Vitamin D3 pretreatment regulates renal inflammatory responses during lipopolysaccharide-induced acute kidney injury

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Xu, Shen ^a   Chen, Yuan Hua ^a   Tan, Zhu Xia ^a   Xie, Dong Dong ^a   Zhang, Cheng ^a   Zhang, Zhi Hui ^a   Wang, Hua ^a   Zhao, Hui ^a   Yu, De Xin ^a   Xu, De Xiang ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL RECEPTOR; CHEMOKINE; COLECALCIFEROL; CYCLOOXYGENASE 2; INTERCELLULAR ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BINDING; PROTEIN KINASE B; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA; VASCULAR CELL ADHESION MOLECULE 1;

ACUTE KIDNEY INJURY; ANIMAL; CELL LINE; CHEMICALLY INDUCED; COMPLICATION; DRUG EFFECTS; ENZYMOLOGY; GENETIC TRANSFECTION; HUMAN; INFLAMMATION; KIDNEY; MALE; METABOLISM; MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION;

ACUTE KIDNEY INJURY; ANIMALS; CELL LINE; CHEMOKINES; CHOLECALCIFEROL; CYCLOOXYGENASE 2; HUMANS; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; KIDNEY; LIPOPOLYSACCHARIDES; MALE; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CALCITRIOL; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TRANSFECTION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84951865162     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep18687     Document Type: Article

References (50)

1. Deutschman, C. S. & Tracey, K. J. Sepsis: current dogma and new perspectives. Immunity 40, 463-475 (2014).
2. Tilahun, A. Y., Chowdhary, V. R., David, C. S. & Rajagopalan, G. Systemic inflammatory response elicited by superantigen destabilizes T regulatory cells, rendering them ineffective during toxic shock syndrome. J. Immunol. 193, 2919-2930 (2014).
3. Lameire, N. H. et al. Acute kidney injury: an increasing global concern. Lancet 382, 170-179 (2013).
4. Jaworska, K. et al. Both PD-1 ligands protect the kidney from ischemia reperfusion injury. J. Immunol. 194, 325-333 (2015).
5. Thomas, M. E. et al. The definition of acute kidney injury and its use in practice. Kidney Int. 87, 62-73 (2015).
6. Uchino, S. et al. Acute renal failure in critically ill patients: A multinational, multicenter study. JAMA 294, 813-818 (2005).
7. Yang, C. C., Yao, C. A., Yang, J. C. & Chien, C. T. Sialic acid rescues repurified lipopolysaccharide-induced acute renal failure via inhibiting TLR4/PKC/gp91-mediated endoplasmic reticulum stress, apoptosis, autophagy, and pyroptosis signaling. Toxicol. Sci. 141, 155-165 (2014).
8. Xu, C. et al. TNF-mediated damage to glomerular endothelium is an important determinant of acute kidney injury in sepsis. Kidney Int. 85, 72-81 (2014).
9. Doi, K., Leelahavanichkul, A., Yuen, P. S. & Star, R. A. Animal models of sepsis and sepsis-induced kidney injury. J. Clin. Invest. 119, 2868-2878 (2009).
10. Cunningham, P. N. et al. Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney. J. Immunol. 168, 5817-5823 (2002).
11. Yu, C., Qi, D., Sun, J. F., Li, P. & Fan, H. Y. Rhein prevents endotoxin-induced acute kidney injury by inhibiting NF-κ B activities. Sci. Rep. 5, 11822 (2015).
12. Wang, W. et al. Pentoxifylline protects against endotoxin-induced acute renal failure in mice. Am. J. Physiol. Renal Physiol. 291, F1090-1095 (2006).
13. Bhargava, R. et al. Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-α antibodies. PLoS One 8, e79037 (2013).
14. Boffa, J. J., Just, A., Coffman, T. M. & Arendshorst, W. J. Thromboxane receptor mediates renal vasoconstriction and contributes to acute renal failure in endotoxemic mice. J. Am. Soc. Nephrol. 15, 2358-2365 (2004).
15. Ranganathan, P. V., Jayakumar, C., Mohamed, R., Dong, Z. & Ramesh, G. Netrin-1 regulates the inflammatory response of neutrophils and macrophages, and suppresses ischemic acute kidney injury by inhibiting COX-2-mediated PGE2 production. Kidney Int. 83, 1087-1098 (2013).
16. Holick, M. F. Resurrection of vitamin D deficiency and rickets. J. Clin. Invest. 116, 2062-2072 (2006).
17. Hewison, M. Vitamin D and the intracrinology of innate immunity. Mol. Cell. Endocrinol. 321, 103-111 (2010).
18. Welsh, J. Cellular and molecular effects of vitamin D on carcinogenesis. Arch. Biochem. Biophys. 523, 107-114 (2012).
19. Bikle, D. D. Vitamin D metabolism, mechanism of action, and clinical applications. Chem. Biol. 21, 319-29 (2014).
20. Schuster, I. Cytochromes P450 are essential players in the vitamin D signaling system. Biochim. Biophys. Acta. 1814, 186-199 (2011).
21. Cunningham, J. & Zehnder, D. New vitamin D analogs and changing therapeutic paradigms. Kidney Int. 79, 702-707 (2011).
22. Blomberg Jensen, M. et al. Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer. J. Steroid. Biochem. Mol. Biol. 121, 376-382 (2010).
23. Wang, Y., Borchert, M. L. & Deluca, H. F. Identification of the vitamin D receptor in various cells of the mouse kidney. Kidney Int. 81, 993-1001 (2012).
24. Ito, I. et al. A nonclassical vitamin D receptor pathway suppresses renal fibrosis. J. Clin. Invest. 123, 4579-4594 (2013).
25. Xiong, M., Gong, J., Liu, Y., Xiang, R. & Tan, X. Loss of vitamin D receptor in chronic kidney disease: a potential mechanism linking inflammation to epithelial-to-mesenchymal transition. Am. J. Physiol. Renal. Physiol. 303, F1107-1115 (2012).
26. Chen, Y. et al. Vitamin D receptor inhibits nuclear factor κ B activation by interacting with Iκ B kinase β protein. J. Biol. Chem. 288, 19450-19458 (2013).
27. Höcherl, K., Schmidt, C., Kurt, B. & Bucher, M. Inhibition of NF-kappaB ameliorates sepsis-induced downregulation of aquaporin-2/V2 receptor expression and acute renal failure in vivo. Am. J. Physiol. Renal. Physiol. 298, F196-204 (2010).
28. Park, J. W. et al. Paricalcitol prevents cisplatin-induced renal injury by suppressing apoptosis and proliferation. Eur. J. Pharmacol. 683, 301-309 (2012).
29. Lee, J. W. et al. Renoprotective effect of paricalcitol via a modulation of the TLR4-NF-κ B pathway in ischemia/reperfusion-induced acute kidney injury. Biochem. Biophys. Res. Commun. 444, 121-127 (2014).
30. Maier, S. et al. Massive chemokine transcription in acute renal failure due to polymicrobial sepsis. Shock 14, 187-192 (2000).
31. Wu, X., Guo, R., Wang, Y. & Cunningham, P. N. The role of ICAM-1 in endotoxin-induced acute renal failure. Am. J. Physiol. Renal Physiol. 293, F1262-1271 (2007).
32. Yamamoto, T. et al. 1,25-dihydroxyvitamin D3 stimulates vascular endothelial growth factor release in aortic smooth muscle cells: role of p38 mitogen-activated protein kinase. Arch. Biochem. Biophys. 398, 1-6 (2002).
33. Molinari, C. et al. 1α,25-dihydroxycholecalciferol induces nitric oxide production in cultured endothelial cells. Cell. Physiol. Biochem. 27, 661-668 (2011).
34. Zhang, Y. et al. Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J. Immunol. 188, 2127-2135 (2012).
35. Wang, Q. et al. Vitamin D inhibits COX-2 expression and inflammatory response by targeting thioesterase superfamily member 4. J. Biol. Chem. 289, 11681-11694 (2014).
36. Joseph, S. B., Castrillo, A., Laffitte, B. A., Mangelsdorf, D. J. & Tontonoz, P. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat. Med. 9, 213-219 (2003).
37. Zhou, C. et al. Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation. J. Clin. Invest. 116, 2280-2289 (2006).
38. Gu, X. et al. Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents. J. Biol. Chem. 281, 17882-17889 (2006).
39. Field, F. J., Watt, K. & Mathur, S. N. TNF-alpha decreases ABCA1 expression and attenuates HDL cholesterol efflux in the human intestinal cell line Caco-2. J. Lipid. Res. 51, 1407-1415 (2010).
40. Kumar, R., Schaefer, J., Grande, J. P. & Roche, P. C. Immunolocalization of calcitriol receptor, 24-hydroxylase cytochrome P-450, and calbindin D28k in human kidney. Am. J. Physiol. 266, F477-485 (1994).
41. Braun, A. B. et al. Association of low serum 25-hydroxyvitamin D levels and acute kidney injury in the critically ill. Crit. Care. Med. 40, 3170-3179 (2012).
42. Lai, L. et al. Is the serum vitamin D level at the time of hospital-acquired acute kidney injury diagnosis associated with prognosis? PLoS One 8, e64964 (2013).
43. Gonçalves, J. G. et al. Vitamin d deficiency aggravates chronic kidney disease progression after ischemic acute kidney injury. PLoS One 9, e107228 (2014).
44. Xu, S. et al. Vitamin D3 pretreatment alleviates renal oxidative stress in lipopolysaccharide-induced acute kidney injury. J. Steroid Biochem. Mol. Biol. 152, 133-141 (2015).
45. Chen, Y. H. et al. Supplementation with vitamin d3 during pregnancy protects against lipopolysaccharide-induced neural tube defects through improving placental folate transportation. Toxicol. Sci. 145, 90-97 (2015).
46. Conger, J. D., Schultz, M. F., Miller, F. & Robinette, J. B. Responses to hemorrhagic arterial pressure reduction in different ischemic renal failure models. Kidney Int. 46, 318-323 (1994).
47. Yuen, P. S. et al. A simplified method for HPLC determination of creatinine in mouse serum. Am. J. Physiol. Renal. Physiol. 286, F1116-1119 (2004).
48. Chen Y. H. et al. Vitamin D3 inhibits lipopolysaccharide-induced placental inflammation through reinforcing interaction between vitamin D receptor and nuclear factor kappa B p65 subunit. Sci. Rep. 5, 10871 (2015).
49. Pervin, S. et al. Down-regulation of vitamin D receptor in mammospheres: implications for vitamin D resistance in breast cancer and potential for combination therapy. PLoS One 8, e53287 (2013).
50. Chen, Y. H. et al. Zinc supplementation during pregnancy protects against lipopolysaccharide-induced fetal growth restriction and demise through its anti-inflammatory effect. J. Immunol. 189, 454-463 (2012).