Moderate alterations of the cytoskeleton in human chondrocytes after short-term microgravity produced by parabolic flight maneuvers could be prevented by up-regulation of BMP-2 and SOX-9

FASEB Journal

Volumn 29, Issue 6, 2015, Pages 2303-2314

  Aleshcheva, Ganna ^a   Wehland, Markus ^a   Sahana, Jayashree ^b   Bauer, Johann ^c   Corydon, Thomas J ^b   Hemmersbach, Ruth ^d   Frett, Timo ^d   Egli, Marcel ^e   Infanger, Manfred ^a   Grosse, Jirka ^f   Grimm, Daniela ^b  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b AARHUS UNIVERSITY   (Denmark)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^d GERMAN AEROSPACE CENTER DLR   (Germany)

^e LUCERNE UNIVERSITY OF APPLIED SCIENCES AND ARTS   (Switzerland)

^f UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

F actin; Gene expression; Hypergravity; Vibration

Indexed keywords

BETA ACTIN; BETA TUBULIN; BETA1 INTEGRIN; BONE MORPHOGENETIC PROTEIN 2; CAVEOLIN 1; CYTOKERATIN; CYTOKERATIN 8; INTERCELLULAR ADHESION MOLECULE 1; ITGA10 PROTEIN; MESSENGER RNA; OSTEOPONTIN; PROTEIN; TRANSCRIPTION FACTOR SOX5; TRANSCRIPTION FACTOR SOX6; TRANSCRIPTION FACTOR SOX9; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VIMENTIN; BMP2 PROTEIN, HUMAN;

ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; CYTOSKELETON; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; MICROGRAVITY; MICROTUBULE; PRIORITY JOURNAL; PROTEIN CONTENT; QUANTITATIVE ANALYSIS; UPREGULATION; VIBRATION; CELL CULTURE; CONFOCAL MICROSCOPY; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPACE FLIGHT; TIME; WEIGHTLESSNESS; WESTERN BLOTTING;

ANTIGENS, CD29; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEIN 2; CELLS, CULTURED; CHONDROCYTES; CYTOSKELETON; GENE EXPRESSION PROFILING; HUMANS; MICROSCOPY, CONFOCAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SOX9 TRANSCRIPTION FACTOR; SPACE FLIGHT; TIME FACTORS; UP-REGULATION; WEIGHTLESSNESS SIMULATION;

EID: 84933565557     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-268151     Document Type: Article

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