Pentoxifylline protects against endotoxin-induced acute renal failure in mice

American Journal of Physiology - Renal Physiology

Volumn 291, Issue 5, 2006, Pages

  Wang, Wei ^a   Zolty, Einath ^a   Falk, Sandor ^a   Basava, Veena ^a   Reznikov, Leonid ^a   Schrier, Robert ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Sepsis; Tumor necrosis factor

Indexed keywords

CYTOKINE; ENDOTOXIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PENTOXIFYLLINE; TUMOR NECROSIS FACTOR ALPHA; 6 OXOPROSTAGLANDIN E1; 6-KETOPROSTAGLANDIN E1; CYCLIC AMP; CYCLIC GMP; DRUG DERIVATIVE; ENZYME INHIBITOR; ICAM1 PROTEIN, MOUSE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; NOS2 PROTEIN, MOUSE; NOS3 PROTEIN, MOUSE; PROSTAGLANDIN E1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG APPROVAL; DRUG EFFECT; DRUG INHIBITION; ENDOTOXEMIA; ERYTHROCYTE DEFORMABILITY; FOOD AND DRUG ADMINISTRATION; GLOMERULUS FILTRATION RATE; KIDNEY BLOOD FLOW; KIDNEY FAILURE; KIDNEY FUNCTION; KIDNEY VASCULAR RESISTANCE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENAL PROTECTION; SEPSIS; UPREGULATION; ACUTE KIDNEY FAILURE; ANIMAL; BLOOD; C57BL MOUSE; DISEASE MODEL; GENETICS; KIDNEY CORTEX; METABOLISM; MOUSE MUTANT; URINE;

ALPROSTADIL; ANIMALS; CYCLIC AMP; CYCLIC GMP; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENDOTOXEMIA; ENZYME INHIBITORS; GLOMERULAR FILTRATION RATE; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-1; KIDNEY CORTEX; KIDNEY FAILURE, ACUTE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PENTOXIFYLLINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33750965109     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00517.2005     Document Type: Article

References (46)

1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, and Pinksy MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29: 1303-1310, 2001.
2. Arrieta O, Ortiz-Reyes A, Rembao D, Calvillo M, Rivera E, and Sotelo J. Protective effect of pentoxifylline plus thalidomide against septic shock in mice. Int J Exp Pathol 80: 11-16, 1999.
3. Aviado DM and Porter JM. Pentoxifylline: a new drug for the treatment of intermittent claudication. Mechanism of action, pharmacokinetics, clinical efficacy and adverse effects. Pharmacotherapy 4: 297-307, 1984.
4. Berens KL, Langston JD, Wasan KM, and Luke DR. Influence of pentoxifylline and related analogues in endotoxemic renal failure. Circ Shock 34: 344-348, 1991.
5. Colson A, Willems B, and Thissen JP. Inhibition of TNF-α production by pentoxifylline does not prevent endotoxin-induced decrease in serum IGF-I. J Endocrinol 178: 101-109, 2003.
6. Cunningham PN, Dyanov HM, Park P, Wang J, Newell KA, and Quigg RJ. Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney. J Immunol 168: 5817-5823, 2002.
7. Cunningham PN, Wang Y, Guo R, He G, and Quigg RJ. Role of Toll-like receptor 4 in endotoxin-induced acute renal failure. J Immunol 172: 2629-2635, 2004.
8. Fantuzzi G, Puren AJ, Harding MW, Livingston DJ, and Dinarello CA. Interleukin-18 regulation of interferon γ production and cell proliferation as shown in interleukin-1β-converting enzyme (caspase-1)-deficient mice. Blood 91: 2118-2125, 1998.
9. Gillings DB. Pentoxifylline and intermittent claudication: review of clinical trials and cost-effectiveness analyses. J Cardiovasc Pharmacol 25, Suppl 2: S44-S50, 1995.
10. Haller H, Dragun D, Miethke A, Park JK, Weis A, Lippoldt A, Gross V, and Luft FC. Antisense oligonucleotides for ICAM-1 attenuate reperfusion injury and renal failure in the rat. Kidney Int 50: 473-480, 1996.
11. Henninger DD, Panes J, Eppihimer M, Russell J, Gerritsen M, Anderson PC, and Granger DN. Cytokine-induced VCAM-1 and ICAM-1 expression in different organs of the mouse. J Immunol 158: 1825-1832, 1997.
12. Iglesias J, Marik PE, and Levine JS. Elevated serum levels of the type I and type II receptors for tumor necrosis factor-α as predictive factors for ARF in patients with septic shock. Am J Kidney Dis 41: 62-75, 2003.
13. Irie K, Fujii E, Ishida H, Wada K, Suganuma T, Nishikori T, Yoshioka T, and Muraki T. Inhibitory effects of cyclic AMP elevating agents on lipopolysaccharide (LPS)-induced microvascular permeability change in mouse skin. Br J Pharmacol 133: 237-242, 2001.
14. Issekutz TB, Miyasaka M, and Issekutz AC. Rat blood neutrophils express very late antigen 4 and it mediates migration to arthritic joint and dermal inflammation. J Exp Med 183: 2175-2184, 1996.
15. Kacimi R, Karliner JS, Koudssi F, and Long CS. Expression and regulation of adhesion molecules in cardiac cells by cytokines: response to acute hypoxia. Circ Res 82: 576-586, 1998.
16. Kelly KJ, Williams WW Jr, Colvin RB, and Bonaventre JV. Antibody to intercellular adhesion molecule 1 protects the kidney against ischemic injury. Proc Natl Acad Sci USA 91: 812-816, 1994.
17. Kelly KJ, Williams WW Jr, Colvin RB, Meehan SM, Springer TA, Gutierrez-Ramos JC, and Bonaventre JV. Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury. J Clin Invest 97: 1056-1063, 1996.
18. Kim YK, Choi TR, Kwon CH, Kim JH, Woo JS, and Jung JS. Beneficial effect of pentoxifylline on cisplatin-induced acute renal failure in rabbits. Ren Fail 25: 909-922, 2003.
19. Knotek M, Rogachev B, Wang W, Ecder T, Melnikov V, Gengaro PE, Esson M, Edelstein CL, Dinarello CA, and Schrier RW. Endotoxemic renal failure in mice: role of tumor necrosis factor independent of inducible nitric oxide synthase. Kidney Int 59: 2243-2249, 2001.
20. Landry DW and Oliver JA. The pathogenesis of vasodilatory shock. N Engl J Med 345: 588-595, 2001.
21. LeMay LG, Vander AJ, and Kluger MJ. The effects of pentoxifylline on lipopolysaccharide (LPS) fever, plasma interleukin 6 (IL 6), and tumor necrosis factor (TNF) in the rat. Cytokine 2: 300-306, 1990.
22. Linas SL, Whittenburg D, and Repine JE. Role of neutrophil derived oxidants and elastase in lipopolysaccharide-mediated renal injury. Kidney Int 39: 618-623, 1991.
23. Lorenz JN and Gruenstein E. A simple, nonradioactive method for evaluating single-nephron filtration rate using FITC-inulin. Am J Physiol Renal Physiol 276: F172-F177, 1999.
24. Marukawa S, Hatake K, Wakabayashi I, and Hishida S. Vasorelaxant effects of oxpentifylline and theophylline on rat isolated aorta. J Pharm Pharmacol 46: 342-345, 1994.
25. Michie HR, Manogue KR, Spriggs DR, Revhaug A, O'Dwyer S, Dinarella CA, Cerami A, Wolff SM, and Wilmore DW. Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med 318: 1481-1486, 1988.
26. Morris SM Jr and Billiar TR. New insights into the regulation of inducible nitric oxide synthesis. Am J Physiol Endocrinol Metab 266: E829-E839, 1994.
27. Muller R and Lebrach F. Hemorheological role of platelet aggregation and hypercoagulability in microcirculation: therapeutical approach with pentoxifylline. Pharmatherapeutica 2: 372-379, 1980.
28. Muller R and Schroer R. Cerebrovascular circulatory disorders: new aspects of pathophysiology and therapy. J Med 10: 347-364, 1979.
29. Poggesi L, Scarti L, Boddi M, Masotti G, and Serneri GG. Pentoxifylline treatment in patients with occlusive peripheral arterial disease. Circulatory changes and effects on prostaglandin synthesis. Angiology 36: 628-637, 1985.
30. + human blood mononuclear cells. J Clin Invest 101: 711-721, 1998.
31. Raeburn CD, Calkins CM, Zimmerman MA, Song Y, Ao L, Banerjee A, Harken AH, and Meng X. ICAM-1 and VCAM-1 mediate endotoxemic myocardial dysfunction independent of neutrophil accumulation. Am J Physiol Regul Integr Comp Physiol 283: R477-R486, 2002.
32. Ramesh G and Reeves WB. TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. J Clin Invest 110: 835-842, 2002.
33. Schrier RW and Wang W. Acute renal failure and sepsis. N Engl J Med 351: 159-169, 2004.
34. Schrier RW, Wang W, Poole B, and Mitra A. Acute renal failure: definitions, diagnosis, pathogenesis, and therapy. J Clin Invest 114: 5-14, 2004.
35. Schwartz D and Blantz RC. Nitric oxide, sepsis, and the kidney. Semin Nephrol 19: 272-276, 1999.
36. Schwartz D, Mendonca M, Schwartz I, Xia Y, Satriano J, Wilson CB, and Blantz RC. Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated by inducible NOS after lipopolysaccharide administration provokes renal dysfunction in rats. J Clin Invest 100: 439-448, 1997.
37. Singbartl K, Bockhorn SG, Zarbock A, Schmolke M, and Van Aken H. T cells modulate neutrophil-dependent acute renal failure during endotoxemia: critical role for CD28. J Am Soc Nephrol 16: 720-728, 2005.
38. Smith CW, Entman ML, Lane CL, Beaudet AL, Ty TI, Youcker K, Hawkins HK, and Anderson DC. Adherence of neutrophils to canine cardiac myocytes in vitro is dependent on intercellular adhesion molecule-1. J Clin Invest 88: 1216-1223, 1991.
39. Sullivan GW, Carper HT, Novick WJ Jr, and Mandell GL. Inhibition of the inflammatory action of interleukin-1 and tumor necrosis factor (α) on neutrophil function by pentoxifylline. Infect Immun 56: 1722-1729, 1988.
40. Teicher BA, Holden SA, Herman TS, Epelbaum R, Pardee AB, and Dezube B. Efficacy of pentoxifylline as a modulator of alkylating agent activity in vitro and in vivo. Anticancer Res 11: 1555-1560, 1991.
41. Thiemermann C. Nitric oxide and septic shock. Gen Pharmacol 29: 159-166, 1997.
42. Traynor TR and Schnermann J. Renin-angiotensin system dependence of renal hemodynamics in mice. J Am Soc Nephrol 10, Suppl 11: S184-S188, 1999.
43. Wang W, Falk SA, Jittikanont S, Gengaro PE, Edelstein CL, and Schrier RW. Protective effect of renal denervation on normotensive endotoxemia- induced acute renal failure in mice. Am J Physiol Renal Physiol 283: F583-F587, 2002.
44. Wang W, Faubel S, Ljubanovic D, Mitra A, Falk SA, Kim J, Tao Y, Soloviev S, Reznikov LL, Dinarello CA, Schrier RW, and Edelstein CL. Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice. Am J Physiol Renal Physiol 288: F997-F1004, 2005.
45. Wang W, Mitra A, Poole B, Falk S, Lucia MS, Tayal S, and Schrier RW. Endothelial nitric oxide synthase-deficient mice exhibit increased susceptibility to endotoxin-induced acute renal failure. Am J Physiol Renal Physiol 287: F1044-F1048, 2004.
46. Zabel P, Schade FU, and Schlaak M. Inhibition of endogenous TNF formation by pentoxifylline. Immunobiology 187: 447-463, 1993.