Consequences of postnatal vascular smooth muscle EGFR deletion on acute angiotensin II action

Clinical Science

Volumn 130, Issue 1, 2016, Pages 19-33

  Schreier, Barbara ^a   Hünerberg, Mirja ^a   Rabe, Sindy ^a   Mildenberger, Sigrid ^a   Bethmann, Daniel ^a   Heise, Christian ^a   Sibilia, Maria ^b   Offermanns, Stefan ^c   Gekle, Michael ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

Author keywords

Angiotensin II; Endothelin 1; Epidermal growth factor receptor; Hypotension; Mouse model; Vascular smooth muscle cells

Indexed keywords

ANGIOTENSIN II; ENDOTHELIN 1; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; PLASMINOGEN ACTIVATOR INHIBITOR 1; POTASSIUM CHLORIDE; SEROTONIN; CCL2 PROTEIN, MOUSE; EGFR PROTEIN, MOUSE; MAPK1 PROTEIN, MOUSE; VASOCONSTRICTOR AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR TISSUE; CELL SPECIFICITY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; EX VIVO STUDY; GENE DELETION; HEART RATE; HEART WEIGHT; IN VIVO STUDY; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PERINATAL PERIOD; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SYSTOLIC BLOOD PRESSURE; UPREGULATION; VASCULAR SMOOTH MUSCLE CELL; VASOCONSTRICTION; VASODILATATION; AGE; ANIMAL; BLOOD PRESSURE; C57BL MOUSE; CARDIOMEGALY; CHEMICALLY INDUCED; DEFICIENCY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; GENETICS; HUMAN; HYPERTENSION; KNOCKOUT MOUSE; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TIME; VASCULAR REMODELING; VASCULAR SMOOTH MUSCLE;

AGE FACTORS; ANGIOTENSIN II; ANIMALS; BLOOD PRESSURE; CARDIOMEGALY; CHEMOKINE CCL2; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE DELETION; HUMANS; HYPERTENSION; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TIME FACTORS; VASCULAR REMODELING; VASOCONSTRICTOR AGENTS;

EID: 84951931052     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20150503     Document Type: Article

References (47)

1. Hackel, P.O., Zwick, E., Prenzel, N. and Ullrich, A. (1999) Epidermal growth factor receptors: critical mediators of multiple receptor pathways. Curr. Opin. Cell Biol. 11, 184-189
2. Yarden, Y. and Sliwkowski, M.X. (2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell Biol. 2, 127-137
3. Harris, R.C., Chung, E. and Coffey, R.J. (2003) EGF receptor ligands. Exp. Cell Res. 284, 2-13
4. Prenzel, N., Zwick, E., Daub, H., Leserer, M., Abraham, R., Wallasch, C. and Ullrich, A. (1999) EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402, 884-888
5. Schlessinger, J. (2002) Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 110, 669-672
6. Schreier, B., Rabe, S., Schneider, B., Bretschneider, M., Rupp, S., Ruhs, S., Neumann, J., Rueckschloss, U., Sibilia, M., Gotthardt, M. et al. (2013) Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy. Hypertension 61, 333-340
7. Messaoudi, S., Di Zhang, A., Griol-Charhbili, V., Escoubet, B., Sadoshima, J., Farman, N. and Jaisser, F. (2012) The epidermal growth factor receptor is involved in angiotensin II but not aldosterone/salt-induced cardiac remodelling. PLoS One 7, e30156
8. Kagiyama, S., Eguchi, S., Frank, G.D., Inagami, T., Zhang, Y.C. and Phillips, M.I. (2002) Angiotensin II-induced cardiac hypertrophy and hypertension are attenuated by epidermal growth factor receptor antisense. Circulation 106, 909-912
9. Takayanagi, T., Kawai, T., Forrester, S.J., Obama, T., Tsuji, T., Fukuda, Y., Elliott, K.J., Tilley, D.G., Davisson, R.L., Park, J.Y. et al. (2015) Role of epidermal growth factor receptor and endoplasmic reticulum stress in vascular remodeling induced by angiotensin II. Hypertension 65, 1349-1355
10. Noma, T., Lemaire, A., Naga Prasad, S.V., Barki-Harrington, L., Tilley, D.G., Chen, J., Le Corvoisier, P., Violin, J.D., Wei, H., Lefkowitz, R.J. et al. (2007) Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. J. Clin. Invest. 117, 2445-2458
11. Ulu, N., Gurdal, H., Landheer, S.W., Duin, M., Guc, M.O., Buikema, H. and Henning, R.H. (2010) alpha1-Adrenoceptor-mediated contraction of rat aorta is partly mediated via transactivation of the epidermal growth factor receptor. Br. J. Pharmacol. 161, 1301-1310
12. Hsieh, H.L., Tung, W.H., Wu, C.Y., Wang, H.H., Lin, C.C., Wang, T.S. and Yang, C.M. (2009) Thrombin induces EGF receptor expression and cell proliferation via a PKC(delta)/c-Src-dependent pathway in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 29, 1594-1601
13. Chansel, D., Ciroldi, M., Vandermeersch, S., Jackson, L.F., Gomez, A.M., Henrion, D., Lee, D.C., Coffman, T.M., Richard, S., Dussaule, J.C. et al. (2006) Heparin binding EGF is necessary for vasospastic response to endothelin. FASEB J. 20, 1936-1938
14. Morris, J.B., Pham, T.M., Kenney, B., Sheppard, K.E. and Woodcock, E.A. (2004) UTP transactivates epidermal growth factor receptors and promotes cardiomyocyte hypertrophy despite inhibiting transcription of the hypertrophic marker gene, atrial natriuretic peptide. J. Biol. Chem. 279, 8740-8746
15. Kagiyama, S., Matsumura, K., Fukuhara, M., Sakagami, K., Fujii, K. and Iida, M. (2007) Aldosterone-and-salt-induced cardiac fibrosis is independent from angiotensin II type 1a receptor signaling in mice. Hypertens. Res. 30, 979-989
16. Schreier, B., Rabe, S., Winter, S., Ruhs, S., Mildenberger, S., Schneider, B., Sibilia, M., Gotthardt, M., Kempe, S., Mader, K. et al. (2014) Moderate inappropriately high aldosterone/NaCl constellation in mice: cardiovascular effects and the role of cardiovascular epidermal growth factor receptor. Sci. Rep. 4, 7430
17. Jagadeesha, D.K., Takapoo, M., Banfi, B., Bhalla, R.C. and Miller, F.J. (2012) Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration. Cardiovasc. Res. 93, 406-413
18. Pullar, C.E. and Isseroff, R.R. (2006) The beta 2-adrenergic receptor activates pro-migratory and pro-proliferative pathways in dermal fibroblasts via divergent mechanisms. J. Cell Sci. 119, 592-602
19. Schreier, B., Dohler, M., Rabe, S., Schneider, B., Schwerdt, G., Ruhs, S., Sibilia, M., Gotthardt, M., Gekle, M. and Grossmann, C. (2011) Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1. Arterioscler. Thromb. Vasc. Biol. 31, 1643-1653
20. Inagami, T. and Eguchi, S. (2000) Angiotensin II-mediated vascular smooth muscle cell growth signaling. Braz. J. Med. Biol. Res. 33, 619-624
21. Yang, C.M., Lin, M.I., Hsieh, H.L., Sun, C.C., Ma, Y.H. and Hsiao, L.D. (2005) Bradykinin-induced p42/p44 MAPK phosphorylation and cell proliferation via Src, EGF receptors, and PI3-K/Akt in vascular smooth muscle cells. J. Cell. Physiol. 203, 538-546
22. Fleisch, J.H. (1981) Age-related decrease in beta adrenoceptor activity of the cardiovascular system. Trends Pharmacol. Sci. 2, 337-339
23. Miller, Jr, F.J., Chu, X., Stanic, B., Tian, X., Sharma, R.V., Davisson, R.L. and Lamb, F.S. (2010) A differential role for endocytosis in receptor-mediated activation of Nox1. Antioxid. Redox Signal. 12, 583-593
24. Flamant, M., Tharaux, P.L., Placier, S., Henrion, D., Coffman, T., Chatziantoniou, C. and Dussaule, J.C. (2003) Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice. FASEB J. 17, 327-329
25. Chan, S.L., Umesalma, S. and Baumbach, G.L. (2015) Epidermal growth factor receptor is critical for angiotensin II-mediated hypertrophy in cerebral arterioles. Hypertension 65, 806-812
26. Iwasaki, H., Eguchi, S., Marumo, F. and Hirata, Y. (1998) Endothelin-1 stimulates DNA synthesis of vascular smooth-muscle cells through transactivation of epidermal growth factor receptor. J. Cardiovasc. Pharmacol. 31 (Suppl. 1), S182-S184
27. Krug, A.W., Allenhofer, L., Monticone, R., Monticone, R., Spinetti, G., Gekle, M., Wang, M. and Lakatta, E.G. (2010) Elevated mineralocorticoid receptor activity in aged rat vascular smooth muscle cells promotes a proinflammatory phenotype via extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase and epidermal growth factor receptor-dependent pathways. Hypertension 55, 1476-1483
28. McCurley, A., Pires, P.W., Bender, S.B., Aronovitz, M., Zhao, M.J., Metzger, D., Chambon, P., Hill, M.A., Dorrance, A.M., Mendelsohn, M.E. et al. (2012) Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat. Med. 18, 1429-1433
29. Wang, M., Monticone, R.E. and Lakatta, E.G. (2014) Proinflammation of aging central arteries: a mini-review. Gerontology 60, 519-529
30. Sibilia, M. and Wagner, E.F. (1995) Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269, 234-238
31. Sibilia, M., Kroismayr, R., Lichtenberger, B.M., Natarajan, A., Hecking, M. and Holcmann, M. (2007) The epidermal growth factor receptor: from development to tumorigenesis. Differentiation 75, 770-787
32. Natarajan, A., Wagner, B. and Sibilia, M. (2007) The EGF receptor is required for efficient liver regeneration. Proc. Natl. Acad. Sci. U.S.A. 104, 17081-17086
33. Wirth, A., Benyo, Z., Lukasova, M., Leutgeb, B., Wettschureck, N., Gorbey, S., Orsy, P., Horvath, B., Maser-Gluth, C., Greiner, E. et al. (2008) G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension. Nat. Med. 14, 64-68
34. Groneberg, D., Koenig, P., Wirth, A., Offermanns, S., Koesling, D. and Friebe, A. (2010) Smooth muscle-specific deletion of nitric oxide-sensitive guanylyl cyclase is sufficient to induce hypertension in mice. Circulation 121, 401-409
35. Liang, M., Ekblad, E., Lydrup, M.L. and Nilsson, B.O. (2003) Combined lack of estrogen receptors alpha and beta affects vascular iNOS protein expression. Cell Tissue Res. 313, 63-70
36. Mulvany, M.J. and Halpern, W. (1977) Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ. Res. 41, 19-26
37. Freeman, G.L., Little, W.C. and O'Rourke, R.A. (1986) The effect of vasoactive agents on the left ventricular end-systolic pressure-volume relation in closed-chest dogs. Circulation 74, 1107-1113
38. Lemmon, M.A. (2009) Ligand-induced ErbB receptor dimerization. Exp. Cell Res. 315, 638-648
39. Keys, J.R., Greene, E.A., Koch, W.J. and Eckhart, A.D. (2002) Gq-Coupled receptor agonists mediate cardiac hypertrophy via the vasculature. Hypertension 40, 660-666
40. Miano, J.M., Ramanan, N., Georger, M.A., Mesy Bentley, K.L., Emerson, R.L., Balza, R.O., Xiao, Q., Weiler, H., Ginty, D.D. and Misra, R.P. (2004) Restricted inactivation of serum response factor to the cardiovascular system. Proc. Natl. Acad. Sci. U.S.A. 101, 17132-17137
41. Dumont, E.C., Lambert, C. and Lamontagne, D. (1996) Modification of aortic contractility in the cardiomyopathic hamster. Br. J. Pharmacol. 118, 1141-1146
42. Babaei, H., Ebrahimi, F., Shahbazi, M.J., Azarmi, Y. and Gharehbagheri, A. (2011) Vasorelaxant effect of a newly synthesized dihydropyridine ethyl ester (DHPEE) on rat thoracic aorta: dual mechanism of action. Adv. Pharm. Bull. 1, 10-17
43. Kuroda, S., Konishi, H., Okishio, M. and Fujisawa, Y. (1994) Novel subtype of human angiotensin II type 1 receptor: analysis of signal transduction mechanism in transfected Chinese hamster ovary cells. Biochem. Biophys. Res. Commun. 199, 475-481
44. Czikora, I., Feher, A., Lucas, R., Fulton, D.J.R. and Bagi, Z. (2015) Caveolin-1 prevents sustained angiotensin II-induced resistance artery constriction and obesity-induced high blood pressure. Am. J. Physiol. Heart Circ. Physiol. 308, H376-H385
45. Beaucage, P. and Moreau, P. (2004) EGF receptor transactivation in angiotensin II and endothelin control of vascular protein synthesis in vivo. J. Cardiovasc. Pharmacol. 44 (Suppl. 1), S20-S23
46. Bokemeyer, D., Schmitz, U. and Kramer, H.J. (2000) Angiotensin II-induced growth of vascular smooth muscle cells requires an Src-dependent activation of the epidermal growth factor receptor. Kidney Int. 58, 549-558
47. Spinetti, G., Wang, M., Monticone, R., Zhang, J., Zhao, D. and Lakatta, E.G. (2004) Rat aortic MCP-1 and its receptor CCR2 increase with age and alter vascular smooth muscle cell function. Arterioscler. Thromb. Vasc. Biol. 24, 1397-1402