F.C., Wuite, G.J., van Loon, J.J.: The role of the cytoskeleton in sensing changes in gravity by nonspecialized cells. FASEB J. 28, 536–547 (2014)
42. Wakitani, S., Goto, T., Pineda, S.J., Young, R.G., Mansour, J.M., Caplan, A.I., Goldberg, V.M.: Mesenchymal cellbased repair of large, full-thickness defects of articular cartilage. J. Bone. Joint. Surg. Am. 76, 579–592 (1994)
43. Warnke, E., Pietsch, J., Wehland, M., Bauer, J., Infanger, M., Görög, M., Hemmersbach, R., Braun, M., Ma, X., Sahana, J., Grimm, D.: Spheroid formation of human thyroid cancer cells under simulated microgravity: a possible role of CTGF and CAV1. Cell Commun. Signal 12, 32 (2014)
44. Wehland, M., Aleshcheva, G., Schulz, H., Saar, K., Hübner, N., Hemmersbach, R., Braun, M., Ma, X., Frett, T., Warnke, E., Riwaldt, S., Pietsch, J., Corydon, T.J., Infanger, M., Grimm, D.: Differential gene expression of human chondrocytes cultured under short-term altered gravity conditions during parabolic flight maneuvers. Cell Commun. Signal 20(13), 18 (2015)
45. Wu, X., Li, S.H, Lou, L.M, Chen, Z.R.: The effect of the microgravity rotating culture system on the chondrogenic differentiation of bone marrow mesenchymal stem cells. Mol. Biotechnol 54, 331–336 (2013)
46. Zanetti, N.C., Solursh, M.: Induction of chondrogenesis in limb mesenchymal cultures by disruption of the actin cytoskeleton. J. Cell Biol 99, 115–123 (1984)